Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBR8_LEIBR

TriTrypDb:

LbrM.21.0790

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HBR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.427
CLV_NRD_NRD_1	153	155	PF00675	0.562
CLV_NRD_NRD_1	187	189	PF00675	0.364
CLV_NRD_NRD_1	224	226	PF00675	0.310
CLV_NRD_NRD_1	307	309	PF00675	0.415
CLV_NRD_NRD_1	318	320	PF00675	0.353
CLV_NRD_NRD_1	359	361	PF00675	0.617
CLV_NRD_NRD_1	371	373	PF00675	0.565
CLV_PCSK_FUR_1	360	364	PF00082	0.519
CLV_PCSK_KEX2_1	187	189	PF00082	0.448
CLV_PCSK_KEX2_1	298	300	PF00082	0.473
CLV_PCSK_KEX2_1	318	320	PF00082	0.399
CLV_PCSK_KEX2_1	362	364	PF00082	0.580
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.332
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.580
CLV_PCSK_SKI1_1	154	158	PF00082	0.449
CLV_PCSK_SKI1_1	212	216	PF00082	0.485
CLV_PCSK_SKI1_1	362	366	PF00082	0.588
CLV_PCSK_SKI1_1	93	97	PF00082	0.278
DEG_APCC_DBOX_1	199	207	PF00400	0.326
DEG_SCF_FBW7_1	156	163	PF00400	0.290
DOC_CDC14_PxL_1	107	115	PF14671	0.313
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.370
DOC_MAPK_gen_1	223	232	PF00069	0.457
DOC_MAPK_gen_1	298	306	PF00069	0.400
DOC_MAPK_gen_1	308	317	PF00069	0.348
DOC_MAPK_gen_1	69	78	PF00069	0.404
DOC_MAPK_MEF2A_6	93	102	PF00069	0.382
DOC_PP2B_LxvP_1	108	111	PF13499	0.416
DOC_PP2B_LxvP_1	195	198	PF13499	0.430
DOC_PP4_FxxP_1	207	210	PF00568	0.377
DOC_PP4_FxxP_1	53	56	PF00568	0.411
DOC_USP7_MATH_1	160	164	PF00917	0.525
DOC_USP7_MATH_1	25	29	PF00917	0.327
DOC_USP7_MATH_1	56	60	PF00917	0.537
DOC_USP7_UBL2_3	212	216	PF12436	0.446
DOC_USP7_UBL2_3	357	361	PF12436	0.642
DOC_USP7_UBL2_3	362	366	PF12436	0.614
DOC_WW_Pin1_4	156	161	PF00397	0.280
DOC_WW_Pin1_4	233	238	PF00397	0.608
DOC_WW_Pin1_4	76	81	PF00397	0.331
LIG_BRCT_BRCA1_1	339	343	PF00533	0.239
LIG_BRCT_BRCA1_1	50	54	PF00533	0.369
LIG_BRCT_BRCA1_1	78	82	PF00533	0.312
LIG_FHA_1	213	219	PF00498	0.337
LIG_FHA_2	157	163	PF00498	0.326
LIG_FHA_2	41	47	PF00498	0.353
LIG_LIR_Apic_2	51	56	PF02991	0.418
LIG_LIR_Gen_1	168	177	PF02991	0.347
LIG_LIR_Nem_3	168	172	PF02991	0.336
LIG_LIR_Nem_3	181	186	PF02991	0.281
LIG_LIR_Nem_3	51	57	PF02991	0.298
LIG_LIR_Nem_3	75	81	PF02991	0.392
LIG_MLH1_MIPbox_1	339	343	PF16413	0.239
LIG_MLH1_MIPbox_1	50	54	PF16413	0.271
LIG_MYND_3	230	234	PF01753	0.361
LIG_PCNA_yPIPBox_3	175	183	PF02747	0.355
LIG_Pex14_2	50	54	PF04695	0.271
LIG_Pex14_2	78	82	PF04695	0.312
LIG_REV1ctd_RIR_1	340	347	PF16727	0.304
LIG_SH2_NCK_1	257	261	PF00017	0.312
LIG_SH2_STAP1	213	217	PF00017	0.380
LIG_SH2_STAP1	29	33	PF00017	0.255
LIG_SH2_STAT3	29	32	PF00017	0.260
LIG_SH2_STAT5	251	254	PF00017	0.330
LIG_SH2_STAT5	264	267	PF00017	0.364
LIG_SH2_STAT5	329	332	PF00017	0.515
LIG_SH2_STAT5	5	8	PF00017	0.525
LIG_SH3_3	301	307	PF00018	0.327
LIG_SUMO_SIM_par_1	178	184	PF11976	0.333
LIG_SUMO_SIM_par_1	96	101	PF11976	0.321
LIG_UBA3_1	218	226	PF00899	0.439
LIG_UBA3_1	326	335	PF00899	0.553
LIG_WRC_WIRS_1	50	55	PF05994	0.545
MOD_CK1_1	28	34	PF00069	0.312
MOD_CK1_1	313	319	PF00069	0.405
MOD_CK2_1	156	162	PF00069	0.461
MOD_GlcNHglycan	132	135	PF01048	0.354
MOD_GlcNHglycan	258	261	PF01048	0.306
MOD_GlcNHglycan	266	269	PF01048	0.311
MOD_GlcNHglycan	282	285	PF01048	0.323
MOD_GSK3_1	150	157	PF00069	0.448
MOD_GSK3_1	161	168	PF00069	0.357
MOD_GSK3_1	208	215	PF00069	0.365
MOD_GSK3_1	293	300	PF00069	0.585
MOD_GSK3_1	313	320	PF00069	0.395
MOD_N-GLC_1	160	165	PF02516	0.471
MOD_NEK2_1	1	6	PF00069	0.451
MOD_NEK2_1	150	155	PF00069	0.392
MOD_NEK2_1	272	277	PF00069	0.351
MOD_NEK2_1	293	298	PF00069	0.452
MOD_NEK2_1	342	347	PF00069	0.588
MOD_PIKK_1	28	34	PF00454	0.324
MOD_PIKK_1	355	361	PF00454	0.605
MOD_PIKK_1	7	13	PF00454	0.450
MOD_PKA_1	154	160	PF00069	0.517
MOD_PKA_2	128	134	PF00069	0.448
MOD_PKA_2	165	171	PF00069	0.322
MOD_PKA_2	317	323	PF00069	0.465
MOD_PKA_2	7	13	PF00069	0.526
MOD_Plk_1	25	31	PF00069	0.481
MOD_Plk_4	1	7	PF00069	0.527
MOD_Plk_4	310	316	PF00069	0.378
MOD_Plk_4	49	55	PF00069	0.500
MOD_Plk_4	82	88	PF00069	0.436
MOD_ProDKin_1	156	162	PF00069	0.284
MOD_ProDKin_1	233	239	PF00069	0.593
MOD_ProDKin_1	76	82	PF00069	0.327
MOD_SUMO_for_1	364	367	PF00179	0.575
TRG_DiLeu_BaEn_1	248	253	PF01217	0.331
TRG_DiLeu_LyEn_5	234	239	PF01217	0.323
TRG_ENDOCYTIC_2	227	230	PF00928	0.418
TRG_ER_diArg_1	186	188	PF00400	0.448
TRG_ER_diArg_1	317	319	PF00400	0.466
TRG_NLS_Bipartite_1	298	312	PF00514	0.323
TRG_NLS_MonoCore_2	359	364	PF00514	0.369
TRG_NLS_MonoExtC_3	360	365	PF00514	0.591
TRG_NLS_MonoExtN_4	307	312	PF00514	0.396
TRG_NLS_MonoExtN_4	357	364	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U9	Leptomonas seymouri	57%	77%
A0A0S4JCB2	Bodo saltans	44%	98%
A0A1X0NY04	Trypanosomatidae	42%	100%
A0A3Q8IAU3	Leishmania donovani	83%	99%
A0A3R7KMU3	Trypanosoma rangeli	44%	100%
A4HZ72	Leishmania infantum	83%	99%
D0A1G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AV39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QCE2	Leishmania major	83%	100%
V5BIF1	Trypanosoma cruzi	41%	100%