Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBQ7_LEIBR

TriTrypDb:

LbrM.21.0660 , LBRM2903_210011200

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.355
CLV_NRD_NRD_1	105	107	PF00675	0.322
CLV_PCSK_KEX2_1	105	107	PF00082	0.322
CLV_PCSK_SKI1_1	263	267	PF00082	0.345
CLV_PCSK_SKI1_1	298	302	PF00082	0.504
CLV_PCSK_SKI1_1	314	318	PF00082	0.421
CLV_PCSK_SKI1_1	355	359	PF00082	0.343
CLV_PCSK_SKI1_1	422	426	PF00082	0.421
CLV_Separin_Metazoa	11	15	PF03568	0.464
DEG_Nend_Nbox_1	1	3	PF02207	0.432
DEG_SPOP_SBC_1	382	386	PF00917	0.535
DEG_SPOP_SBC_1	53	57	PF00917	0.510
DOC_CKS1_1	407	412	PF01111	0.572
DOC_CKS1_1	441	446	PF01111	0.429
DOC_MAPK_gen_1	433	441	PF00069	0.370
DOC_MAPK_MEF2A_6	307	315	PF00069	0.525
DOC_MAPK_MEF2A_6	433	441	PF00069	0.366
DOC_USP7_MATH_1	190	194	PF00917	0.661
DOC_USP7_MATH_1	203	207	PF00917	0.454
DOC_USP7_MATH_1	337	341	PF00917	0.371
DOC_USP7_MATH_1	381	385	PF00917	0.660
DOC_USP7_MATH_1	432	436	PF00917	0.395
DOC_WW_Pin1_4	186	191	PF00397	0.620
DOC_WW_Pin1_4	403	408	PF00397	0.661
DOC_WW_Pin1_4	440	445	PF00397	0.420
LIG_14-3-3_CanoR_1	124	130	PF00244	0.530
LIG_14-3-3_CanoR_1	155	163	PF00244	0.520
LIG_14-3-3_CanoR_1	165	174	PF00244	0.555
LIG_14-3-3_CanoR_1	248	253	PF00244	0.611
LIG_14-3-3_CanoR_1	331	339	PF00244	0.409
LIG_14-3-3_CanoR_1	44	53	PF00244	0.535
LIG_Actin_WH2_2	89	107	PF00022	0.311
LIG_BIR_III_4	335	339	PF00653	0.374
LIG_BRCT_BRCA1_1	401	405	PF00533	0.544
LIG_FHA_1	167	173	PF00498	0.569
LIG_FHA_1	292	298	PF00498	0.331
LIG_FHA_1	66	72	PF00498	0.432
LIG_FHA_1	74	80	PF00498	0.422
LIG_FHA_2	115	121	PF00498	0.484
LIG_FHA_2	227	233	PF00498	0.563
LIG_FHA_2	249	255	PF00498	0.566
LIG_FHA_2	330	336	PF00498	0.499
LIG_FHA_2	339	345	PF00498	0.409
LIG_FHA_2	365	371	PF00498	0.407
LIG_FHA_2	389	395	PF00498	0.556
LIG_FHA_2	46	52	PF00498	0.626
LIG_LIR_Gen_1	140	150	PF02991	0.383
LIG_LIR_Gen_1	269	277	PF02991	0.510
LIG_LIR_Nem_3	127	132	PF02991	0.492
LIG_LIR_Nem_3	140	146	PF02991	0.416
LIG_LIR_Nem_3	148	152	PF02991	0.416
LIG_LIR_Nem_3	269	274	PF02991	0.538
LIG_LIR_Nem_3	35	41	PF02991	0.359
LIG_LIR_Nem_3	423	428	PF02991	0.498
LIG_LIR_Nem_3	63	69	PF02991	0.359
LIG_NRBOX	357	363	PF00104	0.399
LIG_Pex14_1	139	143	PF04695	0.453
LIG_Pex14_1	252	256	PF04695	0.552
LIG_Pex14_2	34	38	PF04695	0.335
LIG_SH2_NCK_1	143	147	PF00017	0.342
LIG_SH2_PTP2	271	274	PF00017	0.503
LIG_SH2_STAT3	74	77	PF00017	0.294
LIG_SH2_STAT5	271	274	PF00017	0.532
LIG_SH2_STAT5	329	332	PF00017	0.452
LIG_SH2_STAT5	74	77	PF00017	0.375
LIG_SH2_STAT5	91	94	PF00017	0.330
LIG_SH3_2	407	412	PF14604	0.415
LIG_SH3_3	375	381	PF00018	0.517
LIG_SH3_3	401	407	PF00018	0.684
LIG_SUMO_SIM_par_1	158	164	PF11976	0.416
LIG_SUMO_SIM_par_1	236	242	PF11976	0.386
LIG_TRAF2_1	251	254	PF00917	0.560
LIG_TRAF2_1	395	398	PF00917	0.550
LIG_TYR_ITSM	139	146	PF00017	0.513
LIG_WRC_WIRS_1	146	151	PF05994	0.380
MOD_CDK_SPxK_1	406	412	PF00069	0.425
MOD_CK1_1	159	165	PF00069	0.503
MOD_CK1_1	166	172	PF00069	0.492
MOD_CK1_1	239	245	PF00069	0.469
MOD_CK1_1	291	297	PF00069	0.429
MOD_CK1_1	393	399	PF00069	0.658
MOD_CK1_1	406	412	PF00069	0.489
MOD_CK1_1	47	53	PF00069	0.492
MOD_CK2_1	114	120	PF00069	0.502
MOD_CK2_1	248	254	PF00069	0.573
MOD_CK2_1	290	296	PF00069	0.481
MOD_CK2_1	338	344	PF00069	0.417
MOD_CK2_1	364	370	PF00069	0.395
MOD_CK2_1	388	394	PF00069	0.557
MOD_CK2_1	45	51	PF00069	0.624
MOD_GlcNHglycan	165	168	PF01048	0.500
MOD_GlcNHglycan	191	195	PF01048	0.636
MOD_GlcNHglycan	241	244	PF01048	0.484
MOD_GlcNHglycan	397	402	PF01048	0.554
MOD_GlcNHglycan	83	86	PF01048	0.441
MOD_GSK3_1	137	144	PF00069	0.484
MOD_GSK3_1	155	162	PF00069	0.501
MOD_GSK3_1	174	181	PF00069	0.340
MOD_GSK3_1	182	189	PF00069	0.619
MOD_GSK3_1	287	294	PF00069	0.438
MOD_GSK3_1	393	400	PF00069	0.624
MOD_GSK3_1	40	47	PF00069	0.606
MOD_NEK2_1	125	130	PF00069	0.487
MOD_NEK2_1	138	143	PF00069	0.336
MOD_NEK2_1	3	8	PF00069	0.356
MOD_NEK2_1	361	366	PF00069	0.361
MOD_NEK2_1	40	45	PF00069	0.533
MOD_NEK2_2	309	314	PF00069	0.436
MOD_PIKK_1	6	12	PF00454	0.325
MOD_PIKK_1	73	79	PF00454	0.308
MOD_PKA_2	125	131	PF00069	0.470
MOD_PKA_2	247	253	PF00069	0.614
MOD_PKA_2	3	9	PF00069	0.353
MOD_PKA_2	43	49	PF00069	0.480
MOD_PKA_2	432	438	PF00069	0.381
MOD_Plk_1	287	293	PF00069	0.373
MOD_Plk_1	382	388	PF00069	0.672
MOD_Plk_2-3	114	120	PF00069	0.502
MOD_Plk_4	156	162	PF00069	0.607
MOD_Plk_4	338	344	PF00069	0.599
MOD_Plk_4	91	97	PF00069	0.463
MOD_ProDKin_1	186	192	PF00069	0.619
MOD_ProDKin_1	403	409	PF00069	0.650
MOD_ProDKin_1	440	446	PF00069	0.431
MOD_SUMO_rev_2	291	300	PF00179	0.324
MOD_SUMO_rev_2	349	357	PF00179	0.363
TRG_DiLeu_BaEn_1	11	16	PF01217	0.459
TRG_DiLeu_BaEn_1	296	301	PF01217	0.486
TRG_DiLeu_BaEn_1	353	358	PF01217	0.423
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.523
TRG_DiLeu_LyEn_5	11	16	PF01217	0.459
TRG_ENDOCYTIC_2	135	138	PF00928	0.517
TRG_ENDOCYTIC_2	143	146	PF00928	0.500
TRG_ENDOCYTIC_2	154	157	PF00928	0.382
TRG_ENDOCYTIC_2	271	274	PF00928	0.536
TRG_ER_diArg_1	104	106	PF00400	0.318
TRG_ER_diArg_1	272	275	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM65	Leptomonas seymouri	38%	74%
A0A3S7WWF0	Leishmania donovani	76%	84%
A4HZ59	Leishmania infantum	75%	84%
E9AV27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QCF5	Leishmania major	75%	100%