19S proteasome regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 5, putative

Species:

Leishmania braziliensis

UniProt:

A4HBS3_LEIBR

TriTrypDb:

LbrM.21.0840 , LBRM2903_210012900

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005838	proteasome regulatory particle	2	12
GO:0032991	protein-containing complex	1	12
GO:0000502	proteasome complex	3	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0031595	nuclear proteasome complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A4HBS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBS3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.422
CLV_C14_Caspase3-7	440	444	PF00656	0.611
CLV_MEL_PAP_1	339	345	PF00089	0.579
CLV_NRD_NRD_1	162	164	PF00675	0.544
CLV_NRD_NRD_1	211	213	PF00675	0.453
CLV_NRD_NRD_1	389	391	PF00675	0.249
CLV_NRD_NRD_1	430	432	PF00675	0.594
CLV_PCSK_KEX2_1	164	166	PF00082	0.453
CLV_PCSK_KEX2_1	389	391	PF00082	0.336
CLV_PCSK_KEX2_1	97	99	PF00082	0.496
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.455
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.508
CLV_PCSK_PC7_1	385	391	PF00082	0.386
CLV_Separin_Metazoa	73	77	PF03568	0.536
DEG_APCC_DBOX_1	384	392	PF00400	0.500
DOC_CDC14_PxL_1	320	328	PF14671	0.486
DOC_CYCLIN_RxL_1	76	90	PF00134	0.511
DOC_MAPK_gen_1	389	397	PF00069	0.520
DOC_MAPK_gen_1	418	428	PF00069	0.500
DOC_MAPK_gen_1	431	437	PF00069	0.458
DOC_MAPK_gen_1	76	86	PF00069	0.515
DOC_MAPK_MEF2A_6	79	88	PF00069	0.538
DOC_MAPK_RevD_3	84	98	PF00069	0.482
DOC_SPAK_OSR1_1	149	153	PF12202	0.437
DOC_USP7_MATH_1	208	212	PF00917	0.453
DOC_WW_Pin1_4	395	400	PF00397	0.500
LIG_14-3-3_CanoR_1	163	171	PF00244	0.555
LIG_14-3-3_CanoR_1	27	37	PF00244	0.575
LIG_14-3-3_CanoR_1	342	350	PF00244	0.503
LIG_14-3-3_CanoR_1	370	378	PF00244	0.504
LIG_14-3-3_CanoR_1	431	436	PF00244	0.591
LIG_14-3-3_CanoR_1	76	86	PF00244	0.516
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_Clathr_ClatBox_1	425	429	PF01394	0.511
LIG_Clathr_ClatBox_1	51	55	PF01394	0.426
LIG_Clathr_ClatBox_1	69	73	PF01394	0.417
LIG_deltaCOP1_diTrp_1	3	11	PF00928	0.621
LIG_eIF4E_1	204	210	PF01652	0.466
LIG_FAT_LD_1	84	92	PF03623	0.560
LIG_FHA_1	111	117	PF00498	0.485
LIG_FHA_1	149	155	PF00498	0.534
LIG_FHA_1	171	177	PF00498	0.611
LIG_FHA_1	19	25	PF00498	0.509
LIG_FHA_1	30	36	PF00498	0.485
LIG_FHA_1	432	438	PF00498	0.534
LIG_FHA_1	65	71	PF00498	0.444
LIG_FHA_2	154	160	PF00498	0.538
LIG_FHA_2	281	287	PF00498	0.588
LIG_FHA_2	309	315	PF00498	0.610
LIG_FHA_2	351	357	PF00498	0.549
LIG_FHA_2	78	84	PF00498	0.514
LIG_LIR_Gen_1	202	210	PF02991	0.534
LIG_LIR_Gen_1	254	263	PF02991	0.565
LIG_LIR_Gen_1	380	391	PF02991	0.480
LIG_LIR_Gen_1	414	422	PF02991	0.531
LIG_LIR_LC3C_4	423	427	PF02991	0.511
LIG_LIR_Nem_3	202	207	PF02991	0.536
LIG_LIR_Nem_3	243	248	PF02991	0.448
LIG_LIR_Nem_3	254	259	PF02991	0.367
LIG_LIR_Nem_3	294	299	PF02991	0.360
LIG_LIR_Nem_3	380	386	PF02991	0.439
LIG_MYND_1	355	359	PF01753	0.590
LIG_MYND_3	182	186	PF01753	0.541
LIG_NRBOX	325	331	PF00104	0.442
LIG_NRP_CendR_1	472	474	PF00754	0.485
LIG_Pex14_1	252	256	PF04695	0.401
LIG_PTB_Apo_2	409	416	PF02174	0.424
LIG_SH2_CRK	256	260	PF00017	0.558
LIG_SH2_CRK	327	331	PF00017	0.567
LIG_SH2_CRK	383	387	PF00017	0.511
LIG_SH2_NCK_1	204	208	PF00017	0.549
LIG_SH2_NCK_1	383	387	PF00017	0.579
LIG_SH2_SRC	204	207	PF00017	0.553
LIG_SH2_SRC	276	279	PF00017	0.413
LIG_SH2_STAT3	78	81	PF00017	0.480
LIG_SH2_STAT5	135	138	PF00017	0.535
LIG_SH2_STAT5	231	234	PF00017	0.402
LIG_SH2_STAT5	276	279	PF00017	0.413
LIG_SH2_STAT5	383	386	PF00017	0.541
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.465
LIG_SUMO_SIM_anti_2	344	351	PF11976	0.488
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.500
LIG_SUMO_SIM_anti_2	448	453	PF11976	0.490
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.527
LIG_SUMO_SIM_par_1	111	118	PF11976	0.349
LIG_SUMO_SIM_par_1	150	156	PF11976	0.526
LIG_SUMO_SIM_par_1	31	40	PF11976	0.547
LIG_SUMO_SIM_par_1	50	55	PF11976	0.293
LIG_SUMO_SIM_par_1	66	73	PF11976	0.430
LIG_SxIP_EBH_1	27	39	PF03271	0.559
LIG_SxIP_EBH_1	379	390	PF03271	0.586
LIG_TRAF2_1	362	365	PF00917	0.499
LIG_TYR_ITIM	229	234	PF00017	0.439
LIG_UBA3_1	376	381	PF00899	0.424
LIG_UBA3_1	406	413	PF00899	0.525
LIG_UBA3_1	464	472	PF00899	0.642
LIG_UBA3_1	51	56	PF00899	0.434
LIG_UBA3_1	87	96	PF00899	0.529
MOD_CK1_1	18	24	PF00069	0.555
MOD_CK1_1	267	273	PF00069	0.496
MOD_CK1_1	310	316	PF00069	0.537
MOD_CK2_1	153	159	PF00069	0.518
MOD_CK2_1	280	286	PF00069	0.529
MOD_CK2_1	308	314	PF00069	0.586
MOD_CK2_1	315	321	PF00069	0.574
MOD_CK2_1	342	348	PF00069	0.528
MOD_CK2_1	350	356	PF00069	0.528
MOD_CK2_1	77	83	PF00069	0.543
MOD_Cter_Amidation	161	164	PF01082	0.546
MOD_GlcNHglycan	105	108	PF01048	0.432
MOD_GlcNHglycan	14	20	PF01048	0.620
MOD_GlcNHglycan	165	168	PF01048	0.503
MOD_GlcNHglycan	266	269	PF01048	0.521
MOD_GSK3_1	110	117	PF00069	0.471
MOD_GSK3_1	255	262	PF00069	0.566
MOD_GSK3_1	365	372	PF00069	0.575
MOD_GSK3_1	377	384	PF00069	0.528
MOD_GSK3_1	395	402	PF00069	0.485
MOD_GSK3_1	437	444	PF00069	0.585
MOD_GSK3_1	453	460	PF00069	0.505
MOD_N-GLC_1	28	33	PF02516	0.518
MOD_N-GLC_1	280	285	PF02516	0.590
MOD_N-GLC_1	411	416	PF02516	0.371
MOD_N-GLC_1	441	446	PF02516	0.527
MOD_N-GLC_2	369	371	PF02516	0.386
MOD_NEK2_1	170	175	PF00069	0.613
MOD_NEK2_1	350	355	PF00069	0.514
MOD_NEK2_1	36	41	PF00069	0.531
MOD_NEK2_1	377	382	PF00069	0.485
MOD_NEK2_1	405	410	PF00069	0.519
MOD_PIKK_1	77	83	PF00454	0.534
MOD_PK_1	332	338	PF00069	0.472
MOD_PKA_1	163	169	PF00069	0.559
MOD_PKA_1	431	437	PF00069	0.590
MOD_PKA_2	148	154	PF00069	0.534
MOD_PKA_2	341	347	PF00069	0.543
MOD_PKA_2	369	375	PF00069	0.501
MOD_PKA_2	37	43	PF00069	0.531
MOD_Plk_1	110	116	PF00069	0.510
MOD_Plk_1	28	34	PF00069	0.522
MOD_Plk_1	291	297	PF00069	0.495
MOD_Plk_1	411	417	PF00069	0.561
MOD_Plk_1	441	447	PF00069	0.497
MOD_Plk_2-3	153	159	PF00069	0.544
MOD_Plk_2-3	50	56	PF00069	0.468
MOD_Plk_4	110	116	PF00069	0.334
MOD_Plk_4	241	247	PF00069	0.469
MOD_Plk_4	405	411	PF00069	0.512
MOD_ProDKin_1	395	401	PF00069	0.500
MOD_SUMO_rev_2	261	267	PF00179	0.541
MOD_SUMO_rev_2	3	9	PF00179	0.691
TRG_DiLeu_BaEn_1	20	25	PF01217	0.625
TRG_ENDOCYTIC_2	204	207	PF00928	0.553
TRG_ENDOCYTIC_2	231	234	PF00928	0.427
TRG_ENDOCYTIC_2	256	259	PF00928	0.523
TRG_ENDOCYTIC_2	327	330	PF00928	0.558
TRG_ENDOCYTIC_2	383	386	PF00928	0.500
TRG_ENDOCYTIC_2	416	419	PF00928	0.500
TRG_ER_diArg_1	388	390	PF00400	0.429
TRG_NES_CRM1_1	189	205	PF08389	0.429
TRG_NES_CRM1_1	337	352	PF08389	0.609
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV3	Leptomonas seymouri	88%	100%
A0A0S4IPZ2	Bodo saltans	50%	96%
A0A1X0NY92	Trypanosomatidae	67%	99%
A0A3S7WWF6	Leishmania donovani	95%	100%
A0A422NHB9	Trypanosoma rangeli	67%	99%
A4HZ77	Leishmania infantum	95%	100%
D0A1G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
E9AV44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O00232	Homo sapiens	31%	100%
P0CU17	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P0CU18	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q12250	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q2KJ25	Bos taurus	31%	100%
Q4QCD7	Leishmania major	95%	100%
Q54UJ0	Dictyostelium discoideum	31%	100%
Q5RBI3	Pongo abelii	31%	100%
Q8VWK0	Arabidopsis thaliana	29%	100%
Q9D8W5	Mus musculus	31%	100%
Q9FIB6	Arabidopsis thaliana	30%	100%
V5BDS8	Trypanosoma cruzi	65%	66%