Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBP6_LEIBR

TriTrypDb:

LbrM.21.0540 , LBRM2903_210009800

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.532
CLV_C14_Caspase3-7	374	378	PF00656	0.480
CLV_C14_Caspase3-7	414	418	PF00656	0.601
CLV_C14_Caspase3-7	444	448	PF00656	0.462
CLV_NRD_NRD_1	118	120	PF00675	0.595
CLV_NRD_NRD_1	146	148	PF00675	0.371
CLV_NRD_NRD_1	498	500	PF00675	0.723
CLV_NRD_NRD_1	509	511	PF00675	0.543
CLV_PCSK_KEX2_1	117	119	PF00082	0.597
CLV_PCSK_KEX2_1	146	148	PF00082	0.371
CLV_PCSK_KEX2_1	498	500	PF00082	0.619
CLV_PCSK_KEX2_1	509	511	PF00082	0.543
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.597
CLV_PCSK_SKI1_1	253	257	PF00082	0.603
CLV_TASPASE1	394	400	PF01112	0.625
DEG_COP1_1	32	40	PF00400	0.558
DEG_Nend_UBRbox_2	1	3	PF02207	0.598
DEG_SPOP_SBC_1	456	460	PF00917	0.516
DOC_ANK_TNKS_1	391	398	PF00023	0.622
DOC_MAPK_MEF2A_6	345	353	PF00069	0.440
DOC_PP1_RVXF_1	260	267	PF00149	0.582
DOC_USP7_MATH_1	286	290	PF00917	0.713
DOC_USP7_MATH_1	36	40	PF00917	0.716
DOC_USP7_MATH_1	41	45	PF00917	0.651
DOC_USP7_MATH_1	411	415	PF00917	0.482
DOC_USP7_MATH_1	456	460	PF00917	0.579
DOC_WW_Pin1_4	329	334	PF00397	0.702
DOC_WW_Pin1_4	44	49	PF00397	0.557
LIG_14-3-3_CanoR_1	372	376	PF00244	0.556
LIG_14-3-3_CanoR_1	437	445	PF00244	0.413
LIG_Actin_WH2_2	176	194	PF00022	0.440
LIG_Actin_WH2_2	487	505	PF00022	0.552
LIG_FHA_1	108	114	PF00498	0.566
LIG_FHA_1	30	36	PF00498	0.559
LIG_FHA_1	502	508	PF00498	0.767
LIG_FHA_1	66	72	PF00498	0.486
LIG_FHA_2	120	126	PF00498	0.361
LIG_FHA_2	213	219	PF00498	0.330
LIG_FHA_2	307	313	PF00498	0.562
LIG_FHA_2	364	370	PF00498	0.598
LIG_FHA_2	64	70	PF00498	0.461
LIG_LIR_Gen_1	267	277	PF02991	0.634
LIG_LIR_Nem_3	267	273	PF02991	0.611
LIG_LIR_Nem_3	337	341	PF02991	0.514
LIG_MYND_3	339	343	PF01753	0.556
LIG_NRBOX	91	97	PF00104	0.476
LIG_Pex14_1	266	270	PF04695	0.473
LIG_Pex14_2	334	338	PF04695	0.575
LIG_PTAP_UEV_1	37	42	PF05743	0.549
LIG_PTB_Apo_2	310	317	PF02174	0.517
LIG_PTB_Phospho_1	310	316	PF10480	0.516
LIG_SH2_SRC	235	238	PF00017	0.357
LIG_SH2_STAT5	227	230	PF00017	0.444
LIG_SH2_STAT5	235	238	PF00017	0.461
LIG_SH3_3	32	38	PF00018	0.812
LIG_SH3_3	327	333	PF00018	0.762
LIG_SH3_3	483	489	PF00018	0.765
LIG_SUMO_SIM_par_1	301	309	PF11976	0.512
LIG_SUMO_SIM_par_1	489	495	PF11976	0.563
LIG_TRAF2_1	122	125	PF00917	0.464
LIG_TRAF2_1	185	188	PF00917	0.347
LIG_TRAF2_1	231	234	PF00917	0.484
LIG_TRAF2_1	245	248	PF00917	0.368
LIG_TRAF2_1	289	292	PF00917	0.725
LIG_TRAF2_1	91	94	PF00917	0.589
LIG_UBA3_1	380	385	PF00899	0.452
MOD_CK1_1	298	304	PF00069	0.729
MOD_CK1_1	321	327	PF00069	0.666
MOD_CK1_1	371	377	PF00069	0.560
MOD_CK1_1	44	50	PF00069	0.645
MOD_CK1_1	448	454	PF00069	0.609
MOD_CK1_1	459	465	PF00069	0.678
MOD_CK1_1	473	479	PF00069	0.734
MOD_CK1_1	492	498	PF00069	0.773
MOD_CK2_1	119	125	PF00069	0.361
MOD_CK2_1	133	139	PF00069	0.580
MOD_CK2_1	182	188	PF00069	0.460
MOD_CK2_1	191	197	PF00069	0.440
MOD_CK2_1	212	218	PF00069	0.331
MOD_CK2_1	227	233	PF00069	0.440
MOD_CK2_1	286	292	PF00069	0.691
MOD_CK2_1	306	312	PF00069	0.530
MOD_CK2_1	63	69	PF00069	0.406
MOD_CK2_1	7	13	PF00069	0.461
MOD_CK2_1	88	94	PF00069	0.585
MOD_Cter_Amidation	507	510	PF01082	0.675
MOD_GlcNHglycan	193	196	PF01048	0.576
MOD_GlcNHglycan	229	232	PF01048	0.475
MOD_GlcNHglycan	296	300	PF01048	0.681
MOD_GlcNHglycan	316	319	PF01048	0.630
MOD_GlcNHglycan	38	41	PF01048	0.802
MOD_GlcNHglycan	43	46	PF01048	0.731
MOD_GlcNHglycan	464	467	PF01048	0.695
MOD_GlcNHglycan	473	476	PF01048	0.713
MOD_GlcNHglycan	77	80	PF01048	0.619
MOD_GSK3_1	104	111	PF00069	0.502
MOD_GSK3_1	156	163	PF00069	0.603
MOD_GSK3_1	25	32	PF00069	0.581
MOD_GSK3_1	272	279	PF00069	0.457
MOD_GSK3_1	295	302	PF00069	0.614
MOD_GSK3_1	314	321	PF00069	0.463
MOD_GSK3_1	371	378	PF00069	0.553
MOD_GSK3_1	441	448	PF00069	0.609
MOD_GSK3_1	451	458	PF00069	0.546
MOD_N-GLC_1	41	46	PF02516	0.573
MOD_N-GLC_1	480	485	PF02516	0.569
MOD_NEK2_1	179	184	PF00069	0.517
MOD_NEK2_1	191	196	PF00069	0.368
MOD_NEK2_1	375	380	PF00069	0.574
MOD_NEK2_1	494	499	PF00069	0.688
MOD_NEK2_1	502	507	PF00069	0.597
MOD_PIKK_1	108	114	PF00454	0.631
MOD_PIKK_1	148	154	PF00454	0.577
MOD_PIKK_1	432	438	PF00454	0.609
MOD_PIKK_1	492	498	PF00454	0.773
MOD_PKA_2	191	197	PF00069	0.438
MOD_PKA_2	371	377	PF00069	0.556
MOD_PKA_2	445	451	PF00069	0.473
MOD_PKA_2	502	508	PF00069	0.550
MOD_PKB_1	499	507	PF00069	0.763
MOD_Plk_1	286	292	PF00069	0.612
MOD_Plk_1	368	374	PF00069	0.595
MOD_Plk_1	376	382	PF00069	0.458
MOD_Plk_1	480	486	PF00069	0.713
MOD_Plk_2-3	2	8	PF00069	0.494
MOD_Plk_2-3	63	69	PF00069	0.406
MOD_Plk_2-3	88	94	PF00069	0.552
MOD_Plk_4	300	306	PF00069	0.525
MOD_Plk_4	376	382	PF00069	0.555
MOD_Plk_4	383	389	PF00069	0.562
MOD_Plk_4	489	495	PF00069	0.580
MOD_ProDKin_1	329	335	PF00069	0.696
MOD_ProDKin_1	44	50	PF00069	0.552
MOD_SUMO_rev_2	170	177	PF00179	0.571
MOD_SUMO_rev_2	337	347	PF00179	0.402
TRG_DiLeu_BaEn_1	164	169	PF01217	0.573
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.572
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.479
TRG_ENDOCYTIC_2	134	137	PF00928	0.451
TRG_ER_diArg_1	146	148	PF00400	0.582
TRG_ER_diArg_1	498	501	PF00400	0.640
TRG_NES_CRM1_1	188	202	PF08389	0.338
TRG_NES_CRM1_1	7	19	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF17	Leptomonas seymouri	38%	91%
A0A3S7WWD2	Leishmania donovani	79%	100%
A4HZ47	Leishmania infantum	78%	100%
E9AV15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCG7	Leishmania major	77%	97%