Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBT9_LEIBR

TriTrypDb:

LbrM.21.1020 , LBRM2903_210015000

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HBT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBT9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.513
CLV_NRD_NRD_1	186	188	PF00675	0.423
CLV_NRD_NRD_1	267	269	PF00675	0.365
CLV_NRD_NRD_1	280	282	PF00675	0.350
CLV_NRD_NRD_1	97	99	PF00675	0.477
CLV_PCSK_KEX2_1	132	134	PF00082	0.514
CLV_PCSK_KEX2_1	185	187	PF00082	0.427
CLV_PCSK_KEX2_1	280	282	PF00082	0.371
CLV_PCSK_KEX2_1	97	99	PF00082	0.477
CLV_PCSK_SKI1_1	124	128	PF00082	0.433
CLV_PCSK_SKI1_1	150	154	PF00082	0.347
CLV_PCSK_SKI1_1	268	272	PF00082	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.436
DEG_SPOP_SBC_1	109	113	PF00917	0.617
DOC_PP4_FxxP_1	144	147	PF00568	0.570
DOC_USP7_MATH_1	109	113	PF00917	0.754
DOC_USP7_MATH_1	117	121	PF00917	0.665
DOC_USP7_MATH_1	13	17	PF00917	0.473
DOC_USP7_UBL2_3	265	269	PF12436	0.567
DOC_WW_Pin1_4	21	26	PF00397	0.497
DOC_WW_Pin1_4	280	285	PF00397	0.587
DOC_WW_Pin1_4	36	41	PF00397	0.383
LIG_14-3-3_CanoR_1	150	156	PF00244	0.485
LIG_14-3-3_CanoR_1	158	167	PF00244	0.464
LIG_14-3-3_CanoR_1	6	12	PF00244	0.391
LIG_14-3-3_CanoR_1	97	105	PF00244	0.719
LIG_FHA_1	245	251	PF00498	0.510
LIG_FHA_1	75	81	PF00498	0.313
LIG_FHA_2	159	165	PF00498	0.521
LIG_FHA_2	170	176	PF00498	0.668
LIG_LIR_Apic_2	141	147	PF02991	0.628
LIG_LIR_Nem_3	149	155	PF02991	0.618
LIG_LIR_Nem_3	39	45	PF02991	0.468
LIG_SH2_CRK	83	87	PF00017	0.530
LIG_SH2_PTP2	63	66	PF00017	0.227
LIG_SH2_SRC	63	66	PF00017	0.369
LIG_SH2_STAT5	155	158	PF00017	0.560
LIG_SH2_STAT5	63	66	PF00017	0.369
LIG_SH3_1	281	287	PF00018	0.603
LIG_SH3_3	281	287	PF00018	0.578
LIG_SUMO_SIM_par_1	72	77	PF11976	0.303
LIG_TYR_ITIM	81	86	PF00017	0.382
LIG_UBA3_1	44	51	PF00899	0.463
MOD_CDK_SPxxK_3	36	43	PF00069	0.474
MOD_CK1_1	31	37	PF00069	0.444
MOD_CK1_1	4	10	PF00069	0.475
MOD_CK1_1	46	52	PF00069	0.513
MOD_CK1_1	99	105	PF00069	0.672
MOD_CK2_1	158	164	PF00069	0.521
MOD_CK2_1	169	175	PF00069	0.596
MOD_CMANNOS	2	5	PF00535	0.612
MOD_Cter_Amidation	95	98	PF01082	0.500
MOD_GlcNHglycan	112	115	PF01048	0.482
MOD_GlcNHglycan	119	122	PF01048	0.559
MOD_GlcNHglycan	17	20	PF01048	0.628
MOD_GlcNHglycan	66	69	PF01048	0.369
MOD_GlcNHglycan	7	10	PF01048	0.684
MOD_GSK3_1	1	8	PF00069	0.446
MOD_GSK3_1	169	176	PF00069	0.537
MOD_GSK3_1	208	215	PF00069	0.741
MOD_GSK3_1	28	35	PF00069	0.475
MOD_GSK3_1	72	79	PF00069	0.502
MOD_GSK3_1	97	104	PF00069	0.640
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	28	33	PF00069	0.548
MOD_NEK2_1	44	49	PF00069	0.358
MOD_NEK2_1	72	77	PF00069	0.369
MOD_PIKK_1	158	164	PF00454	0.475
MOD_PIKK_1	244	250	PF00454	0.507
MOD_PIKK_1	99	105	PF00454	0.615
MOD_PKA_1	97	103	PF00069	0.680
MOD_PKA_2	258	264	PF00069	0.610
MOD_PKA_2	5	11	PF00069	0.392
MOD_PKA_2	96	102	PF00069	0.676
MOD_Plk_4	76	82	PF00069	0.369
MOD_ProDKin_1	21	27	PF00069	0.496
MOD_ProDKin_1	280	286	PF00069	0.586
MOD_ProDKin_1	36	42	PF00069	0.379
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.579
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.418
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.441
TRG_ENDOCYTIC_2	63	66	PF00928	0.227
TRG_ENDOCYTIC_2	83	86	PF00928	0.497
TRG_ER_diArg_1	131	133	PF00400	0.630
TRG_ER_diArg_1	184	187	PF00400	0.619
TRG_ER_diArg_1	280	282	PF00400	0.596
TRG_NES_CRM1_1	248	262	PF08389	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P829	Leptomonas seymouri	42%	100%
A0A3Q8IB47	Leishmania donovani	69%	98%
A4HZ86	Leishmania infantum	70%	98%
E9AV61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4QCC0	Leishmania major	69%	100%