Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBP8_LEIBR

TriTrypDb:

LbrM.21.0570 , LBRM2903_210010100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.503
CLV_C14_Caspase3-7	50	54	PF00656	0.472
CLV_NRD_NRD_1	256	258	PF00675	0.482
CLV_NRD_NRD_1	449	451	PF00675	0.637
CLV_PCSK_KEX2_1	142	144	PF00082	0.403
CLV_PCSK_KEX2_1	448	450	PF00082	0.642
CLV_PCSK_KEX2_1	84	86	PF00082	0.742
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.515
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.763
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.742
CLV_PCSK_SKI1_1	143	147	PF00082	0.423
CLV_PCSK_SKI1_1	29	33	PF00082	0.644
CLV_PCSK_SKI1_1	37	41	PF00082	0.525
CLV_PCSK_SKI1_1	398	402	PF00082	0.728
CLV_PCSK_SKI1_1	494	498	PF00082	0.524
DEG_APCC_DBOX_1	142	150	PF00400	0.412
DEG_SCF_FBW7_1	148	154	PF00400	0.530
DEG_SPOP_SBC_1	76	80	PF00917	0.643
DOC_CDC14_PxL_1	131	139	PF14671	0.536
DOC_CDC14_PxL_1	192	200	PF14671	0.558
DOC_CKS1_1	148	153	PF01111	0.494
DOC_CKS1_1	462	467	PF01111	0.704
DOC_CKS1_1	469	474	PF01111	0.685
DOC_CKS1_1	520	525	PF01111	0.634
DOC_CYCLIN_yCln2_LP_2	198	201	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.599
DOC_MAPK_gen_1	142	148	PF00069	0.402
DOC_PP2B_LxvP_1	193	196	PF13499	0.509
DOC_PP2B_LxvP_1	198	201	PF13499	0.520
DOC_PP4_MxPP_1	470	473	PF00568	0.619
DOC_USP7_MATH_1	112	116	PF00917	0.544
DOC_USP7_MATH_1	214	218	PF00917	0.696
DOC_USP7_MATH_1	240	244	PF00917	0.452
DOC_USP7_MATH_1	480	484	PF00917	0.616
DOC_USP7_MATH_1	505	509	PF00917	0.707
DOC_USP7_MATH_1	528	532	PF00917	0.687
DOC_WW_Pin1_4	147	152	PF00397	0.434
DOC_WW_Pin1_4	461	466	PF00397	0.641
DOC_WW_Pin1_4	468	473	PF00397	0.675
DOC_WW_Pin1_4	508	513	PF00397	0.699
DOC_WW_Pin1_4	519	524	PF00397	0.663
DOC_WW_Pin1_4	77	82	PF00397	0.717
LIG_14-3-3_CanoR_1	37	46	PF00244	0.587
LIG_14-3-3_CanoR_1	449	453	PF00244	0.664
LIG_14-3-3_CanoR_1	8	13	PF00244	0.746
LIG_Actin_WH2_2	127	144	PF00022	0.560
LIG_Actin_WH2_2	68	86	PF00022	0.470
LIG_APCC_ABBA_1	227	232	PF00400	0.440
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BIR_III_4	320	324	PF00653	0.499
LIG_BRCT_BRCA1_1	304	308	PF00533	0.635
LIG_CaM_IQ_9	241	256	PF13499	0.402
LIG_FHA_1	148	154	PF00498	0.493
LIG_FHA_1	176	182	PF00498	0.511
LIG_FHA_1	219	225	PF00498	0.649
LIG_FHA_1	34	40	PF00498	0.516
LIG_FHA_1	361	367	PF00498	0.569
LIG_FHA_1	409	415	PF00498	0.570
LIG_FHA_2	315	321	PF00498	0.504
LIG_FHA_2	38	44	PF00498	0.519
LIG_FHA_2	542	548	PF00498	0.614
LIG_LIR_Gen_1	109	119	PF02991	0.442
LIG_LIR_Gen_1	157	165	PF02991	0.498
LIG_LIR_Gen_1	205	215	PF02991	0.561
LIG_LIR_Gen_1	344	354	PF02991	0.332
LIG_LIR_Gen_1	43	52	PF02991	0.332
LIG_LIR_Nem_3	157	162	PF02991	0.497
LIG_LIR_Nem_3	205	210	PF02991	0.540
LIG_LIR_Nem_3	344	349	PF02991	0.301
LIG_LIR_Nem_3	43	49	PF02991	0.330
LIG_MYND_1	196	200	PF01753	0.619
LIG_MYND_1	435	439	PF01753	0.632
LIG_MYND_3	134	138	PF01753	0.531
LIG_NRBOX	176	182	PF00104	0.429
LIG_NRBOX	223	229	PF00104	0.644
LIG_SH2_CRK	119	123	PF00017	0.508
LIG_SH2_NCK_1	203	207	PF00017	0.402
LIG_SH2_PTP2	516	519	PF00017	0.541
LIG_SH2_SRC	203	206	PF00017	0.623
LIG_SH2_SRC	272	275	PF00017	0.431
LIG_SH2_SRC	516	519	PF00017	0.541
LIG_SH2_STAP1	203	207	PF00017	0.616
LIG_SH2_STAT3	129	132	PF00017	0.422
LIG_SH2_STAT3	62	65	PF00017	0.568
LIG_SH2_STAT5	272	275	PF00017	0.524
LIG_SH2_STAT5	298	301	PF00017	0.609
LIG_SH2_STAT5	516	519	PF00017	0.739
LIG_SH3_3	145	151	PF00018	0.419
LIG_SH3_3	349	355	PF00018	0.532
LIG_SH3_3	403	409	PF00018	0.691
LIG_SH3_3	429	435	PF00018	0.629
LIG_SH3_3	451	457	PF00018	0.700
LIG_SH3_3	459	465	PF00018	0.657
LIG_SH3_3	466	472	PF00018	0.605
LIG_SH3_3	482	488	PF00018	0.760
LIG_SH3_3	517	523	PF00018	0.687
LIG_Sin3_3	440	447	PF02671	0.745
LIG_SUMO_SIM_par_1	189	194	PF11976	0.561
LIG_TRAF2_1	300	303	PF00917	0.636
LIG_TRAF2_1	382	385	PF00917	0.507
LIG_TRAF2_1	40	43	PF00917	0.577
LIG_TYR_ITIM	117	122	PF00017	0.516
LIG_UBA3_1	133	142	PF00899	0.518
LIG_WW_1	200	203	PF00397	0.368
MOD_CDK_SPxxK_3	508	515	PF00069	0.533
MOD_CDK_SPxxK_3	77	84	PF00069	0.712
MOD_CK1_1	13	19	PF00069	0.703
MOD_CK1_1	217	223	PF00069	0.451
MOD_CK1_1	508	514	PF00069	0.633
MOD_CK2_1	151	157	PF00069	0.449
MOD_CK2_1	20	26	PF00069	0.675
MOD_CK2_1	297	303	PF00069	0.566
MOD_CK2_1	37	43	PF00069	0.526
MOD_CK2_1	378	384	PF00069	0.610
MOD_Cter_Amidation	396	399	PF01082	0.564
MOD_GlcNHglycan	114	117	PF01048	0.526
MOD_GlcNHglycan	12	15	PF01048	0.746
MOD_GlcNHglycan	212	215	PF01048	0.665
MOD_GlcNHglycan	303	307	PF01048	0.471
MOD_GlcNHglycan	380	383	PF01048	0.467
MOD_GlcNHglycan	401	404	PF01048	0.693
MOD_GlcNHglycan	465	468	PF01048	0.713
MOD_GlcNHglycan	498	501	PF01048	0.579
MOD_GlcNHglycan	5	8	PF01048	0.741
MOD_GlcNHglycan	530	533	PF01048	0.725
MOD_GlcNHglycan	72	75	PF01048	0.480
MOD_GSK3_1	147	154	PF00069	0.491
MOD_GSK3_1	210	217	PF00069	0.649
MOD_GSK3_1	3	10	PF00069	0.751
MOD_GSK3_1	310	317	PF00069	0.676
MOD_GSK3_1	33	40	PF00069	0.566
MOD_GSK3_1	386	393	PF00069	0.721
MOD_LATS_1	96	102	PF00433	0.510
MOD_N-GLC_1	217	222	PF02516	0.579
MOD_NEK2_1	164	169	PF00069	0.402
MOD_NEK2_1	180	185	PF00069	0.477
MOD_NEK2_1	32	37	PF00069	0.643
MOD_NEK2_1	358	363	PF00069	0.506
MOD_NEK2_1	97	102	PF00069	0.734
MOD_PIKK_1	390	396	PF00454	0.773
MOD_PK_1	8	14	PF00069	0.745
MOD_PKA_1	3	9	PF00069	0.533
MOD_PKA_1	398	404	PF00069	0.726
MOD_PKA_1	448	454	PF00069	0.697
MOD_PKA_2	448	454	PF00069	0.673
MOD_PKA_2	7	13	PF00069	0.538
MOD_Plk_1	494	500	PF00069	0.650
MOD_Plk_4	180	186	PF00069	0.495
MOD_ProDKin_1	147	153	PF00069	0.433
MOD_ProDKin_1	461	467	PF00069	0.642
MOD_ProDKin_1	468	474	PF00069	0.672
MOD_ProDKin_1	508	514	PF00069	0.703
MOD_ProDKin_1	519	525	PF00069	0.662
MOD_ProDKin_1	77	83	PF00069	0.722
TRG_DiLeu_BaEn_1	187	192	PF01217	0.502
TRG_DiLeu_BaEn_2	343	349	PF01217	0.269
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.741
TRG_ENDOCYTIC_2	119	122	PF00928	0.471
TRG_ENDOCYTIC_2	46	49	PF00928	0.321
TRG_NLS_MonoExtN_4	254	261	PF00514	0.525
TRG_NLS_MonoExtN_4	446	452	PF00514	0.760
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT9	Leptomonas seymouri	58%	94%
A0A1X0NXH4	Trypanosomatidae	25%	100%
A0A3Q8IAT2	Leishmania donovani	83%	100%
A0A422NBI2	Trypanosoma rangeli	29%	100%
A4HZ50	Leishmania infantum	75%	95%
D0A1Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AV18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QCG4	Leishmania major	73%	96%
V5BKP0	Trypanosoma cruzi	28%	100%