Putative la RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lupus La protein homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4HBQ1_LEIBR

TriTrypDb:

LbrM.21.0600 , LBRM2903_210010600

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4HBQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.536
CLV_C14_Caspase3-7	198	202	PF00656	0.537
CLV_NRD_NRD_1	125	127	PF00675	0.300
CLV_NRD_NRD_1	191	193	PF00675	0.621
CLV_NRD_NRD_1	330	332	PF00675	0.790
CLV_NRD_NRD_1	80	82	PF00675	0.448
CLV_PCSK_KEX2_1	125	127	PF00082	0.300
CLV_PCSK_KEX2_1	193	195	PF00082	0.679
CLV_PCSK_KEX2_1	330	332	PF00082	0.717
CLV_PCSK_KEX2_1	80	82	PF00082	0.447
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.679
CLV_PCSK_SKI1_1	23	27	PF00082	0.300
CLV_PCSK_SKI1_1	278	282	PF00082	0.654
DOC_CKS1_1	210	215	PF01111	0.704
DOC_MAPK_gen_1	140	149	PF00069	0.512
DOC_MAPK_HePTP_8	137	149	PF00069	0.586
DOC_MAPK_MEF2A_6	140	149	PF00069	0.496
DOC_PP1_RVXF_1	8	15	PF00149	0.500
DOC_USP7_MATH_1	136	140	PF00917	0.586
DOC_USP7_MATH_1	216	220	PF00917	0.501
DOC_WW_Pin1_4	209	214	PF00397	0.650
LIG_14-3-3_CanoR_1	278	283	PF00244	0.529
LIG_14-3-3_CanoR_1	49	54	PF00244	0.512
LIG_APCC_ABBA_1	259	264	PF00400	0.459
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_FHA_1	72	78	PF00498	0.360
LIG_FHA_1	93	99	PF00498	0.353
LIG_FHA_2	252	258	PF00498	0.560
LIG_FHA_2	291	297	PF00498	0.588
LIG_LIR_Apic_2	95	100	PF02991	0.353
LIG_LIR_Gen_1	13	22	PF02991	0.500
LIG_LIR_Gen_1	144	153	PF02991	0.500
LIG_LIR_Gen_1	230	240	PF02991	0.484
LIG_LIR_Gen_1	36	45	PF02991	0.504
LIG_LIR_Gen_1	46	53	PF02991	0.518
LIG_LIR_Nem_3	13	19	PF02991	0.500
LIG_LIR_Nem_3	144	149	PF02991	0.500
LIG_LIR_Nem_3	230	235	PF02991	0.477
LIG_LIR_Nem_3	36	41	PF02991	0.500
LIG_LIR_Nem_3	46	50	PF02991	0.500
LIG_NRBOX	40	46	PF00104	0.479
LIG_Pex14_1	124	128	PF04695	0.500
LIG_SH2_CRK	165	169	PF00017	0.588
LIG_SH2_PTP2	97	100	PF00017	0.500
LIG_SH2_SRC	178	181	PF00017	0.609
LIG_SH2_STAT5	127	130	PF00017	0.498
LIG_SH2_STAT5	15	18	PF00017	0.500
LIG_SH2_STAT5	178	181	PF00017	0.449
LIG_SH2_STAT5	249	252	PF00017	0.449
LIG_SH2_STAT5	97	100	PF00017	0.500
LIG_SH3_3	156	162	PF00018	0.582
LIG_SH3_3	207	213	PF00018	0.660
LIG_SH3_3	247	253	PF00018	0.459
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.611
LIG_TRAF2_1	240	243	PF00917	0.486
LIG_TRAF2_1	254	257	PF00917	0.484
LIG_WRC_WIRS_1	44	49	PF05994	0.500
LIG_WW_1	162	165	PF00397	0.501
MOD_CK1_1	274	280	PF00069	0.615
MOD_CK1_1	88	94	PF00069	0.474
MOD_CK2_1	251	257	PF00069	0.566
MOD_CK2_1	81	87	PF00069	0.566
MOD_Cter_Amidation	328	331	PF01082	0.767
MOD_GlcNHglycan	114	117	PF01048	0.376
MOD_GlcNHglycan	170	173	PF01048	0.582
MOD_GlcNHglycan	206	209	PF01048	0.762
MOD_GlcNHglycan	223	226	PF01048	0.372
MOD_GSK3_1	112	119	PF00069	0.549
MOD_GSK3_1	217	224	PF00069	0.476
MOD_GSK3_1	274	281	PF00069	0.574
MOD_GSK3_1	71	78	PF00069	0.463
MOD_GSK3_1	81	88	PF00069	0.504
MOD_N-GLC_1	217	222	PF02516	0.525
MOD_NEK2_1	26	31	PF00069	0.586
MOD_NEK2_1	271	276	PF00069	0.558
MOD_PIKK_1	185	191	PF00454	0.673
MOD_PKA_1	81	87	PF00069	0.531
MOD_PKA_2	221	227	PF00069	0.487
MOD_Plk_1	217	223	PF00069	0.519
MOD_Plk_1	92	98	PF00069	0.499
MOD_Plk_4	116	122	PF00069	0.586
MOD_Plk_4	141	147	PF00069	0.500
MOD_Plk_4	92	98	PF00069	0.426
MOD_ProDKin_1	209	215	PF00069	0.631
MOD_SUMO_rev_2	230	238	PF00179	0.532
MOD_SUMO_rev_2	242	247	PF00179	0.430
MOD_SUMO_rev_2	294	300	PF00179	0.524
MOD_SUMO_rev_2	52	60	PF00179	0.526
TRG_ENDOCYTIC_2	165	168	PF00928	0.526
TRG_ENDOCYTIC_2	249	252	PF00928	0.463
TRG_ER_diArg_1	124	126	PF00400	0.500
TRG_ER_diArg_1	79	81	PF00400	0.417
TRG_ER_FFAT_2	108	119	PF00635	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU8	Leptomonas seymouri	82%	98%
A0A0S4JIJ0	Bodo saltans	59%	97%
A0A1X0NXX1	Trypanosomatidae	61%	100%
A0A3Q8IB28	Leishmania donovani	93%	100%
A0A3R7NHU1	Trypanosoma rangeli	62%	99%
A4HZ53	Leishmania infantum	92%	100%
D0A1Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AV21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
P32067	Mus musculus	34%	81%
P40796	Drosophila melanogaster	26%	86%
Q4QCG1	Leishmania major	91%	100%
V5DH11	Trypanosoma cruzi	60%	100%