Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 91, putative

Species:

Leishmania braziliensis

UniProt:

A4HBS2_LEIBR

TriTrypDb:

LbrM.21.0830 , LBRM2903_210012800

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBS2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	539	543	PF00656	0.616
CLV_NRD_NRD_1	412	414	PF00675	0.637
CLV_NRD_NRD_1	453	455	PF00675	0.410
CLV_NRD_NRD_1	513	515	PF00675	0.367
CLV_NRD_NRD_1	620	622	PF00675	0.640
CLV_PCSK_KEX2_1	412	414	PF00082	0.637
CLV_PCSK_KEX2_1	453	455	PF00082	0.312
CLV_PCSK_KEX2_1	513	515	PF00082	0.367
CLV_PCSK_KEX2_1	620	622	PF00082	0.594
CLV_PCSK_PC7_1	616	622	PF00082	0.628
CLV_PCSK_SKI1_1	160	164	PF00082	0.395
CLV_PCSK_SKI1_1	206	210	PF00082	0.594
CLV_PCSK_SKI1_1	284	288	PF00082	0.376
CLV_PCSK_SKI1_1	31	35	PF00082	0.377
CLV_PCSK_SKI1_1	453	457	PF00082	0.580
CLV_PCSK_SKI1_1	476	480	PF00082	0.374
CLV_PCSK_SKI1_1	489	493	PF00082	0.365
CLV_PCSK_SKI1_1	513	517	PF00082	0.370
CLV_PCSK_SKI1_1	530	534	PF00082	0.340
CLV_Separin_Metazoa	593	597	PF03568	0.607
DEG_APCC_DBOX_1	185	193	PF00400	0.223
DEG_APCC_DBOX_1	453	461	PF00400	0.313
DEG_APCC_KENBOX_2	309	313	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.298
DEG_SPOP_SBC_1	131	135	PF00917	0.527
DEG_SPOP_SBC_1	353	357	PF00917	0.379
DOC_CYCLIN_RxL_1	510	522	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.409
DOC_MAPK_DCC_7	453	462	PF00069	0.307
DOC_MAPK_gen_1	308	315	PF00069	0.479
DOC_MAPK_gen_1	510	518	PF00069	0.402
DOC_MAPK_gen_1	65	74	PF00069	0.238
DOC_MAPK_HePTP_8	450	462	PF00069	0.285
DOC_MAPK_MEF2A_6	195	203	PF00069	0.238
DOC_MAPK_MEF2A_6	274	282	PF00069	0.360
DOC_MAPK_MEF2A_6	453	462	PF00069	0.540
DOC_MAPK_MEF2A_6	596	605	PF00069	0.626
DOC_MAPK_MEF2A_6	67	76	PF00069	0.222
DOC_PP1_RVXF_1	9	15	PF00149	0.378
DOC_PP2B_LxvP_1	163	166	PF13499	0.389
DOC_PP2B_LxvP_1	333	336	PF13499	0.467
DOC_PP2B_LxvP_1	455	458	PF13499	0.355
DOC_PP2B_LxvP_1	503	506	PF13499	0.422
DOC_PP4_FxxP_1	146	149	PF00568	0.471
DOC_PP4_FxxP_1	162	165	PF00568	0.459
DOC_PP4_FxxP_1	296	299	PF00568	0.232
DOC_PP4_FxxP_1	76	79	PF00568	0.314
DOC_SPAK_OSR1_1	145	149	PF12202	0.471
DOC_USP7_MATH_1	125	129	PF00917	0.406
DOC_USP7_MATH_1	13	17	PF00917	0.363
DOC_USP7_MATH_1	131	135	PF00917	0.483
DOC_USP7_MATH_1	149	153	PF00917	0.429
DOC_USP7_MATH_1	4	8	PF00917	0.323
DOC_USP7_MATH_1	48	52	PF00917	0.379
DOC_USP7_MATH_1	587	591	PF00917	0.480
DOC_USP7_UBL2_3	31	35	PF12436	0.433
DOC_USP7_UBL2_3	669	673	PF12436	0.518
DOC_WW_Pin1_4	439	444	PF00397	0.492
DOC_WW_Pin1_4	540	545	PF00397	0.534
DOC_WW_Pin1_4	704	709	PF00397	0.690
LIG_14-3-3_CanoR_1	186	190	PF00244	0.298
LIG_14-3-3_CanoR_1	206	212	PF00244	0.263
LIG_14-3-3_CanoR_1	517	524	PF00244	0.435
LIG_14-3-3_CanoR_1	655	661	PF00244	0.504
LIG_Actin_WH2_2	282	297	PF00022	0.340
LIG_APCC_ABBA_1	199	204	PF00400	0.345
LIG_APCC_ABBA_1	237	242	PF00400	0.459
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.464
LIG_BRCT_BRCA1_1	400	404	PF00533	0.460
LIG_Clathr_ClatBox_1	200	204	PF01394	0.388
LIG_deltaCOP1_diTrp_1	158	162	PF00928	0.432
LIG_deltaCOP1_diTrp_1	91	97	PF00928	0.323
LIG_EH_1	401	405	PF12763	0.486
LIG_FHA_1	186	192	PF00498	0.280
LIG_FHA_1	320	326	PF00498	0.375
LIG_FHA_1	394	400	PF00498	0.356
LIG_FHA_1	450	456	PF00498	0.371
LIG_FHA_1	473	479	PF00498	0.371
LIG_FHA_1	483	489	PF00498	0.353
LIG_FHA_1	550	556	PF00498	0.445
LIG_FHA_1	559	565	PF00498	0.455
LIG_FHA_1	90	96	PF00498	0.347
LIG_FHA_2	169	175	PF00498	0.410
LIG_FHA_2	265	271	PF00498	0.513
LIG_FHA_2	551	557	PF00498	0.505
LIG_GBD_Chelix_1	372	380	PF00786	0.399
LIG_LIR_Apic_2	144	149	PF02991	0.463
LIG_LIR_Gen_1	245	255	PF02991	0.346
LIG_LIR_Gen_1	50	60	PF02991	0.308
LIG_LIR_Nem_3	158	162	PF02991	0.595
LIG_LIR_Nem_3	215	221	PF02991	0.427
LIG_LIR_Nem_3	245	251	PF02991	0.338
LIG_LIR_Nem_3	327	333	PF02991	0.345
LIG_LIR_Nem_3	348	354	PF02991	0.489
LIG_LIR_Nem_3	396	400	PF02991	0.494
LIG_LIR_Nem_3	401	407	PF02991	0.472
LIG_LIR_Nem_3	438	444	PF02991	0.335
LIG_LIR_Nem_3	50	55	PF02991	0.257
LIG_LIR_Nem_3	636	642	PF02991	0.591
LIG_LIR_Nem_3	699	704	PF02991	0.546
LIG_MYND_1	544	548	PF01753	0.347
LIG_NRBOX	523	529	PF00104	0.484
LIG_PCNA_yPIPBox_3	514	528	PF02747	0.439
LIG_PCNA_yPIPBox_3	611	621	PF02747	0.621
LIG_Pex14_1	14	18	PF04695	0.379
LIG_Pex14_2	296	300	PF04695	0.450
LIG_RPA_C_Fungi	583	595	PF08784	0.496
LIG_SH2_CRK	248	252	PF00017	0.343
LIG_SH2_NCK_1	248	252	PF00017	0.379
LIG_SH2_NCK_1	448	452	PF00017	0.328
LIG_SH2_STAP1	248	252	PF00017	0.343
LIG_SH2_STAP1	597	601	PF00017	0.631
LIG_SH2_STAP1	656	660	PF00017	0.650
LIG_SH2_STAT3	219	222	PF00017	0.416
LIG_SH2_STAT3	407	410	PF00017	0.480
LIG_SH2_STAT5	139	142	PF00017	0.253
LIG_SH2_STAT5	219	222	PF00017	0.548
LIG_SH2_STAT5	656	659	PF00017	0.519
LIG_SH3_3	326	332	PF00018	0.448
LIG_SH3_3	333	339	PF00018	0.416
LIG_SH3_3	397	403	PF00018	0.384
LIG_SH3_3	503	509	PF00018	0.432
LIG_SH3_3	538	544	PF00018	0.527
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.215
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.379
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.380
LIG_SUMO_SIM_par_1	187	194	PF11976	0.456
LIG_TRAF2_1	347	350	PF00917	0.442
LIG_TRAF2_1	415	418	PF00917	0.640
LIG_TRAF2_1	421	424	PF00917	0.526
LIG_UBA3_1	189	195	PF00899	0.371
LIG_WRC_WIRS_1	340	345	PF05994	0.433
LIG_WRC_WIRS_1	49	54	PF05994	0.382
LIG_WW_3	164	168	PF00397	0.397
MOD_CK1_1	129	135	PF00069	0.580
MOD_CK1_1	232	238	PF00069	0.394
MOD_CK1_1	345	351	PF00069	0.588
MOD_CK1_1	388	394	PF00069	0.462
MOD_CK1_1	690	696	PF00069	0.627
MOD_CK2_1	149	155	PF00069	0.537
MOD_CK2_1	168	174	PF00069	0.390
MOD_CK2_1	250	256	PF00069	0.491
MOD_CK2_1	264	270	PF00069	0.488
MOD_CK2_1	344	350	PF00069	0.444
MOD_CK2_1	371	377	PF00069	0.295
MOD_CK2_1	517	523	PF00069	0.508
MOD_CK2_1	587	593	PF00069	0.605
MOD_CK2_1	596	602	PF00069	0.582
MOD_GlcNHglycan	100	104	PF01048	0.308
MOD_GlcNHglycan	129	132	PF01048	0.600
MOD_GlcNHglycan	181	184	PF01048	0.399
MOD_GlcNHglycan	382	385	PF01048	0.344
MOD_GlcNHglycan	416	421	PF01048	0.690
MOD_GlcNHglycan	499	502	PF01048	0.406
MOD_GlcNHglycan	56	59	PF01048	0.540
MOD_GlcNHglycan	622	625	PF01048	0.641
MOD_GlcNHglycan	677	680	PF01048	0.521
MOD_GSK3_1	125	132	PF00069	0.633
MOD_GSK3_1	13	20	PF00069	0.494
MOD_GSK3_1	190	197	PF00069	0.483
MOD_GSK3_1	207	214	PF00069	0.396
MOD_GSK3_1	264	271	PF00069	0.592
MOD_GSK3_1	302	309	PF00069	0.269
MOD_GSK3_1	371	378	PF00069	0.433
MOD_GSK3_1	435	442	PF00069	0.488
MOD_GSK3_1	493	500	PF00069	0.423
MOD_GSK3_1	531	538	PF00069	0.393
MOD_GSK3_1	651	658	PF00069	0.522
MOD_GSK3_1	99	106	PF00069	0.304
MOD_LATS_1	263	269	PF00433	0.344
MOD_LATS_1	653	659	PF00433	0.572
MOD_N-GLC_1	482	487	PF02516	0.373
MOD_N-GLC_1	687	692	PF02516	0.476
MOD_NEK2_1	141	146	PF00069	0.520
MOD_NEK2_1	264	269	PF00069	0.497
MOD_NEK2_1	302	307	PF00069	0.320
MOD_NEK2_1	375	380	PF00069	0.483
MOD_NEK2_1	472	477	PF00069	0.349
MOD_NEK2_1	492	497	PF00069	0.292
MOD_NEK2_1	568	573	PF00069	0.612
MOD_NEK2_1	604	609	PF00069	0.543
MOD_NEK2_2	13	18	PF00069	0.375
MOD_NEK2_2	339	344	PF00069	0.338
MOD_PIKK_1	108	114	PF00454	0.537
MOD_PIKK_1	132	138	PF00454	0.445
MOD_PIKK_1	354	360	PF00454	0.483
MOD_PIKK_1	385	391	PF00454	0.428
MOD_PIKK_1	517	523	PF00454	0.400
MOD_PIKK_1	629	635	PF00454	0.540
MOD_PKA_1	620	626	PF00069	0.644
MOD_PKA_2	185	191	PF00069	0.295
MOD_PKA_2	264	270	PF00069	0.369
MOD_PKA_2	435	441	PF00069	0.441
MOD_PKA_2	587	593	PF00069	0.467
MOD_PKA_2	620	626	PF00069	0.644
MOD_PKA_2	654	660	PF00069	0.523
MOD_Plk_1	106	112	PF00069	0.376
MOD_Plk_1	376	382	PF00069	0.298
MOD_Plk_1	522	528	PF00069	0.488
MOD_Plk_1	648	654	PF00069	0.560
MOD_Plk_1	690	696	PF00069	0.673
MOD_Plk_4	185	191	PF00069	0.413
MOD_Plk_4	194	200	PF00069	0.370
MOD_Plk_4	278	284	PF00069	0.614
MOD_Plk_4	314	320	PF00069	0.338
MOD_Plk_4	324	330	PF00069	0.389
MOD_Plk_4	339	345	PF00069	0.324
MOD_Plk_4	371	377	PF00069	0.420
MOD_Plk_4	523	529	PF00069	0.412
MOD_Plk_4	78	84	PF00069	0.384
MOD_ProDKin_1	439	445	PF00069	0.488
MOD_ProDKin_1	540	546	PF00069	0.533
MOD_ProDKin_1	704	710	PF00069	0.694
MOD_SUMO_for_1	572	575	PF00179	0.477
MOD_SUMO_rev_2	57	64	PF00179	0.557
MOD_SUMO_rev_2	7	13	PF00179	0.377
TRG_DiLeu_BaEn_1	194	199	PF01217	0.240
TRG_DiLeu_BaEn_1	425	430	PF01217	0.572
TRG_DiLeu_BaEn_1	523	528	PF01217	0.425
TRG_DiLeu_BaEn_2	157	163	PF01217	0.436
TRG_DiLeu_BaEn_2	310	316	PF01217	0.387
TRG_DiLeu_BaEn_2	467	473	PF01217	0.326
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.478
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.624
TRG_DiLeu_BaLyEn_6	709	714	PF01217	0.505
TRG_ENDOCYTIC_2	139	142	PF00928	0.213
TRG_ENDOCYTIC_2	248	251	PF00928	0.319
TRG_ER_diArg_1	453	455	PF00400	0.312
TRG_ER_diArg_1	512	514	PF00400	0.368
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD9	Leptomonas seymouri	56%	100%
A0A1X0NXN3	Trypanosomatidae	28%	88%
A0A3S5IR71	Trypanosoma rangeli	30%	88%
A0A3S7WWJ2	Leishmania donovani	84%	100%
A4HZ76	Leishmania infantum	84%	100%
D0A1G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9AV43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QCD8	Leishmania major	83%	100%
V5AYE8	Trypanosoma cruzi	31%	88%