Xanthine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

xanthine phosphoribosyltransferase

Species:

Leishmania braziliensis

UniProt:

A4HBT7_LEIBR

TriTrypDb:

LbrM.21.1000 , LBRM2903_210014800

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HBT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBT7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006144	purine nucleobase metabolic process	5	1
GO:0006163	purine nucleotide metabolic process	5	5
GO:0006164	purine nucleotide biosynthetic process	6	5
GO:0006177	GMP biosynthetic process	8	1
GO:0006178	guanine salvage	6	1
GO:0006188	IMP biosynthetic process	8	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006753	nucleoside phosphate metabolic process	4	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009112	nucleobase metabolic process	4	1
GO:0009113	purine nucleobase biosynthetic process	6	1
GO:0009117	nucleotide metabolic process	5	5
GO:0009123	nucleoside monophosphate metabolic process	5	5
GO:0009124	nucleoside monophosphate biosynthetic process	6	5
GO:0009126	purine nucleoside monophosphate metabolic process	6	5
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	5
GO:0009150	purine ribonucleotide metabolic process	6	5
GO:0009152	purine ribonucleotide biosynthetic process	7	5
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	5
GO:0009161	ribonucleoside monophosphate metabolic process	6	5
GO:0009165	nucleotide biosynthetic process	6	5
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	5
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	5
GO:0009259	ribonucleotide metabolic process	5	5
GO:0009260	ribonucleotide biosynthetic process	6	5
GO:0009987	cellular process	1	5
GO:0018130	heterocycle biosynthetic process	4	5
GO:0019438	aromatic compound biosynthetic process	4	5
GO:0019637	organophosphate metabolic process	3	5
GO:0019693	ribose phosphate metabolic process	4	5
GO:0032261	purine nucleotide salvage	5	5
GO:0032263	GMP salvage	7	1
GO:0032264	IMP salvage	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034654	nucleobase-containing compound biosynthetic process	4	5
GO:0043094	cellular metabolic compound salvage	3	5
GO:0043096	purine nucleobase salvage	5	1
GO:0043101	purine-containing compound salvage	4	5
GO:0043173	nucleotide salvage	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0044281	small molecule metabolic process	2	5
GO:0046037	GMP metabolic process	7	1
GO:0046040	IMP metabolic process	7	5
GO:0046098	guanine metabolic process	6	1
GO:0046099	guanine biosynthetic process	7	1
GO:0046100	hypoxanthine metabolic process	6	1
GO:0046112	nucleobase biosynthetic process	5	1
GO:0046390	ribose phosphate biosynthetic process	5	5
GO:0046483	heterocycle metabolic process	3	5
GO:0055086	nucleobase-containing small molecule metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0072521	purine-containing compound metabolic process	4	5
GO:0072522	purine-containing compound biosynthetic process	5	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:0106380	purine ribonucleotide salvage	6	5
GO:1901135	carbohydrate derivative metabolic process	3	5
GO:1901137	carbohydrate derivative biosynthetic process	4	5
GO:1901293	nucleoside phosphate biosynthetic process	5	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901362	organic cyclic compound biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5
GO:0006166	purine ribonucleoside salvage	5	4
GO:0009116	nucleoside metabolic process	4	4
GO:0009119	ribonucleoside metabolic process	5	4
GO:0009163	nucleoside biosynthetic process	5	4
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	4
GO:0042278	purine nucleoside metabolic process	5	4
GO:0042451	purine nucleoside biosynthetic process	6	4
GO:0042455	ribonucleoside biosynthetic process	6	4
GO:0043174	nucleoside salvage	4	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046128	purine ribonucleoside metabolic process	6	4
GO:0046129	purine ribonucleoside biosynthetic process	7	4
GO:1901657	glycosyl compound metabolic process	4	4
GO:1901659	glycosyl compound biosynthetic process	5	4

Molecular functions
Term	Name	Level	Count
GO:0000310	xanthine phosphoribosyltransferase activity	6	4
GO:0003824	catalytic activity	1	16
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	9
GO:0016740	transferase activity	2	16
GO:0016757	glycosyltransferase activity	3	16
GO:0016763	pentosyltransferase activity	4	9
GO:0052657	guanine phosphoribosyltransferase activity	6	9
GO:0106130	purine phosphoribosyltransferase activity	5	9
GO:0000287	magnesium ion binding	5	1
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0000166	nucleotide binding	3	4
GO:0036094	small molecule binding	2	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.340
CLV_NRD_NRD_1	189	191	PF00675	0.213
CLV_PCSK_SKI1_1	146	150	PF00082	0.225
CLV_PCSK_SKI1_1	175	179	PF00082	0.308
CLV_PCSK_SKI1_1	223	227	PF00082	0.338
CLV_PCSK_SKI1_1	53	57	PF00082	0.314
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DOC_ANK_TNKS_1	15	22	PF00023	0.388
DOC_MAPK_gen_1	144	151	PF00069	0.414
DOC_MAPK_gen_1	175	183	PF00069	0.515
DOC_MAPK_gen_1	218	227	PF00069	0.387
DOC_PP1_RVXF_1	157	164	PF00149	0.483
DOC_PP1_RVXF_1	188	195	PF00149	0.471
DOC_PP2B_PxIxI_1	83	89	PF00149	0.419
DOC_USP7_MATH_1	25	29	PF00917	0.431
DOC_USP7_UBL2_3	171	175	PF12436	0.519
DOC_WW_Pin1_4	200	205	PF00397	0.518
LIG_14-3-3_CanoR_1	118	123	PF00244	0.417
LIG_BIR_III_4	12	16	PF00653	0.508
LIG_BRCT_BRCA1_1	93	97	PF00533	0.411
LIG_DLG_GKlike_1	118	126	PF00625	0.507
LIG_FHA_1	127	133	PF00498	0.478
LIG_FHA_1	164	170	PF00498	0.392
LIG_FHA_1	31	37	PF00498	0.331
LIG_FHA_2	54	60	PF00498	0.386
LIG_FHA_2	66	72	PF00498	0.522
LIG_LIR_Apic_2	80	84	PF02991	0.310
LIG_LIR_Gen_1	115	122	PF02991	0.411
LIG_LIR_Gen_1	195	204	PF02991	0.419
LIG_LIR_Nem_3	115	119	PF02991	0.314
LIG_LIR_Nem_3	195	201	PF02991	0.444
LIG_LIR_Nem_3	217	222	PF02991	0.330
LIG_LIR_Nem_3	51	55	PF02991	0.414
LIG_LIR_Nem_3	98	104	PF02991	0.539
LIG_Pex14_2	97	101	PF04695	0.452
LIG_SH2_CRK	198	202	PF00017	0.340
LIG_SH2_CRK	52	56	PF00017	0.397
LIG_SH2_CRK	81	85	PF00017	0.310
LIG_SH2_GRB2like	81	84	PF00017	0.310
LIG_SH2_SRC	207	210	PF00017	0.237
LIG_SH2_SRC	81	84	PF00017	0.310
LIG_SH2_STAT5	104	107	PF00017	0.419
LIG_SH2_STAT5	207	210	PF00017	0.274
LIG_SH2_STAT5	95	98	PF00017	0.419
LIG_SUMO_SIM_par_1	147	153	PF11976	0.429
LIG_SUMO_SIM_par_1	224	230	PF11976	0.277
LIG_SUMO_SIM_par_1	82	89	PF11976	0.422
LIG_UBA3_1	134	139	PF00899	0.474
MOD_CDC14_SPxK_1	203	206	PF00782	0.340
MOD_CDK_SPxK_1	200	206	PF00069	0.340
MOD_CK1_1	157	163	PF00069	0.418
MOD_CK1_1	176	182	PF00069	0.333
MOD_CK2_1	164	170	PF00069	0.399
MOD_CK2_1	65	71	PF00069	0.601
MOD_GlcNHglycan	135	138	PF01048	0.219
MOD_GlcNHglycan	156	159	PF01048	0.219
MOD_GlcNHglycan	7	10	PF01048	0.443
MOD_GSK3_1	26	33	PF00069	0.329
MOD_GSK3_1	65	72	PF00069	0.576
MOD_GSK3_1	91	98	PF00069	0.411
MOD_NEK2_1	163	168	PF00069	0.453
MOD_NEK2_1	26	31	PF00069	0.356
MOD_NEK2_1	44	49	PF00069	0.442
MOD_NEK2_1	91	96	PF00069	0.416
MOD_PKA_2	117	123	PF00069	0.356
MOD_PKA_2	126	132	PF00069	0.337
MOD_PKA_2	164	170	PF00069	0.340
MOD_PKA_2	5	11	PF00069	0.360
MOD_Plk_1	231	237	PF00069	0.499
MOD_Plk_4	164	170	PF00069	0.492
MOD_Plk_4	176	182	PF00069	0.445
MOD_Plk_4	26	32	PF00069	0.323
MOD_Plk_4	69	75	PF00069	0.603
MOD_Plk_4	86	92	PF00069	0.321
MOD_ProDKin_1	200	206	PF00069	0.518
MOD_SUMO_for_1	138	141	PF00179	0.474
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.265
TRG_ENDOCYTIC_2	198	201	PF00928	0.492
TRG_ENDOCYTIC_2	219	222	PF00928	0.307
TRG_ENDOCYTIC_2	52	55	PF00928	0.378
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.204
TRG_PTS1	237	240	PF00515	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW3	Leptomonas seymouri	66%	100%
A0A0N1PCR6	Leptomonas seymouri	31%	100%
A0A0S4JHI0	Bodo saltans	38%	100%
A0A0S4JLD9	Bodo saltans	38%	100%
A0A1X0NZ20	Trypanosomatidae	34%	100%
A0A1X0NZ92	Trypanosomatidae	57%	100%
A0A422N3N7	Trypanosoma rangeli	53%	100%
A0A422N3S1	Trypanosoma rangeli	38%	100%
A4HBT6	Leishmania braziliensis	35%	100%
A4II60	Xenopus tropicalis	34%	100%
A5A6I1	Pan troglodytes	35%	100%
D0A1D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0A1D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A1E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AGU6	Leishmania infantum	34%	100%
E9AGU7	Leishmania infantum	80%	100%
E9AV58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AV59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O69537	Mycobacterium leprae (strain TN)	31%	100%
P00492	Homo sapiens	35%	100%
P00493	Mus musculus	35%	100%
P00494	Cricetulus griseus	35%	100%
P07833	Plasmodium falciparum (isolate K1 / Thailand)	28%	100%
P0A5T1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P20035	Plasmodium falciparum (isolate FCR-3 / Gambia)	28%	100%
P27605	Rattus norvegicus	35%	100%
P37472	Bacillus subtilis (strain 168)	28%	100%
P43152	Leishmania donovani	34%	100%
P47959	Meriones unguiculatus	36%	100%
P96794	Mycobacterium avium	30%	100%
P9WHQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WHQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q07010	Trypanosoma brucei brucei	40%	100%
Q26997	Toxoplasma gondii	30%	100%
Q27541	Crithidia fasciculata	33%	100%
Q3SZ18	Bos taurus	35%	100%
Q45FY6	Sus scrofa	35%	100%
Q4QCC2	Leishmania major	80%	99%
Q4QCC3	Leishmania major	35%	95%
Q54NJ8	Dictyostelium discoideum	28%	100%
Q5HRP4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	33%	100%
Q6DCP3	Xenopus laevis	32%	100%
Q6LDD9	Macaca fascicularis	35%	100%
Q6WIT9	Canis lupus familiaris	35%	100%
Q7KLF3	Leishmania donovani	34%	100%
Q8CQV4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	33%	100%
Q9U6Y2	Leishmania donovani	80%	100%
Q9W719	Gallus gallus	36%	100%
V5DEL0	Trypanosoma cruzi	54%	78%