Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HBP4_LEIBR

TriTrypDb:

LbrM.21.0520 , LBRM2903_210009600

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.807
CLV_C14_Caspase3-7	708	712	PF00656	0.591
CLV_NRD_NRD_1	280	282	PF00675	0.653
CLV_NRD_NRD_1	377	379	PF00675	0.829
CLV_NRD_NRD_1	425	427	PF00675	0.816
CLV_NRD_NRD_1	49	51	PF00675	0.715
CLV_NRD_NRD_1	669	671	PF00675	0.637
CLV_PCSK_KEX2_1	280	282	PF00082	0.653
CLV_PCSK_KEX2_1	376	378	PF00082	0.824
CLV_PCSK_KEX2_1	406	408	PF00082	0.661
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.591
CLV_PCSK_SKI1_1	209	213	PF00082	0.751
CLV_PCSK_SKI1_1	239	243	PF00082	0.688
CLV_PCSK_SKI1_1	349	353	PF00082	0.734
CLV_PCSK_SKI1_1	422	426	PF00082	0.826
CLV_PCSK_SKI1_1	50	54	PF00082	0.651
CLV_PCSK_SKI1_1	564	568	PF00082	0.576
CLV_PCSK_SKI1_1	721	725	PF00082	0.601
CLV_PCSK_SKI1_1	835	839	PF00082	0.704
CLV_Separin_Metazoa	271	275	PF03568	0.750
DEG_APCC_DBOX_1	265	273	PF00400	0.747
DEG_APCC_DBOX_1	375	383	PF00400	0.573
DEG_SPOP_SBC_1	231	235	PF00917	0.572
DEG_SPOP_SBC_1	705	709	PF00917	0.577
DOC_CKS1_1	10	15	PF01111	0.575
DOC_CKS1_1	665	670	PF01111	0.607
DOC_CKS1_1	728	733	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.509
DOC_MAPK_gen_1	175	185	PF00069	0.538
DOC_MAPK_gen_1	280	287	PF00069	0.790
DOC_MAPK_MEF2A_6	175	183	PF00069	0.729
DOC_PP2B_LxvP_1	812	815	PF13499	0.717
DOC_PP2B_LxvP_1	88	91	PF13499	0.708
DOC_PP2B_PxIxI_1	178	184	PF00149	0.723
DOC_PP4_FxxP_1	728	731	PF00568	0.600
DOC_USP7_MATH_1	173	177	PF00917	0.588
DOC_USP7_MATH_1	2	6	PF00917	0.749
DOC_USP7_MATH_1	227	231	PF00917	0.672
DOC_USP7_MATH_1	232	236	PF00917	0.564
DOC_USP7_MATH_1	305	309	PF00917	0.647
DOC_USP7_MATH_1	314	318	PF00917	0.646
DOC_USP7_MATH_1	337	341	PF00917	0.783
DOC_USP7_MATH_1	34	38	PF00917	0.590
DOC_USP7_MATH_1	363	367	PF00917	0.777
DOC_USP7_MATH_1	381	385	PF00917	0.517
DOC_USP7_MATH_1	415	419	PF00917	0.582
DOC_USP7_MATH_1	478	482	PF00917	0.552
DOC_USP7_MATH_1	683	687	PF00917	0.853
DOC_USP7_MATH_1	705	709	PF00917	0.608
DOC_USP7_MATH_1	737	741	PF00917	0.595
DOC_USP7_MATH_1	837	841	PF00917	0.796
DOC_USP7_MATH_1	849	853	PF00917	0.579
DOC_WW_Pin1_4	139	144	PF00397	0.596
DOC_WW_Pin1_4	196	201	PF00397	0.494
DOC_WW_Pin1_4	212	217	PF00397	0.538
DOC_WW_Pin1_4	444	449	PF00397	0.704
DOC_WW_Pin1_4	527	532	PF00397	0.609
DOC_WW_Pin1_4	577	582	PF00397	0.829
DOC_WW_Pin1_4	61	66	PF00397	0.622
DOC_WW_Pin1_4	652	657	PF00397	0.599
DOC_WW_Pin1_4	664	669	PF00397	0.559
DOC_WW_Pin1_4	670	675	PF00397	0.533
DOC_WW_Pin1_4	701	706	PF00397	0.727
DOC_WW_Pin1_4	727	732	PF00397	0.737
DOC_WW_Pin1_4	761	766	PF00397	0.576
DOC_WW_Pin1_4	828	833	PF00397	0.592
DOC_WW_Pin1_4	9	14	PF00397	0.575
DOC_WW_Pin1_4	925	930	PF00397	0.575
LIG_14-3-3_CanoR_1	221	229	PF00244	0.829
LIG_14-3-3_CanoR_1	239	244	PF00244	0.689
LIG_14-3-3_CanoR_1	307	316	PF00244	0.732
LIG_14-3-3_CanoR_1	368	372	PF00244	0.567
LIG_14-3-3_CanoR_1	416	424	PF00244	0.661
LIG_14-3-3_CanoR_1	45	52	PF00244	0.637
LIG_14-3-3_CanoR_1	457	465	PF00244	0.578
LIG_14-3-3_CanoR_1	593	601	PF00244	0.698
LIG_14-3-3_CanoR_1	691	695	PF00244	0.765
LIG_Actin_WH2_2	87	102	PF00022	0.501
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	480	484	PF00533	0.556
LIG_BRCT_BRCA1_1	926	930	PF00533	0.541
LIG_Clathr_ClatBox_1	203	207	PF01394	0.535
LIG_FHA_1	100	106	PF00498	0.621
LIG_FHA_1	115	121	PF00498	0.566
LIG_FHA_1	13	19	PF00498	0.713
LIG_FHA_1	20	26	PF00498	0.600
LIG_FHA_1	236	242	PF00498	0.594
LIG_FHA_1	274	280	PF00498	0.707
LIG_FHA_1	297	303	PF00498	0.554
LIG_FHA_1	398	404	PF00498	0.646
LIG_FHA_1	483	489	PF00498	0.560
LIG_FHA_1	51	57	PF00498	0.669
LIG_FHA_1	516	522	PF00498	0.691
LIG_FHA_1	664	670	PF00498	0.608
LIG_FHA_1	768	774	PF00498	0.718
LIG_FHA_1	836	842	PF00498	0.695
LIG_FHA_2	109	115	PF00498	0.640
LIG_FHA_2	197	203	PF00498	0.712
LIG_FHA_2	263	269	PF00498	0.750
LIG_FHA_2	400	406	PF00498	0.567
LIG_FHA_2	423	429	PF00498	0.810
LIG_FHA_2	653	659	PF00498	0.596
LIG_FHA_2	81	87	PF00498	0.666
LIG_FHA_2	888	894	PF00498	0.681
LIG_LIR_Apic_2	139	143	PF02991	0.638
LIG_LIR_Apic_2	725	731	PF02991	0.599
LIG_LIR_Apic_2	879	883	PF02991	0.604
LIG_LIR_Gen_1	12	21	PF02991	0.659
LIG_LIR_Gen_1	128	138	PF02991	0.755
LIG_LIR_Gen_1	237	247	PF02991	0.790
LIG_LIR_Gen_1	459	469	PF02991	0.588
LIG_LIR_Gen_1	888	897	PF02991	0.598
LIG_LIR_Nem_3	12	17	PF02991	0.664
LIG_LIR_Nem_3	128	134	PF02991	0.753
LIG_LIR_Nem_3	142	148	PF02991	0.735
LIG_LIR_Nem_3	19	24	PF02991	0.658
LIG_LIR_Nem_3	237	243	PF02991	0.600
LIG_LIR_Nem_3	459	464	PF02991	0.590
LIG_LIR_Nem_3	609	614	PF02991	0.708
LIG_LIR_Nem_3	769	775	PF02991	0.467
LIG_LIR_Nem_3	888	892	PF02991	0.615
LIG_Pex14_2	601	605	PF04695	0.721
LIG_SH2_CRK	14	18	PF00017	0.712
LIG_SH2_CRK	140	144	PF00017	0.728
LIG_SH2_CRK	145	149	PF00017	0.679
LIG_SH2_NCK_1	140	144	PF00017	0.544
LIG_SH2_PTP2	240	243	PF00017	0.544
LIG_SH2_PTP2	880	883	PF00017	0.361
LIG_SH2_STAP1	14	18	PF00017	0.712
LIG_SH2_STAP1	21	25	PF00017	0.598
LIG_SH2_STAP1	611	615	PF00017	0.791
LIG_SH2_STAT5	14	17	PF00017	0.713
LIG_SH2_STAT5	21	24	PF00017	0.600
LIG_SH2_STAT5	240	243	PF00017	0.641
LIG_SH2_STAT5	394	397	PF00017	0.720
LIG_SH2_STAT5	614	617	PF00017	0.712
LIG_SH2_STAT5	880	883	PF00017	0.525
LIG_SH2_STAT5	887	890	PF00017	0.637
LIG_SH3_1	214	220	PF00018	0.606
LIG_SH3_1	629	635	PF00018	0.604
LIG_SH3_1	662	668	PF00018	0.606
LIG_SH3_2	216	221	PF14604	0.608
LIG_SH3_2	665	670	PF14604	0.607
LIG_SH3_3	213	219	PF00018	0.604
LIG_SH3_3	226	232	PF00018	0.546
LIG_SH3_3	322	328	PF00018	0.803
LIG_SH3_3	442	448	PF00018	0.653
LIG_SH3_3	537	543	PF00018	0.587
LIG_SH3_3	57	63	PF00018	0.646
LIG_SH3_3	629	635	PF00018	0.604
LIG_SH3_3	662	668	PF00018	0.625
LIG_SH3_3	689	695	PF00018	0.804
LIG_SH3_3	7	13	PF00018	0.732
LIG_SH3_3	728	734	PF00018	0.828
LIG_SH3_3	76	82	PF00018	0.601
LIG_SH3_3	781	787	PF00018	0.607
LIG_SH3_3	870	876	PF00018	0.524
LIG_SH3_CIN85_PxpxPR_1	216	221	PF14604	0.608
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.745
LIG_SUMO_SIM_par_1	360	366	PF11976	0.758
LIG_SUMO_SIM_par_1	465	470	PF11976	0.574
LIG_TRAF2_1	126	129	PF00917	0.572
LIG_TRAF2_1	265	268	PF00917	0.755
LIG_TRAF2_1	402	405	PF00917	0.565
LIG_TRAF2_1	472	475	PF00917	0.585
LIG_TRAF2_1	616	619	PF00917	0.586
LIG_TRAF2_1	69	72	PF00917	0.598
LIG_TRFH_1	196	200	PF08558	0.605
LIG_TYR_ITSM	10	17	PF00017	0.566
LIG_WW_3	218	222	PF00397	0.864
MOD_CDK_SPxK_1	664	670	PF00069	0.608
MOD_CDK_SPxxK_3	664	671	PF00069	0.609
MOD_CDK_SPxxK_3	828	835	PF00069	0.589
MOD_CK1_1	230	236	PF00069	0.662
MOD_CK1_1	308	314	PF00069	0.554
MOD_CK1_1	384	390	PF00069	0.555
MOD_CK1_1	435	441	PF00069	0.699
MOD_CK1_1	44	50	PF00069	0.600
MOD_CK1_1	516	522	PF00069	0.573
MOD_CK1_1	532	538	PF00069	0.561
MOD_CK1_1	577	583	PF00069	0.771
MOD_CK1_1	704	710	PF00069	0.815
MOD_CK1_1	739	745	PF00069	0.850
MOD_CK1_1	757	763	PF00069	0.560
MOD_CK1_1	830	836	PF00069	0.660
MOD_CK2_1	123	129	PF00069	0.731
MOD_CK2_1	196	202	PF00069	0.705
MOD_CK2_1	262	268	PF00069	0.756
MOD_CK2_1	399	405	PF00069	0.564
MOD_CK2_1	415	421	PF00069	0.524
MOD_CK2_1	567	573	PF00069	0.829
MOD_CK2_1	613	619	PF00069	0.582
MOD_CK2_1	652	658	PF00069	0.598
MOD_CK2_1	66	72	PF00069	0.711
MOD_CK2_1	80	86	PF00069	0.539
MOD_CK2_1	887	893	PF00069	0.678
MOD_CMANNOS	153	156	PF00535	0.707
MOD_GlcNHglycan	229	232	PF01048	0.587
MOD_GlcNHglycan	312	315	PF01048	0.696
MOD_GlcNHglycan	36	39	PF01048	0.559
MOD_GlcNHglycan	383	386	PF01048	0.582
MOD_GlcNHglycan	428	431	PF01048	0.785
MOD_GlcNHglycan	47	50	PF01048	0.617
MOD_GlcNHglycan	515	518	PF01048	0.760
MOD_GlcNHglycan	553	556	PF01048	0.849
MOD_GlcNHglycan	615	618	PF01048	0.835
MOD_GlcNHglycan	708	711	PF01048	0.766
MOD_GlcNHglycan	743	746	PF01048	0.645
MOD_GlcNHglycan	760	763	PF01048	0.771
MOD_GlcNHglycan	784	787	PF01048	0.663
MOD_GlcNHglycan	845	848	PF01048	0.595
MOD_GlcNHglycan	851	854	PF01048	0.545
MOD_GlcNHglycan	869	872	PF01048	0.471
MOD_GSK3_1	119	126	PF00069	0.769
MOD_GSK3_1	205	212	PF00069	0.583
MOD_GSK3_1	221	228	PF00069	0.693
MOD_GSK3_1	230	237	PF00069	0.632
MOD_GSK3_1	305	312	PF00069	0.564
MOD_GSK3_1	350	357	PF00069	0.488
MOD_GSK3_1	363	370	PF00069	0.490
MOD_GSK3_1	41	48	PF00069	0.735
MOD_GSK3_1	422	429	PF00069	0.734
MOD_GSK3_1	456	463	PF00069	0.620
MOD_GSK3_1	478	485	PF00069	0.554
MOD_GSK3_1	573	580	PF00069	0.757
MOD_GSK3_1	623	630	PF00069	0.684
MOD_GSK3_1	634	641	PF00069	0.561
MOD_GSK3_1	700	707	PF00069	0.817
MOD_GSK3_1	722	729	PF00069	0.639
MOD_GSK3_1	737	744	PF00069	0.767
MOD_GSK3_1	751	758	PF00069	0.657
MOD_GSK3_1	827	834	PF00069	0.748
MOD_GSK3_1	849	856	PF00069	0.631
MOD_GSK3_1	863	870	PF00069	0.576
MOD_LATS_1	591	597	PF00433	0.586
MOD_N-GLC_1	577	582	PF02516	0.790
MOD_N-GLC_1	726	731	PF02516	0.600
MOD_NEK2_1	371	376	PF00069	0.572
MOD_NEK2_1	390	395	PF00069	0.490
MOD_NEK2_1	587	592	PF00069	0.681
MOD_NEK2_1	601	606	PF00069	0.783
MOD_NEK2_1	642	647	PF00069	0.627
MOD_NEK2_2	173	178	PF00069	0.599
MOD_NEK2_2	363	368	PF00069	0.533
MOD_NEK2_2	767	772	PF00069	0.494
MOD_NEK2_2	863	868	PF00069	0.558
MOD_OFUCOSY	736	741	PF10250	0.593
MOD_PIKK_1	428	434	PF00454	0.818
MOD_PIKK_1	623	629	PF00454	0.859
MOD_PIKK_1	634	640	PF00454	0.675
MOD_PIKK_1	743	749	PF00454	0.846
MOD_PKA_1	426	432	PF00069	0.831
MOD_PKA_1	50	56	PF00069	0.666
MOD_PKA_2	273	279	PF00069	0.755
MOD_PKA_2	367	373	PF00069	0.566
MOD_PKA_2	415	421	PF00069	0.654
MOD_PKA_2	44	50	PF00069	0.678
MOD_PKA_2	456	462	PF00069	0.581
MOD_PKA_2	574	580	PF00069	0.632
MOD_PKA_2	690	696	PF00069	0.636
MOD_PKA_2	867	873	PF00069	0.759
MOD_PKA_2	99	105	PF00069	0.701
MOD_Plk_1	127	133	PF00069	0.569
MOD_Plk_1	19	25	PF00069	0.532
MOD_Plk_1	863	869	PF00069	0.631
MOD_Plk_4	127	133	PF00069	0.685
MOD_Plk_4	149	155	PF00069	0.564
MOD_Plk_4	19	25	PF00069	0.503
MOD_Plk_4	460	466	PF00069	0.563
MOD_Plk_4	567	573	PF00069	0.576
MOD_Plk_4	767	773	PF00069	0.727
MOD_Plk_4	777	783	PF00069	0.493
MOD_Plk_4	853	859	PF00069	0.591
MOD_Plk_4	90	96	PF00069	0.553
MOD_ProDKin_1	139	145	PF00069	0.595
MOD_ProDKin_1	196	202	PF00069	0.497
MOD_ProDKin_1	212	218	PF00069	0.538
MOD_ProDKin_1	444	450	PF00069	0.703
MOD_ProDKin_1	527	533	PF00069	0.610
MOD_ProDKin_1	577	583	PF00069	0.834
MOD_ProDKin_1	61	67	PF00069	0.622
MOD_ProDKin_1	652	658	PF00069	0.598
MOD_ProDKin_1	664	670	PF00069	0.561
MOD_ProDKin_1	701	707	PF00069	0.727
MOD_ProDKin_1	727	733	PF00069	0.733
MOD_ProDKin_1	761	767	PF00069	0.571
MOD_ProDKin_1	828	834	PF00069	0.590
MOD_ProDKin_1	9	15	PF00069	0.575
MOD_ProDKin_1	925	931	PF00069	0.575
MOD_SUMO_rev_2	103	111	PF00179	0.550
MOD_SUMO_rev_2	157	162	PF00179	0.701
MOD_SUMO_rev_2	202	211	PF00179	0.786
TRG_DiLeu_BaEn_1	268	273	PF01217	0.741
TRG_DiLeu_BaEn_3	19	25	PF01217	0.600
TRG_DiLeu_BaEn_4	157	163	PF01217	0.715
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.771
TRG_ENDOCYTIC_2	14	17	PF00928	0.713
TRG_ENDOCYTIC_2	145	148	PF00928	0.687
TRG_ENDOCYTIC_2	21	24	PF00928	0.600
TRG_ENDOCYTIC_2	240	243	PF00928	0.796
TRG_ENDOCYTIC_2	908	911	PF00928	0.726
TRG_ER_diArg_1	279	281	PF00400	0.781
TRG_ER_diArg_1	376	378	PF00400	0.824
TRG_ER_diArg_1	644	647	PF00400	0.825
TRG_ER_diArg_1	815	818	PF00400	0.661
TRG_NES_CRM1_1	895	909	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	593	597	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	899	903	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA94	Leishmania donovani	59%	100%
A4HZ45	Leishmania infantum	59%	100%
E9AV13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QCG9	Leishmania major	59%	97%