Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBT3_LEIBR

TriTrypDb:

LbrM.21.0960 , LBRM2903_210013700

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBT3

PDB structure(s): 7ane_v

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.621
CLV_NRD_NRD_1	187	189	PF00675	0.647
CLV_NRD_NRD_1	60	62	PF00675	0.622
CLV_PCSK_KEX2_1	132	134	PF00082	0.609
CLV_PCSK_KEX2_1	187	189	PF00082	0.646
CLV_PCSK_KEX2_1	206	208	PF00082	0.479
CLV_PCSK_KEX2_1	60	62	PF00082	0.622
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.598
CLV_PCSK_SKI1_1	197	201	PF00082	0.602
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DOC_CYCLIN_RxL_1	80	91	PF00134	0.646
DOC_USP7_MATH_1	33	37	PF00917	0.717
DOC_WW_Pin1_4	10	15	PF00397	0.582
DOC_WW_Pin1_4	67	72	PF00397	0.640
DOC_WW_Pin1_4	73	78	PF00397	0.632
LIG_14-3-3_CanoR_1	132	142	PF00244	0.612
LIG_14-3-3_CanoR_1	60	67	PF00244	0.656
LIG_Actin_WH2_2	118	134	PF00022	0.561
LIG_AP2alpha_1	142	146	PF02296	0.619
LIG_BRCT_BRCA1_1	3	7	PF00533	0.578
LIG_BRCT_BRCA1_1	75	79	PF00533	0.605
LIG_eIF4E_1	169	175	PF01652	0.619
LIG_FHA_1	11	17	PF00498	0.595
LIG_FHA_1	41	47	PF00498	0.571
LIG_FHA_1	98	104	PF00498	0.543
LIG_FHA_2	50	56	PF00498	0.587
LIG_LIR_Apic_2	36	42	PF02991	0.583
LIG_LIR_Gen_1	34	45	PF02991	0.587
LIG_LIR_Gen_1	52	59	PF02991	0.483
LIG_LIR_Nem_3	164	168	PF02991	0.616
LIG_LIR_Nem_3	34	40	PF02991	0.585
LIG_LIR_Nem_3	52	57	PF02991	0.482
LIG_Pex14_1	165	169	PF04695	0.608
LIG_Pex14_2	142	146	PF04695	0.619
LIG_SH2_CRK	12	16	PF00017	0.659
LIG_SH2_CRK	37	41	PF00017	0.579
LIG_SH2_GRB2like	39	42	PF00017	0.598
LIG_SH2_SRC	39	42	PF00017	0.604
LIG_SH2_STAT3	168	171	PF00017	0.744
LIG_SH2_STAT5	12	15	PF00017	0.634
LIG_SH2_STAT5	198	201	PF00017	0.588
LIG_SH2_STAT5	39	42	PF00017	0.581
LIG_SH3_3	205	211	PF00018	0.609
LIG_SUMO_SIM_par_1	13	19	PF11976	0.634
LIG_TRFH_1	29	33	PF08558	0.609
MOD_CK1_1	123	129	PF00069	0.565
MOD_CK1_1	69	75	PF00069	0.622
MOD_CK1_1	98	104	PF00069	0.499
MOD_CK2_1	109	115	PF00069	0.613
MOD_Cter_Amidation	185	188	PF01082	0.648
MOD_Cter_Amidation	204	207	PF01082	0.470
MOD_GlcNHglycan	23	26	PF01048	0.599
MOD_GlcNHglycan	87	90	PF01048	0.504
MOD_GSK3_1	133	140	PF00069	0.680
MOD_GSK3_1	148	155	PF00069	0.491
MOD_GSK3_1	69	76	PF00069	0.620
MOD_N-GLC_1	148	153	PF02516	0.598
MOD_NEK2_1	120	125	PF00069	0.567
MOD_NEK2_1	16	21	PF00069	0.668
MOD_PIKK_1	133	139	PF00454	0.719
MOD_PIKK_1	77	83	PF00454	0.608
MOD_PIKK_1	98	104	PF00454	0.654
MOD_PKA_2	115	121	PF00069	0.559
MOD_PKA_2	49	55	PF00069	0.571
MOD_PKA_2	59	65	PF00069	0.607
MOD_Plk_1	190	196	PF00069	0.699
MOD_Plk_1	98	104	PF00069	0.652
MOD_Plk_4	115	121	PF00069	0.633
MOD_ProDKin_1	10	16	PF00069	0.584
MOD_ProDKin_1	67	73	PF00069	0.637
MOD_SUMO_for_1	199	202	PF00179	0.634
TRG_DiLeu_BaEn_1	115	120	PF01217	0.673
TRG_ENDOCYTIC_2	12	15	PF00928	0.657
TRG_ENDOCYTIC_2	37	40	PF00928	0.579
TRG_ER_diArg_1	131	133	PF00400	0.619
TRG_ER_diArg_1	187	189	PF00400	0.647
TRG_ER_diArg_1	207	210	PF00400	0.433
TRG_ER_diArg_1	59	61	PF00400	0.615
TRG_NLS_MonoCore_2	205	210	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J8	Leptomonas seymouri	91%	100%
A0A0S4IQC1	Bodo saltans	67%	100%
A0A1X0NXP3	Trypanosomatidae	78%	98%
A0A3R7RD27	Trypanosoma rangeli	84%	100%
A0A3S7WWG7	Leishmania donovani	96%	100%
A4HZM8	Leishmania infantum	96%	100%
D0A1E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AV53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QCC8	Leishmania major	96%	100%