Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative

Species:

Leishmania braziliensis

UniProt:

A4HBR0_LEIBR

TriTrypDb:

LbrM.21.0690 , LBRM2903_210011500

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBR0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003684	damaged DNA binding	5	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	594	598	PF00656	0.639
CLV_NRD_NRD_1	150	152	PF00675	0.312
CLV_NRD_NRD_1	182	184	PF00675	0.302
CLV_NRD_NRD_1	357	359	PF00675	0.792
CLV_NRD_NRD_1	364	366	PF00675	0.692
CLV_NRD_NRD_1	368	370	PF00675	0.611
CLV_PCSK_FUR_1	365	369	PF00082	0.624
CLV_PCSK_KEX2_1	150	152	PF00082	0.312
CLV_PCSK_KEX2_1	182	184	PF00082	0.302
CLV_PCSK_KEX2_1	357	359	PF00082	0.677
CLV_PCSK_KEX2_1	366	368	PF00082	0.619
CLV_PCSK_KEX2_1	545	547	PF00082	0.630
CLV_PCSK_KEX2_1	66	68	PF00082	0.302
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.633
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.582
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.232
CLV_PCSK_SKI1_1	119	123	PF00082	0.280
CLV_PCSK_SKI1_1	235	239	PF00082	0.302
CLV_PCSK_SKI1_1	369	373	PF00082	0.456
CLV_PCSK_SKI1_1	63	67	PF00082	0.214
CLV_Separin_Metazoa	203	207	PF03568	0.502
CLV_Separin_Metazoa	426	430	PF03568	0.468
DEG_APCC_DBOX_1	149	157	PF00400	0.577
DEG_APCC_DBOX_1	368	376	PF00400	0.454
DEG_COP1_1	523	532	PF00400	0.475
DEG_SPOP_SBC_1	384	388	PF00917	0.467
DOC_CYCLIN_RxL_1	232	243	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	724	730	PF00134	0.514
DOC_MAPK_gen_1	453	461	PF00069	0.566
DOC_MAPK_RevD_3	167	183	PF00069	0.469
DOC_PP2B_LxvP_1	286	289	PF13499	0.428
DOC_PP2B_LxvP_1	724	727	PF13499	0.635
DOC_PP2B_LxvP_1	729	732	PF13499	0.585
DOC_PP4_FxxP_1	201	204	PF00568	0.502
DOC_PP4_FxxP_1	297	300	PF00568	0.436
DOC_PP4_FxxP_1	676	679	PF00568	0.533
DOC_PP4_FxxP_1	728	731	PF00568	0.511
DOC_USP7_MATH_1	161	165	PF00917	0.511
DOC_USP7_MATH_1	313	317	PF00917	0.503
DOC_USP7_MATH_1	371	375	PF00917	0.636
DOC_USP7_MATH_1	507	511	PF00917	0.563
DOC_USP7_MATH_1	691	695	PF00917	0.588
DOC_WW_Pin1_4	40	45	PF00397	0.502
DOC_WW_Pin1_4	6	11	PF00397	0.533
DOC_WW_Pin1_4	631	636	PF00397	0.689
DOC_WW_Pin1_4	658	663	PF00397	0.653
DOC_WW_Pin1_4	675	680	PF00397	0.610
DOC_WW_Pin1_4	687	692	PF00397	0.529
DOC_WW_Pin1_4	732	737	PF00397	0.650
DOC_WW_Pin1_4	83	88	PF00397	0.556
LIG_14-3-3_CanoR_1	193	198	PF00244	0.502
LIG_14-3-3_CanoR_1	291	300	PF00244	0.422
LIG_14-3-3_CanoR_1	367	375	PF00244	0.504
LIG_14-3-3_CanoR_1	420	426	PF00244	0.490
LIG_14-3-3_CanoR_1	429	435	PF00244	0.452
LIG_14-3-3_CanoR_1	453	458	PF00244	0.529
LIG_14-3-3_CanoR_1	539	547	PF00244	0.680
LIG_14-3-3_CanoR_1	553	558	PF00244	0.561
LIG_14-3-3_CanoR_1	70	77	PF00244	0.396
LIG_Actin_WH2_2	606	621	PF00022	0.479
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.460
LIG_BRCT_BRCA1_1	219	223	PF00533	0.502
LIG_BRCT_BRCA1_1	293	297	PF00533	0.407
LIG_BRCT_BRCA1_1	414	418	PF00533	0.460
LIG_BRCT_BRCA1_1	7	11	PF00533	0.413
LIG_eIF4E_1	232	238	PF01652	0.502
LIG_FHA_1	174	180	PF00498	0.462
LIG_FHA_1	283	289	PF00498	0.429
LIG_FHA_1	41	47	PF00498	0.454
LIG_FHA_1	420	426	PF00498	0.490
LIG_FHA_1	474	480	PF00498	0.457
LIG_FHA_1	510	516	PF00498	0.490
LIG_FHA_1	524	530	PF00498	0.450
LIG_FHA_1	623	629	PF00498	0.634
LIG_FHA_1	632	638	PF00498	0.625
LIG_FHA_1	644	650	PF00498	0.477
LIG_FHA_1	652	658	PF00498	0.444
LIG_FHA_2	384	390	PF00498	0.543
LIG_FHA_2	421	427	PF00498	0.490
LIG_FHA_2	539	545	PF00498	0.503
LIG_FHA_2	683	689	PF00498	0.697
LIG_FHA_2	739	745	PF00498	0.547
LIG_LIR_Apic_2	294	300	PF02991	0.363
LIG_LIR_Apic_2	327	332	PF02991	0.420
LIG_LIR_Apic_2	673	679	PF02991	0.534
LIG_LIR_Gen_1	139	149	PF02991	0.460
LIG_LIR_Gen_1	25	36	PF02991	0.460
LIG_LIR_Gen_1	430	439	PF02991	0.466
LIG_LIR_Gen_1	441	450	PF02991	0.456
LIG_LIR_Nem_3	139	145	PF02991	0.484
LIG_LIR_Nem_3	25	31	PF02991	0.460
LIG_LIR_Nem_3	387	393	PF02991	0.346
LIG_LIR_Nem_3	415	421	PF02991	0.490
LIG_LIR_Nem_3	430	434	PF02991	0.437
LIG_LIR_Nem_3	441	446	PF02991	0.456
LIG_MYND_1	727	731	PF01753	0.510
LIG_PAM2_1	719	731	PF00658	0.506
LIG_PCNA_yPIPBox_3	549	562	PF02747	0.593
LIG_PTB_Apo_2	460	467	PF02174	0.520
LIG_SH2_NCK_1	28	32	PF00017	0.460
LIG_SH2_PTP2	142	145	PF00017	0.502
LIG_SH2_SRC	142	145	PF00017	0.502
LIG_SH2_SRC	96	99	PF00017	0.381
LIG_SH2_STAP1	259	263	PF00017	0.460
LIG_SH2_STAT5	142	145	PF00017	0.502
LIG_SH2_STAT5	390	393	PF00017	0.413
LIG_SH3_3	168	174	PF00018	0.460
LIG_SH3_3	474	480	PF00018	0.551
LIG_SH3_3	53	59	PF00018	0.460
LIG_SH3_3	666	672	PF00018	0.671
LIG_SH3_3	712	718	PF00018	0.760
LIG_SH3_3	724	730	PF00018	0.575
LIG_SH3_4	280	287	PF00018	0.378
LIG_SUMO_SIM_anti_2	422	430	PF11976	0.403
LIG_SUMO_SIM_anti_2	623	634	PF11976	0.650
LIG_SUMO_SIM_anti_2	747	757	PF11976	0.601
LIG_SUMO_SIM_par_1	166	173	PF11976	0.435
LIG_SUMO_SIM_par_1	284	290	PF11976	0.429
LIG_SUMO_SIM_par_1	473	481	PF11976	0.513
LIG_SUMO_SIM_par_1	609	615	PF11976	0.567
LIG_SUMO_SIM_par_1	623	634	PF11976	0.546
LIG_SUMO_SIM_par_1	653	661	PF11976	0.508
LIG_SUMO_SIM_par_1	80	86	PF11976	0.484
LIG_TRAF2_1	686	689	PF00917	0.655
LIG_WRC_WIRS_1	558	563	PF05994	0.574
LIG_WW_3	730	734	PF00397	0.539
MOD_CDC14_SPxK_1	690	693	PF00782	0.528
MOD_CDK_SPxK_1	687	693	PF00069	0.531
MOD_CDK_SPxxK_3	83	90	PF00069	0.351
MOD_CK1_1	12	18	PF00069	0.451
MOD_CK1_1	430	436	PF00069	0.293
MOD_CK1_1	470	476	PF00069	0.328
MOD_CK1_1	5	11	PF00069	0.520
MOD_CK1_1	520	526	PF00069	0.561
MOD_CK1_1	598	604	PF00069	0.577
MOD_CK1_1	612	618	PF00069	0.465
MOD_CK1_1	658	664	PF00069	0.560
MOD_CK1_1	687	693	PF00069	0.622
MOD_CK1_1	69	75	PF00069	0.336
MOD_CK1_1	734	740	PF00069	0.629
MOD_CK2_1	370	376	PF00069	0.492
MOD_CK2_1	383	389	PF00069	0.435
MOD_CK2_1	420	426	PF00069	0.351
MOD_CK2_1	538	544	PF00069	0.661
MOD_CK2_1	584	590	PF00069	0.510
MOD_CK2_1	658	664	PF00069	0.636
MOD_CK2_1	682	688	PF00069	0.753
MOD_GlcNHglycan	11	14	PF01048	0.487
MOD_GlcNHglycan	260	264	PF01048	0.309
MOD_GlcNHglycan	275	278	PF01048	0.388
MOD_GlcNHglycan	293	296	PF01048	0.355
MOD_GlcNHglycan	301	304	PF01048	0.447
MOD_GlcNHglycan	463	466	PF01048	0.198
MOD_GlcNHglycan	469	472	PF01048	0.180
MOD_GlcNHglycan	577	580	PF01048	0.682
MOD_GlcNHglycan	586	589	PF01048	0.636
MOD_GlcNHglycan	620	623	PF01048	0.614
MOD_GlcNHglycan	737	740	PF01048	0.673
MOD_GSK3_1	103	110	PF00069	0.367
MOD_GSK3_1	2	9	PF00069	0.575
MOD_GSK3_1	367	374	PF00069	0.499
MOD_GSK3_1	408	415	PF00069	0.349
MOD_GSK3_1	430	437	PF00069	0.464
MOD_GSK3_1	461	468	PF00069	0.313
MOD_GSK3_1	507	514	PF00069	0.358
MOD_GSK3_1	533	540	PF00069	0.600
MOD_GSK3_1	549	556	PF00069	0.651
MOD_GSK3_1	614	621	PF00069	0.623
MOD_GSK3_1	651	658	PF00069	0.566
MOD_GSK3_1	670	677	PF00069	0.666
MOD_GSK3_1	687	694	PF00069	0.704
MOD_GSK3_1	709	716	PF00069	0.538
MOD_GSK3_1	731	738	PF00069	0.690
MOD_LATS_1	451	457	PF00433	0.275
MOD_LATS_1	551	557	PF00433	0.595
MOD_N-GLC_1	598	603	PF02516	0.770
MOD_NEK2_1	217	222	PF00069	0.455
MOD_NEK2_1	3	8	PF00069	0.491
MOD_NEK2_1	408	413	PF00069	0.315
MOD_NEK2_1	461	466	PF00069	0.422
MOD_NEK2_1	557	562	PF00069	0.582
MOD_NEK2_1	611	616	PF00069	0.611
MOD_NEK2_1	674	679	PF00069	0.549
MOD_PK_1	693	699	PF00069	0.533
MOD_PKA_1	367	373	PF00069	0.552
MOD_PKA_1	66	72	PF00069	0.336
MOD_PKA_2	192	198	PF00069	0.367
MOD_PKA_2	367	373	PF00069	0.544
MOD_PKA_2	419	425	PF00069	0.360
MOD_PKA_2	538	544	PF00069	0.576
MOD_PKA_2	568	574	PF00069	0.550
MOD_PKA_2	618	624	PF00069	0.719
MOD_PKA_2	66	72	PF00069	0.348
MOD_PKB_1	365	373	PF00069	0.547
MOD_Plk_1	399	405	PF00069	0.458
MOD_Plk_1	444	450	PF00069	0.351
MOD_Plk_1	598	604	PF00069	0.505
MOD_Plk_1	623	629	PF00069	0.627
MOD_Plk_1	92	98	PF00069	0.198
MOD_Plk_2-3	751	757	PF00069	0.684
MOD_Plk_4	282	288	PF00069	0.373
MOD_Plk_4	313	319	PF00069	0.257
MOD_Plk_4	408	414	PF00069	0.296
MOD_Plk_4	430	436	PF00069	0.236
MOD_Plk_4	49	55	PF00069	0.367
MOD_Plk_4	553	559	PF00069	0.585
MOD_Plk_4	624	630	PF00069	0.676
MOD_Plk_4	670	676	PF00069	0.529
MOD_Plk_4	719	725	PF00069	0.576
MOD_Plk_4	751	757	PF00069	0.666
MOD_ProDKin_1	40	46	PF00069	0.367
MOD_ProDKin_1	6	12	PF00069	0.525
MOD_ProDKin_1	631	637	PF00069	0.688
MOD_ProDKin_1	658	664	PF00069	0.655
MOD_ProDKin_1	675	681	PF00069	0.607
MOD_ProDKin_1	687	693	PF00069	0.531
MOD_ProDKin_1	732	738	PF00069	0.652
MOD_ProDKin_1	83	89	PF00069	0.443
TRG_DiLeu_BaEn_1	234	239	PF01217	0.367
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.367
TRG_ENDOCYTIC_2	142	145	PF00928	0.367
TRG_ENDOCYTIC_2	254	257	PF00928	0.367
TRG_ENDOCYTIC_2	28	31	PF00928	0.309
TRG_ENDOCYTIC_2	443	446	PF00928	0.330
TRG_ER_diArg_1	249	252	PF00400	0.376
TRG_ER_diArg_1	365	368	PF00400	0.586
TRG_ER_diArg_1	452	455	PF00400	0.351
TRG_NES_CRM1_1	14	25	PF08389	0.383
TRG_NES_CRM1_1	481	495	PF08389	0.351
TRG_NLS_MonoCore_2	364	369	PF00514	0.582
TRG_NLS_MonoExtC_3	357	362	PF00514	0.671
TRG_NLS_MonoExtC_3	364	369	PF00514	0.606
TRG_NLS_MonoExtN_4	357	362	PF00514	0.658
TRG_NLS_MonoExtN_4	365	370	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	55%	95%
A4HZ62	Leishmania infantum	78%	100%
D0A1I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QCF2	Leishmania major	79%	100%
Q8H2D5	Arabidopsis thaliana	28%	100%