Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBP7_LEIBR

TriTrypDb:

LbrM.21.0560 , LBRM2903_210010000

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.659
CLV_NRD_NRD_1	88	90	PF00675	0.339
CLV_PCSK_KEX2_1	149	151	PF00082	0.446
CLV_PCSK_KEX2_1	88	90	PF00082	0.339
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.469
CLV_PCSK_SKI1_1	175	179	PF00082	0.586
CLV_PCSK_SKI1_1	184	188	PF00082	0.449
CLV_PCSK_SKI1_1	50	54	PF00082	0.416
CLV_PCSK_SKI1_1	7	11	PF00082	0.560
DOC_CYCLIN_RxL_1	86	97	PF00134	0.325
DOC_MAPK_gen_1	130	140	PF00069	0.490
DOC_MAPK_gen_1	175	185	PF00069	0.324
DOC_MAPK_MEF2A_6	178	187	PF00069	0.309
DOC_MAPK_MEF2A_6	45	53	PF00069	0.545
DOC_MAPK_MEF2A_6	7	14	PF00069	0.506
DOC_PP1_RVXF_1	87	94	PF00149	0.557
DOC_PP2B_LxvP_1	10	13	PF13499	0.427
DOC_USP7_MATH_1	115	119	PF00917	0.480
DOC_USP7_MATH_1	33	37	PF00917	0.557
DOC_USP7_MATH_1	78	82	PF00917	0.562
DOC_WW_Pin1_4	29	34	PF00397	0.484
LIG_14-3-3_CanoR_1	175	181	PF00244	0.477
LIG_14-3-3_CanoR_1	58	64	PF00244	0.575
LIG_14-3-3_CterR_2	206	209	PF00244	0.437
LIG_Actin_WH2_2	117	135	PF00022	0.382
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	91	95	PF00533	0.302
LIG_CSL_BTD_1	10	13	PF09270	0.404
LIG_DLG_GKlike_1	89	97	PF00625	0.298
LIG_EH1_1	106	114	PF00400	0.426
LIG_FHA_1	103	109	PF00498	0.419
LIG_FHA_1	161	167	PF00498	0.527
LIG_FHA_2	177	183	PF00498	0.494
LIG_FHA_2	18	24	PF00498	0.292
LIG_IRF3_LxIS_1	25	32	PF10401	0.300
LIG_LIR_Gen_1	156	167	PF02991	0.438
LIG_LIR_LC3C_4	136	141	PF02991	0.279
LIG_LIR_Nem_3	156	162	PF02991	0.396
LIG_PTB_Apo_2	15	22	PF02174	0.514
LIG_SH2_STAP1	190	194	PF00017	0.491
LIG_SH2_STAT5	153	156	PF00017	0.473
LIG_SH3_3	159	165	PF00018	0.488
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.421
LIG_SUMO_SIM_par_1	136	143	PF11976	0.394
MOD_CK1_1	102	108	PF00069	0.427
MOD_CK1_1	118	124	PF00069	0.469
MOD_CK1_1	32	38	PF00069	0.488
MOD_CK2_1	17	23	PF00069	0.342
MOD_CK2_1	176	182	PF00069	0.539
MOD_CK2_1	78	84	PF00069	0.536
MOD_Cter_Amidation	147	150	PF01082	0.436
MOD_GlcNHglycan	194	197	PF01048	0.516
MOD_GlcNHglycan	74	77	PF01048	0.533
MOD_GSK3_1	29	36	PF00069	0.508
MOD_GSK3_1	95	102	PF00069	0.383
MOD_NEK2_1	139	144	PF00069	0.385
MOD_NEK2_1	63	68	PF00069	0.493
MOD_NEK2_1	95	100	PF00069	0.377
MOD_PKA_2	57	63	PF00069	0.365
MOD_Plk_1	89	95	PF00069	0.568
MOD_Plk_4	17	23	PF00069	0.305
MOD_Plk_4	63	69	PF00069	0.524
MOD_Plk_4	78	84	PF00069	0.305
MOD_ProDKin_1	29	35	PF00069	0.475
MOD_SUMO_for_1	44	47	PF00179	0.548
TRG_DiLeu_BaEn_1	134	139	PF01217	0.422
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.450
TRG_NES_CRM1_1	61	73	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P855	Leptomonas seymouri	51%	97%
A0A1X0NXQ6	Trypanosomatidae	29%	91%
A0A1X0NZ15	Trypanosomatidae	37%	96%
A0A3S7WWD9	Leishmania donovani	78%	98%
A0A422NBM7	Trypanosoma rangeli	34%	100%
A4HZ49	Leishmania infantum	78%	98%
D0A1Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AV17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QCG5	Leishmania major	77%	100%