Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HBU2_LEIBR

TriTrypDb:

LbrM.21.1050 , LBRM2903_210015400

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.682
CLV_C14_Caspase3-7	214	218	PF00656	0.583
CLV_C14_Caspase3-7	507	511	PF00656	0.562
CLV_C14_Caspase3-7	685	689	PF00656	0.750
CLV_NRD_NRD_1	121	123	PF00675	0.728
CLV_NRD_NRD_1	699	701	PF00675	0.694
CLV_NRD_NRD_1	70	72	PF00675	0.525
CLV_NRD_NRD_1	706	708	PF00675	0.649
CLV_PCSK_FUR_1	703	707	PF00082	0.661
CLV_PCSK_KEX2_1	121	123	PF00082	0.728
CLV_PCSK_KEX2_1	604	606	PF00082	0.532
CLV_PCSK_KEX2_1	699	701	PF00082	0.694
CLV_PCSK_KEX2_1	70	72	PF00082	0.525
CLV_PCSK_KEX2_1	705	707	PF00082	0.622
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.532
CLV_PCSK_SKI1_1	128	132	PF00082	0.592
CLV_PCSK_SKI1_1	188	192	PF00082	0.578
CLV_PCSK_SKI1_1	389	393	PF00082	0.685
CLV_PCSK_SKI1_1	65	69	PF00082	0.626
CLV_PCSK_SKI1_1	694	698	PF00082	0.584
CLV_PCSK_SKI1_1	745	749	PF00082	0.695
DEG_Nend_UBRbox_2	1	3	PF02207	0.561
DEG_SCF_FBW7_1	362	369	PF00400	0.680
DEG_SCF_FBW7_1	741	746	PF00400	0.676
DEG_SPOP_SBC_1	178	182	PF00917	0.735
DEG_SPOP_SBC_1	410	414	PF00917	0.525
DEG_SPOP_SBC_1	665	669	PF00917	0.571
DEG_SPOP_SBC_1	819	823	PF00917	0.538
DEG_SPOP_SBC_1	857	861	PF00917	0.565
DEG_SPOP_SBC_1	874	878	PF00917	0.624
DEG_SPOP_SBC_1	88	92	PF00917	0.538
DOC_ANK_TNKS_1	628	635	PF00023	0.592
DOC_CKS1_1	225	230	PF01111	0.697
DOC_CKS1_1	363	368	PF01111	0.520
DOC_CKS1_1	493	498	PF01111	0.539
DOC_CKS1_1	59	64	PF01111	0.642
DOC_CKS1_1	779	784	PF01111	0.707
DOC_CKS1_1	834	839	PF01111	0.512
DOC_CYCLIN_yClb5_NLxxxL_5	383	392	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.529
DOC_MAPK_DCC_7	224	233	PF00069	0.699
DOC_MAPK_DCC_7	492	501	PF00069	0.548
DOC_MAPK_gen_1	113	120	PF00069	0.697
DOC_MAPK_gen_1	224	233	PF00069	0.699
DOC_MAPK_gen_1	430	440	PF00069	0.547
DOC_MAPK_gen_1	604	611	PF00069	0.539
DOC_MAPK_MEF2A_6	224	233	PF00069	0.699
DOC_MAPK_MEF2A_6	492	501	PF00069	0.548
DOC_PP1_RVXF_1	81	88	PF00149	0.545
DOC_PP2B_LxvP_1	129	132	PF13499	0.676
DOC_PP2B_LxvP_1	158	161	PF13499	0.542
DOC_PP2B_LxvP_1	18	21	PF13499	0.695
DOC_PP2B_LxvP_1	235	238	PF13499	0.688
DOC_PP2B_LxvP_1	242	245	PF13499	0.622
DOC_PP2B_LxvP_1	392	395	PF13499	0.674
DOC_PP2B_LxvP_1	831	834	PF13499	0.534
DOC_PP4_FxxP_1	371	374	PF00568	0.559
DOC_PP4_FxxP_1	57	60	PF00568	0.672
DOC_PP4_FxxP_1	592	595	PF00568	0.671
DOC_PP4_FxxP_1	842	845	PF00568	0.534
DOC_USP7_MATH_1	238	242	PF00917	0.576
DOC_USP7_MATH_1	266	270	PF00917	0.568
DOC_USP7_MATH_1	272	276	PF00917	0.583
DOC_USP7_MATH_1	306	310	PF00917	0.588
DOC_USP7_MATH_1	410	414	PF00917	0.576
DOC_USP7_MATH_1	584	588	PF00917	0.568
DOC_USP7_MATH_1	596	600	PF00917	0.603
DOC_USP7_MATH_1	632	636	PF00917	0.734
DOC_USP7_MATH_1	723	727	PF00917	0.685
DOC_USP7_MATH_1	731	735	PF00917	0.658
DOC_USP7_MATH_1	795	799	PF00917	0.670
DOC_USP7_MATH_1	825	829	PF00917	0.675
DOC_USP7_MATH_1	88	92	PF00917	0.624
DOC_WW_Pin1_4	135	140	PF00397	0.635
DOC_WW_Pin1_4	171	176	PF00397	0.770
DOC_WW_Pin1_4	217	222	PF00397	0.666
DOC_WW_Pin1_4	224	229	PF00397	0.682
DOC_WW_Pin1_4	273	278	PF00397	0.709
DOC_WW_Pin1_4	350	355	PF00397	0.519
DOC_WW_Pin1_4	362	367	PF00397	0.674
DOC_WW_Pin1_4	374	379	PF00397	0.672
DOC_WW_Pin1_4	492	497	PF00397	0.698
DOC_WW_Pin1_4	542	547	PF00397	0.797
DOC_WW_Pin1_4	554	559	PF00397	0.639
DOC_WW_Pin1_4	576	581	PF00397	0.767
DOC_WW_Pin1_4	58	63	PF00397	0.581
DOC_WW_Pin1_4	620	625	PF00397	0.766
DOC_WW_Pin1_4	628	633	PF00397	0.640
DOC_WW_Pin1_4	688	693	PF00397	0.730
DOC_WW_Pin1_4	716	721	PF00397	0.589
DOC_WW_Pin1_4	737	742	PF00397	0.653
DOC_WW_Pin1_4	778	783	PF00397	0.755
DOC_WW_Pin1_4	798	803	PF00397	0.549
DOC_WW_Pin1_4	833	838	PF00397	0.656
DOC_WW_Pin1_4	845	850	PF00397	0.578
DOC_WW_Pin1_4	870	875	PF00397	0.717
DOC_WW_Pin1_4	883	888	PF00397	0.588
DOC_WW_Pin1_4	89	94	PF00397	0.543
LIG_14-3-3_CanoR_1	177	187	PF00244	0.629
LIG_14-3-3_CanoR_1	249	254	PF00244	0.565
LIG_14-3-3_CanoR_1	430	440	PF00244	0.612
LIG_14-3-3_CanoR_1	492	496	PF00244	0.546
LIG_14-3-3_CanoR_1	65	73	PF00244	0.623
LIG_14-3-3_CanoR_1	751	757	PF00244	0.561
LIG_14-3-3_CanoR_1	86	96	PF00244	0.687
LIG_BIR_III_2	487	491	PF00653	0.720
LIG_CtBP_PxDLS_1	228	232	PF00389	0.694
LIG_CtBP_PxDLS_1	616	620	PF00389	0.572
LIG_CtBP_PxDLS_1	849	853	PF00389	0.536
LIG_FHA_1	211	217	PF00498	0.682
LIG_FHA_1	218	224	PF00498	0.631
LIG_FHA_1	250	256	PF00498	0.623
LIG_FHA_1	274	280	PF00498	0.662
LIG_FHA_1	298	304	PF00498	0.584
LIG_FHA_1	319	325	PF00498	0.624
LIG_FHA_1	345	351	PF00498	0.574
LIG_FHA_1	363	369	PF00498	0.680
LIG_FHA_1	402	408	PF00498	0.603
LIG_FHA_1	481	487	PF00498	0.596
LIG_FHA_1	691	697	PF00498	0.579
LIG_FHA_1	717	723	PF00498	0.589
LIG_FHA_1	834	840	PF00498	0.535
LIG_FHA_1	851	857	PF00498	0.648
LIG_FHA_2	105	111	PF00498	0.687
LIG_FHA_2	180	186	PF00498	0.758
LIG_FHA_2	189	195	PF00498	0.624
LIG_FHA_2	212	218	PF00498	0.649
LIG_FHA_2	286	292	PF00498	0.610
LIG_FHA_2	379	385	PF00498	0.543
LIG_Integrin_RGD_1	641	643	PF01839	0.581
LIG_LIR_Apic_2	369	374	PF02991	0.552
LIG_LIR_Apic_2	400	406	PF02991	0.522
LIG_LIR_Apic_2	54	60	PF02991	0.679
LIG_LIR_Gen_1	284	295	PF02991	0.687
LIG_LIR_Gen_1	358	368	PF02991	0.518
LIG_LIR_Gen_1	500	505	PF02991	0.561
LIG_LIR_Gen_1	781	790	PF02991	0.550
LIG_LIR_Nem_3	252	256	PF02991	0.609
LIG_LIR_Nem_3	284	290	PF02991	0.701
LIG_LIR_Nem_3	358	363	PF02991	0.516
LIG_LIR_Nem_3	500	504	PF02991	0.565
LIG_LIR_Nem_3	781	786	PF02991	0.551
LIG_LYPXL_yS_3	796	799	PF13949	0.549
LIG_MYND_1	366	370	PF01753	0.530
LIG_RPA_C_Fungi	746	758	PF08784	0.529
LIG_SH2_CRK	403	407	PF00017	0.527
LIG_SH2_GRB2like	477	480	PF00017	0.533
LIG_SH2_NCK_1	890	894	PF00017	0.509
LIG_SH2_SRC	890	893	PF00017	0.505
LIG_SH2_STAP1	320	324	PF00017	0.520
LIG_SH2_STAT5	315	318	PF00017	0.525
LIG_SH2_STAT5	320	323	PF00017	0.508
LIG_SH2_STAT5	403	406	PF00017	0.524
LIG_SH3_1	583	589	PF00018	0.538
LIG_SH3_3	147	153	PF00018	0.522
LIG_SH3_3	222	228	PF00018	0.705
LIG_SH3_3	348	354	PF00018	0.612
LIG_SH3_3	370	376	PF00018	0.674
LIG_SH3_3	537	543	PF00018	0.702
LIG_SH3_3	583	589	PF00018	0.685
LIG_SH3_3	738	744	PF00018	0.687
LIG_SH3_3	831	837	PF00018	0.524
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.516
LIG_SUMO_SIM_anti_2	811	816	PF11976	0.583
LIG_SUMO_SIM_par_1	353	359	PF11976	0.508
LIG_SUMO_SIM_par_1	813	818	PF11976	0.685
LIG_SxIP_EBH_1	574	587	PF03271	0.538
LIG_TRAF2_1	21	24	PF00917	0.525
LIG_TRFH_1	142	146	PF08558	0.526
LIG_WRC_WIRS_1	100	105	PF05994	0.699
LIG_WRC_WIRS_1	357	362	PF05994	0.515
LIG_WW_3	742	746	PF00397	0.678
MOD_CDC14_SPxK_1	174	177	PF00782	0.634
MOD_CDC14_SPxK_1	691	694	PF00782	0.730
MOD_CDK_SPK_2	554	559	PF00069	0.588
MOD_CDK_SPK_2	89	94	PF00069	0.538
MOD_CDK_SPxK_1	171	177	PF00069	0.636
MOD_CDK_SPxK_1	688	694	PF00069	0.732
MOD_CDK_SPxK_1	739	745	PF00069	0.684
MOD_CDK_SPxxK_3	217	224	PF00069	0.561
MOD_CDK_SPxxK_3	576	583	PF00069	0.539
MOD_CDK_SPxxK_3	58	65	PF00069	0.647
MOD_CDK_SPxxK_3	620	627	PF00069	0.587
MOD_CK1_1	138	144	PF00069	0.581
MOD_CK1_1	168	174	PF00069	0.824
MOD_CK1_1	181	187	PF00069	0.620
MOD_CK1_1	201	207	PF00069	0.519
MOD_CK1_1	210	216	PF00069	0.612
MOD_CK1_1	275	281	PF00069	0.614
MOD_CK1_1	283	289	PF00069	0.617
MOD_CK1_1	297	303	PF00069	0.598
MOD_CK1_1	361	367	PF00069	0.769
MOD_CK1_1	44	50	PF00069	0.670
MOD_CK1_1	503	509	PF00069	0.625
MOD_CK1_1	523	529	PF00069	0.662
MOD_CK1_1	620	626	PF00069	0.735
MOD_CK1_1	726	732	PF00069	0.559
MOD_CK1_1	74	80	PF00069	0.638
MOD_CK1_1	798	804	PF00069	0.701
MOD_CK1_1	813	819	PF00069	0.533
MOD_CK1_1	873	879	PF00069	0.691
MOD_CK1_1	89	95	PF00069	0.504
MOD_CK1_1	99	105	PF00069	0.655
MOD_CK2_1	179	185	PF00069	0.745
MOD_CK2_1	285	291	PF00069	0.636
MOD_CK2_1	306	312	PF00069	0.695
MOD_CK2_1	316	322	PF00069	0.623
MOD_CK2_1	361	367	PF00069	0.673
MOD_CK2_1	411	417	PF00069	0.583
MOD_CK2_1	42	48	PF00069	0.647
MOD_CK2_1	649	655	PF00069	0.691
MOD_CK2_1	863	869	PF00069	0.644
MOD_Cter_Amidation	703	706	PF01082	0.662
MOD_DYRK1A_RPxSP_1	224	228	PF00069	0.701
MOD_GlcNHglycan	200	203	PF01048	0.677
MOD_GlcNHglycan	268	271	PF01048	0.578
MOD_GlcNHglycan	27	30	PF01048	0.670
MOD_GlcNHglycan	435	438	PF01048	0.547
MOD_GlcNHglycan	506	509	PF01048	0.705
MOD_GlcNHglycan	510	513	PF01048	0.654
MOD_GlcNHglycan	526	529	PF01048	0.617
MOD_GlcNHglycan	551	554	PF01048	0.582
MOD_GlcNHglycan	563	566	PF01048	0.778
MOD_GlcNHglycan	567	570	PF01048	0.814
MOD_GlcNHglycan	597	601	PF01048	0.618
MOD_GlcNHglycan	707	710	PF01048	0.659
MOD_GlcNHglycan	758	761	PF01048	0.675
MOD_GlcNHglycan	763	766	PF01048	0.643
MOD_GlcNHglycan	822	825	PF01048	0.664
MOD_GlcNHglycan	865	868	PF01048	0.630
MOD_GlcNHglycan	879	882	PF01048	0.571
MOD_GSK3_1	177	184	PF00069	0.704
MOD_GSK3_1	197	204	PF00069	0.556
MOD_GSK3_1	205	212	PF00069	0.590
MOD_GSK3_1	268	275	PF00069	0.693
MOD_GSK3_1	279	286	PF00069	0.670
MOD_GSK3_1	358	365	PF00069	0.768
MOD_GSK3_1	374	381	PF00069	0.660
MOD_GSK3_1	397	404	PF00069	0.548
MOD_GSK3_1	40	47	PF00069	0.695
MOD_GSK3_1	471	478	PF00069	0.584
MOD_GSK3_1	500	507	PF00069	0.621
MOD_GSK3_1	520	527	PF00069	0.757
MOD_GSK3_1	561	568	PF00069	0.596
MOD_GSK3_1	628	635	PF00069	0.637
MOD_GSK3_1	665	672	PF00069	0.745
MOD_GSK3_1	683	690	PF00069	0.695
MOD_GSK3_1	705	712	PF00069	0.657
MOD_GSK3_1	71	78	PF00069	0.553
MOD_GSK3_1	723	730	PF00069	0.551
MOD_GSK3_1	739	746	PF00069	0.639
MOD_GSK3_1	752	759	PF00069	0.550
MOD_GSK3_1	785	792	PF00069	0.700
MOD_GSK3_1	797	804	PF00069	0.557
MOD_GSK3_1	815	822	PF00069	0.616
MOD_GSK3_1	825	832	PF00069	0.628
MOD_GSK3_1	851	858	PF00069	0.637
MOD_GSK3_1	869	876	PF00069	0.615
MOD_GSK3_1	88	95	PF00069	0.573
MOD_GSK3_1	99	106	PF00069	0.569
MOD_N-GLC_1	195	200	PF02516	0.588
MOD_N-GLC_1	208	213	PF02516	0.675
MOD_N-GLC_1	238	243	PF02516	0.537
MOD_N-GLC_1	508	513	PF02516	0.560
MOD_N-GLC_1	665	670	PF02516	0.583
MOD_N-GLC_1	829	834	PF02516	0.693
MOD_N-GLC_1	850	855	PF02516	0.548
MOD_N-GLC_2	479	481	PF02516	0.535
MOD_N-GLC_2	522	524	PF02516	0.683
MOD_NEK2_1	195	200	PF00069	0.674
MOD_NEK2_1	260	265	PF00069	0.504
MOD_NEK2_1	295	300	PF00069	0.718
MOD_NEK2_1	356	361	PF00069	0.665
MOD_NEK2_1	411	416	PF00069	0.529
MOD_NEK2_1	66	71	PF00069	0.685
MOD_NEK2_1	664	669	PF00069	0.609
MOD_NEK2_1	756	761	PF00069	0.582
MOD_NEK2_1	810	815	PF00069	0.680
MOD_NEK2_1	852	857	PF00069	0.662
MOD_NEK2_1	96	101	PF00069	0.546
MOD_NEK2_2	238	243	PF00069	0.537
MOD_NEK2_2	752	757	PF00069	0.610
MOD_PIKK_1	104	110	PF00454	0.529
MOD_PIKK_1	179	185	PF00454	0.715
MOD_PIKK_1	440	446	PF00454	0.554
MOD_PIKK_1	633	639	PF00454	0.712
MOD_PIKK_1	801	807	PF00454	0.527
MOD_PKA_1	699	705	PF00069	0.586
MOD_PKA_2	168	174	PF00069	0.560
MOD_PKA_2	471	477	PF00069	0.533
MOD_PKA_2	491	497	PF00069	0.547
MOD_PKA_2	669	675	PF00069	0.574
MOD_PKA_2	699	705	PF00069	0.586
MOD_PKA_2	756	762	PF00069	0.681
MOD_PKA_2	826	832	PF00069	0.695
MOD_PKA_2	863	869	PF00069	0.564
MOD_PKB_1	703	711	PF00069	0.575
MOD_Plk_1	124	130	PF00069	0.541
MOD_Plk_1	188	194	PF00069	0.576
MOD_Plk_1	238	244	PF00069	0.534
MOD_Plk_1	283	289	PF00069	0.675
MOD_Plk_1	316	322	PF00069	0.520
MOD_Plk_1	424	430	PF00069	0.697
MOD_Plk_1	440	446	PF00069	0.547
MOD_Plk_1	74	80	PF00069	0.520
MOD_Plk_1	810	816	PF00069	0.681
MOD_Plk_1	829	835	PF00069	0.496
MOD_Plk_4	138	144	PF00069	0.529
MOD_Plk_4	168	174	PF00069	0.560
MOD_Plk_4	211	217	PF00069	0.703
MOD_Plk_4	260	266	PF00069	0.572
MOD_Plk_4	497	503	PF00069	0.651
MOD_Plk_4	731	737	PF00069	0.560
MOD_Plk_4	810	816	PF00069	0.681
MOD_Plk_4	96	102	PF00069	0.544
MOD_ProDKin_1	135	141	PF00069	0.636
MOD_ProDKin_1	171	177	PF00069	0.771
MOD_ProDKin_1	217	223	PF00069	0.664
MOD_ProDKin_1	224	230	PF00069	0.681
MOD_ProDKin_1	273	279	PF00069	0.710
MOD_ProDKin_1	350	356	PF00069	0.520
MOD_ProDKin_1	362	368	PF00069	0.678
MOD_ProDKin_1	374	380	PF00069	0.670
MOD_ProDKin_1	492	498	PF00069	0.701
MOD_ProDKin_1	542	548	PF00069	0.793
MOD_ProDKin_1	554	560	PF00069	0.637
MOD_ProDKin_1	576	582	PF00069	0.765
MOD_ProDKin_1	58	64	PF00069	0.582
MOD_ProDKin_1	620	626	PF00069	0.766
MOD_ProDKin_1	628	634	PF00069	0.640
MOD_ProDKin_1	688	694	PF00069	0.732
MOD_ProDKin_1	716	722	PF00069	0.590
MOD_ProDKin_1	737	743	PF00069	0.645
MOD_ProDKin_1	778	784	PF00069	0.755
MOD_ProDKin_1	798	804	PF00069	0.548
MOD_ProDKin_1	833	839	PF00069	0.656
MOD_ProDKin_1	845	851	PF00069	0.581
MOD_ProDKin_1	870	876	PF00069	0.717
MOD_ProDKin_1	883	889	PF00069	0.582
MOD_ProDKin_1	89	95	PF00069	0.542
TRG_DiLeu_BaEn_1	358	363	PF01217	0.516
TRG_DiLeu_BaEn_2	366	372	PF01217	0.540
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.573
TRG_ENDOCYTIC_2	796	799	PF00928	0.549
TRG_ER_diArg_1	120	122	PF00400	0.741
TRG_ER_diArg_1	223	226	PF00400	0.710
TRG_ER_diArg_1	588	591	PF00400	0.782
TRG_ER_diArg_1	70	72	PF00400	0.525
TRG_ER_diArg_1	703	706	PF00400	0.662
TRG_ER_diArg_1	862	865	PF00400	0.557
TRG_NES_CRM1_1	384	396	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	773	778	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC08	Leishmania donovani	57%	100%
E9AGU8	Leishmania infantum	57%	100%
E9AV64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4QCB7	Leishmania major	54%	100%