Dihydrolipoamide acetyltransferaselike protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide acetyltransferase precursorlike protein

Species:

Leishmania braziliensis

UniProt:

A4HBQ2_LEIBR

TriTrypDb:

LbrM.21.0610 , LBRM2903_210010700

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0045254	pyruvate dehydrogenase complex	4	11
GO:1902494	catalytic complex	2	11
GO:1990204	oxidoreductase complex	3	11
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4HBQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006084	acetyl-CoA metabolic process	5	11
GO:0006085	acetyl-CoA biosynthetic process	6	11
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	11
GO:0006090	pyruvate metabolic process	7	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006637	acyl-CoA metabolic process	4	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0035383	thioester metabolic process	3	11
GO:0035384	thioester biosynthetic process	4	11
GO:0043436	oxoacid metabolic process	4	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044272	sulfur compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071616	acyl-CoA biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	3	7
GO:0016407	acetyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016418	S-acetyltransferase activity	6	7
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.521
CLV_NRD_NRD_1	3	5	PF00675	0.673
CLV_PCSK_KEX2_1	3	5	PF00082	0.673
CLV_PCSK_SKI1_1	171	175	PF00082	0.535
CLV_PCSK_SKI1_1	4	8	PF00082	0.650
DEG_APCC_DBOX_1	2	10	PF00400	0.645
DOC_MAPK_gen_1	3	9	PF00069	0.633
DOC_PP1_RVXF_1	2	9	PF00149	0.627
DOC_USP7_MATH_1	123	127	PF00917	0.623
DOC_USP7_MATH_1	210	214	PF00917	0.701
DOC_USP7_MATH_1	233	237	PF00917	0.597
DOC_USP7_UBL2_3	208	212	PF12436	0.757
DOC_WW_Pin1_4	18	23	PF00397	0.368
LIG_14-3-3_CanoR_1	171	181	PF00244	0.594
LIG_14-3-3_CanoR_1	3	7	PF00244	0.661
LIG_Actin_WH2_2	216	231	PF00022	0.705
LIG_Clathr_ClatBox_1	9	13	PF01394	0.569
LIG_FHA_1	147	153	PF00498	0.404
LIG_FHA_1	238	244	PF00498	0.526
LIG_FHA_1	81	87	PF00498	0.359
LIG_FHA_2	192	198	PF00498	0.510
LIG_FHA_2	26	32	PF00498	0.382
LIG_LIR_Gen_1	222	232	PF02991	0.691
LIG_LIR_Gen_1	44	54	PF02991	0.316
LIG_LIR_Nem_3	222	227	PF02991	0.651
LIG_LIR_Nem_3	44	49	PF02991	0.316
LIG_MYND_1	18	22	PF01753	0.335
LIG_PCNA_yPIPBox_3	244	254	PF02747	0.414
LIG_Pex14_1	8	12	PF04695	0.589
LIG_Pex14_2	12	16	PF04695	0.540
LIG_SH2_CRK	224	228	PF00017	0.700
LIG_SH2_CRK	234	238	PF00017	0.513
LIG_SH2_GRB2like	58	61	PF00017	0.355
LIG_SH2_STAP1	185	189	PF00017	0.602
LIG_SH2_STAP1	224	228	PF00017	0.448
LIG_SH2_STAP1	58	62	PF00017	0.355
LIG_SH2_STAT5	251	254	PF00017	0.434
LIG_SH2_STAT5	58	61	PF00017	0.342
LIG_SH2_STAT5	66	69	PF00017	0.324
LIG_SH2_STAT5	71	74	PF00017	0.317
LIG_SH3_3	12	18	PF00018	0.480
LIG_SH3_3	224	230	PF00018	0.645
LIG_SH3_3	249	255	PF00018	0.657
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.428
LIG_UBA3_1	246	254	PF00899	0.546
MOD_CK1_1	144	150	PF00069	0.611
MOD_CK1_1	175	181	PF00069	0.647
MOD_CK2_1	191	197	PF00069	0.508
MOD_CK2_1	25	31	PF00069	0.382
MOD_GlcNHglycan	125	128	PF01048	0.682
MOD_GlcNHglycan	143	146	PF01048	0.308
MOD_GlcNHglycan	156	160	PF01048	0.453
MOD_GlcNHglycan	165	168	PF01048	0.595
MOD_GlcNHglycan	219	222	PF01048	0.651
MOD_GlcNHglycan	63	66	PF01048	0.471
MOD_GlcNHglycan	76	79	PF01048	0.394
MOD_GSK3_1	104	111	PF00069	0.509
MOD_GSK3_1	206	213	PF00069	0.690
MOD_GSK3_1	233	240	PF00069	0.679
MOD_NEK2_1	2	7	PF00069	0.665
MOD_PKA_2	191	197	PF00069	0.508
MOD_PKA_2	2	8	PF00069	0.662
MOD_PKA_2	25	31	PF00069	0.227
MOD_Plk_2-3	25	31	PF00069	0.408
MOD_Plk_4	219	225	PF00069	0.526
MOD_Plk_4	25	31	PF00069	0.422
MOD_ProDKin_1	18	24	PF00069	0.368
TRG_ENDOCYTIC_2	224	227	PF00928	0.702
TRG_ENDOCYTIC_2	234	237	PF00928	0.518
TRG_ER_diArg_1	2	4	PF00400	0.688
TRG_NLS_MonoExtC_3	32	38	PF00514	0.324
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JIJ4	Bodo saltans	53%	96%
A0A1X0NXH9	Trypanosomatidae	49%	67%
A0A3R7KWN7	Trypanosoma rangeli	51%	97%
A0A3S7WWI7	Leishmania donovani	76%	66%
A4HZ54	Leishmania infantum	76%	66%
D0A1Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AV22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	66%
Q4QCG0	Leishmania major	76%	66%
V5B0M9	Trypanosoma cruzi	53%	97%