Putative 60S Ribosomal protein L36

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L36, putative

Species:

Leishmania braziliensis

UniProt:

A4HBR9_LEIBR

TriTrypDb:

LbrM.21.0800 , LBRM2903_210012600

Length:

105

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 25

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	17
GO:0032991	protein-containing complex	1	19
GO:0043226	organelle	2	18
GO:0043228	non-membrane-bounded organelle	3	18
GO:0043229	intracellular organelle	3	18
GO:0043232	intracellular non-membrane-bounded organelle	4	18
GO:0110165	cellular anatomical entity	1	19
GO:1990904	ribonucleoprotein complex	2	19
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A4HBR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR9

PDB structure(s): 6az3_i

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	19
GO:0006518	peptide metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009058	biosynthetic process	2	19
GO:0009059	macromolecule biosynthetic process	4	19
GO:0009987	cellular process	1	19
GO:0019538	protein metabolic process	3	19
GO:0034641	cellular nitrogen compound metabolic process	3	19
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	19
GO:0043043	peptide biosynthetic process	5	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043603	amide metabolic process	3	19
GO:0043604	amide biosynthetic process	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044249	cellular biosynthetic process	3	19
GO:0044260	obsolete cellular macromolecule metabolic process	3	19
GO:0044271	cellular nitrogen compound biosynthetic process	4	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:1901566	organonitrogen compound biosynthetic process	4	19
GO:1901576	organic substance biosynthetic process	3	19
GO:0002181	cytoplasmic translation	5	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	19
GO:0005198	structural molecule activity	1	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.278
CLV_PCSK_KEX2_1	22	24	PF00082	0.278
CLV_PCSK_KEX2_1	38	40	PF00082	0.278
CLV_PCSK_KEX2_1	58	60	PF00082	0.270
CLV_PCSK_KEX2_1	70	72	PF00082	0.278
CLV_PCSK_KEX2_1	78	80	PF00082	0.278
CLV_PCSK_KEX2_1	89	91	PF00082	0.294
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.317
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.345
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.278
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.278
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.294
CLV_PCSK_SKI1_1	41	45	PF00082	0.304
CLV_PCSK_SKI1_1	70	74	PF00082	0.278
CLV_PCSK_SKI1_1	98	102	PF00082	0.294
DOC_MAPK_gen_1	58	66	PF00069	0.478
DOC_PP4_FxxP_1	33	36	PF00568	0.547
DOC_SPAK_OSR1_1	32	36	PF12202	0.528
DOC_USP7_UBL2_3	70	74	PF12436	0.478
DOC_USP7_UBL2_3	88	92	PF12436	0.569
DOC_WW_Pin1_4	2	7	PF00397	0.644
DOC_WW_Pin1_4	25	30	PF00397	0.533
DOC_WW_Pin1_4	51	56	PF00397	0.494
LIG_14-3-3_CanoR_1	32	36	PF00244	0.395
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_FHA_1	6	12	PF00498	0.320
LIG_LIR_Apic_2	31	36	PF02991	0.484
LIG_LIR_Gen_1	62	69	PF02991	0.586
LIG_LIR_Nem_3	62	66	PF02991	0.586
LIG_SH2_STAT5	75	78	PF00017	0.586
LIG_SH3_3	21	27	PF00018	0.554
MOD_CDK_SPK_2	2	7	PF00069	0.644
MOD_CDK_SPxxK_3	25	32	PF00069	0.533
MOD_CDK_SPxxK_3	51	58	PF00069	0.478
MOD_CK1_1	2	8	PF00069	0.663
MOD_CK2_1	51	57	PF00069	0.478
MOD_CK2_1	88	94	PF00069	0.564
MOD_GlcNHglycan	1	4	PF01048	0.707
MOD_PKA_1	88	94	PF00069	0.564
MOD_PKA_2	31	37	PF00069	0.455
MOD_ProDKin_1	2	8	PF00069	0.639
MOD_ProDKin_1	25	31	PF00069	0.533
MOD_ProDKin_1	51	57	PF00069	0.494
TRG_ER_diArg_1	22	25	PF00400	0.478
TRG_ER_diLys_1	102	105	PF00400	0.716
TRG_NLS_Bipartite_1	22	42	PF00514	0.410
TRG_NLS_Bipartite_1	70	92	PF00514	0.478
TRG_NLS_MonoCore_2	86	91	PF00514	0.482
TRG_NLS_MonoExtC_3	76	82	PF00514	0.586
TRG_NLS_MonoExtC_3	87	92	PF00514	0.494
TRG_NLS_MonoExtN_4	36	42	PF00514	0.410
TRG_NLS_MonoExtN_4	74	81	PF00514	0.486
TRG_NLS_MonoExtN_4	87	93	PF00514	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM67	Leptomonas seymouri	94%	100%
A0A0S4JFE8	Bodo saltans	68%	94%
A0A1X0NZ05	Trypanosomatidae	79%	91%
A0A1X0P5V0	Trypanosomatidae	79%	97%
A0A3Q8IDW6	Leishmania donovani	96%	100%
A0A3R7MLS5	Trypanosoma rangeli	79%	92%
A0A3S7X961	Leishmania donovani	96%	100%
A4HML2	Leishmania braziliensis	96%	100%
A4HZ73	Leishmania infantum	96%	100%
A4IB89	Leishmania infantum	96%	100%
C9ZZL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	96%
D0A1G5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	96%
E9AF13	Leishmania major	95%	100%
E9AV40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B669	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14455	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
O80929	Arabidopsis thaliana	46%	93%
O94658	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P05745	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P39032	Rattus norvegicus	36%	100%
P47964	Mus musculus	37%	100%
P49181	Caenorhabditis elegans	37%	100%
P49630	Drosophila melanogaster	32%	91%
P52866	Daucus carota	39%	99%
P9WEU2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	100%
Q24F59	Tetrahymena thermophila (strain SB210)	36%	100%
Q3T171	Bos taurus	38%	100%
Q4PM12	Ixodes scapularis	39%	95%
Q4QCE1	Leishmania major	97%	100%
Q55AQ9	Dictyostelium discoideum	43%	100%
Q5RAZ9	Pongo abelii	37%	100%
Q66KU4	Xenopus laevis	37%	100%
Q6DER2	Xenopus tropicalis	37%	100%
Q6Q415	Danio rerio	36%	100%
Q8UW19	Hydrophis hardwickii	37%	100%
Q90YT2	Ictalurus punctatus	36%	100%
Q92365	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q98TF6	Gallus gallus	36%	100%
Q9HFR7	Trichoderma hamatum	38%	100%
Q9LRB8	Ulva compressa	44%	100%
Q9LZ57	Arabidopsis thaliana	46%	97%
Q9M352	Arabidopsis thaliana	45%	94%
Q9Y3U8	Homo sapiens	37%	100%
V5BDJ2	Trypanosoma cruzi	77%	92%