C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBS4_LEIBR

TriTrypDb:

LbrM.21.0850 , LBRM2903_210013000

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.523
CLV_NRD_NRD_1	487	489	PF00675	0.774
CLV_NRD_NRD_1	81	83	PF00675	0.398
CLV_PCSK_KEX2_1	187	189	PF00082	0.481
CLV_PCSK_KEX2_1	208	210	PF00082	0.722
CLV_PCSK_KEX2_1	302	304	PF00082	0.612
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.722
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.651
CLV_PCSK_SKI1_1	161	165	PF00082	0.555
DEG_APCC_DBOX_1	84	92	PF00400	0.456
DEG_COP1_1	97	106	PF00400	0.483
DEG_SPOP_SBC_1	266	270	PF00917	0.646
DOC_CKS1_1	357	362	PF01111	0.744
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.484
DOC_MAPK_gen_1	82	92	PF00069	0.424
DOC_MAPK_MEF2A_6	82	90	PF00069	0.476
DOC_PP2B_LxvP_1	218	221	PF13499	0.406
DOC_PP2B_LxvP_1	253	256	PF13499	0.492
DOC_PP2B_LxvP_1	84	87	PF13499	0.405
DOC_PP2B_LxvP_1	90	93	PF13499	0.453
DOC_USP7_MATH_1	14	18	PF00917	0.769
DOC_USP7_MATH_1	195	199	PF00917	0.693
DOC_USP7_MATH_1	316	320	PF00917	0.664
DOC_USP7_MATH_1	409	413	PF00917	0.651
DOC_USP7_MATH_1	51	55	PF00917	0.803
DOC_USP7_UBL2_3	68	72	PF12436	0.626
DOC_WW_Pin1_4	137	142	PF00397	0.581
DOC_WW_Pin1_4	280	285	PF00397	0.527
DOC_WW_Pin1_4	308	313	PF00397	0.609
DOC_WW_Pin1_4	333	338	PF00397	0.626
DOC_WW_Pin1_4	356	361	PF00397	0.693
DOC_WW_Pin1_4	363	368	PF00397	0.707
DOC_WW_Pin1_4	369	374	PF00397	0.669
DOC_WW_Pin1_4	377	382	PF00397	0.648
DOC_WW_Pin1_4	407	412	PF00397	0.765
DOC_WW_Pin1_4	413	418	PF00397	0.744
DOC_WW_Pin1_4	440	445	PF00397	0.686
DOC_WW_Pin1_4	466	471	PF00397	0.737
DOC_WW_Pin1_4	96	101	PF00397	0.578
LIG_14-3-3_CanoR_1	179	185	PF00244	0.385
LIG_14-3-3_CanoR_1	209	218	PF00244	0.659
LIG_14-3-3_CanoR_1	307	312	PF00244	0.638
LIG_14-3-3_CanoR_1	354	358	PF00244	0.716
LIG_14-3-3_CanoR_1	482	488	PF00244	0.626
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BRCT_BRCA1_1	371	375	PF00533	0.767
LIG_deltaCOP1_diTrp_1	69	75	PF00928	0.489
LIG_FHA_1	181	187	PF00498	0.409
LIG_FHA_1	268	274	PF00498	0.523
LIG_FHA_1	360	366	PF00498	0.797
LIG_FHA_1	48	54	PF00498	0.802
LIG_FHA_1	482	488	PF00498	0.520
LIG_FHA_1	79	85	PF00498	0.422
LIG_FHA_2	347	353	PF00498	0.651
LIG_FHA_2	38	44	PF00498	0.730
LIG_LIR_Gen_1	25	31	PF02991	0.685
LIG_LIR_Gen_1	292	301	PF02991	0.566
LIG_LIR_Gen_1	70	80	PF02991	0.449
LIG_LIR_Nem_3	157	163	PF02991	0.334
LIG_LIR_Nem_3	25	30	PF02991	0.685
LIG_LIR_Nem_3	292	298	PF02991	0.514
LIG_LIR_Nem_3	349	353	PF02991	0.700
LIG_LIR_Nem_3	473	479	PF02991	0.740
LIG_LIR_Nem_3	70	76	PF02991	0.448
LIG_RPA_C_Fungi	3	15	PF08784	0.504
LIG_SH2_CRK	476	480	PF00017	0.778
LIG_SH2_NCK_1	340	344	PF00017	0.713
LIG_SH2_NCK_1	476	480	PF00017	0.778
LIG_SH2_PTP2	162	165	PF00017	0.459
LIG_SH2_STAP1	324	328	PF00017	0.769
LIG_SH2_STAT3	3	6	PF00017	0.499
LIG_SH2_STAT5	162	165	PF00017	0.459
LIG_SH2_STAT5	189	192	PF00017	0.530
LIG_SH2_STAT5	236	239	PF00017	0.411
LIG_SH2_STAT5	280	283	PF00017	0.560
LIG_SH2_STAT5	355	358	PF00017	0.584
LIG_SH2_STAT5	39	42	PF00017	0.690
LIG_SH2_STAT5	438	441	PF00017	0.774
LIG_SH3_3	345	351	PF00018	0.691
LIG_SH3_3	362	368	PF00018	0.777
LIG_SH3_3	73	79	PF00018	0.436
LIG_SUMO_SIM_par_1	267	278	PF11976	0.530
LIG_SUMO_SIM_par_1	283	289	PF11976	0.552
LIG_SxIP_EBH_1	123	134	PF03271	0.468
LIG_TRAF2_1	41	44	PF00917	0.778
LIG_TRAF2_1	422	425	PF00917	0.548
LIG_TYR_ITIM	133	138	PF00017	0.523
MOD_CK1_1	139	145	PF00069	0.482
MOD_CK1_1	154	160	PF00069	0.345
MOD_CK1_1	17	23	PF00069	0.661
MOD_CK1_1	210	216	PF00069	0.441
MOD_CK1_1	262	268	PF00069	0.632
MOD_CK1_1	269	275	PF00069	0.323
MOD_CK1_1	329	335	PF00069	0.562
MOD_CK1_1	369	375	PF00069	0.811
MOD_CK1_1	442	448	PF00069	0.519
MOD_CK1_1	452	458	PF00069	0.756
MOD_CK1_1	461	467	PF00069	0.748
MOD_CK1_1	477	483	PF00069	0.719
MOD_CK1_1	59	65	PF00069	0.700
MOD_CK2_1	346	352	PF00069	0.495
MOD_CK2_1	37	43	PF00069	0.773
MOD_CK2_1	419	425	PF00069	0.791
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.514
MOD_GlcNHglycan	127	130	PF01048	0.447
MOD_GlcNHglycan	197	200	PF01048	0.646
MOD_GlcNHglycan	209	212	PF01048	0.481
MOD_GlcNHglycan	318	321	PF01048	0.648
MOD_GlcNHglycan	328	331	PF01048	0.669
MOD_GlcNHglycan	333	336	PF01048	0.632
MOD_GlcNHglycan	368	371	PF01048	0.756
MOD_GlcNHglycan	421	424	PF01048	0.599
MOD_GlcNHglycan	427	430	PF01048	0.541
MOD_GlcNHglycan	43	48	PF01048	0.797
MOD_GlcNHglycan	451	454	PF01048	0.645
MOD_GlcNHglycan	457	460	PF01048	0.617
MOD_GlcNHglycan	464	467	PF01048	0.488
MOD_GlcNHglycan	479	482	PF01048	0.729
MOD_GSK3_1	195	202	PF00069	0.595
MOD_GSK3_1	203	210	PF00069	0.570
MOD_GSK3_1	258	265	PF00069	0.596
MOD_GSK3_1	267	274	PF00069	0.524
MOD_GSK3_1	307	314	PF00069	0.604
MOD_GSK3_1	329	336	PF00069	0.712
MOD_GSK3_1	359	366	PF00069	0.690
MOD_GSK3_1	39	46	PF00069	0.718
MOD_GSK3_1	403	410	PF00069	0.718
MOD_GSK3_1	436	443	PF00069	0.693
MOD_GSK3_1	451	458	PF00069	0.671
MOD_GSK3_1	462	469	PF00069	0.746
MOD_GSK3_1	47	54	PF00069	0.718
MOD_GSK3_1	470	477	PF00069	0.665
MOD_GSK3_1	56	63	PF00069	0.548
MOD_GSK3_1	9	16	PF00069	0.572
MOD_GSK3_1	91	98	PF00069	0.519
MOD_N-GLC_1	203	208	PF02516	0.492
MOD_N-GLC_1	307	312	PF02516	0.667
MOD_NEK2_1	13	18	PF00069	0.632
MOD_NEK2_1	328	333	PF00069	0.729
MOD_NEK2_1	451	456	PF00069	0.658
MOD_NEK2_1	462	467	PF00069	0.793
MOD_NEK2_2	353	358	PF00069	0.719
MOD_PIKK_1	379	385	PF00454	0.787
MOD_PK_1	271	277	PF00069	0.478
MOD_PKA_2	353	359	PF00069	0.621
MOD_PKA_2	449	455	PF00069	0.694
MOD_PKA_2	481	487	PF00069	0.638
MOD_Plk_1	151	157	PF00069	0.449
MOD_Plk_4	442	448	PF00069	0.519
MOD_ProDKin_1	137	143	PF00069	0.579
MOD_ProDKin_1	280	286	PF00069	0.529
MOD_ProDKin_1	308	314	PF00069	0.613
MOD_ProDKin_1	333	339	PF00069	0.620
MOD_ProDKin_1	356	362	PF00069	0.697
MOD_ProDKin_1	363	369	PF00069	0.709
MOD_ProDKin_1	377	383	PF00069	0.688
MOD_ProDKin_1	407	413	PF00069	0.767
MOD_ProDKin_1	440	446	PF00069	0.688
MOD_ProDKin_1	466	472	PF00069	0.736
MOD_ProDKin_1	96	102	PF00069	0.578
MOD_SUMO_rev_2	294	304	PF00179	0.614
MOD_SUMO_rev_2	52	59	PF00179	0.694
MOD_SUMO_rev_2	64	74	PF00179	0.538
TRG_ENDOCYTIC_2	135	138	PF00928	0.535
TRG_ENDOCYTIC_2	162	165	PF00928	0.459
TRG_ENDOCYTIC_2	476	479	PF00928	0.738
TRG_ER_diArg_1	186	188	PF00400	0.516
TRG_ER_diArg_1	233	236	PF00400	0.448
TRG_NLS_Bipartite_1	67	86	PF00514	0.552
TRG_NLS_MonoExtN_4	79	86	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P864	Leptomonas seymouri	64%	99%
A0A3R7KEE9	Trypanosoma rangeli	42%	86%
A0A3S5H796	Leishmania donovani	84%	98%
A4HZ78	Leishmania infantum	84%	98%
D0A1F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	87%
E9AV45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QCD6	Leishmania major	84%	100%
V5BMY3	Trypanosoma cruzi	42%	87%