Putative ATP-binding cassette sub-family E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease L inhibitor, putative

Species:

Leishmania braziliensis

UniProt:

A4HBR7_LEIBR

TriTrypDb:

LbrM.21.0770 , LBRM2903_210012300

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR7

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0006413	translational initiation	3	1
GO:0006415	translational termination	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0033750	ribosome localization	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005215	transporter activity	1	1
GO:0005506	iron ion binding	6	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043024	ribosomal small subunit binding	4	1
GO:0043169	cation binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	621	625	PF00656	0.645
CLV_C14_Caspase3-7	647	651	PF00656	0.499
CLV_NRD_NRD_1	26	28	PF00675	0.390
CLV_NRD_NRD_1	3	5	PF00675	0.476
CLV_NRD_NRD_1	352	354	PF00675	0.615
CLV_NRD_NRD_1	575	577	PF00675	0.376
CLV_PCSK_KEX2_1	351	353	PF00082	0.555
CLV_PCSK_KEX2_1	513	515	PF00082	0.322
CLV_PCSK_KEX2_1	520	522	PF00082	0.330
CLV_PCSK_KEX2_1	575	577	PF00082	0.376
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.539
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.322
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.330
CLV_PCSK_SKI1_1	173	177	PF00082	0.258
CLV_PCSK_SKI1_1	202	206	PF00082	0.277
CLV_PCSK_SKI1_1	268	272	PF00082	0.329
CLV_PCSK_SKI1_1	433	437	PF00082	0.258
CLV_PCSK_SKI1_1	455	459	PF00082	0.258
CLV_PCSK_SKI1_1	510	514	PF00082	0.315
CLV_PCSK_SKI1_1	521	525	PF00082	0.289
CLV_PCSK_SKI1_1	565	569	PF00082	0.373
DOC_CKS1_1	484	489	PF01111	0.298
DOC_CYCLIN_yClb5_NLxxxL_5	78	87	PF00134	0.359
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.258
DOC_MAPK_gen_1	202	211	PF00069	0.302
DOC_MAPK_gen_1	331	339	PF00069	0.373
DOC_MAPK_gen_1	565	574	PF00069	0.343
DOC_MAPK_MEF2A_6	314	321	PF00069	0.306
DOC_MAPK_MEF2A_6	477	484	PF00069	0.258
DOC_MAPK_MEF2A_6	565	574	PF00069	0.343
DOC_PP1_SILK_1	128	133	PF00149	0.171
DOC_PP2B_LxvP_1	105	108	PF13499	0.320
DOC_SPAK_OSR1_1	232	236	PF12202	0.258
DOC_USP7_UBL2_3	132	136	PF12436	0.231
DOC_USP7_UBL2_3	423	427	PF12436	0.258
DOC_USP7_UBL2_3	616	620	PF12436	0.672
DOC_USP7_UBL2_3	633	637	PF12436	0.521
DOC_USP7_UBL2_3	654	658	PF12436	0.715
DOC_WW_Pin1_4	483	488	PF00397	0.287
DOC_WW_Pin1_4	543	548	PF00397	0.399
LIG_14-3-3_CanoR_1	258	267	PF00244	0.364
LIG_14-3-3_CanoR_1	268	278	PF00244	0.396
LIG_AP2alpha_1	320	324	PF02296	0.315
LIG_APCC_ABBA_1	245	250	PF00400	0.258
LIG_APCC_ABBA_1	317	322	PF00400	0.305
LIG_BRCT_BRCA1_1	335	339	PF00533	0.334
LIG_deltaCOP1_diTrp_1	144	155	PF00928	0.276
LIG_FHA_1	272	278	PF00498	0.452
LIG_FHA_1	325	331	PF00498	0.359
LIG_FHA_1	336	342	PF00498	0.394
LIG_FHA_1	360	366	PF00498	0.270
LIG_FHA_1	392	398	PF00498	0.258
LIG_FHA_1	449	455	PF00498	0.258
LIG_FHA_1	520	526	PF00498	0.330
LIG_FHA_1	544	550	PF00498	0.388
LIG_FHA_1	607	613	PF00498	0.475
LIG_FHA_2	429	435	PF00498	0.258
LIG_FHA_2	456	462	PF00498	0.258
LIG_IRF3_LxIS_1	412	418	PF10401	0.258
LIG_LIR_Apic_2	442	447	PF02991	0.258
LIG_LIR_Gen_1	145	155	PF02991	0.276
LIG_LIR_Gen_1	206	214	PF02991	0.277
LIG_LIR_Gen_1	252	261	PF02991	0.327
LIG_LIR_Gen_1	273	284	PF02991	0.300
LIG_LIR_Gen_1	291	301	PF02991	0.299
LIG_LIR_Gen_1	394	404	PF02991	0.277
LIG_LIR_Nem_3	145	151	PF02991	0.276
LIG_LIR_Nem_3	206	211	PF02991	0.277
LIG_LIR_Nem_3	252	257	PF02991	0.325
LIG_LIR_Nem_3	273	279	PF02991	0.311
LIG_LIR_Nem_3	291	296	PF02991	0.285
LIG_LIR_Nem_3	438	444	PF02991	0.298
LIG_LYPXL_yS_3	358	361	PF13949	0.336
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.390
LIG_PCNA_yPIPBox_3	423	436	PF02747	0.258
LIG_Pex14_2	320	324	PF04695	0.315
LIG_SH2_CRK	298	302	PF00017	0.331
LIG_SH2_CRK	304	308	PF00017	0.285
LIG_SH2_CRK	75	79	PF00017	0.277
LIG_SH2_NCK_1	248	252	PF00017	0.334
LIG_SH2_PTP2	276	279	PF00017	0.282
LIG_SH2_SRC	248	251	PF00017	0.302
LIG_SH2_SRC	254	257	PF00017	0.289
LIG_SH2_SRC	276	279	PF00017	0.361
LIG_SH2_SRC	499	502	PF00017	0.325
LIG_SH2_STAT3	419	422	PF00017	0.258
LIG_SH2_STAT5	154	157	PF00017	0.282
LIG_SH2_STAT5	163	166	PF00017	0.321
LIG_SH2_STAT5	180	183	PF00017	0.258
LIG_SH2_STAT5	254	257	PF00017	0.327
LIG_SH2_STAT5	276	279	PF00017	0.282
LIG_SH2_STAT5	444	447	PF00017	0.390
LIG_SH2_STAT5	491	494	PF00017	0.258
LIG_SH2_STAT5	499	502	PF00017	0.325
LIG_SH2_STAT5	535	538	PF00017	0.328
LIG_SH2_STAT5	602	605	PF00017	0.421
LIG_SH3_3	304	310	PF00018	0.317
LIG_SH3_3	407	413	PF00018	0.402
LIG_SH3_3	450	456	PF00018	0.258
LIG_SH3_4	633	640	PF00018	0.531
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.294
LIG_SUMO_SIM_anti_2	14	22	PF11976	0.258
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.362
LIG_SUMO_SIM_anti_2	378	388	PF11976	0.258
LIG_SUMO_SIM_par_1	276	281	PF11976	0.282
LIG_SUMO_SIM_par_1	378	388	PF11976	0.311
LIG_SUMO_SIM_par_1	455	461	PF11976	0.277
LIG_TRAF2_1	458	461	PF00917	0.258
LIG_TYR_ITSM	272	279	PF00017	0.447
LIG_UBA3_1	559	568	PF00899	0.334
LIG_WRC_WIRS_1	365	370	PF05994	0.398
LIG_WW_3	1	5	PF00397	0.487
MOD_CK1_1	11	17	PF00069	0.258
MOD_CK1_1	269	275	PF00069	0.469
MOD_CK1_1	364	370	PF00069	0.448
MOD_CK1_1	519	525	PF00069	0.463
MOD_CK1_1	53	59	PF00069	0.365
MOD_CK2_1	223	229	PF00069	0.258
MOD_CK2_1	375	381	PF00069	0.258
MOD_CK2_1	455	461	PF00069	0.258
MOD_CK2_1	82	88	PF00069	0.402
MOD_Cter_Amidation	613	616	PF01082	0.642
MOD_GlcNHglycan	225	228	PF01048	0.263
MOD_GlcNHglycan	470	473	PF01048	0.258
MOD_GlcNHglycan	494	499	PF01048	0.258
MOD_GlcNHglycan	52	55	PF01048	0.289
MOD_GlcNHglycan	598	601	PF01048	0.556
MOD_GSK3_1	119	126	PF00069	0.258
MOD_GSK3_1	364	371	PF00069	0.446
MOD_GSK3_1	566	573	PF00069	0.356
MOD_N-GLC_1	119	124	PF02516	0.258
MOD_N-GLC_1	468	473	PF02516	0.301
MOD_N-GLC_1	549	554	PF02516	0.476
MOD_N-GLC_1	570	575	PF02516	0.420
MOD_N-GLC_2	389	391	PF02516	0.258
MOD_NEK2_1	271	276	PF00069	0.484
MOD_NEK2_1	361	366	PF00069	0.289
MOD_NEK2_1	415	420	PF00069	0.274
MOD_NEK2_1	428	433	PF00069	0.343
MOD_NEK2_1	435	440	PF00069	0.208
MOD_NEK2_1	566	571	PF00069	0.359
MOD_PIKK_1	638	644	PF00454	0.589
MOD_PK_1	587	593	PF00069	0.405
MOD_PKA_2	11	17	PF00069	0.334
MOD_PKA_2	155	161	PF00069	0.258
MOD_PKA_2	231	237	PF00069	0.277
MOD_PKA_2	259	265	PF00069	0.367
MOD_PKA_2	88	94	PF00069	0.433
MOD_PKB_1	331	339	PF00069	0.334
MOD_Plk_1	200	206	PF00069	0.334
MOD_Plk_1	218	224	PF00069	0.390
MOD_Plk_1	282	288	PF00069	0.285
MOD_Plk_1	333	339	PF00069	0.389
MOD_Plk_1	570	576	PF00069	0.343
MOD_Plk_1	8	14	PF00069	0.560
MOD_Plk_2-3	200	206	PF00069	0.334
MOD_Plk_2-3	250	256	PF00069	0.322
MOD_Plk_2-3	627	633	PF00069	0.516
MOD_Plk_4	126	132	PF00069	0.294
MOD_Plk_4	250	256	PF00069	0.361
MOD_Plk_4	282	288	PF00069	0.363
MOD_Plk_4	392	398	PF00069	0.258
MOD_Plk_4	531	537	PF00069	0.299
MOD_ProDKin_1	483	489	PF00069	0.287
MOD_ProDKin_1	543	549	PF00069	0.401
MOD_SUMO_rev_2	210	217	PF00179	0.390
MOD_SUMO_rev_2	589	599	PF00179	0.410
MOD_SUMO_rev_2	625	635	PF00179	0.749
MOD_SUMO_rev_2	646	653	PF00179	0.502
TRG_DiLeu_BaEn_1	381	386	PF01217	0.258
TRG_DiLeu_BaEn_4	8	14	PF01217	0.484
TRG_ENDOCYTIC_2	254	257	PF00928	0.327
TRG_ENDOCYTIC_2	276	279	PF00928	0.282
TRG_ENDOCYTIC_2	304	307	PF00928	0.285
TRG_ENDOCYTIC_2	358	361	PF00928	0.336
TRG_ENDOCYTIC_2	602	605	PF00928	0.385
TRG_ENDOCYTIC_2	75	78	PF00928	0.277
TRG_ER_diArg_1	257	260	PF00400	0.329
TRG_ER_diArg_1	574	576	PF00400	0.351
TRG_ER_diArg_1	581	584	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M4	Leptomonas seymouri	90%	99%
A0A1X0NXL9	Trypanosomatidae	82%	100%
A0A3S7WWG1	Leishmania donovani	93%	100%
A0A422NHA0	Trypanosoma rangeli	82%	100%
A4HZ70	Leishmania infantum	93%	100%
D0A1G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AV37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
G0SEV9	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	63%	100%
O60102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
P0AAF3	Escherichia coli (strain K12)	25%	100%
P0AAF4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P0AAF5	Escherichia coli O157:H7	25%	100%
P33916	Escherichia coli (strain K12)	24%	100%
P61221	Homo sapiens	64%	100%
P61222	Mus musculus	64%	100%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	22%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
Q03195	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	64%	100%
Q03CA4	Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL B-441)	24%	100%
Q0TGT7	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	25%	100%
Q1JUP7	Azospirillum brasilense	24%	100%
Q1RAN8	Escherichia coli (strain UTI89 / UPEC)	25%	100%
Q322L1	Shigella boydii serotype 4 (strain Sb227)	25%	100%
Q32HC7	Shigella dysenteriae serotype 1 (strain Sd197)	25%	100%
Q3K3R2	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	23%	100%
Q3Z2S7	Shigella sonnei (strain Ss046)	25%	100%
Q4QCE4	Leishmania major	92%	100%
Q58129	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	47%	100%
Q6HI76	Bacillus thuringiensis subsp. konkukian (strain 97-27)	24%	100%
Q73P93	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q83KP2	Shigella flexneri	25%	100%
Q87FK7	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	24%	100%
Q8D3Z9	Vibrio vulnificus (strain CMCP6)	21%	100%
Q8E7N9	Streptococcus agalactiae serotype III (strain NEM316)	23%	100%
Q8LPJ4	Arabidopsis thaliana	65%	100%
Q8PUE7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	20%	100%
Q97WT4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
Q97X60	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	23%	100%
Q9LID6	Arabidopsis thaliana	62%	100%
Q9LV93	Arabidopsis thaliana	23%	95%
Q9VSS1	Drosophila melanogaster	65%	100%
Q9WXX0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	22%	100%
V5BDT2	Trypanosoma cruzi	82%	100%