Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBR4_LEIBR

TriTrypDb:

LbrM.21.0740 , LBRM2903_210012000

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HBR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006476	protein deacetylation	6	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016570	histone modification	5	10
GO:0016575	histone deacetylation	6	10
GO:0019538	protein metabolic process	3	10
GO:0035601	protein deacylation	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0098732	macromolecule deacylation	5	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004407	histone deacetylase activity	4	10
GO:0005488	binding	1	9
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10
GO:0019213	deacetylase activity	3	10
GO:0033558	protein lysine deacetylase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.262
CLV_NRD_NRD_1	57	59	PF00675	0.160
CLV_PCSK_KEX2_1	265	267	PF00082	0.299
CLV_PCSK_SKI1_1	107	111	PF00082	0.262
CLV_PCSK_SKI1_1	206	210	PF00082	0.216
CLV_PCSK_SKI1_1	21	25	PF00082	0.403
CLV_PCSK_SKI1_1	257	261	PF00082	0.239
CLV_PCSK_SKI1_1	58	62	PF00082	0.303
CLV_Separin_Metazoa	55	59	PF03568	0.492
DEG_APCC_DBOX_1	284	292	PF00400	0.499
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.432
DOC_MAPK_DCC_7	304	313	PF00069	0.415
DOC_MAPK_DCC_7	67	76	PF00069	0.448
DOC_MAPK_gen_1	203	212	PF00069	0.412
DOC_MAPK_gen_1	233	241	PF00069	0.499
DOC_MAPK_gen_1	265	273	PF00069	0.413
DOC_MAPK_gen_1	46	56	PF00069	0.415
DOC_MAPK_MEF2A_6	183	191	PF00069	0.415
DOC_MAPK_MEF2A_6	235	243	PF00069	0.415
DOC_MAPK_MEF2A_6	265	273	PF00069	0.393
DOC_MAPK_MEF2A_6	304	313	PF00069	0.415
DOC_MAPK_MEF2A_6	67	76	PF00069	0.415
DOC_PP1_RVXF_1	105	111	PF00149	0.466
DOC_PP2B_LxvP_1	306	309	PF13499	0.415
DOC_USP7_MATH_1	103	107	PF00917	0.462
DOC_USP7_MATH_1	126	130	PF00917	0.465
DOC_USP7_MATH_1	259	263	PF00917	0.432
DOC_USP7_MATH_1	29	33	PF00917	0.326
DOC_USP7_MATH_1	9	13	PF00917	0.638
DOC_WW_Pin1_4	265	270	PF00397	0.462
DOC_WW_Pin1_4	357	362	PF00397	0.357
LIG_14-3-3_CanoR_1	206	211	PF00244	0.416
LIG_14-3-3_CanoR_1	235	240	PF00244	0.432
LIG_APCC_Cbox_2	391	397	PF00515	0.420
LIG_BRCT_BRCA1_1	105	109	PF00533	0.462
LIG_Clathr_ClatBox_1	73	77	PF01394	0.432
LIG_DLG_GKlike_1	235	243	PF00625	0.499
LIG_FHA_1	103	109	PF00498	0.469
LIG_FHA_1	207	213	PF00498	0.415
LIG_FHA_1	329	335	PF00498	0.429
LIG_FHA_1	422	428	PF00498	0.635
LIG_GBD_Chelix_1	170	178	PF00786	0.215
LIG_LIR_Gen_1	162	172	PF02991	0.415
LIG_LIR_Nem_3	162	167	PF02991	0.415
LIG_LIR_Nem_3	248	253	PF02991	0.447
LIG_NRP_CendR_1	431	432	PF00754	0.463
LIG_Pex14_2	215	219	PF04695	0.415
LIG_SH2_CRK	48	52	PF00017	0.415
LIG_SH2_GRB2like	166	169	PF00017	0.415
LIG_SH2_PTP2	186	189	PF00017	0.415
LIG_SH2_SRC	186	189	PF00017	0.499
LIG_SH2_STAP1	237	241	PF00017	0.450
LIG_SH2_STAP1	30	34	PF00017	0.496
LIG_SH2_STAP1	329	333	PF00017	0.415
LIG_SH2_STAT5	166	169	PF00017	0.415
LIG_SH2_STAT5	186	189	PF00017	0.329
LIG_SH2_STAT5	252	255	PF00017	0.504
LIG_SH2_STAT5	318	321	PF00017	0.432
LIG_SH2_STAT5	87	90	PF00017	0.440
LIG_SH3_3	66	72	PF00018	0.431
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.412
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.388
LIG_TYR_ITIM	184	189	PF00017	0.415
LIG_UBA3_1	174	179	PF00899	0.415
LIG_UBA3_1	207	214	PF00899	0.360
LIG_WRC_WIRS_1	291	296	PF05994	0.499
MOD_CK1_1	124	130	PF00069	0.484
MOD_CK1_1	332	338	PF00069	0.501
MOD_CK1_1	95	101	PF00069	0.434
MOD_GlcNHglycan	110	113	PF01048	0.220
MOD_GlcNHglycan	128	131	PF01048	0.334
MOD_GlcNHglycan	139	142	PF01048	0.250
MOD_GlcNHglycan	160	164	PF01048	0.215
MOD_GlcNHglycan	26	30	PF01048	0.383
MOD_GlcNHglycan	352	355	PF01048	0.313
MOD_GlcNHglycan	36	39	PF01048	0.336
MOD_GSK3_1	124	131	PF00069	0.432
MOD_GSK3_1	25	32	PF00069	0.288
MOD_GSK3_1	328	335	PF00069	0.499
MOD_GSK3_1	421	428	PF00069	0.556
MOD_GSK3_1	9	16	PF00069	0.560
MOD_N-GLC_1	289	294	PF02516	0.215
MOD_N-GLC_1	34	39	PF02516	0.498
MOD_NEK2_1	121	126	PF00069	0.446
MOD_NEK2_1	137	142	PF00069	0.410
MOD_NEK2_1	153	158	PF00069	0.511
MOD_NEK2_1	208	213	PF00069	0.433
MOD_NEK2_1	215	220	PF00069	0.477
MOD_NEK2_1	24	29	PF00069	0.342
MOD_NEK2_1	289	294	PF00069	0.415
MOD_NEK2_1	34	39	PF00069	0.415
MOD_NEK2_2	316	321	PF00069	0.432
MOD_NEK2_2	92	97	PF00069	0.499
MOD_PKB_1	233	241	PF00069	0.462
MOD_Plk_1	121	127	PF00069	0.415
MOD_Plk_1	25	31	PF00069	0.275
MOD_Plk_1	289	295	PF00069	0.431
MOD_Plk_1	329	335	PF00069	0.415
MOD_Plk_1	34	40	PF00069	0.391
MOD_Plk_1	9	15	PF00069	0.507
MOD_Plk_4	128	134	PF00069	0.422
MOD_Plk_4	215	221	PF00069	0.415
MOD_Plk_4	259	265	PF00069	0.466
MOD_Plk_4	329	335	PF00069	0.446
MOD_Plk_4	340	346	PF00069	0.354
MOD_Plk_4	83	89	PF00069	0.499
MOD_Plk_4	9	15	PF00069	0.497
MOD_ProDKin_1	265	271	PF00069	0.462
MOD_ProDKin_1	357	363	PF00069	0.349
MOD_SUMO_for_1	74	77	PF00179	0.499
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.446
TRG_ENDOCYTIC_2	186	189	PF00928	0.415
TRG_ENDOCYTIC_2	236	239	PF00928	0.446
TRG_ENDOCYTIC_2	252	255	PF00928	0.366
TRG_ENDOCYTIC_2	383	386	PF00928	0.465
TRG_ENDOCYTIC_2	48	51	PF00928	0.415
TRG_ER_diArg_1	19	22	PF00400	0.430
TRG_ER_diArg_1	233	236	PF00400	0.462
TRG_ER_diArg_1	264	266	PF00400	0.462
TRG_ER_diArg_1	430	432	PF00400	0.461
TRG_NLS_MonoExtC_3	57	63	PF00514	0.360
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.215
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.232

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	38%	81%
A0A0N1PFX6	Leptomonas seymouri	82%	100%
A0A1X0NVQ2	Trypanosomatidae	39%	95%
A0A1X0NXU7	Trypanosomatidae	69%	100%
A0A3Q8IC47	Leishmania donovani	39%	81%
A0A3R7L005	Trypanosoma rangeli	71%	100%
A0A3S7WWE6	Leishmania donovani	92%	100%
A0A422N1V5	Trypanosoma rangeli	38%	96%
A4HDK5	Leishmania braziliensis	36%	100%
A4HZ67	Leishmania infantum	92%	100%
A4I0X6	Leishmania infantum	39%	81%
B1H369	Xenopus tropicalis	41%	100%
B1WC68	Rattus norvegicus	40%	100%
D0A1H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AV34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	95%
E9AWY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	79%
O09106	Mus musculus	42%	90%
O13298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
O15379	Homo sapiens	40%	100%
O17695	Caenorhabditis elegans	45%	94%
O22446	Arabidopsis thaliana	42%	86%
O30107	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O42227	Xenopus laevis	40%	90%
O59702	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O88895	Mus musculus	40%	100%
P32561	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P39067	Bacillus subtilis (strain 168)	32%	100%
P53096	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	96%
P56517	Gallus gallus	42%	90%
P56518	Strongylocentrotus purpuratus	47%	75%
P56519	Gallus gallus	40%	89%
P56520	Gallus gallus	43%	100%
P56521	Zea mays	40%	84%
P64375	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
P64376	Staphylococcus aureus (strain N315)	29%	100%
P70288	Mus musculus	41%	89%
Q09440	Caenorhabditis elegans	44%	85%
Q0VCB2	Bos taurus	38%	100%
Q13547	Homo sapiens	41%	90%
Q28DV3	Xenopus tropicalis	40%	100%
Q32PJ8	Bos taurus	42%	90%
Q4QAJ4	Leishmania major	39%	81%
Q4QCE7	Leishmania major	92%	99%
Q4QQW4	Rattus norvegicus	42%	90%
Q4SFA0	Tetraodon nigroviridis	38%	100%
Q55BW2	Dictyostelium discoideum	42%	100%
Q55FN5	Dictyostelium discoideum	43%	87%
Q56195	Staphylococcus xylosus	29%	100%
Q5HF39	Staphylococcus aureus (strain COL)	29%	100%
Q5RAG0	Pongo abelii	41%	90%
Q5RB76	Pongo abelii	43%	100%
Q6G8J2	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GFX3	Staphylococcus aureus (strain MRSA252)	29%	100%
Q6IRL9	Xenopus laevis	44%	100%
Q6P6W3	Rattus norvegicus	40%	100%
Q6YV04	Oryza sativa subsp. japonica	48%	85%
Q7SXM0	Danio rerio	37%	100%
Q7Y0Y6	Oryza sativa subsp. japonica	41%	85%
Q7Y0Y8	Oryza sativa subsp. japonica	41%	83%
Q803C3	Danio rerio	42%	100%
Q8H0W2	Arabidopsis thaliana	43%	100%
Q8NW34	Staphylococcus aureus (strain MW2)	29%	100%
Q8VH37	Mus musculus	40%	100%
Q91695	Xenopus laevis	40%	90%
Q92769	Homo sapiens	41%	89%
Q944K3	Arabidopsis thaliana	27%	100%
Q94517	Drosophila melanogaster	43%	83%
Q9BY41	Homo sapiens	38%	100%
Q9FH09	Arabidopsis thaliana	43%	100%
Q9FML2	Arabidopsis thaliana	47%	92%
V5B3T3	Trypanosoma cruzi	34%	97%