DUF3395 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBT1_LEIBR

TriTrypDb:

LbrM.21.0940 , LBRM2903_210014400

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.556
CLV_NRD_NRD_1	60	62	PF00675	0.337
CLV_NRD_NRD_1	76	78	PF00675	0.207
CLV_PCSK_KEX2_1	59	61	PF00082	0.348
DEG_Nend_UBRbox_4	1	2	PF02207	0.443
DOC_CDC14_PxL_1	139	147	PF14671	0.575
DOC_MAPK_MEF2A_6	179	188	PF00069	0.260
DOC_PP2B_LxvP_1	140	143	PF13499	0.604
DOC_USP7_MATH_1	105	109	PF00917	0.760
DOC_USP7_MATH_1	131	135	PF00917	0.633
DOC_USP7_MATH_1	27	31	PF00917	0.337
DOC_USP7_MATH_1	32	36	PF00917	0.338
DOC_WW_Pin1_4	161	166	PF00397	0.753
LIG_Actin_WH2_2	90	106	PF00022	0.428
LIG_FHA_1	150	156	PF00498	0.553
LIG_FHA_1	179	185	PF00498	0.194
LIG_FHA_1	67	73	PF00498	0.307
LIG_FHA_1	82	88	PF00498	0.407
LIG_FHA_2	157	163	PF00498	0.720
LIG_FHA_2	224	230	PF00498	0.308
LIG_LIR_Nem_3	229	235	PF02991	0.414
LIG_SH2_CRK	210	214	PF00017	0.303
LIG_SH2_PTP2	217	220	PF00017	0.254
LIG_SH2_SRC	200	203	PF00017	0.252
LIG_SH2_SRC	217	220	PF00017	0.225
LIG_SH2_STAT5	200	203	PF00017	0.300
LIG_SH2_STAT5	217	220	PF00017	0.238
LIG_SH2_STAT5	3	6	PF00017	0.295
LIG_SUMO_SIM_anti_2	180	186	PF11976	0.180
LIG_TYR_ITIM	215	220	PF00017	0.210
MOD_CDK_SPxxK_3	161	168	PF00069	0.573
MOD_CK1_1	133	139	PF00069	0.379
MOD_CK1_1	224	230	PF00069	0.303
MOD_CK1_1	35	41	PF00069	0.371
MOD_CK1_1	86	92	PF00069	0.334
MOD_CK2_1	156	162	PF00069	0.760
MOD_CK2_1	223	229	PF00069	0.256
MOD_CK2_1	4	10	PF00069	0.368
MOD_CMANNOS	135	138	PF00535	0.609
MOD_GlcNHglycan	29	32	PF01048	0.284
MOD_GSK3_1	150	157	PF00069	0.737
MOD_GSK3_1	220	227	PF00069	0.351
MOD_N-GLC_1	32	37	PF02516	0.179
MOD_NEK2_1	178	183	PF00069	0.252
MOD_NEK2_1	19	24	PF00069	0.418
MOD_PKA_2	178	184	PF00069	0.463
MOD_Plk_2-3	71	77	PF00069	0.462
MOD_Plk_4	178	184	PF00069	0.327
MOD_Plk_4	191	197	PF00069	0.245
MOD_Plk_4	83	89	PF00069	0.280
MOD_ProDKin_1	161	167	PF00069	0.747
MOD_SUMO_rev_2	202	209	PF00179	0.284
MOD_SUMO_rev_2	71	80	PF00179	0.386
TRG_ENDOCYTIC_2	217	220	PF00928	0.238
TRG_ENDOCYTIC_2	232	235	PF00928	0.363
TRG_ER_diArg_1	59	61	PF00400	0.378
TRG_NES_CRM1_1	192	205	PF08389	0.252
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	58%	73%
A0A1X0NXM7	Trypanosomatidae	41%	95%
A0A3Q8IF47	Leishmania donovani	76%	73%
A0A3R7N4N0	Trypanosoma rangeli	39%	91%
A4HZM6	Leishmania infantum	76%	73%
D0A1E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	73%
Q4QCC6	Leishmania major	77%	100%
V5BDR4	Trypanosoma cruzi	36%	91%