Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4499), putative

Species:

Leishmania braziliensis

UniProt:

A4HBU7_LEIBR

TriTrypDb:

LbrM.21.1100 , LBRM2903_210015900

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.274
CLV_PCSK_KEX2_1	35	37	PF00082	0.278
CLV_PCSK_KEX2_1	79	81	PF00082	0.631
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.599
CLV_PCSK_PC7_1	31	37	PF00082	0.313
CLV_PCSK_SKI1_1	118	122	PF00082	0.393
CLV_PCSK_SKI1_1	80	84	PF00082	0.635
DOC_CYCLIN_RxL_1	115	123	PF00134	0.230
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.258
DOC_MAPK_DCC_7	35	44	PF00069	0.452
DOC_MAPK_MEF2A_6	35	44	PF00069	0.520
DOC_MAPK_RevD_3	183	198	PF00069	0.262
DOC_MAPK_RevD_3	66	80	PF00069	0.229
DOC_PP1_RVXF_1	145	151	PF00149	0.531
DOC_USP7_MATH_1	2	6	PF00917	0.704
DOC_WW_Pin1_4	172	177	PF00397	0.320
LIG_14-3-3_CanoR_1	147	157	PF00244	0.488
LIG_Actin_WH2_2	69	86	PF00022	0.318
LIG_APCC_ABBA_1	101	106	PF00400	0.286
LIG_FHA_1	17	23	PF00498	0.669
LIG_FHA_1	189	195	PF00498	0.423
LIG_FHA_1	92	98	PF00498	0.461
LIG_HP1_1	43	47	PF01393	0.193
LIG_NRBOX	45	51	PF00104	0.242
LIG_Pex14_2	121	125	PF04695	0.246
LIG_Pex14_2	146	150	PF04695	0.482
LIG_SH2_CRK	34	38	PF00017	0.505
LIG_SH2_SRC	72	75	PF00017	0.231
LIG_SH2_STAT5	164	167	PF00017	0.192
LIG_SH2_STAT5	53	56	PF00017	0.235
LIG_SH2_STAT5	72	75	PF00017	0.428
LIG_SH3_1	34	40	PF00018	0.443
LIG_SH3_2	23	28	PF14604	0.550
LIG_SH3_3	20	26	PF00018	0.619
LIG_SH3_3	34	40	PF00018	0.444
LIG_SH3_3	64	70	PF00018	0.295
LIG_SUMO_SIM_anti_2	64	71	PF11976	0.232
LIG_SUMO_SIM_par_1	64	71	PF11976	0.416
LIG_TRAF2_1	190	193	PF00917	0.363
MOD_GlcNHglycan	13	16	PF01048	0.453
MOD_GSK3_1	105	112	PF00069	0.263
MOD_GSK3_1	11	18	PF00069	0.639
MOD_GSK3_1	148	155	PF00069	0.471
MOD_N-GLC_1	152	157	PF02516	0.282
MOD_NEK2_1	105	110	PF00069	0.302
MOD_NEK2_1	120	125	PF00069	0.247
MOD_NEK2_1	163	168	PF00069	0.390
MOD_OFUCOSY	145	152	PF10250	0.331
MOD_PIKK_1	169	175	PF00454	0.314
MOD_PKA_2	188	194	PF00069	0.364
MOD_Plk_1	105	111	PF00069	0.384
MOD_Plk_1	152	158	PF00069	0.528
MOD_Plk_4	105	111	PF00069	0.340
MOD_Plk_4	152	158	PF00069	0.575
MOD_ProDKin_1	172	178	PF00069	0.320
MOD_SUMO_rev_2	187	196	PF00179	0.266
MOD_SUMO_rev_2	3	8	PF00179	0.664
TRG_DiLeu_BaEn_1	64	69	PF01217	0.259
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.267
TRG_ENDOCYTIC_2	53	56	PF00928	0.280
TRG_ER_diArg_1	34	36	PF00400	0.484
TRG_ER_diLys_1	195	200	PF00400	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P5	Leptomonas seymouri	48%	100%
A0A0S4IZY4	Bodo saltans	31%	100%
A0A1X0NXR6	Trypanosomatidae	39%	100%
A0A3Q8IAC8	Leishmania donovani	67%	99%
A0A3R7KU69	Trypanosoma rangeli	36%	100%
D0A1C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AGV3	Leishmania infantum	67%	99%
E9AV69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%
Q4QCB2	Leishmania major	69%	100%