DUF4042 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBU4_LEIBR

TriTrypDb:

LbrM.21.1070 , LBRM2903_210015600

Length:

1140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.594
CLV_C14_Caspase3-7	234	238	PF00656	0.835
CLV_C14_Caspase3-7	570	574	PF00656	0.473
CLV_C14_Caspase3-7	721	725	PF00656	0.369
CLV_C14_Caspase3-7	823	827	PF00656	0.601
CLV_C14_Caspase3-7	847	851	PF00656	0.328
CLV_C14_Caspase3-7	985	989	PF00656	0.592
CLV_NRD_NRD_1	66	68	PF00675	0.710
CLV_NRD_NRD_1	782	784	PF00675	0.525
CLV_PCSK_FUR_1	780	784	PF00082	0.517
CLV_PCSK_KEX2_1	65	67	PF00082	0.694
CLV_PCSK_KEX2_1	782	784	PF00082	0.525
CLV_PCSK_SKI1_1	1107	1111	PF00082	0.593
CLV_PCSK_SKI1_1	1125	1129	PF00082	0.335
CLV_PCSK_SKI1_1	542	546	PF00082	0.476
CLV_PCSK_SKI1_1	789	793	PF00082	0.447
CLV_PCSK_SKI1_1	875	879	PF00082	0.464
CLV_PCSK_SKI1_1	958	962	PF00082	0.452
CLV_Separin_Metazoa	773	777	PF03568	0.481
DEG_APCC_DBOX_1	1106	1114	PF00400	0.594
DEG_APCC_DBOX_1	730	738	PF00400	0.441
DEG_APCC_DBOX_1	957	965	PF00400	0.406
DEG_SCF_FBW7_2	11	18	PF00400	0.600
DEG_SPOP_SBC_1	283	287	PF00917	0.610
DEG_SPOP_SBC_1	718	722	PF00917	0.551
DOC_CDC14_PxL_1	71	79	PF14671	0.588
DOC_CKS1_1	167	172	PF01111	0.816
DOC_CYCLIN_RxL_1	955	962	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	281	284	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	384	390	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	671	677	PF00134	0.612
DOC_MAPK_DCC_7	65	73	PF00069	0.572
DOC_MAPK_gen_1	496	505	PF00069	0.473
DOC_MAPK_gen_1	65	73	PF00069	0.572
DOC_MAPK_MEF2A_6	1107	1114	PF00069	0.599
DOC_MAPK_MEF2A_6	134	143	PF00069	0.495
DOC_MAPK_MEF2A_6	65	73	PF00069	0.572
DOC_PP1_RVXF_1	1015	1022	PF00149	0.319
DOC_PP1_SILK_1	533	538	PF00149	0.335
DOC_PP2B_LxvP_1	281	284	PF13499	0.608
DOC_PP2B_LxvP_1	508	511	PF13499	0.488
DOC_PP2B_PxIxI_1	249	255	PF00149	0.494
DOC_PP4_FxxP_1	167	170	PF00568	0.561
DOC_USP7_MATH_1	1105	1109	PF00917	0.538
DOC_USP7_MATH_1	1117	1121	PF00917	0.472
DOC_USP7_MATH_1	128	132	PF00917	0.524
DOC_USP7_MATH_1	189	193	PF00917	0.558
DOC_USP7_MATH_1	284	288	PF00917	0.798
DOC_USP7_MATH_1	644	648	PF00917	0.646
DOC_USP7_MATH_1	656	660	PF00917	0.499
DOC_USP7_MATH_1	663	667	PF00917	0.760
DOC_USP7_MATH_1	713	717	PF00917	0.690
DOC_USP7_MATH_1	719	723	PF00917	0.606
DOC_USP7_MATH_1	808	812	PF00917	0.641
DOC_USP7_MATH_1	856	860	PF00917	0.465
DOC_USP7_UBL2_3	1132	1136	PF12436	0.451
DOC_WW_Pin1_4	1115	1120	PF00397	0.652
DOC_WW_Pin1_4	166	171	PF00397	0.713
DOC_WW_Pin1_4	191	196	PF00397	0.683
DOC_WW_Pin1_4	20	25	PF00397	0.760
DOC_WW_Pin1_4	223	228	PF00397	0.581
DOC_WW_Pin1_4	246	251	PF00397	0.551
DOC_WW_Pin1_4	489	494	PF00397	0.417
DOC_WW_Pin1_4	543	548	PF00397	0.501
DOC_WW_Pin1_4	7	12	PF00397	0.787
DOC_WW_Pin1_4	707	712	PF00397	0.786
DOC_WW_Pin1_4	895	900	PF00397	0.500
DOC_WW_Pin1_4	92	97	PF00397	0.728
LIG_14-3-3_CanoR_1	239	245	PF00244	0.823
LIG_14-3-3_CanoR_1	293	298	PF00244	0.624
LIG_14-3-3_CanoR_1	761	765	PF00244	0.524
LIG_14-3-3_CanoR_1	789	794	PF00244	0.416
LIG_14-3-3_CanoR_1	886	894	PF00244	0.360
LIG_Actin_WH2_2	528	544	PF00022	0.355
LIG_APCC_ABBAyCdc20_2	767	773	PF00400	0.488
LIG_BIR_III_2	826	830	PF00653	0.625
LIG_BRCT_BRCA1_1	192	196	PF00533	0.805
LIG_deltaCOP1_diTrp_1	809	816	PF00928	0.394
LIG_FHA_1	1035	1041	PF00498	0.465
LIG_FHA_1	1071	1077	PF00498	0.422
LIG_FHA_1	247	253	PF00498	0.570
LIG_FHA_1	337	343	PF00498	0.464
LIG_FHA_1	358	364	PF00498	0.489
LIG_FHA_1	405	411	PF00498	0.429
LIG_FHA_1	45	51	PF00498	0.407
LIG_FHA_1	505	511	PF00498	0.582
LIG_FHA_1	527	533	PF00498	0.561
LIG_FHA_1	538	544	PF00498	0.513
LIG_FHA_1	718	724	PF00498	0.580
LIG_FHA_1	788	794	PF00498	0.449
LIG_FHA_1	836	842	PF00498	0.542
LIG_FHA_1	882	888	PF00498	0.415
LIG_FHA_1	95	101	PF00498	0.755
LIG_FHA_2	1066	1072	PF00498	0.636
LIG_FHA_2	1086	1092	PF00498	0.333
LIG_FHA_2	147	153	PF00498	0.578
LIG_FHA_2	251	257	PF00498	0.712
LIG_FHA_2	325	331	PF00498	0.689
LIG_FHA_2	568	574	PF00498	0.647
LIG_FHA_2	589	595	PF00498	0.472
LIG_FHA_2	804	810	PF00498	0.625
LIG_FHA_2	845	851	PF00498	0.576
LIG_FHA_2	935	941	PF00498	0.568
LIG_GBD_Chelix_1	1076	1084	PF00786	0.472
LIG_LIR_Apic_2	164	170	PF02991	0.557
LIG_LIR_Apic_2	659	665	PF02991	0.545
LIG_LIR_Apic_2	79	84	PF02991	0.828
LIG_LIR_Gen_1	483	493	PF02991	0.454
LIG_LIR_Gen_1	613	622	PF02991	0.482
LIG_LIR_Gen_1	850	860	PF02991	0.458
LIG_LIR_Gen_1	937	945	PF02991	0.489
LIG_LIR_Gen_1	954	964	PF02991	0.449
LIG_LIR_Nem_3	1090	1096	PF02991	0.590
LIG_LIR_Nem_3	360	365	PF02991	0.494
LIG_LIR_Nem_3	447	453	PF02991	0.465
LIG_LIR_Nem_3	483	488	PF02991	0.417
LIG_LIR_Nem_3	603	609	PF02991	0.526
LIG_LIR_Nem_3	613	617	PF02991	0.432
LIG_LIR_Nem_3	732	736	PF02991	0.434
LIG_LIR_Nem_3	814	819	PF02991	0.474
LIG_LIR_Nem_3	850	855	PF02991	0.467
LIG_LIR_Nem_3	937	941	PF02991	0.475
LIG_LIR_Nem_3	954	959	PF02991	0.444
LIG_LYPXL_S_1	605	609	PF13949	0.487
LIG_LYPXL_yS_3	606	609	PF13949	0.490
LIG_MYND_1	364	368	PF01753	0.484
LIG_MYND_1	383	387	PF01753	0.498
LIG_NRBOX	405	411	PF00104	0.455
LIG_NRBOX	956	962	PF00104	0.445
LIG_PCNA_PIPBox_1	509	518	PF02747	0.481
LIG_PCNA_PIPBox_1	599	608	PF02747	0.475
LIG_Pex14_1	812	816	PF04695	0.323
LIG_Pex14_1	842	846	PF04695	0.458
LIG_PTAP_UEV_1	469	474	PF05743	0.476
LIG_SH2_CRK	485	489	PF00017	0.442
LIG_SH2_CRK	81	85	PF00017	0.790
LIG_SH2_NCK_1	81	85	PF00017	0.674
LIG_SH2_STAP1	1027	1031	PF00017	0.457
LIG_SH2_STAP1	485	489	PF00017	0.405
LIG_SH2_STAT3	1096	1099	PF00017	0.551
LIG_SH2_STAT5	1067	1070	PF00017	0.644
LIG_SH2_STAT5	145	148	PF00017	0.495
LIG_SH2_STAT5	739	742	PF00017	0.472
LIG_SH2_STAT5	803	806	PF00017	0.407
LIG_SH2_STAT5	819	822	PF00017	0.559
LIG_SH2_STAT5	846	849	PF00017	0.566
LIG_SH2_STAT5	901	904	PF00017	0.479
LIG_SH3_1	315	321	PF00018	0.592
LIG_SH3_1	66	72	PF00018	0.779
LIG_SH3_3	106	112	PF00018	0.814
LIG_SH3_3	124	130	PF00018	0.614
LIG_SH3_3	167	173	PF00018	0.678
LIG_SH3_3	315	321	PF00018	0.592
LIG_SH3_3	33	39	PF00018	0.734
LIG_SH3_3	358	364	PF00018	0.489
LIG_SH3_3	377	383	PF00018	0.315
LIG_SH3_3	467	473	PF00018	0.624
LIG_SH3_3	66	72	PF00018	0.732
LIG_SH3_3	671	677	PF00018	0.564
LIG_SH3_3	686	692	PF00018	0.813
LIG_Sin3_3	346	353	PF02671	0.311
LIG_SUMO_SIM_anti_2	1108	1116	PF11976	0.611
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.501
LIG_SUMO_SIM_anti_2	500	507	PF11976	0.311
LIG_SUMO_SIM_par_1	249	257	PF11976	0.516
LIG_SUMO_SIM_par_1	40	45	PF11976	0.642
LIG_SUMO_SIM_par_1	487	492	PF11976	0.451
LIG_SUMO_SIM_par_1	500	507	PF11976	0.462
LIG_TRAF2_1	937	940	PF00917	0.586
LIG_UBA3_1	960	967	PF00899	0.337
LIG_WRC_WIRS_1	935	940	PF05994	0.471
LIG_WW_2	38	41	PF00397	0.447
LIG_WW_2	69	72	PF00397	0.654
MOD_CDK_SPxxK_3	489	496	PF00069	0.464
MOD_CK1_1	158	164	PF00069	0.714
MOD_CK1_1	26	32	PF00069	0.798
MOD_CK1_1	286	292	PF00069	0.728
MOD_CK1_1	306	312	PF00069	0.659
MOD_CK1_1	316	322	PF00069	0.609
MOD_CK1_1	468	474	PF00069	0.556
MOD_CK1_1	654	660	PF00069	0.513
MOD_CK1_1	881	887	PF00069	0.349
MOD_CK1_1	888	894	PF00069	0.528
MOD_CK1_1	92	98	PF00069	0.690
MOD_CK2_1	1085	1091	PF00069	0.549
MOD_CK2_1	145	151	PF00069	0.623
MOD_CK2_1	330	336	PF00069	0.521
MOD_CK2_1	441	447	PF00069	0.443
MOD_CK2_1	588	594	PF00069	0.475
MOD_CK2_1	682	688	PF00069	0.670
MOD_CK2_1	808	814	PF00069	0.513
MOD_CK2_1	934	940	PF00069	0.471
MOD_GlcNHglycan	104	107	PF01048	0.551
MOD_GlcNHglycan	1063	1066	PF01048	0.531
MOD_GlcNHglycan	1107	1110	PF01048	0.541
MOD_GlcNHglycan	1115	1118	PF01048	0.518
MOD_GlcNHglycan	119	123	PF01048	0.625
MOD_GlcNHglycan	130	133	PF01048	0.621
MOD_GlcNHglycan	157	160	PF01048	0.661
MOD_GlcNHglycan	164	167	PF01048	0.670
MOD_GlcNHglycan	20	23	PF01048	0.810
MOD_GlcNHglycan	205	208	PF01048	0.827
MOD_GlcNHglycan	221	224	PF01048	0.606
MOD_GlcNHglycan	25	28	PF01048	0.837
MOD_GlcNHglycan	286	289	PF01048	0.576
MOD_GlcNHglycan	304	308	PF01048	0.716
MOD_GlcNHglycan	310	314	PF01048	0.745
MOD_GlcNHglycan	315	318	PF01048	0.671
MOD_GlcNHglycan	462	465	PF01048	0.727
MOD_GlcNHglycan	470	473	PF01048	0.625
MOD_GlcNHglycan	474	477	PF01048	0.534
MOD_GlcNHglycan	646	649	PF01048	0.590
MOD_GlcNHglycan	665	668	PF01048	0.803
MOD_GlcNHglycan	684	687	PF01048	0.724
MOD_GlcNHglycan	698	703	PF01048	0.569
MOD_GlcNHglycan	822	825	PF01048	0.498
MOD_GlcNHglycan	858	861	PF01048	0.557
MOD_GlcNHglycan	91	94	PF01048	0.641
MOD_GlcNHglycan	918	921	PF01048	0.607
MOD_GlcNHglycan	977	980	PF01048	0.735
MOD_GlcNHglycan	984	987	PF01048	0.719
MOD_GSK3_1	1061	1068	PF00069	0.558
MOD_GSK3_1	1072	1079	PF00069	0.347
MOD_GSK3_1	1083	1090	PF00069	0.431
MOD_GSK3_1	1113	1120	PF00069	0.479
MOD_GSK3_1	154	161	PF00069	0.677
MOD_GSK3_1	162	169	PF00069	0.689
MOD_GSK3_1	203	210	PF00069	0.828
MOD_GSK3_1	215	222	PF00069	0.651
MOD_GSK3_1	239	246	PF00069	0.710
MOD_GSK3_1	248	255	PF00069	0.707
MOD_GSK3_1	26	33	PF00069	0.784
MOD_GSK3_1	282	289	PF00069	0.725
MOD_GSK3_1	302	309	PF00069	0.587
MOD_GSK3_1	437	444	PF00069	0.461
MOD_GSK3_1	44	51	PF00069	0.581
MOD_GSK3_1	468	475	PF00069	0.710
MOD_GSK3_1	480	487	PF00069	0.326
MOD_GSK3_1	526	533	PF00069	0.472
MOD_GSK3_1	567	574	PF00069	0.504
MOD_GSK3_1	584	591	PF00069	0.577
MOD_GSK3_1	651	658	PF00069	0.584
MOD_GSK3_1	663	670	PF00069	0.703
MOD_GSK3_1	687	694	PF00069	0.636
MOD_GSK3_1	7	14	PF00069	0.761
MOD_GSK3_1	713	720	PF00069	0.670
MOD_GSK3_1	73	80	PF00069	0.779
MOD_GSK3_1	815	822	PF00069	0.507
MOD_GSK3_1	881	888	PF00069	0.319
MOD_GSK3_1	901	908	PF00069	0.429
MOD_N-GLC_1	357	362	PF02516	0.487
MOD_N-GLC_1	394	399	PF02516	0.637
MOD_N-GLC_1	537	542	PF02516	0.476
MOD_N-GLC_1	746	751	PF02516	0.711
MOD_N-GLC_1	881	886	PF02516	0.404
MOD_NEK2_1	1063	1068	PF00069	0.527
MOD_NEK2_1	1072	1077	PF00069	0.472
MOD_NEK2_1	1113	1118	PF00069	0.496
MOD_NEK2_1	155	160	PF00069	0.549
MOD_NEK2_1	240	245	PF00069	0.597
MOD_NEK2_1	30	35	PF00069	0.703
MOD_NEK2_1	357	362	PF00069	0.487
MOD_NEK2_1	44	49	PF00069	0.346
MOD_NEK2_1	441	446	PF00069	0.451
MOD_NEK2_1	481	486	PF00069	0.459
MOD_NEK2_1	531	536	PF00069	0.344
MOD_NEK2_1	618	623	PF00069	0.478
MOD_NEK2_1	878	883	PF00069	0.481
MOD_NEK2_1	905	910	PF00069	0.425
MOD_PIKK_1	1046	1052	PF00454	0.462
MOD_PIKK_1	316	322	PF00454	0.590
MOD_PIKK_1	45	51	PF00454	0.630
MOD_PIKK_1	52	58	PF00454	0.653
MOD_PIKK_1	526	532	PF00454	0.506
MOD_PK_1	215	221	PF00069	0.687
MOD_PK_1	687	693	PF00069	0.584
MOD_PKA_2	128	134	PF00069	0.600
MOD_PKA_2	238	244	PF00069	0.723
MOD_PKA_2	413	419	PF00069	0.627
MOD_PKA_2	57	63	PF00069	0.701
MOD_PKA_2	760	766	PF00069	0.523
MOD_PKA_2	885	891	PF00069	0.351
MOD_PKA_2	968	974	PF00069	0.571
MOD_PKA_2	982	988	PF00069	0.567
MOD_Plk_1	303	309	PF00069	0.764
MOD_Plk_1	330	336	PF00069	0.428
MOD_Plk_1	357	363	PF00069	0.482
MOD_Plk_1	394	400	PF00069	0.586
MOD_Plk_1	537	543	PF00069	0.489
MOD_Plk_1	808	814	PF00069	0.517
MOD_Plk_2-3	1098	1104	PF00069	0.507
MOD_Plk_2-3	324	330	PF00069	0.807
MOD_Plk_2-3	940	946	PF00069	0.500
MOD_Plk_4	1072	1078	PF00069	0.474
MOD_Plk_4	357	363	PF00069	0.482
MOD_Plk_4	437	443	PF00069	0.410
MOD_Plk_4	445	451	PF00069	0.416
MOD_Plk_4	484	490	PF00069	0.553
MOD_Plk_4	531	537	PF00069	0.458
MOD_Plk_4	624	630	PF00069	0.332
MOD_Plk_4	691	697	PF00069	0.578
MOD_Plk_4	815	821	PF00069	0.436
MOD_ProDKin_1	1115	1121	PF00069	0.654
MOD_ProDKin_1	166	172	PF00069	0.713
MOD_ProDKin_1	191	197	PF00069	0.686
MOD_ProDKin_1	20	26	PF00069	0.759
MOD_ProDKin_1	223	229	PF00069	0.577
MOD_ProDKin_1	246	252	PF00069	0.542
MOD_ProDKin_1	489	495	PF00069	0.424
MOD_ProDKin_1	543	549	PF00069	0.510
MOD_ProDKin_1	7	13	PF00069	0.788
MOD_ProDKin_1	707	713	PF00069	0.784
MOD_ProDKin_1	895	901	PF00069	0.496
MOD_ProDKin_1	92	98	PF00069	0.728
MOD_SUMO_for_1	536	539	PF00179	0.392
MOD_SUMO_rev_2	1018	1028	PF00179	0.474
TRG_DiLeu_BaEn_1	613	618	PF01217	0.479
TRG_DiLeu_BaEn_2	520	526	PF01217	0.606
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.570
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.482
TRG_ENDOCYTIC_2	485	488	PF00928	0.443
TRG_ENDOCYTIC_2	606	609	PF00928	0.490
TRG_ENDOCYTIC_2	846	849	PF00928	0.464
TRG_ER_diArg_1	498	501	PF00400	0.484
TRG_ER_diArg_1	65	67	PF00400	0.704
TRG_ER_diArg_1	779	782	PF00400	0.514
TRG_ER_diArg_1	829	832	PF00400	0.493
TRG_NES_CRM1_1	1122	1137	PF08389	0.502
TRG_NES_CRM1_1	506	521	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	958	962	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M1	Leptomonas seymouri	54%	89%
A0A3Q8IBY1	Leishmania donovani	76%	89%
E9AGV0	Leishmania infantum	76%	89%
E9AV66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	90%
Q4QCB5	Leishmania major	76%	100%