NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBP1_LEIBR

TriTrypDb:

LbrM.21.0490 , LBRM2903_210009400

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HBP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.440
CLV_NRD_NRD_1	173	175	PF00675	0.497
CLV_NRD_NRD_1	181	183	PF00675	0.498
CLV_NRD_NRD_1	261	263	PF00675	0.741
CLV_NRD_NRD_1	270	272	PF00675	0.839
CLV_NRD_NRD_1	285	287	PF00675	0.641
CLV_NRD_NRD_1	315	317	PF00675	0.738
CLV_NRD_NRD_1	338	340	PF00675	0.739
CLV_NRD_NRD_1	342	344	PF00675	0.553
CLV_NRD_NRD_1	85	87	PF00675	0.433
CLV_PCSK_KEX2_1	117	119	PF00082	0.440
CLV_PCSK_KEX2_1	173	175	PF00082	0.521
CLV_PCSK_KEX2_1	181	183	PF00082	0.501
CLV_PCSK_KEX2_1	308	310	PF00082	0.603
CLV_PCSK_KEX2_1	342	344	PF00082	0.699
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.603
CLV_PCSK_SKI1_1	117	121	PF00082	0.422
CLV_PCSK_SKI1_1	182	186	PF00082	0.556
CLV_PCSK_SKI1_1	358	362	PF00082	0.462
CLV_PCSK_SKI1_1	378	382	PF00082	0.583
CLV_PCSK_SKI1_1	406	410	PF00082	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.551
DOC_ANK_TNKS_1	301	308	PF00023	0.745
DOC_CYCLIN_RxL_1	179	186	PF00134	0.548
DOC_CYCLIN_RxL_1	403	410	PF00134	0.512
DOC_MAPK_gen_1	114	123	PF00069	0.432
DOC_MAPK_gen_1	181	187	PF00069	0.551
DOC_MAPK_gen_1	86	93	PF00069	0.427
DOC_MAPK_MEF2A_6	114	123	PF00069	0.465
DOC_PP1_RVXF_1	376	383	PF00149	0.523
DOC_PP2B_LxvP_1	354	357	PF13499	0.486
DOC_PP4_FxxP_1	374	377	PF00568	0.363
DOC_USP7_MATH_1	208	212	PF00917	0.678
DOC_USP7_MATH_1	222	226	PF00917	0.760
DOC_USP7_MATH_1	264	268	PF00917	0.725
DOC_USP7_MATH_1	298	302	PF00917	0.714
DOC_USP7_MATH_1	320	324	PF00917	0.712
DOC_USP7_MATH_1	41	45	PF00917	0.471
DOC_WW_Pin1_4	296	301	PF00397	0.740
DOC_WW_Pin1_4	325	330	PF00397	0.706
LIG_14-3-3_CanoR_1	132	137	PF00244	0.465
LIG_14-3-3_CanoR_1	50	56	PF00244	0.453
LIG_BRCT_BRCA1_1	370	374	PF00533	0.540
LIG_CaM_IQ_9	184	199	PF13499	0.560
LIG_FHA_1	133	139	PF00498	0.440
LIG_FHA_1	207	213	PF00498	0.640
LIG_FHA_1	346	352	PF00498	0.580
LIG_FHA_1	93	99	PF00498	0.474
LIG_FHA_2	52	58	PF00498	0.457
LIG_LIR_Apic_2	371	377	PF02991	0.381
LIG_LIR_Gen_1	140	146	PF02991	0.474
LIG_LIR_Gen_1	32	41	PF02991	0.502
LIG_LIR_Gen_1	401	411	PF02991	0.369
LIG_LIR_Gen_1	49	58	PF02991	0.463
LIG_LIR_Nem_3	115	119	PF02991	0.506
LIG_LIR_Nem_3	140	145	PF02991	0.413
LIG_LIR_Nem_3	24	29	PF02991	0.459
LIG_LIR_Nem_3	32	37	PF02991	0.435
LIG_LIR_Nem_3	49	55	PF02991	0.579
LIG_Pex14_2	120	124	PF04695	0.368
LIG_Rb_pABgroove_1	41	49	PF01858	0.465
LIG_SH2_CRK	116	120	PF00017	0.458
LIG_SH2_CRK	52	56	PF00017	0.481
LIG_SH2_STAP1	31	35	PF00017	0.446
LIG_SH2_STAT5	112	115	PF00017	0.433
LIG_SH2_STAT5	142	145	PF00017	0.414
LIG_SH2_STAT5	168	171	PF00017	0.544
LIG_SH3_2	246	251	PF14604	0.704
LIG_SH3_3	243	249	PF00018	0.707
LIG_SH3_3	270	276	PF00018	0.637
LIG_SH3_3	93	99	PF00018	0.474
LIG_SUMO_SIM_par_1	89	95	PF11976	0.491
LIG_TRFH_1	124	128	PF08558	0.390
LIG_UBA3_1	351	359	PF00899	0.460
MOD_CDC14_SPxK_1	299	302	PF00782	0.734
MOD_CDK_SPxK_1	296	302	PF00069	0.740
MOD_CK1_1	345	351	PF00069	0.596
MOD_CK1_1	51	57	PF00069	0.385
MOD_CK2_1	145	151	PF00069	0.509
MOD_CK2_1	264	270	PF00069	0.591
MOD_CK2_1	300	306	PF00069	0.698
MOD_CK2_1	392	398	PF00069	0.513
MOD_Cter_Amidation	306	309	PF01082	0.750
MOD_GlcNHglycan	224	227	PF01048	0.777
MOD_GlcNHglycan	322	325	PF01048	0.591
MOD_GlcNHglycan	344	347	PF01048	0.658
MOD_GlcNHglycan	386	389	PF01048	0.455
MOD_GlcNHglycan	394	397	PF01048	0.444
MOD_GSK3_1	126	133	PF00069	0.476
MOD_GSK3_1	18	25	PF00069	0.486
MOD_GSK3_1	296	303	PF00069	0.594
MOD_GSK3_1	325	332	PF00069	0.731
MOD_GSK3_1	368	375	PF00069	0.530
MOD_GSK3_1	6	13	PF00069	0.577
MOD_NEK2_1	169	174	PF00069	0.549
MOD_NEK2_1	392	397	PF00069	0.388
MOD_NEK2_1	407	412	PF00069	0.380
MOD_NEK2_1	79	84	PF00069	0.508
MOD_PIKK_1	230	236	PF00454	0.588
MOD_PIKK_1	368	374	PF00454	0.531
MOD_PKA_1	342	348	PF00069	0.643
MOD_PKA_2	264	270	PF00069	0.662
MOD_PKA_2	342	348	PF00069	0.624
MOD_PKA_2	384	390	PF00069	0.527
MOD_PKA_2	41	47	PF00069	0.461
MOD_Plk_1	48	54	PF00069	0.406
MOD_Plk_1	79	85	PF00069	0.478
MOD_Plk_2-3	89	95	PF00069	0.491
MOD_Plk_4	22	28	PF00069	0.472
MOD_Plk_4	51	57	PF00069	0.391
MOD_ProDKin_1	296	302	PF00069	0.740
MOD_ProDKin_1	325	331	PF00069	0.705
MOD_SUMO_for_1	365	368	PF00179	0.521
MOD_SUMO_rev_2	257	264	PF00179	0.610
MOD_SUMO_rev_2	266	273	PF00179	0.762
MOD_SUMO_rev_2	281	288	PF00179	0.780
MOD_SUMO_rev_2	290	296	PF00179	0.685
MOD_SUMO_rev_2	332	341	PF00179	0.645
MOD_SUMO_rev_2	363	367	PF00179	0.520
MOD_SUMO_rev_2	371	380	PF00179	0.521
TRG_ENDOCYTIC_2	116	119	PF00928	0.469
TRG_ENDOCYTIC_2	142	145	PF00928	0.414
TRG_ENDOCYTIC_2	31	34	PF00928	0.424
TRG_ENDOCYTIC_2	52	55	PF00928	0.448
TRG_ER_diArg_1	116	118	PF00400	0.470
TRG_ER_diArg_1	190	193	PF00400	0.546
TRG_ER_diArg_1	341	343	PF00400	0.832
TRG_NLS_Bipartite_1	342	362	PF00514	0.564
TRG_NLS_MonoExtN_4	355	362	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P850	Leptomonas seymouri	57%	89%
A0A3Q8IBY3	Leishmania donovani	82%	100%
A0A422MZN2	Trypanosoma rangeli	33%	86%
A4HZ42	Leishmania infantum	83%	100%
E9AV10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCH2	Leishmania major	81%	94%