Ubiquitin-conjugating enzyme-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme-like protein

Species:

Leishmania braziliensis

UniProt:

A4HBP2_LEIBR

TriTrypDb:

LbrM.21.0500 , LBRM2903_210009500

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.259
CLV_NRD_NRD_1	224	226	PF00675	0.159
CLV_NRD_NRD_1	25	27	PF00675	0.333
CLV_NRD_NRD_1	37	39	PF00675	0.300
CLV_PCSK_FUR_1	38	42	PF00082	0.325
CLV_PCSK_KEX2_1	224	226	PF00082	0.177
CLV_PCSK_KEX2_1	25	27	PF00082	0.376
CLV_PCSK_KEX2_1	40	42	PF00082	0.246
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.262
CLV_PCSK_SKI1_1	40	44	PF00082	0.300
CLV_Separin_Metazoa	265	269	PF03568	0.460
DOC_CDC14_PxL_1	144	152	PF14671	0.413
DOC_CKS1_1	105	110	PF01111	0.413
DOC_CYCLIN_RxL_1	37	44	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.243
DOC_MAPK_gen_1	206	216	PF00069	0.505
DOC_MAPK_MEF2A_6	209	218	PF00069	0.497
DOC_PP2B_LxvP_1	78	81	PF13499	0.171
DOC_WW_Pin1_4	104	109	PF00397	0.413
DOC_WW_Pin1_4	216	221	PF00397	0.430
LIG_AP2alpha_2	229	231	PF02296	0.497
LIG_BRCT_BRCA1_1	247	251	PF00533	0.497
LIG_CSL_BTD_1	78	81	PF09270	0.248
LIG_FHA_1	141	147	PF00498	0.445
LIG_FHA_1	190	196	PF00498	0.468
LIG_FHA_1	232	238	PF00498	0.442
LIG_FHA_1	261	267	PF00498	0.413
LIG_FHA_2	136	142	PF00498	0.431
LIG_FHA_2	87	93	PF00498	0.317
LIG_LIR_Apic_2	103	108	PF02991	0.413
LIG_LIR_Apic_2	238	244	PF02991	0.497
LIG_LIR_Gen_1	184	191	PF02991	0.447
LIG_LIR_Nem_3	110	116	PF02991	0.430
LIG_LIR_Nem_3	184	189	PF02991	0.449
LIG_LIR_Nem_3	249	255	PF02991	0.533
LIG_Pex14_1	79	83	PF04695	0.365
LIG_Pex14_2	116	120	PF04695	0.413
LIG_Pex14_2	182	186	PF04695	0.489
LIG_PTB_Apo_2	240	247	PF02174	0.358
LIG_Rb_pABgroove_1	240	248	PF01858	0.358
LIG_SH2_CRK	154	158	PF00017	0.460
LIG_SH2_GRB2like	167	170	PF00017	0.358
LIG_SH2_STAT5	156	159	PF00017	0.356
LIG_SH2_STAT5	167	170	PF00017	0.522
LIG_SH2_STAT5	235	238	PF00017	0.413
LIG_SH2_STAT5	36	39	PF00017	0.494
LIG_SH2_STAT5	47	50	PF00017	0.248
LIG_SH2_STAT5	65	68	PF00017	0.253
LIG_SH3_3	105	111	PF00018	0.456
LIG_SH3_3	142	148	PF00018	0.444
LIG_TYR_ITIM	152	157	PF00017	0.497
LIG_WRC_WIRS_1	113	118	PF05994	0.427
MOD_CK1_1	257	263	PF00069	0.456
MOD_CK1_1	49	55	PF00069	0.272
MOD_CK2_1	116	122	PF00069	0.413
MOD_CK2_1	8	14	PF00069	0.676
MOD_GlcNHglycan	10	13	PF01048	0.475
MOD_GlcNHglycan	127	130	PF01048	0.158
MOD_GlcNHglycan	162	165	PF01048	0.297
MOD_GlcNHglycan	48	51	PF01048	0.365
MOD_GlcNHglycan	94	97	PF01048	0.329
MOD_GSK3_1	112	119	PF00069	0.460
MOD_GSK3_1	135	142	PF00069	0.413
MOD_GSK3_1	152	159	PF00069	0.413
MOD_GSK3_1	231	238	PF00069	0.439
MOD_GSK3_1	254	261	PF00069	0.537
MOD_GSK3_1	4	11	PF00069	0.614
MOD_N-GLC_1	160	165	PF02516	0.257
MOD_NEK2_1	116	121	PF00069	0.442
MOD_NEK2_1	135	140	PF00069	0.507
MOD_NEK2_1	152	157	PF00069	0.413
MOD_NEK2_1	181	186	PF00069	0.413
MOD_NEK2_1	231	236	PF00069	0.456
MOD_NEK2_1	245	250	PF00069	0.456
MOD_NEK2_1	258	263	PF00069	0.425
MOD_NEK2_1	48	53	PF00069	0.291
MOD_OFUCOSY	56	62	PF10250	0.355
MOD_PIKK_1	123	129	PF00454	0.358
MOD_Plk_1	140	146	PF00069	0.381
MOD_Plk_1	231	237	PF00069	0.413
MOD_Plk_4	112	118	PF00069	0.473
MOD_Plk_4	152	158	PF00069	0.413
MOD_Plk_4	181	187	PF00069	0.459
MOD_Plk_4	254	260	PF00069	0.430
MOD_Plk_4	4	10	PF00069	0.629
MOD_Plk_4	49	55	PF00069	0.297
MOD_ProDKin_1	104	110	PF00069	0.413
MOD_ProDKin_1	216	222	PF00069	0.430
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.413
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.524
TRG_ENDOCYTIC_2	154	157	PF00928	0.457
TRG_ENDOCYTIC_2	65	68	PF00928	0.326
TRG_ER_diArg_1	24	26	PF00400	0.486
TRG_LysEnd_GGAAcLL_1	271	277	PF00790	0.543
TRG_NLS_Bipartite_1	25	43	PF00514	0.545
TRG_NLS_MonoCore_2	37	42	PF00514	0.522
TRG_NLS_MonoExtC_3	38	44	PF00514	0.513
TRG_NLS_MonoExtN_4	38	43	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L1	Leptomonas seymouri	78%	100%
A0A1X0NXG4	Trypanosomatidae	57%	96%
A0A3Q8IBV2	Leishmania donovani	86%	100%
A4HZ43	Leishmania infantum	86%	100%
A5PLL7	Homo sapiens	39%	100%
A6QLM0	Bos taurus	37%	100%
D0A1P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	93%
E9AV11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O04584	Arabidopsis thaliana	28%	94%
O81006	Arabidopsis thaliana	31%	99%
Q4QCH1	Leishmania major	87%	100%
Q5UR78	Acanthamoeba polyphaga mimivirus	30%	100%
Q99LQ7	Mus musculus	38%	100%
Q9AE87	Myxococcus xanthus	32%	99%
Q9SZ42	Arabidopsis thaliana	31%	86%
V5B0L9	Trypanosoma cruzi	59%	100%