Putative small GTPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-related protein Rab21, putative

Species:

Leishmania braziliensis

UniProt:

A4HBS6_LEIBR

TriTrypDb:

LbrM.21.0870 , LBRM2903_210013200

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005769	early endosome	8	1
GO:0016020	membrane	2	5
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HBS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBS6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006886	intracellular protein transport	4	1
GO:0007165	signal transduction	2	5
GO:0007264	small GTPase mediated signal transduction	4	5
GO:0007265	Ras protein signal transduction	5	5
GO:0008104	protein localization	4	5
GO:0009987	cellular process	1	5
GO:0015031	protein transport	4	5
GO:0032482	Rab protein signal transduction	6	5
GO:0033036	macromolecule localization	2	5
GO:0035556	intracellular signal transduction	3	5
GO:0045184	establishment of protein localization	3	5
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051641	cellular localization	2	5
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	5
GO:0070727	cellular macromolecule localization	3	5
GO:0071702	organic substance transport	4	5
GO:0071705	nitrogen compound transport	4	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.334
CLV_NRD_NRD_1	106	108	PF00675	0.399
CLV_NRD_NRD_1	220	222	PF00675	0.653
CLV_PCSK_FUR_1	218	222	PF00082	0.657
CLV_PCSK_KEX2_1	220	222	PF00082	0.640
CLV_PCSK_PC7_1	216	222	PF00082	0.655
CLV_PCSK_SKI1_1	11	15	PF00082	0.335
CLV_PCSK_SKI1_1	185	189	PF00082	0.592
DEG_APCC_DBOX_1	219	227	PF00400	0.689
DEG_Nend_UBRbox_2	1	3	PF02207	0.602
DOC_MAPK_gen_1	216	225	PF00069	0.650
DOC_PP1_RVXF_1	4	11	PF00149	0.536
DOC_USP7_MATH_1	194	198	PF00917	0.756
DOC_USP7_MATH_1	214	218	PF00917	0.633
DOC_USP7_MATH_1	235	239	PF00917	0.697
DOC_USP7_MATH_1	270	274	PF00917	0.686
DOC_USP7_MATH_1	278	282	PF00917	0.674
DOC_WW_Pin1_4	134	139	PF00397	0.413
DOC_WW_Pin1_4	210	215	PF00397	0.759
DOC_WW_Pin1_4	236	241	PF00397	0.665
DOC_WW_Pin1_4	247	252	PF00397	0.544
LIG_14-3-3_CanoR_1	107	113	PF00244	0.412
LIG_14-3-3_CanoR_1	19	29	PF00244	0.331
LIG_Actin_WH2_2	93	109	PF00022	0.384
LIG_BIR_III_2	135	139	PF00653	0.214
LIG_FHA_1	177	183	PF00498	0.327
LIG_FHA_1	21	27	PF00498	0.331
LIG_FHA_2	137	143	PF00498	0.397
LIG_FHA_2	99	105	PF00498	0.331
LIG_LIR_Gen_1	115	125	PF02991	0.399
LIG_LIR_Gen_1	172	182	PF02991	0.367
LIG_LIR_Gen_1	78	88	PF02991	0.331
LIG_LIR_Nem_3	115	120	PF02991	0.399
LIG_LIR_Nem_3	172	177	PF02991	0.243
LIG_LIR_Nem_3	7	13	PF02991	0.481
LIG_LIR_Nem_3	78	83	PF02991	0.310
LIG_Rb_pABgroove_1	28	36	PF01858	0.214
LIG_SH2_CRK	117	121	PF00017	0.412
LIG_SH2_CRK	206	210	PF00017	0.766
LIG_SH2_CRK	246	250	PF00017	0.716
LIG_SH2_NCK_1	117	121	PF00017	0.412
LIG_SH2_NCK_1	206	210	PF00017	0.513
LIG_SH2_SRC	29	32	PF00017	0.214
LIG_SH2_STAT5	29	32	PF00017	0.412
LIG_SUMO_SIM_par_1	11	17	PF11976	0.331
LIG_SUMO_SIM_par_1	264	269	PF11976	0.693
LIG_TRAF2_1	75	78	PF00917	0.331
LIG_WW_3	250	254	PF00397	0.706
MOD_CDK_SPxK_1	210	216	PF00069	0.760
MOD_CDK_SPxK_1	247	253	PF00069	0.626
MOD_CDK_SPxxK_3	134	141	PF00069	0.214
MOD_CK1_1	163	169	PF00069	0.364
MOD_CK1_1	197	203	PF00069	0.691
MOD_CK1_1	238	244	PF00069	0.663
MOD_CK1_1	24	30	PF00069	0.364
MOD_CK1_1	259	265	PF00069	0.713
MOD_CK1_1	269	275	PF00069	0.502
MOD_CK1_1	45	51	PF00069	0.412
MOD_CK2_1	1	7	PF00069	0.405
MOD_CK2_1	134	140	PF00069	0.369
MOD_CK2_1	141	147	PF00069	0.360
MOD_CK2_1	236	242	PF00069	0.702
MOD_GlcNHglycan	162	165	PF01048	0.331
MOD_GlcNHglycan	174	177	PF01048	0.431
MOD_GlcNHglycan	196	199	PF01048	0.633
MOD_GlcNHglycan	200	203	PF01048	0.674
MOD_GlcNHglycan	259	262	PF01048	0.720
MOD_GlcNHglycan	268	271	PF01048	0.765
MOD_GlcNHglycan	282	285	PF01048	0.633
MOD_GSK3_1	172	179	PF00069	0.332
MOD_GSK3_1	181	188	PF00069	0.423
MOD_GSK3_1	194	201	PF00069	0.570
MOD_GSK3_1	20	27	PF00069	0.364
MOD_GSK3_1	210	217	PF00069	0.569
MOD_GSK3_1	266	273	PF00069	0.737
MOD_GSK3_1	38	45	PF00069	0.314
MOD_GSK3_1	98	105	PF00069	0.331
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	160	165	PF00069	0.315
MOD_NEK2_1	46	51	PF00069	0.337
MOD_NEK2_1	71	76	PF00069	0.412
MOD_NEK2_2	29	34	PF00069	0.214
MOD_PIKK_1	176	182	PF00454	0.466
MOD_PKB_1	183	191	PF00069	0.646
MOD_Plk_1	1	7	PF00069	0.660
MOD_Plk_1	270	276	PF00069	0.494
MOD_Plk_1	37	43	PF00069	0.460
MOD_Plk_4	21	27	PF00069	0.331
MOD_Plk_4	29	35	PF00069	0.331
MOD_ProDKin_1	134	140	PF00069	0.413
MOD_ProDKin_1	210	216	PF00069	0.760
MOD_ProDKin_1	236	242	PF00069	0.668
MOD_ProDKin_1	247	253	PF00069	0.544
MOD_SUMO_rev_2	32	39	PF00179	0.214
TRG_ENDOCYTIC_2	117	120	PF00928	0.412
TRG_ENDOCYTIC_2	206	209	PF00928	0.765
TRG_ENDOCYTIC_2	246	249	PF00928	0.720
TRG_ENDOCYTIC_2	31	34	PF00928	0.214
TRG_ER_diArg_1	182	185	PF00400	0.502
TRG_ER_diArg_1	216	219	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I1	Leptomonas seymouri	34%	100%
A0A0N1HU31	Leptomonas seymouri	30%	100%
A0A0N1HYV5	Leptomonas seymouri	29%	100%
A0A0N1IC49	Leptomonas seymouri	33%	92%
A0A0N1IL60	Leptomonas seymouri	38%	100%
A0A0N1PBC8	Leptomonas seymouri	71%	100%
A0A0N1PE58	Leptomonas seymouri	24%	100%
A0A0S4IJB7	Bodo saltans	30%	100%
A0A0S4IRD6	Bodo saltans	27%	100%
A0A0S4IWD9	Bodo saltans	32%	84%
A0A0S4IY79	Bodo saltans	34%	100%
A0A0S4J1G8	Bodo saltans	32%	100%
A0A0S4J9T5	Bodo saltans	31%	100%
A0A0S4JBJ9	Bodo saltans	39%	100%
A0A0S4JDW3	Bodo saltans	36%	100%
A0A0S4JKI9	Bodo saltans	42%	100%
A0A0S4JRU1	Bodo saltans	32%	100%
A0A0S4JUQ8	Bodo saltans	30%	100%
A0A0S4JVK4	Bodo saltans	35%	100%
A0A0S4KHE5	Bodo saltans	40%	100%
A0A1X0NKS6	Trypanosomatidae	29%	100%
A0A1X0NLM1	Trypanosomatidae	36%	100%
A0A1X0NN55	Trypanosomatidae	27%	100%
A0A1X0NQ87	Trypanosomatidae	31%	78%
A0A1X0NQG4	Trypanosomatidae	27%	100%
A0A1X0NR18	Trypanosomatidae	29%	100%
A0A1X0NVM5	Trypanosomatidae	31%	100%
A0A1X0NWF8	Trypanosomatidae	33%	100%
A0A1X0NXM2	Trypanosomatidae	50%	85%
A0A1X0P706	Trypanosomatidae	34%	100%
A0A3Q8I8T8	Leishmania donovani	28%	100%
A0A3Q8IC02	Leishmania donovani	86%	99%
A0A3Q8ICX9	Leishmania donovani	31%	100%
A0A3Q8ID64	Leishmania donovani	33%	100%
A0A3Q8IE68	Leishmania donovani	34%	100%
A0A3Q8IK84	Leishmania donovani	34%	100%
A0A3R7KA22	Trypanosoma rangeli	31%	100%
A0A3R7LYA6	Trypanosoma rangeli	28%	100%
A0A3R7ME44	Trypanosoma rangeli	32%	100%
A0A3R7N3U0	Trypanosoma rangeli	28%	100%
A0A3R7N9H9	Trypanosoma rangeli	31%	100%
A0A3R7N9V4	Trypanosoma rangeli	29%	100%
A0A3R7RHV7	Trypanosoma rangeli	30%	100%
A0A3R7RKC1	Trypanosoma rangeli	32%	100%
A0A3S5H4Z2	Leishmania donovani	37%	100%
A0A3S5H5Y5	Leishmania donovani	35%	100%
A0A3S5H6H3	Leishmania donovani	26%	100%
A0A3S7WUY8	Leishmania donovani	34%	100%
A0A3S7WV84	Leishmania donovani	40%	100%
A0A3S7X3D1	Leishmania donovani	31%	100%
A0A3S7X5J2	Leishmania donovani	30%	100%
A0A422P0L6	Trypanosoma rangeli	35%	100%
A1KXP5	Leishmania donovani	41%	100%
A4H506	Leishmania braziliensis	33%	100%
A4H6A4	Leishmania braziliensis	29%	100%
A4H6A5	Leishmania braziliensis	27%	100%
A4H9M3	Leishmania braziliensis	38%	100%
A4HEE8	Leishmania braziliensis	30%	100%
A4HFK0	Leishmania braziliensis	34%	100%
A4HHR8	Leishmania braziliensis	39%	100%
A4HIB4	Leishmania braziliensis	30%	100%
A4HK33	Leishmania braziliensis	31%	100%
A4HKH2	Leishmania braziliensis	30%	100%
A4HKJ3	Leishmania braziliensis	33%	100%
A4HLP5	Leishmania braziliensis	32%	100%
A4HRM3	Leishmania infantum	37%	100%
A4HT72	Leishmania infantum	35%	100%
A4HUM8	Leishmania infantum	28%	100%
A4HUM9	Leishmania infantum	26%	100%
A4HVF7	Leishmania infantum	41%	100%
A4HXY7	Leishmania infantum	40%	100%
A4HZ80	Leishmania infantum	86%	99%
A4I1I6	Leishmania infantum	30%	100%
A4I5J8	Leishmania infantum	31%	100%
A4I7N3	Leishmania infantum	31%	100%
A4I7Z9	Leishmania infantum	30%	100%
A4I825	Leishmania infantum	32%	100%
A4I946	Leishmania infantum	34%	100%
B1A5Z4	Leishmania donovani	30%	100%
C8VQY7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZZR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	84%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0AA91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E2RQ15	Canis lupus familiaris	34%	100%
E9AD53	Leishmania major	34%	100%
E9AGQ4	Leishmania infantum	34%	100%
E9AHE8	Leishmania infantum	34%	100%
E9AJI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9ARM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AV47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
G4MYS1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	100%
I1RMF2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O01803	Caenorhabditis elegans	33%	100%
O23561	Arabidopsis thaliana	32%	100%
O24461	Prunus armeniaca	33%	100%
O80501	Arabidopsis thaliana	35%	100%
P05714	Rattus norvegicus	31%	100%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P20338	Homo sapiens	32%	100%
P24409	Canis lupus familiaris	32%	100%
P28185	Arabidopsis thaliana	32%	100%
P29687	Nicotiana tabacum	39%	100%
P31582	Arabidopsis thaliana	40%	100%
P31583	Nicotiana plumbaginifolia	38%	100%
P34140	Dictyostelium discoideum	32%	100%
P35281	Rattus norvegicus	31%	100%
P35282	Mus musculus	42%	100%
P35286	Rattus norvegicus	33%	100%
P35288	Mus musculus	31%	100%
P35294	Mus musculus	32%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P36862	Volvox carteri	34%	100%
P38555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P41924	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	100%
P46629	Oryctolagus cuniculus	35%	100%
P51996	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P55745	Canis lupus familiaris	41%	100%
P56371	Mus musculus	31%	100%
P57735	Homo sapiens	35%	100%
P59279	Mus musculus	29%	100%
P61026	Homo sapiens	32%	100%
P61027	Mus musculus	32%	100%
P61028	Mus musculus	29%	100%
P61106	Homo sapiens	30%	100%
P61107	Rattus norvegicus	30%	100%
P70550	Rattus norvegicus	29%	100%
P92963	Arabidopsis thaliana	31%	100%
Q01111	Nicotiana plumbaginifolia	33%	100%
Q01387	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q17R06	Bos taurus	41%	100%
Q2HJI8	Bos taurus	29%	100%
Q2TBH7	Bos taurus	32%	100%
Q38922	Arabidopsis thaliana	31%	100%
Q40191	Lotus japonicus	31%	100%
Q40194	Lotus japonicus	36%	100%
Q4Q404	Leishmania major	34%	100%
Q4Q573	Leishmania major	33%	100%
Q4Q595	Leishmania major	30%	100%
Q4Q5N4	Leishmania major	32%	100%
Q4Q7C3	Leishmania major	30%	100%
Q4Q9V1	Leishmania major	30%	100%
Q4QCD4	Leishmania major	85%	100%
Q4QDS9	Leishmania major	40%	100%
Q4QGD2	Leishmania major	41%	100%
Q4QH97	Leishmania major	26%	100%
Q4QH98	Leishmania major	30%	100%
Q4QIN6	Leishmania major	35%	100%
Q52NJ6	Sus scrofa	30%	100%
Q55CB7	Dictyostelium discoideum	29%	100%
Q5R4W9	Pongo abelii	34%	100%
Q5R5U1	Pongo abelii	32%	100%
Q5R8Z8	Pongo abelii	30%	100%
Q5REC9	Pongo abelii	28%	100%
Q5ZIT5	Gallus gallus	32%	100%
Q5ZKU5	Gallus gallus	30%	100%
Q6AXT5	Rattus norvegicus	42%	100%
Q6PHI9	Danio rerio	31%	100%
Q86JP3	Dictyostelium discoideum	38%	100%
Q8CFP6	Mus musculus	30%	100%
Q8HZJ5	Bos taurus	35%	100%
Q8MXQ2	Dictyostelium discoideum	26%	100%
Q8WQ53	Geodia cydonium	39%	100%
Q91V41	Mus musculus	30%	100%
Q92930	Homo sapiens	28%	100%
Q948K6	Arabidopsis thaliana	32%	100%
Q9C2L8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	100%
Q9C9U7	Arabidopsis thaliana	34%	100%
Q9FGK5	Arabidopsis thaliana	33%	100%
Q9FJH0	Arabidopsis thaliana	33%	100%
Q9FPJ4	Arabidopsis thaliana	32%	100%
Q9GP33	Echinococcus multilocularis	29%	100%
Q9H0T7	Homo sapiens	37%	100%
Q9LFT9	Arabidopsis thaliana	35%	100%
Q9LK99	Arabidopsis thaliana	32%	100%
Q9N2P5	Leishmania major	34%	100%
Q9NP90	Homo sapiens	33%	100%
Q9SEH3	Arabidopsis thaliana	32%	100%
Q9UL25	Homo sapiens	41%	100%
Q9ULC3	Homo sapiens	31%	100%
Q9WTL2	Mus musculus	35%	100%
V5BBM5	Trypanosoma cruzi	32%	100%
V5C1F1	Trypanosoma cruzi	27%	100%
V5C2R1	Trypanosoma cruzi	32%	78%
V5D027	Trypanosoma cruzi	35%	100%
V5D9W7	Trypanosoma cruzi	39%	100%
V5DKQ7	Trypanosoma cruzi	29%	90%