Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBQ5_LEIBR

TriTrypDb:

LbrM.21.0640 , LBRM2903_210011000

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.526
CLV_NRD_NRD_1	125	127	PF00675	0.561
CLV_NRD_NRD_1	272	274	PF00675	0.534
CLV_NRD_NRD_1	378	380	PF00675	0.601
CLV_NRD_NRD_1	430	432	PF00675	0.525
CLV_PCSK_KEX2_1	120	122	PF00082	0.426
CLV_PCSK_KEX2_1	125	127	PF00082	0.461
CLV_PCSK_KEX2_1	272	274	PF00082	0.534
CLV_PCSK_KEX2_1	430	432	PF00082	0.441
CLV_PCSK_KEX2_1	457	459	PF00082	0.592
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.592
CLV_PCSK_PC7_1	121	127	PF00082	0.473
CLV_PCSK_SKI1_1	240	244	PF00082	0.522
CLV_PCSK_SKI1_1	273	277	PF00082	0.495
CLV_PCSK_SKI1_1	305	309	PF00082	0.442
CLV_PCSK_SKI1_1	449	453	PF00082	0.604
CLV_PCSK_SKI1_1	454	458	PF00082	0.493
CLV_Separin_Metazoa	151	155	PF03568	0.489
CLV_Separin_Metazoa	246	250	PF03568	0.552
DEG_APCC_DBOX_1	304	312	PF00400	0.575
DEG_Nend_UBRbox_2	1	3	PF02207	0.395
DEG_SPOP_SBC_1	167	171	PF00917	0.573
DEG_SPOP_SBC_1	177	181	PF00917	0.552
DEG_SPOP_SBC_1	195	199	PF00917	0.467
DEG_SPOP_SBC_1	278	282	PF00917	0.550
DEG_SPOP_SBC_1	75	79	PF00917	0.620
DOC_MAPK_gen_1	430	437	PF00069	0.436
DOC_PP1_RVXF_1	423	429	PF00149	0.678
DOC_PP4_FxxP_1	253	256	PF00568	0.569
DOC_PP4_FxxP_1	411	414	PF00568	0.565
DOC_USP7_MATH_1	139	143	PF00917	0.535
DOC_USP7_MATH_1	166	170	PF00917	0.736
DOC_USP7_MATH_1	203	207	PF00917	0.568
DOC_USP7_MATH_1	221	225	PF00917	0.297
DOC_USP7_MATH_1	232	236	PF00917	0.450
DOC_USP7_MATH_1	298	302	PF00917	0.467
DOC_USP7_MATH_1	342	346	PF00917	0.556
DOC_USP7_MATH_1	386	390	PF00917	0.543
DOC_USP7_MATH_1	73	77	PF00917	0.606
DOC_USP7_MATH_1	99	103	PF00917	0.399
DOC_WW_Pin1_4	71	76	PF00397	0.537
LIG_14-3-3_CanoR_1	220	230	PF00244	0.604
LIG_14-3-3_CanoR_1	331	337	PF00244	0.500
LIG_14-3-3_CanoR_1	449	456	PF00244	0.457
LIG_14-3-3_CanoR_1	47	53	PF00244	0.502
LIG_APCC_ABBAyCdc20_2	240	246	PF00400	0.409
LIG_BRCT_BRCA1_1	249	253	PF00533	0.604
LIG_BRCT_BRCA1_1	259	263	PF00533	0.456
LIG_BRCT_BRCA1_1	391	395	PF00533	0.474
LIG_CaM_IQ_9	8	23	PF13499	0.336
LIG_Clathr_ClatBox_1	137	141	PF01394	0.410
LIG_deltaCOP1_diTrp_1	91	100	PF00928	0.344
LIG_EH1_1	56	64	PF00400	0.332
LIG_FHA_1	132	138	PF00498	0.472
LIG_FHA_1	196	202	PF00498	0.670
LIG_FHA_1	345	351	PF00498	0.572
LIG_FHA_1	48	54	PF00498	0.299
LIG_FHA_2	290	296	PF00498	0.593
LIG_FHA_2	5	11	PF00498	0.529
LIG_FHA_2	75	81	PF00498	0.608
LIG_LIR_Apic_2	250	256	PF02991	0.513
LIG_LIR_Gen_1	259	268	PF02991	0.488
LIG_LIR_Gen_1	356	366	PF02991	0.577
LIG_LIR_Gen_1	433	441	PF02991	0.396
LIG_LIR_Nem_3	259	264	PF02991	0.491
LIG_LIR_Nem_3	356	361	PF02991	0.567
LIG_LIR_Nem_3	372	377	PF02991	0.608
LIG_LIR_Nem_3	393	399	PF02991	0.648
LIG_LIR_Nem_3	433	437	PF02991	0.474
LIG_LIR_Nem_3	54	60	PF02991	0.340
LIG_LIR_Nem_3	90	95	PF02991	0.380
LIG_NRBOX	307	313	PF00104	0.516
LIG_PDZ_Class_3	458	463	PF00595	0.710
LIG_Pex14_2	118	122	PF04695	0.278
LIG_PTB_Apo_2	352	359	PF02174	0.589
LIG_SH2_GRB2like	353	356	PF00017	0.423
LIG_SH2_SRC	353	356	PF00017	0.423
LIG_SH2_STAP1	396	400	PF00017	0.684
LIG_SH2_STAT3	362	365	PF00017	0.638
LIG_SH2_STAT5	244	247	PF00017	0.429
LIG_SH2_STAT5	353	356	PF00017	0.547
LIG_SH2_STAT5	396	399	PF00017	0.683
LIG_SH3_3	125	131	PF00018	0.473
LIG_UBA3_1	357	364	PF00899	0.505
MOD_CK1_1	144	150	PF00069	0.572
MOD_CK1_1	169	175	PF00069	0.589
MOD_CK1_1	185	191	PF00069	0.719
MOD_CK1_1	210	216	PF00069	0.578
MOD_CK1_1	257	263	PF00069	0.565
MOD_CK1_1	279	285	PF00069	0.568
MOD_CK1_1	345	351	PF00069	0.606
MOD_CK1_1	356	362	PF00069	0.512
MOD_CK1_1	387	393	PF00069	0.717
MOD_CK1_1	74	80	PF00069	0.600
MOD_CK2_1	228	234	PF00069	0.478
MOD_CK2_1	315	321	PF00069	0.667
MOD_CK2_1	4	10	PF00069	0.439
MOD_CK2_1	74	80	PF00069	0.620
MOD_GlcNHglycan	141	144	PF01048	0.359
MOD_GlcNHglycan	171	174	PF01048	0.535
MOD_GlcNHglycan	180	183	PF01048	0.619
MOD_GlcNHglycan	203	206	PF01048	0.655
MOD_GlcNHglycan	230	233	PF01048	0.439
MOD_GlcNHglycan	26	29	PF01048	0.463
MOD_GlcNHglycan	300	303	PF01048	0.522
MOD_GlcNHglycan	317	320	PF01048	0.676
MOD_GlcNHglycan	326	329	PF01048	0.711
MOD_GlcNHglycan	344	347	PF01048	0.509
MOD_GlcNHglycan	386	389	PF01048	0.685
MOD_GlcNHglycan	392	395	PF01048	0.572
MOD_GlcNHglycan	71	74	PF01048	0.593
MOD_GSK3_1	153	160	PF00069	0.679
MOD_GSK3_1	168	175	PF00069	0.560
MOD_GSK3_1	178	185	PF00069	0.584
MOD_GSK3_1	186	193	PF00069	0.725
MOD_GSK3_1	203	210	PF00069	0.621
MOD_GSK3_1	228	235	PF00069	0.435
MOD_GSK3_1	273	280	PF00069	0.534
MOD_GSK3_1	369	376	PF00069	0.643
MOD_GSK3_1	384	391	PF00069	0.698
MOD_GSK3_1	441	448	PF00069	0.701
MOD_GSK3_1	63	70	PF00069	0.471
MOD_GSK3_1	71	78	PF00069	0.588
MOD_GSK3_1	87	94	PF00069	0.256
MOD_LATS_1	252	258	PF00433	0.559
MOD_NEK2_1	186	191	PF00069	0.756
MOD_NEK2_1	212	217	PF00069	0.606
MOD_NEK2_1	222	227	PF00069	0.515
MOD_NEK2_1	247	252	PF00069	0.630
MOD_NEK2_1	277	282	PF00069	0.485
MOD_NEK2_1	315	320	PF00069	0.451
MOD_NEK2_1	395	400	PF00069	0.667
MOD_NEK2_1	63	68	PF00069	0.460
MOD_NEK2_2	353	358	PF00069	0.417
MOD_NEK2_2	99	104	PF00069	0.487
MOD_PIKK_1	17	23	PF00454	0.317
MOD_PIKK_1	247	253	PF00454	0.498
MOD_PIKK_1	441	447	PF00454	0.559
MOD_PKA_2	12	18	PF00069	0.652
MOD_PKA_2	153	159	PF00069	0.657
MOD_PKA_2	222	228	PF00069	0.522
MOD_PKA_2	321	327	PF00069	0.530
MOD_PKA_2	330	336	PF00069	0.470
MOD_PKA_2	369	375	PF00069	0.588
MOD_PKA_2	46	52	PF00069	0.512
MOD_Plk_1	273	279	PF00069	0.553
MOD_Plk_1	441	447	PF00069	0.622
MOD_Plk_1	63	69	PF00069	0.461
MOD_Plk_2-3	433	439	PF00069	0.398
MOD_Plk_4	273	279	PF00069	0.432
MOD_Plk_4	353	359	PF00069	0.633
MOD_Plk_4	395	401	PF00069	0.702
MOD_Plk_4	63	69	PF00069	0.349
MOD_ProDKin_1	71	77	PF00069	0.540
MOD_SUMO_for_1	145	148	PF00179	0.589
MOD_SUMO_for_1	401	404	PF00179	0.591
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.479
TRG_ENDOCYTIC_2	244	247	PF00928	0.450
TRG_ER_diArg_1	119	121	PF00400	0.529
TRG_ER_diArg_1	125	127	PF00400	0.563
TRG_ER_diArg_1	271	273	PF00400	0.517
TRG_ER_diArg_1	429	431	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P858	Leptomonas seymouri	53%	100%
A0A1X0NY71	Trypanosomatidae	28%	100%
A0A3Q8IL02	Leishmania donovani	81%	100%
A0A422NH97	Trypanosoma rangeli	32%	100%
A4HZ57	Leishmania infantum	80%	100%
D0A1I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AV25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QCF7	Leishmania major	81%	99%
V5DEP6	Trypanosoma cruzi	30%	100%