Conserved plasma membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBV4_LEIBR

TriTrypDb:

LbrM.21.1170 , LBRM2903_210016300

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.636
CLV_PCSK_KEX2_1	105	107	PF00082	0.470
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.510
CLV_PCSK_SKI1_1	10	14	PF00082	0.437
CLV_PCSK_SKI1_1	150	154	PF00082	0.543
CLV_PCSK_SKI1_1	210	214	PF00082	0.594
DOC_CYCLIN_RxL_1	182	194	PF00134	0.520
DOC_CYCLIN_RxL_1	7	17	PF00134	0.555
DOC_MAPK_gen_1	123	130	PF00069	0.305
DOC_MAPK_gen_1	182	191	PF00069	0.454
DOC_MAPK_gen_1	281	288	PF00069	0.451
DOC_PP1_RVXF_1	148	155	PF00149	0.273
DOC_PP1_RVXF_1	180	186	PF00149	0.415
DOC_PP4_FxxP_1	311	314	PF00568	0.325
DOC_PP4_FxxP_1	331	334	PF00568	0.558
DOC_USP7_UBL2_3	14	18	PF12436	0.534
DOC_WW_Pin1_4	1	6	PF00397	0.684
DOC_WW_Pin1_4	42	47	PF00397	0.669
LIG_Actin_WH2_2	196	212	PF00022	0.433
LIG_Actin_WH2_2	89	107	PF00022	0.484
LIG_BIR_III_2	211	215	PF00653	0.368
LIG_BRCT_BRCA1_1	44	48	PF00533	0.523
LIG_BRCT_BRCA1_2	44	50	PF00533	0.524
LIG_EH_1	303	307	PF12763	0.365
LIG_eIF4E_1	320	326	PF01652	0.190
LIG_FHA_1	142	148	PF00498	0.438
LIG_FHA_1	259	265	PF00498	0.529
LIG_FHA_1	85	91	PF00498	0.308
LIG_FHA_1	93	99	PF00498	0.321
LIG_FHA_2	297	303	PF00498	0.566
LIG_FHA_2	314	320	PF00498	0.194
LIG_LIR_Gen_1	107	115	PF02991	0.353
LIG_LIR_Gen_1	26	34	PF02991	0.584
LIG_LIR_Gen_1	319	326	PF02991	0.337
LIG_LIR_Gen_1	53	58	PF02991	0.674
LIG_LIR_Gen_1	85	93	PF02991	0.330
LIG_LIR_Nem_3	107	111	PF02991	0.352
LIG_LIR_Nem_3	201	205	PF02991	0.387
LIG_LIR_Nem_3	26	30	PF02991	0.579
LIG_LIR_Nem_3	319	323	PF02991	0.445
LIG_LIR_Nem_3	53	57	PF02991	0.661
LIG_LIR_Nem_3	85	89	PF02991	0.362
LIG_MLH1_MIPbox_1	44	48	PF16413	0.523
LIG_Pex14_2	311	315	PF04695	0.372
LIG_Rb_LxCxE_1	94	107	PF01857	0.390
LIG_SH2_CRK	54	58	PF00017	0.689
LIG_SH2_CRK	86	90	PF00017	0.355
LIG_SH2_GRB2like	112	115	PF00017	0.355
LIG_SH2_NCK_1	115	119	PF00017	0.418
LIG_SH2_PTP2	202	205	PF00017	0.398
LIG_SH2_STAP1	115	119	PF00017	0.387
LIG_SH2_STAP1	320	324	PF00017	0.190
LIG_SH2_STAP1	54	58	PF00017	0.655
LIG_SH2_STAP1	86	90	PF00017	0.328
LIG_SH2_STAT5	202	205	PF00017	0.366
LIG_SH2_STAT5	47	50	PF00017	0.620
LIG_SH2_STAT5	86	89	PF00017	0.344
LIG_SH3_2	5	10	PF14604	0.514
LIG_SH3_3	2	8	PF00018	0.643
LIG_SUMO_SIM_par_1	87	95	PF11976	0.306
LIG_TRAF2_1	204	207	PF00917	0.249
LIG_UBA3_1	12	19	PF00899	0.585
MOD_CDC14_SPxK_1	7	10	PF00782	0.612
MOD_CDK_SPxK_1	4	10	PF00069	0.623
MOD_CK1_1	238	244	PF00069	0.386
MOD_CK1_1	4	10	PF00069	0.660
MOD_CK2_1	296	302	PF00069	0.375
MOD_CK2_1	313	319	PF00069	0.284
MOD_GlcNHglycan	240	243	PF01048	0.364
MOD_GSK3_1	141	148	PF00069	0.406
MOD_NEK2_1	104	109	PF00069	0.383
MOD_NEK2_1	185	190	PF00069	0.339
MOD_NEK2_1	191	196	PF00069	0.328
MOD_NEK2_1	235	240	PF00069	0.356
MOD_NEK2_1	246	251	PF00069	0.367
MOD_NEK2_1	82	87	PF00069	0.399
MOD_OFUCOSY	142	149	PF10250	0.492
MOD_Plk_1	273	279	PF00069	0.609
MOD_Plk_2-3	273	279	PF00069	0.618
MOD_Plk_4	235	241	PF00069	0.304
MOD_Plk_4	84	90	PF00069	0.348
MOD_ProDKin_1	1	7	PF00069	0.676
MOD_ProDKin_1	42	48	PF00069	0.671
MOD_SUMO_for_1	65	68	PF00179	0.485
MOD_SUMO_rev_2	102	107	PF00179	0.393
TRG_DiLeu_BaEn_1	94	99	PF01217	0.408
TRG_DiLeu_BaEn_3	68	74	PF01217	0.445
TRG_ENDOCYTIC_2	202	205	PF00928	0.362
TRG_ENDOCYTIC_2	320	323	PF00928	0.432
TRG_ENDOCYTIC_2	54	57	PF00928	0.690
TRG_ENDOCYTIC_2	86	89	PF00928	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II52	Leptomonas seymouri	58%	98%
A0A0S4JMI1	Bodo saltans	32%	100%
A0A1X0NXQ9	Trypanosomatidae	32%	98%
A0A3S5H798	Leishmania donovani	73%	100%
A0A422NWG5	Trypanosoma rangeli	36%	100%
D0A1C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
E9AGW2	Leishmania infantum	73%	100%
E9AV78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QCA2	Leishmania major	75%	100%
V5BFJ0	Trypanosoma cruzi	32%	99%