Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP41

Species:

Leishmania braziliensis

UniProt:

A4HBP9_LEIBR

TriTrypDb:

LbrM.21.0580 , LBRM2903_210010200

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HBP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.333
CLV_C14_Caspase3-7	96	100	PF00656	0.604
CLV_NRD_NRD_1	111	113	PF00675	0.375
CLV_NRD_NRD_1	3	5	PF00675	0.499
CLV_NRD_NRD_1	311	313	PF00675	0.578
CLV_PCSK_KEX2_1	111	113	PF00082	0.375
CLV_PCSK_KEX2_1	3	5	PF00082	0.512
CLV_PCSK_KEX2_1	311	313	PF00082	0.578
CLV_PCSK_SKI1_1	292	296	PF00082	0.419
CLV_PCSK_SKI1_1	67	71	PF00082	0.315
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DEG_SPOP_SBC_1	101	105	PF00917	0.334
DOC_CKS1_1	334	339	PF01111	0.426
DOC_MAPK_gen_1	3	10	PF00069	0.284
DOC_MAPK_gen_1	402	409	PF00069	0.360
DOC_PP1_RVXF_1	432	438	PF00149	0.222
DOC_PP2B_LxvP_1	233	236	PF13499	0.548
DOC_PP2B_LxvP_1	341	344	PF13499	0.329
DOC_USP7_MATH_1	133	137	PF00917	0.539
DOC_USP7_MATH_1	152	156	PF00917	0.548
DOC_USP7_MATH_1	177	181	PF00917	0.684
DOC_USP7_MATH_1	257	261	PF00917	0.552
DOC_USP7_MATH_1	263	267	PF00917	0.565
DOC_USP7_MATH_1	30	34	PF00917	0.388
DOC_USP7_MATH_1	328	332	PF00917	0.585
DOC_USP7_MATH_1	389	393	PF00917	0.482
DOC_USP7_MATH_1	400	404	PF00917	0.550
DOC_USP7_MATH_1	427	431	PF00917	0.332
DOC_WW_Pin1_4	129	134	PF00397	0.495
DOC_WW_Pin1_4	183	188	PF00397	0.560
DOC_WW_Pin1_4	333	338	PF00397	0.467
DOC_WW_Pin1_4	36	41	PF00397	0.478
LIG_14-3-3_CanoR_1	151	161	PF00244	0.464
LIG_14-3-3_CanoR_1	279	283	PF00244	0.471
LIG_14-3-3_CanoR_1	312	322	PF00244	0.471
LIG_14-3-3_CanoR_1	67	72	PF00244	0.317
LIG_Actin_WH2_2	246	261	PF00022	0.468
LIG_BIR_III_2	99	103	PF00653	0.358
LIG_BIR_III_4	353	357	PF00653	0.470
LIG_BRCT_BRCA1_1	38	42	PF00533	0.561
LIG_BRCT_BRCA1_1	395	399	PF00533	0.461
LIG_EH1_1	226	234	PF00400	0.487
LIG_FHA_1	104	110	PF00498	0.432
LIG_FHA_1	216	222	PF00498	0.406
LIG_FHA_1	236	242	PF00498	0.445
LIG_FHA_1	345	351	PF00498	0.433
LIG_FHA_2	409	415	PF00498	0.545
LIG_FHA_2	42	48	PF00498	0.521
LIG_FHA_2	94	100	PF00498	0.537
LIG_LIR_Apic_2	216	222	PF02991	0.426
LIG_LIR_Gen_1	159	169	PF02991	0.435
LIG_LIR_Gen_1	423	429	PF02991	0.501
LIG_LIR_Gen_1	85	93	PF02991	0.479
LIG_LIR_Nem_3	159	164	PF02991	0.504
LIG_LIR_Nem_3	339	345	PF02991	0.449
LIG_LIR_Nem_3	39	45	PF02991	0.525
LIG_LIR_Nem_3	423	428	PF02991	0.506
LIG_LIR_Nem_3	85	90	PF02991	0.477
LIG_SH2_CRK	146	150	PF00017	0.411
LIG_SH2_CRK	7	11	PF00017	0.436
LIG_SH2_GRB2like	370	373	PF00017	0.466
LIG_SH2_PTP2	87	90	PF00017	0.462
LIG_SH2_SRC	87	90	PF00017	0.378
LIG_SH2_STAT3	110	113	PF00017	0.566
LIG_SH2_STAT3	370	373	PF00017	0.466
LIG_SH2_STAT5	108	111	PF00017	0.406
LIG_SH2_STAT5	34	37	PF00017	0.294
LIG_SH2_STAT5	438	441	PF00017	0.459
LIG_SH2_STAT5	87	90	PF00017	0.462
LIG_SH3_3	127	133	PF00018	0.508
LIG_SH3_3	163	169	PF00018	0.294
LIG_SH3_3	404	410	PF00018	0.527
LIG_SH3_3	60	66	PF00018	0.396
LIG_SH3_3	8	14	PF00018	0.366
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.468
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.351
LIG_SUMO_SIM_par_1	405	411	PF11976	0.372
LIG_TRAF2_1	228	231	PF00917	0.345
LIG_TRAF2_1	411	414	PF00917	0.567
LIG_TRFH_1	7	11	PF08558	0.436
LIG_TYR_ITIM	144	149	PF00017	0.393
LIG_TYR_ITIM	5	10	PF00017	0.430
MOD_CK1_1	104	110	PF00069	0.398
MOD_CK1_1	266	272	PF00069	0.457
MOD_CK1_1	315	321	PF00069	0.590
MOD_CK1_1	73	79	PF00069	0.438
MOD_CK2_1	246	252	PF00069	0.450
MOD_CK2_1	278	284	PF00069	0.307
MOD_CK2_1	408	414	PF00069	0.527
MOD_CK2_1	41	47	PF00069	0.521
MOD_GlcNHglycan	135	138	PF01048	0.607
MOD_GlcNHglycan	154	157	PF01048	0.589
MOD_GlcNHglycan	255	258	PF01048	0.545
MOD_GlcNHglycan	259	262	PF01048	0.399
MOD_GlcNHglycan	330	333	PF01048	0.521
MOD_GlcNHglycan	353	357	PF01048	0.474
MOD_GlcNHglycan	391	394	PF01048	0.606
MOD_GlcNHglycan	72	75	PF01048	0.463
MOD_GlcNHglycan	79	82	PF01048	0.440
MOD_GSK3_1	100	107	PF00069	0.349
MOD_GSK3_1	129	136	PF00069	0.692
MOD_GSK3_1	152	159	PF00069	0.420
MOD_GSK3_1	172	179	PF00069	0.722
MOD_GSK3_1	211	218	PF00069	0.406
MOD_GSK3_1	231	238	PF00069	0.502
MOD_GSK3_1	253	260	PF00069	0.418
MOD_GSK3_1	30	37	PF00069	0.370
MOD_GSK3_1	311	318	PF00069	0.574
MOD_GSK3_1	344	351	PF00069	0.373
MOD_GSK3_1	389	396	PF00069	0.551
MOD_GSK3_1	73	80	PF00069	0.408
MOD_N-GLC_1	253	258	PF02516	0.407
MOD_NEK2_1	20	25	PF00069	0.516
MOD_NEK2_1	208	213	PF00069	0.388
MOD_NEK2_1	215	220	PF00069	0.402
MOD_NEK2_1	388	393	PF00069	0.670
MOD_NEK2_1	41	46	PF00069	0.465
MOD_NEK2_2	278	283	PF00069	0.287
MOD_PIKK_1	235	241	PF00454	0.510
MOD_PIKK_1	394	400	PF00454	0.522
MOD_PKA_1	311	317	PF00069	0.566
MOD_PKA_2	208	214	PF00069	0.315
MOD_PKA_2	278	284	PF00069	0.459
MOD_PKA_2	311	317	PF00069	0.514
MOD_Plk_1	215	221	PF00069	0.448
MOD_Plk_1	253	259	PF00069	0.502
MOD_Plk_4	104	110	PF00069	0.382
MOD_Plk_4	246	252	PF00069	0.397
MOD_Plk_4	269	275	PF00069	0.313
MOD_Plk_4	67	73	PF00069	0.340
MOD_ProDKin_1	129	135	PF00069	0.498
MOD_ProDKin_1	183	189	PF00069	0.544
MOD_ProDKin_1	333	339	PF00069	0.463
MOD_ProDKin_1	36	42	PF00069	0.469
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.539
TRG_ENDOCYTIC_2	146	149	PF00928	0.401
TRG_ENDOCYTIC_2	7	10	PF00928	0.392
TRG_ENDOCYTIC_2	87	90	PF00928	0.472
TRG_ER_diArg_1	110	112	PF00400	0.363
TRG_ER_diArg_1	143	146	PF00400	0.495
TRG_ER_diArg_1	2	4	PF00400	0.490
TRG_ER_diArg_1	310	312	PF00400	0.539
TRG_ER_diArg_1	361	364	PF00400	0.404
TRG_ER_diArg_1	401	404	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P853	Leptomonas seymouri	52%	87%
A0A1X0NY38	Trypanosomatidae	30%	100%
A0A3Q8IDW0	Leishmania donovani	87%	99%
A0A422NBK7	Trypanosoma rangeli	30%	100%
A4HZ51	Leishmania infantum	87%	99%
D0A1Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AV19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QCG3	Leishmania major	85%	100%
V5BQ65	Trypanosoma cruzi	27%	100%