Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBQ4_LEIBR

TriTrypDb:

LbrM.21.0630 , LBRM2903_210010900

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.663
CLV_NRD_NRD_1	202	204	PF00675	0.721
CLV_NRD_NRD_1	212	214	PF00675	0.660
CLV_NRD_NRD_1	267	269	PF00675	0.790
CLV_NRD_NRD_1	338	340	PF00675	0.797
CLV_NRD_NRD_1	428	430	PF00675	0.556
CLV_NRD_NRD_1	432	434	PF00675	0.586
CLV_NRD_NRD_1	52	54	PF00675	0.641
CLV_NRD_NRD_1	66	68	PF00675	0.545
CLV_PCSK_KEX2_1	261	263	PF00082	0.718
CLV_PCSK_KEX2_1	267	269	PF00082	0.767
CLV_PCSK_KEX2_1	302	304	PF00082	0.789
CLV_PCSK_KEX2_1	338	340	PF00082	0.702
CLV_PCSK_KEX2_1	391	393	PF00082	0.563
CLV_PCSK_KEX2_1	402	404	PF00082	0.835
CLV_PCSK_KEX2_1	432	434	PF00082	0.586
CLV_PCSK_KEX2_1	52	54	PF00082	0.641
CLV_PCSK_KEX2_1	66	68	PF00082	0.545
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.564
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.789
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.563
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.835
CLV_PCSK_SKI1_1	236	240	PF00082	0.755
CLV_PCSK_SKI1_1	267	271	PF00082	0.800
CLV_PCSK_SKI1_1	299	303	PF00082	0.819
CLV_PCSK_SKI1_1	348	352	PF00082	0.475
CLV_PCSK_SKI1_1	365	369	PF00082	0.565
CLV_PCSK_SKI1_1	403	407	PF00082	0.817
CLV_PCSK_SKI1_1	45	49	PF00082	0.513
CLV_PCSK_SKI1_1	92	96	PF00082	0.716
DEG_APCC_DBOX_1	87	95	PF00400	0.603
DEG_SPOP_SBC_1	256	260	PF00917	0.549
DEG_SPOP_SBC_1	277	281	PF00917	0.579
DEG_SPOP_SBC_1	322	326	PF00917	0.555
DOC_CDC14_PxL_1	331	339	PF14671	0.560
DOC_CKS1_1	225	230	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.571
DOC_MAPK_DCC_7	141	150	PF00069	0.640
DOC_MAPK_MEF2A_6	141	150	PF00069	0.527
DOC_MAPK_RevD_3	148	164	PF00069	0.625
DOC_MAPK_RevD_3	379	392	PF00069	0.491
DOC_PP2B_LxvP_1	142	145	PF13499	0.546
DOC_PP2B_LxvP_1	358	361	PF13499	0.676
DOC_PP2B_LxvP_1	386	389	PF13499	0.658
DOC_USP7_MATH_1	194	198	PF00917	0.498
DOC_USP7_MATH_1	240	244	PF00917	0.710
DOC_USP7_MATH_1	27	31	PF00917	0.564
DOC_USP7_MATH_1	277	281	PF00917	0.774
DOC_USP7_MATH_1	322	326	PF00917	0.729
DOC_USP7_MATH_1	330	334	PF00917	0.805
DOC_USP7_MATH_1	372	376	PF00917	0.494
DOC_USP7_MATH_1	401	405	PF00917	0.732
DOC_USP7_UBL2_3	204	208	PF12436	0.541
DOC_USP7_UBL2_3	210	214	PF12436	0.522
DOC_USP7_UBL2_3	402	406	PF12436	0.824
DOC_WW_Pin1_4	104	109	PF00397	0.581
DOC_WW_Pin1_4	224	229	PF00397	0.564
DOC_WW_Pin1_4	278	283	PF00397	0.739
LIG_14-3-3_CanoR_1	254	263	PF00244	0.728
LIG_14-3-3_CanoR_1	267	277	PF00244	0.695
LIG_14-3-3_CanoR_1	403	409	PF00244	0.589
LIG_14-3-3_CanoR_1	432	438	PF00244	0.447
LIG_14-3-3_CanoR_1	45	54	PF00244	0.624
LIG_BRCT_BRCA1_1	324	328	PF00533	0.556
LIG_Clathr_ClatBox_1	68	72	PF01394	0.645
LIG_FHA_1	126	132	PF00498	0.479
LIG_FHA_1	154	160	PF00498	0.620
LIG_FHA_1	200	206	PF00498	0.726
LIG_FHA_1	349	355	PF00498	0.460
LIG_FHA_2	93	99	PF00498	0.691
LIG_LIR_Gen_1	154	162	PF02991	0.523
LIG_LIR_Gen_1	166	175	PF02991	0.534
LIG_LIR_Nem_3	112	117	PF02991	0.502
LIG_LIR_Nem_3	125	130	PF02991	0.366
LIG_LIR_Nem_3	154	160	PF02991	0.518
LIG_LIR_Nem_3	166	171	PF02991	0.537
LIG_LIR_Nem_3	418	422	PF02991	0.537
LIG_MYND_1	177	181	PF01753	0.627
LIG_MYND_1	341	345	PF01753	0.495
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.714
LIG_SH2_CRK	117	121	PF00017	0.514
LIG_SH2_STAP1	168	172	PF00017	0.374
LIG_SH2_STAT5	130	133	PF00017	0.579
LIG_SH2_STAT5	43	46	PF00017	0.525
LIG_SH2_STAT5	93	96	PF00017	0.618
LIG_SH3_2	177	182	PF14604	0.634
LIG_SH3_2	228	233	PF14604	0.650
LIG_SH3_3	103	109	PF00018	0.576
LIG_SH3_3	141	147	PF00018	0.534
LIG_SH3_3	174	180	PF00018	0.611
LIG_SH3_3	222	228	PF00018	0.767
LIG_SUMO_SIM_par_1	146	152	PF11976	0.631
LIG_SUMO_SIM_par_1	378	384	PF11976	0.430
LIG_TRAF2_1	36	39	PF00917	0.549
LIG_TRAF2_1	423	426	PF00917	0.525
LIG_TYR_ITIM	115	120	PF00017	0.633
LIG_WW_3	160	164	PF00397	0.654
LIG_WW_3	179	183	PF00397	0.384
MOD_CK1_1	107	113	PF00069	0.537
MOD_CK1_1	125	131	PF00069	0.477
MOD_CK1_1	280	286	PF00069	0.798
MOD_CK1_1	318	324	PF00069	0.718
MOD_CK1_1	396	402	PF00069	0.816
MOD_CK1_1	404	410	PF00069	0.679
MOD_CK2_1	372	378	PF00069	0.507
MOD_DYRK1A_RPxSP_1	224	228	PF00069	0.564
MOD_GlcNHglycan	124	127	PF01048	0.474
MOD_GlcNHglycan	20	23	PF01048	0.495
MOD_GlcNHglycan	242	245	PF01048	0.750
MOD_GlcNHglycan	272	275	PF01048	0.650
MOD_GlcNHglycan	29	32	PF01048	0.534
MOD_GlcNHglycan	3	6	PF01048	0.759
MOD_GlcNHglycan	304	308	PF01048	0.765
MOD_GlcNHglycan	317	320	PF01048	0.539
MOD_GlcNHglycan	383	386	PF01048	0.631
MOD_GlcNHglycan	395	398	PF01048	0.730
MOD_GlcNHglycan	403	406	PF01048	0.760
MOD_GSK3_1	195	202	PF00069	0.694
MOD_GSK3_1	23	30	PF00069	0.721
MOD_GSK3_1	240	247	PF00069	0.803
MOD_GSK3_1	268	275	PF00069	0.814
MOD_GSK3_1	276	283	PF00069	0.711
MOD_GSK3_1	289	296	PF00069	0.677
MOD_GSK3_1	303	310	PF00069	0.573
MOD_GSK3_1	317	324	PF00069	0.609
MOD_LATS_1	90	96	PF00433	0.714
MOD_N-GLC_1	315	320	PF02516	0.662
MOD_NEK2_1	1	6	PF00069	0.769
MOD_NEK2_1	153	158	PF00069	0.608
MOD_NEK2_1	209	214	PF00069	0.801
MOD_NEK2_1	239	244	PF00069	0.556
MOD_NEK2_1	269	274	PF00069	0.584
MOD_NEK2_1	371	376	PF00069	0.480
MOD_NEK2_1	381	386	PF00069	0.501
MOD_NEK2_2	372	377	PF00069	0.498
MOD_PIKK_1	289	295	PF00454	0.825
MOD_PIKK_1	323	329	PF00454	0.798
MOD_PIKK_1	404	410	PF00454	0.582
MOD_PKA_1	267	273	PF00069	0.716
MOD_PKA_2	267	273	PF00069	0.731
MOD_PKA_2	428	434	PF00069	0.569
MOD_Plk_1	372	378	PF00069	0.605
MOD_Plk_4	433	439	PF00069	0.442
MOD_ProDKin_1	104	110	PF00069	0.575
MOD_ProDKin_1	224	230	PF00069	0.559
MOD_ProDKin_1	278	284	PF00069	0.740
MOD_SUMO_for_1	301	304	PF00179	0.788
MOD_SUMO_rev_2	185	191	PF00179	0.518
TRG_ENDOCYTIC_2	117	120	PF00928	0.624
TRG_ENDOCYTIC_2	168	171	PF00928	0.635
TRG_ER_diArg_1	223	226	PF00400	0.724
TRG_ER_diArg_1	267	269	PF00400	0.711
TRG_ER_diArg_1	337	339	PF00400	0.804
TRG_ER_diArg_1	52	54	PF00400	0.538
TRG_ER_diArg_1	65	67	PF00400	0.535
TRG_NLS_MonoExtC_3	428	433	PF00514	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U2	Leptomonas seymouri	45%	100%
A0A3S7WWD6	Leishmania donovani	76%	100%
A4HZ56	Leishmania infantum	76%	100%
E9AV24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QCF8	Leishmania major	77%	100%