Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBT5_LEIBR

TriTrypDb:

LbrM.21.0980 , LBRM2903_210014600

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.619
CLV_NRD_NRD_1	21	23	PF00675	0.616
CLV_NRD_NRD_1	262	264	PF00675	0.589
CLV_NRD_NRD_1	328	330	PF00675	0.421
CLV_NRD_NRD_1	334	336	PF00675	0.480
CLV_NRD_NRD_1	386	388	PF00675	0.453
CLV_NRD_NRD_1	421	423	PF00675	0.440
CLV_NRD_NRD_1	62	64	PF00675	0.624
CLV_NRD_NRD_1	86	88	PF00675	0.614
CLV_NRD_NRD_1	94	96	PF00675	0.717
CLV_PCSK_FUR_1	307	311	PF00082	0.623
CLV_PCSK_FUR_1	384	388	PF00082	0.452
CLV_PCSK_KEX2_1	25	27	PF00082	0.626
CLV_PCSK_KEX2_1	309	311	PF00082	0.546
CLV_PCSK_KEX2_1	328	330	PF00082	0.421
CLV_PCSK_KEX2_1	333	335	PF00082	0.476
CLV_PCSK_KEX2_1	369	371	PF00082	0.513
CLV_PCSK_KEX2_1	386	388	PF00082	0.453
CLV_PCSK_KEX2_1	421	423	PF00082	0.440
CLV_PCSK_KEX2_1	62	64	PF00082	0.624
CLV_PCSK_KEX2_1	85	87	PF00082	0.619
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.626
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.546
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.479
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.513
CLV_PCSK_PC7_1	329	335	PF00082	0.523
CLV_PCSK_SKI1_1	226	230	PF00082	0.652
CLV_PCSK_SKI1_1	264	268	PF00082	0.620
CLV_PCSK_SKI1_1	292	296	PF00082	0.646
CLV_PCSK_SKI1_1	310	314	PF00082	0.411
CLV_PCSK_SKI1_1	397	401	PF00082	0.340
CLV_PCSK_SKI1_1	63	67	PF00082	0.624
DEG_APCC_DBOX_1	102	110	PF00400	0.396
DEG_APCC_DBOX_1	291	299	PF00400	0.450
DEG_SPOP_SBC_1	78	82	PF00917	0.417
DOC_CYCLIN_RxL_1	393	404	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.389
DOC_MAPK_gen_1	95	102	PF00069	0.378
DOC_MAPK_MEF2A_6	95	104	PF00069	0.378
DOC_MAPK_RevD_3	313	329	PF00069	0.411
DOC_PP1_RVXF_1	307	314	PF00149	0.346
DOC_PP2B_LxvP_1	35	38	PF13499	0.416
DOC_USP7_MATH_1	165	169	PF00917	0.615
DOC_USP7_MATH_1	171	175	PF00917	0.593
DOC_USP7_MATH_1	78	82	PF00917	0.417
DOC_WW_Pin1_4	181	186	PF00397	0.616
DOC_WW_Pin1_4	348	353	PF00397	0.715
DOC_WW_Pin1_4	74	79	PF00397	0.427
LIG_14-3-3_CanoR_1	103	107	PF00244	0.479
LIG_14-3-3_CanoR_1	226	234	PF00244	0.446
LIG_14-3-3_CanoR_1	41	46	PF00244	0.391
LIG_14-3-3_CanoR_1	85	93	PF00244	0.558
LIG_BRCT_BRCA1_1	117	121	PF00533	0.494
LIG_BRCT_BRCA1_1	173	177	PF00533	0.614
LIG_eIF4E_1	45	51	PF01652	0.385
LIG_FHA_1	271	277	PF00498	0.432
LIG_FHA_2	209	215	PF00498	0.587
LIG_FHA_2	227	233	PF00498	0.436
LIG_FHA_2	375	381	PF00498	0.675
LIG_FHA_2	59	65	PF00498	0.420
LIG_LIR_Gen_1	128	135	PF02991	0.371
LIG_LIR_Gen_1	317	327	PF02991	0.381
LIG_LIR_Gen_1	346	354	PF02991	0.787
LIG_LIR_Nem_3	128	132	PF02991	0.372
LIG_LIR_Nem_3	317	322	PF02991	0.381
LIG_Pex14_1	319	323	PF04695	0.411
LIG_SH2_CRK	129	133	PF00017	0.398
LIG_SH2_CRK	14	18	PF00017	0.406
LIG_SH2_STAT5	331	334	PF00017	0.648
LIG_SH2_STAT5	45	48	PF00017	0.386
LIG_SH3_3	6	12	PF00018	0.389
LIG_TRAF2_1	212	215	PF00917	0.458
LIG_WRC_WIRS_1	251	256	PF05994	0.511
MOD_CK1_1	172	178	PF00069	0.713
MOD_CK1_1	194	200	PF00069	0.819
MOD_CK1_1	201	207	PF00069	0.798
MOD_CK1_1	208	214	PF00069	0.640
MOD_CK1_1	77	83	PF00069	0.510
MOD_CK2_1	175	181	PF00069	0.695
MOD_CK2_1	208	214	PF00069	0.640
MOD_CK2_1	226	232	PF00069	0.620
MOD_CK2_1	374	380	PF00069	0.504
MOD_CK2_1	77	83	PF00069	0.510
MOD_GlcNHglycan	117	120	PF01048	0.616
MOD_GlcNHglycan	167	170	PF01048	0.685
MOD_GlcNHglycan	197	200	PF01048	0.809
MOD_GlcNHglycan	201	204	PF01048	0.632
MOD_GSK3_1	110	117	PF00069	0.644
MOD_GSK3_1	165	172	PF00069	0.794
MOD_GSK3_1	175	182	PF00069	0.574
MOD_GSK3_1	188	195	PF00069	0.733
MOD_GSK3_1	199	206	PF00069	0.667
MOD_GSK3_1	270	277	PF00069	0.531
MOD_GSK3_1	348	355	PF00069	0.593
MOD_GSK3_1	74	81	PF00069	0.521
MOD_N-GLC_1	401	406	PF02516	0.378
MOD_NEK2_1	102	107	PF00069	0.564
MOD_NEK2_1	109	114	PF00069	0.590
MOD_NEK2_1	13	18	PF00069	0.493
MOD_NEK2_1	173	178	PF00069	0.792
MOD_NEK2_1	188	193	PF00069	0.815
MOD_NEK2_1	233	238	PF00069	0.544
MOD_NEK2_1	274	279	PF00069	0.511
MOD_NEK2_1	364	369	PF00069	0.730
MOD_NEK2_1	374	379	PF00069	0.650
MOD_NEK2_2	69	74	PF00069	0.519
MOD_PIKK_1	274	280	PF00454	0.542
MOD_PKA_1	85	91	PF00069	0.502
MOD_PKA_2	102	108	PF00069	0.617
MOD_PKA_2	218	224	PF00069	0.601
MOD_PKA_2	374	380	PF00069	0.680
MOD_PKA_2	85	91	PF00069	0.720
MOD_Plk_1	270	276	PF00069	0.528
MOD_Plk_2-3	218	224	PF00069	0.480
MOD_Plk_4	314	320	PF00069	0.411
MOD_Plk_4	41	47	PF00069	0.471
MOD_Plk_4	69	75	PF00069	0.520
MOD_ProDKin_1	181	187	PF00069	0.789
MOD_ProDKin_1	348	354	PF00069	0.648
MOD_ProDKin_1	74	80	PF00069	0.524
MOD_SUMO_for_1	132	135	PF00179	0.486
TRG_DiLeu_BaEn_1	135	140	PF01217	0.461
TRG_ENDOCYTIC_2	129	132	PF00928	0.488
TRG_ENDOCYTIC_2	14	17	PF00928	0.491
TRG_ENDOCYTIC_2	225	228	PF00928	0.559
TRG_ENDOCYTIC_2	251	254	PF00928	0.522
TRG_ER_diArg_1	237	240	PF00400	0.545
TRG_ER_diArg_1	327	329	PF00400	0.502
TRG_ER_diArg_1	85	87	PF00400	0.514
TRG_NLS_MonoCore_2	22	27	PF00514	0.517
TRG_NLS_MonoExtC_3	23	28	PF00514	0.522
TRG_NLS_MonoExtN_4	22	29	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ9	Leptomonas seymouri	60%	100%
A0A3S7WWJ0	Leishmania donovani	80%	100%
A4HZM4	Leishmania infantum	80%	100%
E9AV57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCC4	Leishmania major	80%	100%