Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBQ8_LEIBR

TriTrypDb:

LbrM.21.0670 , LBRM2903_210011300

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.747
CLV_C14_Caspase3-7	331	335	PF00656	0.557
CLV_MEL_PAP_1	307	313	PF00089	0.432
CLV_NRD_NRD_1	236	238	PF00675	0.717
CLV_NRD_NRD_1	284	286	PF00675	0.470
CLV_NRD_NRD_1	316	318	PF00675	0.408
CLV_NRD_NRD_1	326	328	PF00675	0.431
CLV_PCSK_KEX2_1	20	22	PF00082	0.701
CLV_PCSK_KEX2_1	238	240	PF00082	0.654
CLV_PCSK_KEX2_1	284	286	PF00082	0.470
CLV_PCSK_KEX2_1	316	318	PF00082	0.408
CLV_PCSK_KEX2_1	326	328	PF00082	0.431
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.502
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.654
CLV_PCSK_PC7_1	16	22	PF00082	0.510
CLV_PCSK_SKI1_1	101	105	PF00082	0.276
CLV_PCSK_SKI1_1	130	134	PF00082	0.362
CLV_PCSK_SKI1_1	165	169	PF00082	0.258
CLV_PCSK_SKI1_1	316	320	PF00082	0.432
CLV_PCSK_SKI1_1	401	405	PF00082	0.520
CLV_PCSK_SKI1_1	420	424	PF00082	0.473
CLV_PCSK_SKI1_1	483	487	PF00082	0.311
CLV_PCSK_SKI1_1	534	538	PF00082	0.360
CLV_PCSK_SKI1_1	557	561	PF00082	0.431
CLV_PCSK_SKI1_1	655	659	PF00082	0.604
CLV_PCSK_SKI1_1	71	75	PF00082	0.541
DEG_APCC_KENBOX_2	403	407	PF00400	0.353
DEG_SPOP_SBC_1	468	472	PF00917	0.633
DEG_SPOP_SBC_1	473	477	PF00917	0.550
DOC_CYCLIN_RxL_1	127	135	PF00134	0.537
DOC_CYCLIN_RxL_1	514	525	PF00134	0.466
DOC_CYCLIN_RxL_1	652	660	PF00134	0.607
DOC_CYCLIN_yClb1_LxF_4	319	325	PF00134	0.421
DOC_MAPK_gen_1	18	27	PF00069	0.570
DOC_MAPK_gen_1	316	324	PF00069	0.431
DOC_MAPK_gen_1	401	409	PF00069	0.460
DOC_MAPK_gen_1	551	561	PF00069	0.600
DOC_MAPK_gen_1	631	639	PF00069	0.642
DOC_MAPK_gen_1	81	89	PF00069	0.323
DOC_MAPK_MEF2A_6	174	182	PF00069	0.489
DOC_MAPK_MEF2A_6	631	639	PF00069	0.675
DOC_PP1_RVXF_1	410	417	PF00149	0.391
DOC_PP1_RVXF_1	46	52	PF00149	0.622
DOC_PP1_RVXF_1	515	522	PF00149	0.476
DOC_PP2B_LxvP_1	530	533	PF13499	0.476
DOC_PP4_FxxP_1	674	677	PF00568	0.400
DOC_USP7_MATH_1	12	16	PF00917	0.652
DOC_USP7_MATH_1	265	269	PF00917	0.769
DOC_USP7_MATH_1	446	450	PF00917	0.767
DOC_USP7_MATH_1	467	471	PF00917	0.767
DOC_USP7_MATH_1	473	477	PF00917	0.705
DOC_USP7_MATH_1	536	540	PF00917	0.530
DOC_USP7_MATH_1	592	596	PF00917	0.654
DOC_USP7_MATH_1	612	616	PF00917	0.711
DOC_USP7_MATH_1	618	622	PF00917	0.505
DOC_USP7_UBL2_3	319	323	PF12436	0.462
DOC_USP7_UBL2_3	451	455	PF12436	0.811
DOC_USP7_UBL2_3	456	460	PF12436	0.708
DOC_USP7_UBL2_3	634	638	PF12436	0.656
DOC_USP7_UBL2_3	655	659	PF12436	0.481
DOC_WW_Pin1_4	188	193	PF00397	0.506
DOC_WW_Pin1_4	288	293	PF00397	0.585
DOC_WW_Pin1_4	469	474	PF00397	0.649
LIG_14-3-3_CanoR_1	174	179	PF00244	0.532
LIG_14-3-3_CanoR_1	239	246	PF00244	0.768
LIG_14-3-3_CanoR_1	310	318	PF00244	0.536
LIG_14-3-3_CanoR_1	395	403	PF00244	0.454
LIG_14-3-3_CanoR_1	483	492	PF00244	0.550
LIG_14-3-3_CanoR_1	545	555	PF00244	0.480
LIG_14-3-3_CanoR_1	627	631	PF00244	0.393
LIG_14-3-3_CanoR_1	675	684	PF00244	0.577
LIG_Actin_WH2_2	164	181	PF00022	0.543
LIG_Actin_WH2_2	307	325	PF00022	0.481
LIG_Actin_WH2_2	643	661	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	538	542	PF00533	0.562
LIG_DLG_GKlike_1	174	182	PF00625	0.404
LIG_FHA_1	162	168	PF00498	0.468
LIG_FHA_1	20	26	PF00498	0.577
LIG_FHA_1	273	279	PF00498	0.586
LIG_FHA_1	387	393	PF00498	0.477
LIG_FHA_1	460	466	PF00498	0.535
LIG_FHA_1	547	553	PF00498	0.537
LIG_FHA_1	575	581	PF00498	0.580
LIG_FHA_1	589	595	PF00498	0.614
LIG_FHA_1	77	83	PF00498	0.464
LIG_FHA_2	219	225	PF00498	0.609
LIG_FHA_2	33	39	PF00498	0.525
LIG_FHA_2	421	427	PF00498	0.525
LIG_FHA_2	520	526	PF00498	0.562
LIG_FHA_2	690	696	PF00498	0.623
LIG_Integrin_isoDGR_2	105	107	PF01839	0.362
LIG_Integrin_isoDGR_2	410	412	PF01839	0.564
LIG_LIR_Apic_2	120	126	PF02991	0.466
LIG_LIR_Apic_2	629	635	PF02991	0.439
LIG_LIR_Gen_1	184	192	PF02991	0.404
LIG_LIR_Gen_1	34	45	PF02991	0.430
LIG_LIR_Gen_1	520	529	PF02991	0.500
LIG_LIR_LC3C_4	477	482	PF02991	0.516
LIG_LIR_LC3C_4	621	626	PF02991	0.529
LIG_LIR_Nem_3	184	188	PF02991	0.562
LIG_LIR_Nem_3	34	40	PF02991	0.398
LIG_LIR_Nem_3	520	524	PF02991	0.476
LIG_Pex14_2	150	154	PF04695	0.476
LIG_SH2_CRK	100	104	PF00017	0.476
LIG_SH2_CRK	123	127	PF00017	0.467
LIG_SH2_CRK	369	373	PF00017	0.405
LIG_SH2_CRK	632	636	PF00017	0.603
LIG_SH2_NCK_1	632	636	PF00017	0.603
LIG_SH2_STAT3	172	175	PF00017	0.551
LIG_SH2_STAT3	367	370	PF00017	0.466
LIG_SH2_STAT3	691	694	PF00017	0.574
LIG_SH2_STAT5	345	348	PF00017	0.359
LIG_SH2_STAT5	632	635	PF00017	0.607
LIG_SH2_STAT5	691	694	PF00017	0.599
LIG_SH3_3	549	555	PF00018	0.537
LIG_SH3_3	634	640	PF00018	0.549
LIG_SH3_3	647	653	PF00018	0.561
LIG_SH3_4	634	641	PF00018	0.652
LIG_SUMO_SIM_anti_2	615	621	PF11976	0.521
LIG_SUMO_SIM_par_1	370	376	PF11976	0.439
LIG_TRAF2_1	222	225	PF00917	0.645
LIG_TRAF2_1	692	695	PF00917	0.532
MOD_CDC14_SPxK_1	291	294	PF00782	0.519
MOD_CDK_SPxK_1	288	294	PF00069	0.527
MOD_CDK_SPxxK_3	188	195	PF00069	0.227
MOD_CK1_1	117	123	PF00069	0.318
MOD_CK1_1	2	8	PF00069	0.680
MOD_CK1_1	428	434	PF00069	0.555
MOD_CK1_1	461	467	PF00069	0.749
MOD_CK1_1	472	478	PF00069	0.630
MOD_CK1_1	69	75	PF00069	0.582
MOD_CK2_1	163	169	PF00069	0.351
MOD_CK2_1	203	209	PF00069	0.352
MOD_CK2_1	218	224	PF00069	0.621
MOD_CK2_1	420	426	PF00069	0.529
MOD_CK2_1	664	670	PF00069	0.540
MOD_CK2_1	689	695	PF00069	0.588
MOD_Cter_Amidation	235	238	PF01082	0.752
MOD_Cter_Amidation	314	317	PF01082	0.426
MOD_GlcNHglycan	116	119	PF01048	0.328
MOD_GlcNHglycan	142	146	PF01048	0.227
MOD_GlcNHglycan	234	237	PF01048	0.738
MOD_GlcNHglycan	241	244	PF01048	0.762
MOD_GlcNHglycan	311	314	PF01048	0.603
MOD_GlcNHglycan	375	378	PF01048	0.621
MOD_GlcNHglycan	594	597	PF01048	0.705
MOD_GlcNHglycan	614	617	PF01048	0.655
MOD_GSK3_1	110	117	PF00069	0.328
MOD_GSK3_1	272	279	PF00069	0.617
MOD_GSK3_1	421	428	PF00069	0.476
MOD_GSK3_1	468	475	PF00069	0.677
MOD_GSK3_1	49	56	PF00069	0.444
MOD_GSK3_1	519	526	PF00069	0.423
MOD_GSK3_1	588	595	PF00069	0.549
MOD_GSK3_1	626	633	PF00069	0.500
MOD_GSK3_1	69	76	PF00069	0.532
MOD_LATS_1	112	118	PF00433	0.328
MOD_N-GLC_1	328	333	PF02516	0.457
MOD_N-GLC_1	405	410	PF02516	0.371
MOD_NEK2_1	200	205	PF00069	0.363
MOD_NEK2_1	386	391	PF00069	0.557
MOD_NEK2_1	425	430	PF00069	0.436
MOD_NEK2_1	474	479	PF00069	0.598
MOD_NEK2_1	588	593	PF00069	0.438
MOD_NEK2_1	630	635	PF00069	0.589
MOD_NEK2_1	75	80	PF00069	0.488
MOD_NEK2_2	618	623	PF00069	0.552
MOD_OFUCOSY	385	390	PF10250	0.462
MOD_PKA_2	173	179	PF00069	0.227
MOD_PKA_2	232	238	PF00069	0.679
MOD_PKA_2	309	315	PF00069	0.444
MOD_PKA_2	626	632	PF00069	0.577
MOD_PKB_1	237	245	PF00069	0.692
MOD_Plk_1	303	309	PF00069	0.440
MOD_Plk_1	33	39	PF00069	0.384
MOD_Plk_1	405	411	PF00069	0.606
MOD_Plk_1	425	431	PF00069	0.240
MOD_Plk_2-3	328	334	PF00069	0.353
MOD_Plk_2-3	388	394	PF00069	0.320
MOD_Plk_2-3	53	59	PF00069	0.474
MOD_Plk_4	163	169	PF00069	0.351
MOD_Plk_4	21	27	PF00069	0.575
MOD_Plk_4	476	482	PF00069	0.640
MOD_Plk_4	523	529	PF00069	0.379
MOD_Plk_4	538	544	PF00069	0.203
MOD_ProDKin_1	188	194	PF00069	0.371
MOD_ProDKin_1	288	294	PF00069	0.584
MOD_ProDKin_1	469	475	PF00069	0.645
MOD_SUMO_rev_2	187	197	PF00179	0.420
MOD_SUMO_rev_2	454	462	PF00179	0.543
MOD_SUMO_rev_2	47	56	PF00179	0.435
TRG_DiLeu_BaEn_1	129	134	PF01217	0.449
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.474
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.425
TRG_ENDOCYTIC_2	100	103	PF00928	0.328
TRG_ENDOCYTIC_2	368	371	PF00928	0.428
TRG_ER_diArg_1	237	240	PF00400	0.678
TRG_ER_diArg_1	316	318	PF00400	0.408
TRG_ER_diArg_1	325	327	PF00400	0.409
TRG_NLS_MonoCore_2	237	242	PF00514	0.735
TRG_NLS_MonoExtC_3	236	241	PF00514	0.735
TRG_NLS_MonoExtN_4	237	242	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P856	Leptomonas seymouri	64%	100%
A0A0S4J214	Bodo saltans	46%	100%
A0A1X0NXJ9	Trypanosomatidae	47%	100%
A0A3R7MLR3	Trypanosoma rangeli	48%	100%
A0A3S7WWF8	Leishmania donovani	82%	100%
A4HZ60	Leishmania infantum	82%	100%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AV28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCF4	Leishmania major	83%	100%
V5BDT6	Trypanosoma cruzi	47%	100%