LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HBU3_LEIBR
TriTrypDb:
LbrM.21.1060 , LBRM2903_210015500 *
Length:
849

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HBU3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBU3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0019538 protein metabolic process 3 5
GO:0036211 protein modification process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0043412 macromolecule modification 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004672 protein kinase activity 3 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 5
GO:0017076 purine nucleotide binding 4 5
GO:0030554 adenyl nucleotide binding 5 5
GO:0032553 ribonucleotide binding 3 5
GO:0032555 purine ribonucleotide binding 4 5
GO:0032559 adenyl ribonucleotide binding 5 5
GO:0035639 purine ribonucleoside triphosphate binding 4 5
GO:0036094 small molecule binding 2 5
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:0097367 carbohydrate derivative binding 2 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:1901265 nucleoside phosphate binding 3 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 708 712 PF00656 0.506
CLV_NRD_NRD_1 127 129 PF00675 0.443
CLV_NRD_NRD_1 207 209 PF00675 0.385
CLV_NRD_NRD_1 301 303 PF00675 0.479
CLV_NRD_NRD_1 719 721 PF00675 0.485
CLV_NRD_NRD_1 837 839 PF00675 0.590
CLV_NRD_NRD_1 84 86 PF00675 0.450
CLV_PCSK_KEX2_1 127 129 PF00082 0.494
CLV_PCSK_KEX2_1 207 209 PF00082 0.385
CLV_PCSK_KEX2_1 84 86 PF00082 0.340
CLV_PCSK_SKI1_1 118 122 PF00082 0.389
CLV_PCSK_SKI1_1 533 537 PF00082 0.380
CLV_PCSK_SKI1_1 84 88 PF00082 0.357
CLV_Separin_Metazoa 367 371 PF03568 0.344
DEG_APCC_DBOX_1 354 362 PF00400 0.428
DEG_SCF_FBW7_1 677 684 PF00400 0.638
DEG_SCF_FBW7_1 685 692 PF00400 0.473
DEG_SPOP_SBC_1 59 63 PF00917 0.430
DEG_SPOP_SBC_1 620 624 PF00917 0.669
DEG_SPOP_SBC_1 633 637 PF00917 0.455
DEG_SPOP_SBC_1 752 756 PF00917 0.474
DOC_CDC14_PxL_1 774 782 PF14671 0.478
DOC_CKS1_1 18 23 PF01111 0.463
DOC_CKS1_1 409 414 PF01111 0.401
DOC_CKS1_1 42 47 PF01111 0.377
DOC_CKS1_1 686 691 PF01111 0.633
DOC_CKS1_1 739 744 PF01111 0.473
DOC_CYCLIN_RxL_1 3 13 PF00134 0.509
DOC_CYCLIN_yCln2_LP_2 625 631 PF00134 0.456
DOC_CYCLIN_yCln2_LP_2 739 745 PF00134 0.472
DOC_MAPK_gen_1 207 213 PF00069 0.420
DOC_MAPK_gen_1 84 91 PF00069 0.338
DOC_MAPK_MEF2A_6 504 513 PF00069 0.305
DOC_PP2B_LxvP_1 294 297 PF13499 0.481
DOC_PP2B_LxvP_1 566 569 PF13499 0.326
DOC_PP2B_LxvP_1 625 628 PF13499 0.454
DOC_PP2B_LxvP_1 89 92 PF13499 0.346
DOC_PP4_FxxP_1 360 363 PF00568 0.368
DOC_PP4_FxxP_1 42 45 PF00568 0.263
DOC_PP4_FxxP_1 56 59 PF00568 0.267
DOC_USP7_MATH_1 155 159 PF00917 0.398
DOC_USP7_MATH_1 304 308 PF00917 0.260
DOC_USP7_MATH_1 438 442 PF00917 0.239
DOC_USP7_MATH_1 477 481 PF00917 0.490
DOC_USP7_MATH_1 547 551 PF00917 0.310
DOC_USP7_MATH_1 59 63 PF00917 0.467
DOC_USP7_MATH_1 614 618 PF00917 0.546
DOC_USP7_MATH_1 66 70 PF00917 0.571
DOC_USP7_MATH_1 668 672 PF00917 0.654
DOC_USP7_MATH_1 710 714 PF00917 0.631
DOC_USP7_MATH_1 773 777 PF00917 0.604
DOC_USP7_MATH_1 790 794 PF00917 0.704
DOC_USP7_MATH_2 218 224 PF00917 0.483
DOC_USP7_UBL2_3 836 840 PF12436 0.576
DOC_WW_Pin1_4 17 22 PF00397 0.443
DOC_WW_Pin1_4 30 35 PF00397 0.397
DOC_WW_Pin1_4 408 413 PF00397 0.420
DOC_WW_Pin1_4 41 46 PF00397 0.390
DOC_WW_Pin1_4 516 521 PF00397 0.485
DOC_WW_Pin1_4 569 574 PF00397 0.436
DOC_WW_Pin1_4 649 654 PF00397 0.586
DOC_WW_Pin1_4 664 669 PF00397 0.747
DOC_WW_Pin1_4 672 677 PF00397 0.675
DOC_WW_Pin1_4 685 690 PF00397 0.667
DOC_WW_Pin1_4 738 743 PF00397 0.647
DOC_WW_Pin1_4 780 785 PF00397 0.739
DOC_WW_Pin1_4 812 817 PF00397 0.512
LIG_14-3-3_CanoR_1 262 267 PF00244 0.434
LIG_14-3-3_CanoR_1 28 34 PF00244 0.539
LIG_14-3-3_CanoR_1 280 284 PF00244 0.242
LIG_14-3-3_CanoR_1 419 427 PF00244 0.332
LIG_14-3-3_CanoR_1 84 90 PF00244 0.355
LIG_Actin_WH2_2 263 278 PF00022 0.474
LIG_Actin_WH2_2 522 539 PF00022 0.411
LIG_BIR_II_1 1 5 PF00653 0.458
LIG_BIR_III_4 239 243 PF00653 0.357
LIG_BIR_III_4 498 502 PF00653 0.260
LIG_BRCT_BRCA1_1 727 731 PF00533 0.601
LIG_BRCT_BRCA1_2 727 733 PF00533 0.600
LIG_Clathr_ClatBox_1 182 186 PF01394 0.276
LIG_Clathr_ClatBox_1 330 334 PF01394 0.415
LIG_CtBP_PxDLS_1 218 222 PF00389 0.500
LIG_DLG_GKlike_1 262 270 PF00625 0.263
LIG_eIF4E_1 409 415 PF01652 0.341
LIG_eIF4E_1 467 473 PF01652 0.350
LIG_FHA_1 104 110 PF00498 0.327
LIG_FHA_1 137 143 PF00498 0.402
LIG_FHA_1 189 195 PF00498 0.248
LIG_FHA_1 248 254 PF00498 0.409
LIG_FHA_1 265 271 PF00498 0.452
LIG_FHA_1 344 350 PF00498 0.331
LIG_FHA_1 409 415 PF00498 0.416
LIG_FHA_1 419 425 PF00498 0.434
LIG_FHA_1 506 512 PF00498 0.316
LIG_FHA_1 55 61 PF00498 0.417
LIG_FHA_1 583 589 PF00498 0.539
LIG_FHA_1 678 684 PF00498 0.633
LIG_FHA_1 686 692 PF00498 0.621
LIG_FHA_1 748 754 PF00498 0.709
LIG_FHA_2 132 138 PF00498 0.527
LIG_FHA_2 252 258 PF00498 0.454
LIG_FHA_2 42 48 PF00498 0.442
LIG_FHA_2 577 583 PF00498 0.503
LIG_Integrin_isoDGR_2 260 262 PF01839 0.446
LIG_LIR_Apic_2 39 45 PF02991 0.433
LIG_LIR_Apic_2 407 412 PF02991 0.368
LIG_LIR_Apic_2 530 534 PF02991 0.251
LIG_LIR_Apic_2 54 59 PF02991 0.269
LIG_LIR_Nem_3 177 183 PF02991 0.286
LIG_LIR_Nem_3 318 323 PF02991 0.432
LIG_LIR_Nem_3 404 409 PF02991 0.358
LIG_LIR_Nem_3 448 453 PF02991 0.226
LIG_LIR_Nem_3 637 643 PF02991 0.647
LIG_LRP6_Inhibitor_1 78 84 PF00058 0.241
LIG_NRBOX 326 332 PF00104 0.404
LIG_Pex14_1 38 42 PF04695 0.346
LIG_Pex14_2 179 183 PF04695 0.358
LIG_REV1ctd_RIR_1 1 10 PF16727 0.516
LIG_SH2_CRK 215 219 PF00017 0.361
LIG_SH2_CRK 31 35 PF00017 0.444
LIG_SH2_CRK 427 431 PF00017 0.327
LIG_SH2_CRK 459 463 PF00017 0.460
LIG_SH2_CRK 531 535 PF00017 0.402
LIG_SH2_NCK_1 248 252 PF00017 0.389
LIG_SH2_NCK_1 31 35 PF00017 0.383
LIG_SH2_NCK_1 459 463 PF00017 0.429
LIG_SH2_PTP2 409 412 PF00017 0.316
LIG_SH2_STAP1 138 142 PF00017 0.448
LIG_SH2_STAP1 436 440 PF00017 0.260
LIG_SH2_STAP1 467 471 PF00017 0.347
LIG_SH2_STAT3 130 133 PF00017 0.265
LIG_SH2_STAT5 108 111 PF00017 0.284
LIG_SH2_STAT5 138 141 PF00017 0.333
LIG_SH2_STAT5 31 34 PF00017 0.489
LIG_SH2_STAT5 409 412 PF00017 0.316
LIG_SH2_STAT5 453 456 PF00017 0.385
LIG_SH2_STAT5 531 534 PF00017 0.408
LIG_SH3_2 113 118 PF14604 0.316
LIG_SH3_3 110 116 PF00018 0.230
LIG_SH3_3 12 18 PF00018 0.404
LIG_SH3_3 386 392 PF00018 0.244
LIG_SH3_3 626 632 PF00018 0.613
LIG_SH3_3 739 745 PF00018 0.758
LIG_Sin3_3 469 476 PF02671 0.387
LIG_SUMO_SIM_anti_2 328 334 PF11976 0.422
LIG_SUMO_SIM_par_1 525 530 PF11976 0.242
LIG_SUMO_SIM_par_1 572 577 PF11976 0.378
LIG_TRAF2_1 134 137 PF00917 0.299
LIG_TRAF2_1 254 257 PF00917 0.482
LIG_TYR_ITIM 246 251 PF00017 0.267
LIG_TYR_ITIM 425 430 PF00017 0.362
LIG_WRC_WIRS_1 305 310 PF05994 0.256
MOD_CK1_1 174 180 PF00069 0.367
MOD_CK1_1 292 298 PF00069 0.481
MOD_CK1_1 441 447 PF00069 0.301
MOD_CK1_1 460 466 PF00069 0.360
MOD_CK1_1 54 60 PF00069 0.439
MOD_CK1_1 572 578 PF00069 0.470
MOD_CK1_1 580 586 PF00069 0.444
MOD_CK1_1 61 67 PF00069 0.593
MOD_CK1_1 621 627 PF00069 0.659
MOD_CK1_1 649 655 PF00069 0.628
MOD_CK1_1 69 75 PF00069 0.539
MOD_CK1_1 702 708 PF00069 0.724
MOD_CK1_1 729 735 PF00069 0.540
MOD_CK1_1 747 753 PF00069 0.638
MOD_CK1_1 759 765 PF00069 0.578
MOD_CK1_1 783 789 PF00069 0.742
MOD_CK1_1 793 799 PF00069 0.656
MOD_CK2_1 131 137 PF00069 0.404
MOD_CK2_1 251 257 PF00069 0.457
MOD_CK2_1 268 274 PF00069 0.488
MOD_CK2_1 304 310 PF00069 0.369
MOD_CK2_1 460 466 PF00069 0.388
MOD_CK2_1 576 582 PF00069 0.465
MOD_GlcNHglycan 149 152 PF01048 0.254
MOD_GlcNHglycan 173 176 PF01048 0.371
MOD_GlcNHglycan 188 191 PF01048 0.334
MOD_GlcNHglycan 195 198 PF01048 0.526
MOD_GlcNHglycan 204 207 PF01048 0.337
MOD_GlcNHglycan 224 227 PF01048 0.379
MOD_GlcNHglycan 270 273 PF01048 0.456
MOD_GlcNHglycan 441 444 PF01048 0.306
MOD_GlcNHglycan 459 462 PF01048 0.379
MOD_GlcNHglycan 466 470 PF01048 0.374
MOD_GlcNHglycan 479 482 PF01048 0.450
MOD_GlcNHglycan 579 582 PF01048 0.552
MOD_GlcNHglycan 670 673 PF01048 0.697
MOD_GlcNHglycan 68 71 PF01048 0.550
MOD_GlcNHglycan 701 704 PF01048 0.715
MOD_GlcNHglycan 746 749 PF01048 0.629
MOD_GlcNHglycan 758 761 PF01048 0.550
MOD_GlcNHglycan 764 767 PF01048 0.502
MOD_GlcNHglycan 793 796 PF01048 0.720
MOD_GlcNHglycan 831 834 PF01048 0.573
MOD_GSK3_1 167 174 PF00069 0.421
MOD_GSK3_1 193 200 PF00069 0.413
MOD_GSK3_1 247 254 PF00069 0.394
MOD_GSK3_1 262 269 PF00069 0.390
MOD_GSK3_1 279 286 PF00069 0.369
MOD_GSK3_1 372 379 PF00069 0.500
MOD_GSK3_1 441 448 PF00069 0.278
MOD_GSK3_1 512 519 PF00069 0.436
MOD_GSK3_1 54 61 PF00069 0.421
MOD_GSK3_1 547 554 PF00069 0.368
MOD_GSK3_1 572 579 PF00069 0.520
MOD_GSK3_1 582 589 PF00069 0.503
MOD_GSK3_1 614 621 PF00069 0.582
MOD_GSK3_1 644 651 PF00069 0.583
MOD_GSK3_1 65 72 PF00069 0.540
MOD_GSK3_1 664 671 PF00069 0.654
MOD_GSK3_1 677 684 PF00069 0.669
MOD_GSK3_1 685 692 PF00069 0.563
MOD_GSK3_1 725 732 PF00069 0.493
MOD_GSK3_1 734 741 PF00069 0.488
MOD_GSK3_1 747 754 PF00069 0.693
MOD_GSK3_1 755 762 PF00069 0.757
MOD_GSK3_1 779 786 PF00069 0.702
MOD_GSK3_1 790 797 PF00069 0.668
MOD_GSK3_1 799 806 PF00069 0.703
MOD_GSK3_1 820 827 PF00069 0.727
MOD_LATS_1 601 607 PF00433 0.438
MOD_N-GLC_1 292 297 PF02516 0.526
MOD_N-GLC_1 445 450 PF02516 0.390
MOD_N-GLC_1 505 510 PF02516 0.297
MOD_N-GLC_1 614 619 PF02516 0.576
MOD_N-GLC_1 824 829 PF02516 0.592
MOD_N-GLC_2 277 279 PF02516 0.439
MOD_NEK2_1 10 15 PF00069 0.423
MOD_NEK2_1 202 207 PF00069 0.504
MOD_NEK2_1 221 226 PF00069 0.458
MOD_NEK2_1 266 271 PF00069 0.376
MOD_NEK2_1 333 338 PF00069 0.466
MOD_NEK2_1 341 346 PF00069 0.448
MOD_NEK2_1 36 41 PF00069 0.370
MOD_NEK2_1 445 450 PF00069 0.402
MOD_NEK2_1 457 462 PF00069 0.301
MOD_NEK2_1 479 484 PF00069 0.417
MOD_NEK2_1 591 596 PF00069 0.478
MOD_NEK2_1 60 65 PF00069 0.572
MOD_NEK2_1 646 651 PF00069 0.655
MOD_NEK2_1 725 730 PF00069 0.640
MOD_NEK2_1 753 758 PF00069 0.650
MOD_NEK2_1 785 790 PF00069 0.610
MOD_NEK2_2 103 108 PF00069 0.261
MOD_NEK2_2 547 552 PF00069 0.360
MOD_NEK2_2 79 84 PF00069 0.455
MOD_PIKK_1 333 339 PF00454 0.407
MOD_PIKK_1 519 525 PF00454 0.479
MOD_PIKK_1 747 753 PF00454 0.479
MOD_PIKK_1 783 789 PF00454 0.615
MOD_PK_1 603 609 PF00069 0.320
MOD_PKA_1 316 322 PF00069 0.285
MOD_PKA_2 279 285 PF00069 0.429
MOD_PKA_2 418 424 PF00069 0.421
MOD_PKA_2 51 57 PF00069 0.415
MOD_PKA_2 615 621 PF00069 0.558
MOD_Plk_1 445 451 PF00069 0.221
MOD_Plk_1 505 511 PF00069 0.308
MOD_Plk_1 689 695 PF00069 0.483
MOD_Plk_4 103 109 PF00069 0.320
MOD_Plk_4 167 173 PF00069 0.274
MOD_Plk_4 316 322 PF00069 0.348
MOD_Plk_4 445 451 PF00069 0.298
MOD_Plk_4 479 485 PF00069 0.459
MOD_Plk_4 51 57 PF00069 0.334
MOD_Plk_4 586 592 PF00069 0.419
MOD_Plk_4 681 687 PF00069 0.702
MOD_Plk_4 726 732 PF00069 0.462
MOD_Plk_4 734 740 PF00069 0.440
MOD_Plk_4 803 809 PF00069 0.728
MOD_Plk_4 85 91 PF00069 0.334
MOD_ProDKin_1 17 23 PF00069 0.454
MOD_ProDKin_1 30 36 PF00069 0.392
MOD_ProDKin_1 408 414 PF00069 0.415
MOD_ProDKin_1 41 47 PF00069 0.400
MOD_ProDKin_1 516 522 PF00069 0.487
MOD_ProDKin_1 569 575 PF00069 0.437
MOD_ProDKin_1 649 655 PF00069 0.588
MOD_ProDKin_1 664 670 PF00069 0.746
MOD_ProDKin_1 672 678 PF00069 0.676
MOD_ProDKin_1 685 691 PF00069 0.668
MOD_ProDKin_1 738 744 PF00069 0.648
MOD_ProDKin_1 780 786 PF00069 0.740
MOD_ProDKin_1 812 818 PF00069 0.512
MOD_SUMO_for_1 596 599 PF00179 0.339
MOD_SUMO_rev_2 713 722 PF00179 0.631
TRG_DiLeu_BaEn_2 309 315 PF01217 0.406
TRG_ENDOCYTIC_2 248 251 PF00928 0.256
TRG_ENDOCYTIC_2 427 430 PF00928 0.318
TRG_ER_diArg_1 126 128 PF00400 0.433
TRG_ER_diArg_1 299 302 PF00400 0.578
TRG_ER_diArg_1 83 85 PF00400 0.449
TRG_NES_CRM1_1 322 334 PF08389 0.399
TRG_NLS_MonoExtN_4 836 842 PF00514 0.484
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.331
TRG_Pf-PMV_PEXEL_1 561 565 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PER2 Leptomonas seymouri 53% 95%
A0A0S4KHN7 Bodo saltans 34% 100%
A0A1X0NY37 Trypanosomatidae 38% 100%
A0A3S5IS35 Trypanosoma rangeli 37% 100%
A0A3S7WWH4 Leishmania donovani 78% 99%
D0A1C9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AGU9 Leishmania infantum 78% 99%
E9AV65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
O13733 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q4QCB6 Leishmania major 76% 100%
Q55GS2 Dictyostelium discoideum 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS