Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative

Species:

Leishmania braziliensis

UniProt:

A4HBQ9_LEIBR

TriTrypDb:

LbrM.21.0680 , LBRM2903_210011400

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005657	replication fork	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0035861	site of double-strand break	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0090734	site of DNA damage	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.644
CLV_C14_Caspase3-7	526	530	PF00656	0.702
CLV_MEL_PAP_1	426	432	PF00089	0.371
CLV_NRD_NRD_1	136	138	PF00675	0.419
CLV_NRD_NRD_1	168	170	PF00675	0.306
CLV_NRD_NRD_1	353	355	PF00675	0.682
CLV_NRD_NRD_1	458	460	PF00675	0.692
CLV_NRD_NRD_1	61	63	PF00675	0.331
CLV_NRD_NRD_1	618	620	PF00675	0.718
CLV_PCSK_KEX2_1	136	138	PF00082	0.419
CLV_PCSK_KEX2_1	168	170	PF00082	0.306
CLV_PCSK_KEX2_1	353	355	PF00082	0.649
CLV_PCSK_KEX2_1	458	460	PF00082	0.692
CLV_PCSK_KEX2_1	51	53	PF00082	0.348
CLV_PCSK_KEX2_1	61	63	PF00082	0.348
CLV_PCSK_KEX2_1	620	622	PF00082	0.722
CLV_PCSK_KEX2_1	693	695	PF00082	0.626
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.303
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.711
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.596
CLV_PCSK_SKI1_1	105	109	PF00082	0.348
CLV_PCSK_SKI1_1	221	225	PF00082	0.338
CLV_PCSK_SKI1_1	477	481	PF00082	0.413
CLV_PCSK_SKI1_1	48	52	PF00082	0.296
CLV_PCSK_SKI1_1	495	499	PF00082	0.529
CLV_PCSK_SKI1_1	694	698	PF00082	0.594
CLV_PCSK_SKI1_1	723	727	PF00082	0.778
CLV_Separin_Metazoa	189	193	PF03568	0.548
DEG_APCC_DBOX_1	135	143	PF00400	0.621
DEG_APCC_DBOX_1	60	68	PF00400	0.579
DEG_COP1_1	521	530	PF00400	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.323
DOC_CKS1_1	451	456	PF01111	0.521
DOC_CYCLIN_RxL_1	218	229	PF00134	0.548
DOC_CYCLIN_RxL_1	545	553	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	681	687	PF00134	0.572
DOC_MAPK_DCC_7	61	69	PF00069	0.579
DOC_MAPK_gen_1	439	448	PF00069	0.554
DOC_MAPK_gen_1	633	643	PF00069	0.635
DOC_MAPK_MEF2A_6	112	119	PF00069	0.537
DOC_MAPK_MEF2A_6	439	448	PF00069	0.535
DOC_MAPK_MEF2A_6	61	69	PF00069	0.537
DOC_MAPK_MEF2A_6	636	643	PF00069	0.637
DOC_MAPK_RevD_3	153	169	PF00069	0.541
DOC_PP2B_LxvP_1	272	275	PF13499	0.474
DOC_PP4_FxxP_1	187	190	PF00568	0.548
DOC_PP4_FxxP_1	283	286	PF00568	0.481
DOC_PP4_FxxP_1	520	523	PF00568	0.579
DOC_USP7_MATH_1	147	151	PF00917	0.557
DOC_USP7_MATH_1	299	303	PF00917	0.588
DOC_USP7_MATH_1	407	411	PF00917	0.536
DOC_USP7_MATH_1	599	603	PF00917	0.761
DOC_USP7_MATH_1	685	689	PF00917	0.758
DOC_USP7_UBL2_3	693	697	PF12436	0.781
DOC_WW_Pin1_4	25	30	PF00397	0.548
DOC_WW_Pin1_4	450	455	PF00397	0.523
DOC_WW_Pin1_4	513	518	PF00397	0.686
DOC_WW_Pin1_4	53	58	PF00397	0.540
DOC_WW_Pin1_4	686	691	PF00397	0.755
LIG_14-3-3_CanoR_1	179	184	PF00244	0.548
LIG_14-3-3_CanoR_1	277	286	PF00244	0.464
LIG_14-3-3_CanoR_1	429	437	PF00244	0.594
LIG_14-3-3_CanoR_1	702	706	PF00244	0.655
LIG_14-3-3_CanoR_1	723	729	PF00244	0.705
LIG_14-3-3_CanoR_1	89	97	PF00244	0.510
LIG_AP2alpha_2	698	700	PF02296	0.579
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.548
LIG_BRCT_BRCA1_1	205	209	PF00533	0.548
LIG_BRCT_BRCA1_1	279	283	PF00533	0.448
LIG_BRCT_BRCA1_1	401	405	PF00533	0.470
LIG_BRCT_BRCA1_1	671	675	PF00533	0.702
LIG_deltaCOP1_diTrp_1	425	430	PF00928	0.379
LIG_eIF4E_1	218	224	PF01652	0.548
LIG_EVH1_2	545	549	PF00568	0.344
LIG_FHA_1	160	166	PF00498	0.524
LIG_FHA_1	269	275	PF00498	0.475
LIG_FHA_1	509	515	PF00498	0.592
LIG_FHA_1	522	528	PF00498	0.578
LIG_FHA_1	608	614	PF00498	0.575
LIG_FHA_1	630	636	PF00498	0.575
LIG_FHA_1	704	710	PF00498	0.708
LIG_FHA_1	72	78	PF00498	0.474
LIG_FHA_1	725	731	PF00498	0.575
LIG_FHA_1	734	740	PF00498	0.664
LIG_FHA_1	90	96	PF00498	0.615
LIG_FHA_2	387	393	PF00498	0.608
LIG_FHA_2	496	502	PF00498	0.455
LIG_FHA_2	693	699	PF00498	0.731
LIG_LIR_Apic_2	280	286	PF02991	0.465
LIG_LIR_Apic_2	313	318	PF02991	0.466
LIG_LIR_Apic_2	450	454	PF02991	0.428
LIG_LIR_Apic_2	79	85	PF02991	0.537
LIG_LIR_Gen_1	10	21	PF02991	0.548
LIG_LIR_Gen_1	125	135	PF02991	0.548
LIG_LIR_Gen_1	28	38	PF02991	0.548
LIG_LIR_Gen_1	425	433	PF02991	0.478
LIG_LIR_Gen_1	489	497	PF02991	0.606
LIG_LIR_Gen_1	590	599	PF02991	0.651
LIG_LIR_LC3C_4	443	446	PF02991	0.329
LIG_LIR_Nem_3	10	16	PF02991	0.548
LIG_LIR_Nem_3	125	131	PF02991	0.506
LIG_LIR_Nem_3	28	33	PF02991	0.548
LIG_LIR_Nem_3	374	380	PF02991	0.440
LIG_LIR_Nem_3	402	408	PF02991	0.384
LIG_LIR_Nem_3	425	430	PF02991	0.466
LIG_LIR_Nem_3	489	493	PF02991	0.593
LIG_LIR_Nem_3	590	595	PF02991	0.643
LIG_REV1ctd_RIR_1	673	682	PF16727	0.546
LIG_SH2_GRB2like	349	352	PF00017	0.533
LIG_SH2_NCK_1	13	17	PF00017	0.548
LIG_SH2_PTP2	128	131	PF00017	0.548
LIG_SH2_PTP2	451	454	PF00017	0.514
LIG_SH2_SRC	128	131	PF00017	0.518
LIG_SH2_STAP1	245	249	PF00017	0.548
LIG_SH2_STAP1	433	437	PF00017	0.594
LIG_SH2_STAT3	466	469	PF00017	0.587
LIG_SH2_STAT5	128	131	PF00017	0.548
LIG_SH2_STAT5	377	380	PF00017	0.393
LIG_SH2_STAT5	451	454	PF00017	0.564
LIG_SH2_STAT5	82	85	PF00017	0.579
LIG_SH3_1	558	564	PF00018	0.492
LIG_SH3_1	82	88	PF00018	0.537
LIG_SH3_3	154	160	PF00018	0.548
LIG_SH3_3	38	44	PF00018	0.548
LIG_SH3_3	387	393	PF00018	0.544
LIG_SH3_3	525	531	PF00018	0.789
LIG_SH3_3	558	564	PF00018	0.729
LIG_SH3_3	734	740	PF00018	0.703
LIG_SH3_3	82	88	PF00018	0.537
LIG_SH3_4	266	273	PF00018	0.482
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.517
LIG_SUMO_SIM_anti_2	551	556	PF11976	0.549
LIG_SUMO_SIM_par_1	152	159	PF11976	0.441
LIG_SUMO_SIM_par_1	270	276	PF11976	0.473
LIG_SUMO_SIM_par_1	638	645	PF11976	0.681
LIG_TRAF2_1	498	501	PF00917	0.433
LIG_TRFH_1	53	57	PF08558	0.457
MOD_CDK_SPxxK_3	686	693	PF00069	0.608
MOD_CK1_1	410	416	PF00069	0.551
MOD_CK1_1	508	514	PF00069	0.593
MOD_CK1_1	581	587	PF00069	0.729
MOD_CK1_1	602	608	PF00069	0.704
MOD_CK2_1	428	434	PF00069	0.590
MOD_CK2_1	495	501	PF00069	0.644
MOD_CK2_1	53	59	PF00069	0.398
MOD_CK2_1	707	713	PF00069	0.812
MOD_CK2_1	743	749	PF00069	0.697
MOD_GlcNHglycan	246	250	PF01048	0.414
MOD_GlcNHglycan	261	264	PF01048	0.488
MOD_GlcNHglycan	279	282	PF01048	0.455
MOD_GlcNHglycan	287	290	PF01048	0.496
MOD_GlcNHglycan	371	374	PF01048	0.419
MOD_GlcNHglycan	412	415	PF01048	0.458
MOD_GlcNHglycan	507	510	PF01048	0.579
MOD_GlcNHglycan	540	544	PF01048	0.664
MOD_GlcNHglycan	580	583	PF01048	0.716
MOD_GlcNHglycan	595	598	PF01048	0.615
MOD_GlcNHglycan	601	604	PF01048	0.704
MOD_GlcNHglycan	623	626	PF01048	0.637
MOD_GlcNHglycan	708	712	PF01048	0.738
MOD_GlcNHglycan	719	722	PF01048	0.745
MOD_GSK3_1	365	372	PF00069	0.662
MOD_GSK3_1	428	435	PF00069	0.590
MOD_GSK3_1	505	512	PF00069	0.698
MOD_GSK3_1	569	576	PF00069	0.740
MOD_GSK3_1	577	584	PF00069	0.784
MOD_GSK3_1	593	600	PF00069	0.593
MOD_GSK3_1	67	74	PF00069	0.457
MOD_GSK3_1	700	707	PF00069	0.782
MOD_GSK3_1	745	752	PF00069	0.739
MOD_GSK3_1	89	96	PF00069	0.414
MOD_N-GLC_1	597	602	PF02516	0.540
MOD_NEK2_1	203	208	PF00069	0.516
MOD_NEK2_1	399	404	PF00069	0.408
MOD_NEK2_1	408	413	PF00069	0.426
MOD_NEK2_1	550	555	PF00069	0.386
MOD_NEK2_1	692	697	PF00069	0.761
MOD_NEK2_1	700	705	PF00069	0.547
MOD_PIKK_1	477	483	PF00454	0.542
MOD_PIKK_1	581	587	PF00454	0.759
MOD_PKA_1	353	359	PF00069	0.642
MOD_PKA_2	178	184	PF00069	0.414
MOD_PKA_2	353	359	PF00069	0.633
MOD_PKA_2	399	405	PF00069	0.418
MOD_PKA_2	428	434	PF00069	0.557
MOD_PKA_2	701	707	PF00069	0.711
MOD_PKB_1	619	627	PF00069	0.724
MOD_Plk_1	477	483	PF00069	0.368
MOD_Plk_1	539	545	PF00069	0.517
MOD_Plk_1	550	556	PF00069	0.433
MOD_Plk_1	648	654	PF00069	0.546
MOD_Plk_1	733	739	PF00069	0.509
MOD_Plk_2-3	648	654	PF00069	0.697
MOD_Plk_2-3	749	755	PF00069	0.668
MOD_Plk_4	268	274	PF00069	0.476
MOD_Plk_4	299	305	PF00069	0.329
MOD_Plk_4	510	516	PF00069	0.558
MOD_Plk_4	550	556	PF00069	0.473
MOD_Plk_4	671	677	PF00069	0.551
MOD_ProDKin_1	25	31	PF00069	0.414
MOD_ProDKin_1	450	456	PF00069	0.525
MOD_ProDKin_1	513	519	PF00069	0.687
MOD_ProDKin_1	53	59	PF00069	0.402
MOD_ProDKin_1	686	692	PF00069	0.758
MOD_SUMO_rev_2	366	372	PF00179	0.550
MOD_SUMO_rev_2	500	508	PF00179	0.518
TRG_DiLeu_BaEn_1	220	225	PF01217	0.516
TRG_DiLeu_BaEn_1	440	445	PF01217	0.538
TRG_DiLeu_BaEn_1	489	494	PF01217	0.473
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.414
TRG_ENDOCYTIC_2	128	131	PF00928	0.414
TRG_ENDOCYTIC_2	13	16	PF00928	0.414
TRG_ENDOCYTIC_2	240	243	PF00928	0.414
TRG_ER_diArg_1	235	238	PF00400	0.422
TRG_ER_diArg_1	380	383	PF00400	0.450
TRG_ER_diArg_1	457	459	PF00400	0.473
TRG_ER_diArg_1	557	560	PF00400	0.565
TRG_ER_diArg_1	60	62	PF00400	0.389
TRG_ER_diArg_1	618	621	PF00400	0.724
TRG_NLS_MonoExtC_3	618	623	PF00514	0.712
TRG_NLS_MonoExtN_4	619	624	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	694	698	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	52%	95%
A0A3S5H795	Leishmania donovani	74%	99%
A4HZ61	Leishmania infantum	80%	96%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AV29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4QCF3	Leishmania major	79%	100%