Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBR6_LEIBR

TriTrypDb:

LbrM.21.0760 , LBRM2903_210012200

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.670
CLV_NRD_NRD_1	272	274	PF00675	0.593
CLV_NRD_NRD_1	486	488	PF00675	0.705
CLV_NRD_NRD_1	533	535	PF00675	0.668
CLV_NRD_NRD_1	608	610	PF00675	0.617
CLV_NRD_NRD_1	618	620	PF00675	0.558
CLV_PCSK_KEX2_1	153	155	PF00082	0.373
CLV_PCSK_KEX2_1	272	274	PF00082	0.595
CLV_PCSK_KEX2_1	532	534	PF00082	0.674
CLV_PCSK_KEX2_1	608	610	PF00082	0.617
CLV_PCSK_KEX2_1	618	620	PF00082	0.558
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.373
CLV_PCSK_PC7_1	149	155	PF00082	0.271
CLV_PCSK_PC7_1	528	534	PF00082	0.727
CLV_PCSK_SKI1_1	24	28	PF00082	0.409
CLV_PCSK_SKI1_1	300	304	PF00082	0.543
CLV_PCSK_SKI1_1	410	414	PF00082	0.579
DEG_APCC_DBOX_1	299	307	PF00400	0.657
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DOC_ANK_TNKS_1	328	335	PF00023	0.501
DOC_CKS1_1	498	503	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.485
DOC_MAPK_gen_1	215	223	PF00069	0.601
DOC_MAPK_gen_1	298	305	PF00069	0.533
DOC_MAPK_gen_1	397	406	PF00069	0.504
DOC_MAPK_MEF2A_6	324	332	PF00069	0.501
DOC_MAPK_MEF2A_6	82	91	PF00069	0.193
DOC_PP1_RVXF_1	505	511	PF00149	0.507
DOC_PP1_RVXF_1	80	87	PF00149	0.289
DOC_PP2B_LxvP_1	379	382	PF13499	0.619
DOC_PP4_FxxP_1	426	429	PF00568	0.488
DOC_USP7_MATH_1	333	337	PF00917	0.733
DOC_USP7_MATH_1	363	367	PF00917	0.606
DOC_USP7_MATH_1	446	450	PF00917	0.503
DOC_USP7_MATH_1	491	495	PF00917	0.604
DOC_USP7_MATH_1	524	528	PF00917	0.673
DOC_USP7_MATH_1	63	67	PF00917	0.349
DOC_USP7_UBL2_3	119	123	PF12436	0.271
DOC_USP7_UBL2_3	411	415	PF12436	0.652
DOC_WW_Pin1_4	105	110	PF00397	0.271
DOC_WW_Pin1_4	280	285	PF00397	0.571
DOC_WW_Pin1_4	384	389	PF00397	0.570
DOC_WW_Pin1_4	399	404	PF00397	0.579
DOC_WW_Pin1_4	421	426	PF00397	0.587
DOC_WW_Pin1_4	451	456	PF00397	0.580
DOC_WW_Pin1_4	458	463	PF00397	0.610
DOC_WW_Pin1_4	497	502	PF00397	0.720
DOC_WW_Pin1_4	512	517	PF00397	0.560
DOC_WW_Pin1_4	534	539	PF00397	0.628
DOC_WW_Pin1_4	543	548	PF00397	0.585
DOC_WW_Pin1_4	563	568	PF00397	0.479
LIG_14-3-3_CanoR_1	154	158	PF00244	0.307
LIG_14-3-3_CanoR_1	181	185	PF00244	0.325
LIG_14-3-3_CanoR_1	280	284	PF00244	0.661
LIG_14-3-3_CanoR_1	420	425	PF00244	0.717
LIG_14-3-3_CanoR_1	493	501	PF00244	0.641
LIG_14-3-3_CanoR_1	507	517	PF00244	0.573
LIG_14-3-3_CanoR_1	518	522	PF00244	0.544
LIG_Actin_WH2_2	255	271	PF00022	0.581
LIG_AP2alpha_2	250	252	PF02296	0.459
LIG_BIR_III_4	62	66	PF00653	0.404
LIG_BRCT_BRCA1_1	422	426	PF00533	0.502
LIG_FHA_1	23	29	PF00498	0.303
LIG_FHA_1	235	241	PF00498	0.690
LIG_FHA_1	31	37	PF00498	0.239
LIG_FHA_1	311	317	PF00498	0.697
LIG_FHA_1	430	436	PF00498	0.665
LIG_FHA_1	575	581	PF00498	0.498
LIG_FHA_1	602	608	PF00498	0.745
LIG_FHA_1	67	73	PF00498	0.308
LIG_FHA_2	220	226	PF00498	0.628
LIG_FHA_2	228	234	PF00498	0.585
LIG_FHA_2	411	417	PF00498	0.602
LIG_FHA_2	498	504	PF00498	0.634
LIG_LIR_Apic_2	423	429	PF02991	0.491
LIG_LIR_Gen_1	373	382	PF02991	0.679
LIG_LIR_Gen_1	50	59	PF02991	0.358
LIG_LIR_Gen_1	83	93	PF02991	0.335
LIG_LIR_Nem_3	258	262	PF02991	0.628
LIG_LIR_Nem_3	373	379	PF02991	0.672
LIG_LIR_Nem_3	387	392	PF02991	0.461
LIG_LIR_Nem_3	50	56	PF02991	0.358
LIG_LIR_Nem_3	582	587	PF02991	0.524
LIG_LIR_Nem_3	83	89	PF02991	0.360
LIG_NRBOX	184	190	PF00104	0.475
LIG_PCNA_yPIPBox_3	181	189	PF02747	0.469
LIG_PTB_Apo_2	193	200	PF02174	0.485
LIG_PTB_Phospho_1	193	199	PF10480	0.479
LIG_RPA_C_Fungi	523	535	PF08784	0.519
LIG_SH2_CRK	376	380	PF00017	0.673
LIG_SH2_CRK	486	490	PF00017	0.595
LIG_SH2_SRC	572	575	PF00017	0.512
LIG_SH2_STAP1	376	380	PF00017	0.673
LIG_SH2_STAT3	190	193	PF00017	0.501
LIG_SH2_STAT5	55	58	PF00017	0.298
LIG_SH3_3	205	211	PF00018	0.521
LIG_SH3_3	327	333	PF00018	0.608
LIG_SH3_3	357	363	PF00018	0.571
LIG_SH3_3	475	481	PF00018	0.588
LIG_SH3_3	495	501	PF00018	0.613
LIG_SH3_4	141	148	PF00018	0.404
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.335
LIG_SUMO_SIM_par_1	431	437	PF11976	0.467
LIG_SUMO_SIM_par_1	454	461	PF11976	0.492
LIG_TYR_ITIM	374	379	PF00017	0.678
LIG_UBA3_1	128	132	PF00899	0.335
LIG_UBA3_1	26	31	PF00899	0.335
MOD_CDC14_SPxK_1	515	518	PF00782	0.651
MOD_CDK_SPK_2	458	463	PF00069	0.749
MOD_CDK_SPK_2	543	548	PF00069	0.635
MOD_CDK_SPK_2	563	568	PF00069	0.655
MOD_CDK_SPxK_1	512	518	PF00069	0.654
MOD_CDK_SPxxK_3	421	428	PF00069	0.593
MOD_CDK_SPxxK_3	463	470	PF00069	0.513
MOD_CK1_1	234	240	PF00069	0.630
MOD_CK1_1	276	282	PF00069	0.641
MOD_CK1_1	283	289	PF00069	0.633
MOD_CK1_1	308	314	PF00069	0.706
MOD_CK1_1	336	342	PF00069	0.580
MOD_CK1_1	367	373	PF00069	0.698
MOD_CK1_1	424	430	PF00069	0.600
MOD_CK1_1	434	440	PF00069	0.660
MOD_CK1_1	454	460	PF00069	0.606
MOD_CK1_1	479	485	PF00069	0.613
MOD_CK1_1	54	60	PF00069	0.390
MOD_CK1_1	576	582	PF00069	0.668
MOD_CK1_1	586	592	PF00069	0.606
MOD_CK1_1	613	619	PF00069	0.731
MOD_CK1_1	66	72	PF00069	0.241
MOD_CK2_1	339	345	PF00069	0.690
MOD_CK2_1	363	369	PF00069	0.725
MOD_CK2_1	410	416	PF00069	0.654
MOD_CK2_1	497	503	PF00069	0.637
MOD_CK2_1	551	557	PF00069	0.749
MOD_Cter_Amidation	270	273	PF01082	0.666
MOD_DYRK1A_RPxSP_1	534	538	PF00069	0.556
MOD_GlcNHglycan	125	128	PF01048	0.314
MOD_GlcNHglycan	247	250	PF01048	0.617
MOD_GlcNHglycan	252	255	PF01048	0.654
MOD_GlcNHglycan	307	310	PF01048	0.552
MOD_GlcNHglycan	335	338	PF01048	0.615
MOD_GlcNHglycan	357	360	PF01048	0.712
MOD_GlcNHglycan	442	445	PF01048	0.693
MOD_GlcNHglycan	481	484	PF01048	0.671
MOD_GlcNHglycan	510	513	PF01048	0.530
MOD_GlcNHglycan	528	531	PF01048	0.665
MOD_GlcNHglycan	553	556	PF01048	0.641
MOD_GSK3_1	219	226	PF00069	0.578
MOD_GSK3_1	227	234	PF00069	0.513
MOD_GSK3_1	263	270	PF00069	0.571
MOD_GSK3_1	276	283	PF00069	0.543
MOD_GSK3_1	288	295	PF00069	0.499
MOD_GSK3_1	301	308	PF00069	0.575
MOD_GSK3_1	311	318	PF00069	0.616
MOD_GSK3_1	332	339	PF00069	0.581
MOD_GSK3_1	363	370	PF00069	0.700
MOD_GSK3_1	380	387	PF00069	0.617
MOD_GSK3_1	388	395	PF00069	0.606
MOD_GSK3_1	416	423	PF00069	0.580
MOD_GSK3_1	429	436	PF00069	0.538
MOD_GSK3_1	454	461	PF00069	0.601
MOD_GSK3_1	502	509	PF00069	0.653
MOD_GSK3_1	522	529	PF00069	0.649
MOD_GSK3_1	539	546	PF00069	0.518
MOD_GSK3_1	549	556	PF00069	0.625
MOD_GSK3_1	559	566	PF00069	0.638
MOD_GSK3_1	576	583	PF00069	0.483
MOD_GSK3_1	610	617	PF00069	0.583
MOD_GSK3_1	63	70	PF00069	0.404
MOD_LATS_1	418	424	PF00433	0.769
MOD_N-GLC_1	399	404	PF02516	0.682
MOD_N-GLC_1	580	585	PF02516	0.701
MOD_N-GLC_1	596	601	PF02516	0.585
MOD_NEK2_1	180	185	PF00069	0.322
MOD_NEK2_1	223	228	PF00069	0.529
MOD_NEK2_1	278	283	PF00069	0.568
MOD_NEK2_1	316	321	PF00069	0.700
MOD_NEK2_1	392	397	PF00069	0.589
MOD_NEK2_1	580	585	PF00069	0.669
MOD_NEK2_1	601	606	PF00069	0.523
MOD_NEK2_1	98	103	PF00069	0.271
MOD_PIKK_1	231	237	PF00454	0.521
MOD_PIKK_1	380	386	PF00454	0.684
MOD_PIKK_1	510	516	PF00454	0.724
MOD_PIKK_1	549	555	PF00454	0.816
MOD_PK_1	153	159	PF00069	0.506
MOD_PK_1	273	279	PF00069	0.617
MOD_PKA_1	153	159	PF00069	0.404
MOD_PKA_1	227	233	PF00069	0.662
MOD_PKA_1	410	416	PF00069	0.674
MOD_PKA_2	153	159	PF00069	0.404
MOD_PKA_2	180	186	PF00069	0.330
MOD_PKA_2	279	285	PF00069	0.676
MOD_PKA_2	479	485	PF00069	0.507
MOD_PKA_2	492	498	PF00069	0.566
MOD_PKA_2	506	512	PF00069	0.616
MOD_PKA_2	517	523	PF00069	0.642
MOD_Plk_1	166	172	PF00069	0.434
MOD_Plk_1	22	28	PF00069	0.404
MOD_Plk_1	311	317	PF00069	0.565
MOD_Plk_1	580	586	PF00069	0.712
MOD_Plk_4	180	186	PF00069	0.330
MOD_Plk_4	22	28	PF00069	0.404
MOD_Plk_4	255	261	PF00069	0.746
MOD_Plk_4	263	269	PF00069	0.643
MOD_Plk_4	273	279	PF00069	0.459
MOD_Plk_4	301	307	PF00069	0.565
MOD_Plk_4	580	586	PF00069	0.502
MOD_Plk_4	610	616	PF00069	0.618
MOD_Plk_4	67	73	PF00069	0.364
MOD_Plk_4	98	104	PF00069	0.361
MOD_ProDKin_1	105	111	PF00069	0.271
MOD_ProDKin_1	280	286	PF00069	0.571
MOD_ProDKin_1	384	390	PF00069	0.571
MOD_ProDKin_1	399	405	PF00069	0.580
MOD_ProDKin_1	421	427	PF00069	0.586
MOD_ProDKin_1	451	457	PF00069	0.581
MOD_ProDKin_1	458	464	PF00069	0.610
MOD_ProDKin_1	497	503	PF00069	0.720
MOD_ProDKin_1	512	518	PF00069	0.561
MOD_ProDKin_1	534	540	PF00069	0.628
MOD_ProDKin_1	543	549	PF00069	0.587
MOD_ProDKin_1	563	569	PF00069	0.478
MOD_SUMO_rev_2	137	142	PF00179	0.404
MOD_SUMO_rev_2	339	349	PF00179	0.643
MOD_SUMO_rev_2	552	560	PF00179	0.647
TRG_ENDOCYTIC_2	115	118	PF00928	0.271
TRG_ENDOCYTIC_2	376	379	PF00928	0.677
TRG_ENDOCYTIC_2	486	489	PF00928	0.598
TRG_ENDOCYTIC_2	55	58	PF00928	0.271
TRG_ER_diArg_1	272	274	PF00400	0.600
TRG_ER_diArg_1	532	534	PF00400	0.715
TRG_ER_diArg_1	560	563	PF00400	0.785
TRG_ER_diArg_1	607	609	PF00400	0.620
TRG_ER_diArg_1	618	620	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I8	Leptomonas seymouri	56%	93%
A0A0S4JFG5	Bodo saltans	44%	81%
A0A1X0NXL0	Trypanosomatidae	43%	100%
A0A3Q8IAA7	Leishmania donovani	81%	100%
A0A3R7MFE4	Trypanosoma rangeli	40%	100%
A4HZ69	Leishmania infantum	81%	100%
D0A1G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AV36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCE5	Leishmania major	80%	100%