RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBU1_LEIBR

TriTrypDb:

LbrM.21.1040 , LBRM2903_210015300

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBU1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.804
CLV_C14_Caspase3-7	602	606	PF00656	0.551
CLV_C14_Caspase3-7	649	653	PF00656	0.534
CLV_NRD_NRD_1	19	21	PF00675	0.449
CLV_NRD_NRD_1	215	217	PF00675	0.400
CLV_NRD_NRD_1	339	341	PF00675	0.490
CLV_NRD_NRD_1	44	46	PF00675	0.491
CLV_NRD_NRD_1	611	613	PF00675	0.622
CLV_PCSK_FUR_1	609	613	PF00082	0.595
CLV_PCSK_KEX2_1	19	21	PF00082	0.449
CLV_PCSK_KEX2_1	205	207	PF00082	0.474
CLV_PCSK_KEX2_1	215	217	PF00082	0.329
CLV_PCSK_KEX2_1	339	341	PF00082	0.490
CLV_PCSK_KEX2_1	44	46	PF00082	0.459
CLV_PCSK_KEX2_1	608	610	PF00082	0.603
CLV_PCSK_KEX2_1	611	613	PF00082	0.561
CLV_PCSK_KEX2_1	81	83	PF00082	0.551
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.364
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.654
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.467
CLV_PCSK_SKI1_1	166	170	PF00082	0.416
CLV_PCSK_SKI1_1	206	210	PF00082	0.529
CLV_PCSK_SKI1_1	215	219	PF00082	0.565
CLV_PCSK_SKI1_1	531	535	PF00082	0.622
CLV_PCSK_SKI1_1	611	615	PF00082	0.377
CLV_PCSK_SKI1_1	78	82	PF00082	0.629
DEG_COP1_1	183	191	PF00400	0.477
DOC_CKS1_1	122	127	PF01111	0.502
DOC_CKS1_1	208	213	PF01111	0.395
DOC_CYCLIN_RxL_1	203	213	PF00134	0.353
DOC_CYCLIN_RxL_1	528	536	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.475
DOC_MAPK_gen_1	339	346	PF00069	0.348
DOC_MAPK_gen_1	385	392	PF00069	0.482
DOC_MAPK_MEF2A_6	339	346	PF00069	0.445
DOC_PP1_RVXF_1	160	166	PF00149	0.595
DOC_PP2B_LxvP_1	453	456	PF13499	0.567
DOC_SPAK_OSR1_1	387	391	PF12202	0.429
DOC_USP7_MATH_1	105	109	PF00917	0.754
DOC_USP7_MATH_1	134	138	PF00917	0.715
DOC_USP7_MATH_1	177	181	PF00917	0.692
DOC_USP7_MATH_1	197	201	PF00917	0.544
DOC_USP7_MATH_1	246	250	PF00917	0.489
DOC_USP7_MATH_1	256	260	PF00917	0.684
DOC_USP7_MATH_1	449	453	PF00917	0.684
DOC_USP7_MATH_1	556	560	PF00917	0.614
DOC_USP7_MATH_1	57	61	PF00917	0.513
DOC_USP7_MATH_1	646	650	PF00917	0.541
DOC_WW_Pin1_4	121	126	PF00397	0.651
DOC_WW_Pin1_4	132	137	PF00397	0.570
DOC_WW_Pin1_4	200	205	PF00397	0.532
DOC_WW_Pin1_4	207	212	PF00397	0.420
DOC_WW_Pin1_4	445	450	PF00397	0.690
DOC_WW_Pin1_4	468	473	PF00397	0.677
DOC_WW_Pin1_4	481	486	PF00397	0.549
DOC_WW_Pin1_4	49	54	PF00397	0.588
DOC_WW_Pin1_4	523	528	PF00397	0.422
DOC_WW_Pin1_4	560	565	PF00397	0.441
DOC_WW_Pin1_4	593	598	PF00397	0.560
DOC_WW_Pin1_4	64	69	PF00397	0.626
DOC_WW_Pin1_4	85	90	PF00397	0.774
LIG_14-3-3_CanoR_1	11	15	PF00244	0.537
LIG_14-3-3_CanoR_1	387	393	PF00244	0.566
LIG_14-3-3_CanoR_1	558	566	PF00244	0.428
LIG_14-3-3_CanoR_1	680	689	PF00244	0.347
LIG_14-3-3_CanoR_1	692	702	PF00244	0.427
LIG_14-3-3_CanoR_1	705	710	PF00244	0.444
LIG_BIR_III_2	190	194	PF00653	0.481
LIG_CtBP_PxDLS_1	429	433	PF00389	0.444
LIG_FHA_1	174	180	PF00498	0.609
LIG_FHA_1	318	324	PF00498	0.354
LIG_FHA_1	339	345	PF00498	0.487
LIG_FHA_1	394	400	PF00498	0.411
LIG_FHA_1	50	56	PF00498	0.579
LIG_FHA_1	649	655	PF00498	0.276
LIG_FHA_2	122	128	PF00498	0.676
LIG_FHA_2	133	139	PF00498	0.573
LIG_FHA_2	217	223	PF00498	0.480
LIG_FHA_2	456	462	PF00498	0.461
LIG_FHA_2	600	606	PF00498	0.440
LIG_Integrin_RGDW_4	676	679	PF00362	0.378
LIG_LIR_Gen_1	238	246	PF02991	0.455
LIG_LIR_Gen_1	282	291	PF02991	0.460
LIG_LIR_Gen_1	511	521	PF02991	0.535
LIG_LIR_Gen_1	584	591	PF02991	0.517
LIG_LIR_Nem_3	238	244	PF02991	0.378
LIG_LIR_Nem_3	282	286	PF02991	0.541
LIG_LIR_Nem_3	41	46	PF02991	0.452
LIG_LIR_Nem_3	511	516	PF02991	0.599
LIG_LIR_Nem_3	584	590	PF02991	0.507
LIG_MYND_1	207	211	PF01753	0.357
LIG_NRBOX	529	535	PF00104	0.509
LIG_Pex14_1	165	169	PF04695	0.567
LIG_Pex14_1	566	570	PF04695	0.367
LIG_SH2_CRK	513	517	PF00017	0.559
LIG_SH2_CRK	587	591	PF00017	0.546
LIG_SH2_STAT5	285	288	PF00017	0.373
LIG_SH2_STAT5	470	473	PF00017	0.450
LIG_SH2_STAT5	570	573	PF00017	0.385
LIG_SH3_2	89	94	PF14604	0.496
LIG_SH3_3	119	125	PF00018	0.645
LIG_SH3_3	138	144	PF00018	0.553
LIG_SH3_3	201	207	PF00018	0.416
LIG_SH3_3	389	395	PF00018	0.420
LIG_SH3_3	86	92	PF00018	0.544
LIG_SUMO_SIM_par_1	340	345	PF11976	0.432
LIG_SUMO_SIM_par_1	428	433	PF11976	0.445
LIG_TRAF2_1	219	222	PF00917	0.487
LIG_TRFH_1	121	125	PF08558	0.490
MOD_CDC14_SPxK_1	526	529	PF00782	0.405
MOD_CDC14_SPxK_1	88	91	PF00782	0.483
MOD_CDK_SPK_2	200	205	PF00069	0.504
MOD_CDK_SPxK_1	200	206	PF00069	0.399
MOD_CDK_SPxK_1	523	529	PF00069	0.406
MOD_CDK_SPxK_1	85	91	PF00069	0.472
MOD_CK1_1	110	116	PF00069	0.711
MOD_CK1_1	200	206	PF00069	0.553
MOD_CK1_1	257	263	PF00069	0.687
MOD_CK1_1	393	399	PF00069	0.557
MOD_CK1_1	49	55	PF00069	0.647
MOD_CK1_1	557	563	PF00069	0.732
MOD_CK1_1	593	599	PF00069	0.500
MOD_CK1_1	672	678	PF00069	0.409
MOD_CK1_1	683	689	PF00069	0.433
MOD_CK1_1	696	702	PF00069	0.321
MOD_CK2_1	121	127	PF00069	0.706
MOD_CK2_1	132	138	PF00069	0.613
MOD_CK2_1	177	183	PF00069	0.689
MOD_CK2_1	216	222	PF00069	0.481
MOD_CK2_1	455	461	PF00069	0.463
MOD_CK2_1	533	539	PF00069	0.488
MOD_CK2_1	595	601	PF00069	0.428
MOD_GlcNHglycan	132	135	PF01048	0.714
MOD_GlcNHglycan	173	176	PF01048	0.642
MOD_GlcNHglycan	179	182	PF01048	0.685
MOD_GlcNHglycan	183	186	PF01048	0.782
MOD_GlcNHglycan	197	200	PF01048	0.506
MOD_GlcNHglycan	254	257	PF01048	0.694
MOD_GlcNHglycan	40	43	PF01048	0.451
MOD_GlcNHglycan	413	416	PF01048	0.553
MOD_GlcNHglycan	535	538	PF01048	0.682
MOD_GlcNHglycan	539	543	PF01048	0.648
MOD_GlcNHglycan	548	551	PF01048	0.531
MOD_GlcNHglycan	559	562	PF01048	0.582
MOD_GlcNHglycan	59	62	PF01048	0.622
MOD_GlcNHglycan	702	705	PF01048	0.368
MOD_GSK3_1	128	135	PF00069	0.637
MOD_GSK3_1	169	176	PF00069	0.686
MOD_GSK3_1	177	184	PF00069	0.731
MOD_GSK3_1	195	202	PF00069	0.684
MOD_GSK3_1	216	223	PF00069	0.495
MOD_GSK3_1	235	242	PF00069	0.346
MOD_GSK3_1	252	259	PF00069	0.682
MOD_GSK3_1	281	288	PF00069	0.564
MOD_GSK3_1	318	325	PF00069	0.421
MOD_GSK3_1	354	361	PF00069	0.469
MOD_GSK3_1	411	418	PF00069	0.588
MOD_GSK3_1	445	452	PF00069	0.725
MOD_GSK3_1	468	475	PF00069	0.656
MOD_GSK3_1	556	563	PF00069	0.542
MOD_GSK3_1	592	599	PF00069	0.549
MOD_GSK3_1	696	703	PF00069	0.454
MOD_N-GLC_1	181	186	PF02516	0.653
MOD_N-GLC_1	358	363	PF02516	0.559
MOD_N-GLC_1	472	477	PF02516	0.557
MOD_N-GLC_2	648	650	PF02516	0.353
MOD_NEK2_1	10	15	PF00069	0.603
MOD_NEK2_1	171	176	PF00069	0.651
MOD_NEK2_1	195	200	PF00069	0.709
MOD_NEK2_1	388	393	PF00069	0.426
MOD_NEK2_1	430	435	PF00069	0.521
MOD_NEK2_1	533	538	PF00069	0.664
MOD_NEK2_1	654	659	PF00069	0.493
MOD_NEK2_2	164	169	PF00069	0.401
MOD_NEK2_2	285	290	PF00069	0.434
MOD_NEK2_2	76	81	PF00069	0.479
MOD_OFUCOSY	644	650	PF10250	0.271
MOD_PIKK_1	105	111	PF00454	0.577
MOD_PIKK_1	331	337	PF00454	0.492
MOD_PIKK_1	472	478	PF00454	0.603
MOD_PIKK_1	540	546	PF00454	0.562
MOD_PKA_2	10	16	PF00069	0.544
MOD_PKA_2	257	263	PF00069	0.430
MOD_PKA_2	318	324	PF00069	0.477
MOD_PKA_2	338	344	PF00069	0.550
MOD_PKA_2	359	365	PF00069	0.444
MOD_PKA_2	38	44	PF00069	0.566
MOD_PKA_2	415	421	PF00069	0.653
MOD_PKA_2	557	563	PF00069	0.540
MOD_PKA_2	700	706	PF00069	0.450
MOD_PKA_2	90	96	PF00069	0.551
MOD_Plk_1	449	455	PF00069	0.552
MOD_Plk_1	460	466	PF00069	0.689
MOD_Plk_1	472	478	PF00069	0.599
MOD_Plk_4	10	16	PF00069	0.643
MOD_Plk_4	164	170	PF00069	0.403
MOD_Plk_4	493	499	PF00069	0.642
MOD_ProDKin_1	121	127	PF00069	0.651
MOD_ProDKin_1	132	138	PF00069	0.566
MOD_ProDKin_1	200	206	PF00069	0.528
MOD_ProDKin_1	207	213	PF00069	0.412
MOD_ProDKin_1	445	451	PF00069	0.689
MOD_ProDKin_1	468	474	PF00069	0.670
MOD_ProDKin_1	481	487	PF00069	0.547
MOD_ProDKin_1	49	55	PF00069	0.591
MOD_ProDKin_1	523	529	PF00069	0.426
MOD_ProDKin_1	560	566	PF00069	0.434
MOD_ProDKin_1	593	599	PF00069	0.561
MOD_ProDKin_1	64	70	PF00069	0.627
MOD_ProDKin_1	85	91	PF00069	0.776
MOD_SUMO_for_1	97	100	PF00179	0.500
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.584
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.363
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.403
TRG_ENDOCYTIC_2	513	516	PF00928	0.552
TRG_ENDOCYTIC_2	587	590	PF00928	0.564
TRG_ER_diArg_1	18	20	PF00400	0.463
TRG_ER_diArg_1	214	216	PF00400	0.391
TRG_ER_diArg_1	289	292	PF00400	0.514
TRG_ER_diArg_1	338	340	PF00400	0.518
TRG_ER_diArg_1	36	39	PF00400	0.580
TRG_ER_diArg_1	43	45	PF00400	0.491
TRG_ER_diArg_1	516	519	PF00400	0.474
TRG_ER_diArg_1	609	612	PF00400	0.603
TRG_ER_diArg_1	689	692	PF00400	0.553
TRG_NLS_MonoExtC_3	607	612	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ9	Leptomonas seymouri	42%	100%
A0A1X0NXN9	Trypanosomatidae	33%	100%
A0A3S5H797	Leishmania donovani	71%	100%
A0A422NWI0	Trypanosoma rangeli	33%	100%
A4HZ88	Leishmania infantum	71%	100%
D0A1D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AV63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QCB8	Leishmania major	69%	100%
V5BMW0	Trypanosoma cruzi	32%	100%