Ferredoxin NADP+ reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADPH:adrenodoxin oxidoreductase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4HBP0_LEIBR

TriTrypDb:

LbrM.21.0480 , LBRM2903_210009300

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004324	ferredoxin-NADP+ reductase activity	6	5
GO:0008937	ferredoxin-NAD(P) reductase activity	5	5
GO:0016491	oxidoreductase activity	2	10
GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors	3	7
GO:0016731	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	4	7
GO:0015039	NADPH-adrenodoxin reductase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.425
CLV_C14_Caspase3-7	498	502	PF00656	0.401
CLV_C14_Caspase3-7	539	543	PF00656	0.451
CLV_NRD_NRD_1	272	274	PF00675	0.400
CLV_NRD_NRD_1	427	429	PF00675	0.494
CLV_NRD_NRD_1	75	77	PF00675	0.489
CLV_PCSK_FUR_1	219	223	PF00082	0.496
CLV_PCSK_KEX2_1	221	223	PF00082	0.459
CLV_PCSK_KEX2_1	272	274	PF00082	0.400
CLV_PCSK_KEX2_1	322	324	PF00082	0.420
CLV_PCSK_KEX2_1	74	76	PF00082	0.536
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.459
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.420
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.599
CLV_PCSK_SKI1_1	286	290	PF00082	0.388
CLV_PCSK_SKI1_1	621	625	PF00082	0.416
CLV_PCSK_SKI1_1	641	645	PF00082	0.612
CLV_PCSK_SKI1_1	655	659	PF00082	0.555
DEG_APCC_DBOX_1	395	403	PF00400	0.394
DEG_Nend_UBRbox_4	1	3	PF02207	0.443
DEG_SCF_FBW7_1	643	648	PF00400	0.662
DEG_SPOP_SBC_1	536	540	PF00917	0.681
DOC_ANK_TNKS_1	221	228	PF00023	0.470
DOC_CYCLIN_RxL_1	19	27	PF00134	0.440
DOC_CYCLIN_RxL_1	652	662	PF00134	0.617
DOC_CYCLIN_yClb1_LxF_4	390	395	PF00134	0.265
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.311
DOC_MAPK_DCC_7	394	404	PF00069	0.397
DOC_MAPK_gen_1	219	226	PF00069	0.478
DOC_MAPK_gen_1	290	300	PF00069	0.275
DOC_MAPK_gen_1	319	327	PF00069	0.443
DOC_MAPK_gen_1	385	395	PF00069	0.416
DOC_MAPK_gen_1	586	593	PF00069	0.384
DOC_MAPK_gen_1	74	81	PF00069	0.440
DOC_MAPK_gen_1	97	106	PF00069	0.295
DOC_MAPK_MEF2A_6	293	300	PF00069	0.273
DOC_MAPK_MEF2A_6	621	628	PF00069	0.412
DOC_MAPK_MEF2A_6	74	81	PF00069	0.526
DOC_MAPK_MEF2A_6	97	106	PF00069	0.295
DOC_PP1_RVXF_1	13	19	PF00149	0.448
DOC_PP1_RVXF_1	141	147	PF00149	0.371
DOC_PP1_RVXF_1	390	396	PF00149	0.322
DOC_PP2B_LxvP_1	110	113	PF13499	0.311
DOC_PP2B_LxvP_1	180	183	PF13499	0.408
DOC_PP2B_LxvP_1	26	29	PF13499	0.436
DOC_USP7_MATH_1	174	178	PF00917	0.440
DOC_USP7_MATH_1	367	371	PF00917	0.669
DOC_USP7_MATH_1	47	51	PF00917	0.741
DOC_USP7_MATH_1	535	539	PF00917	0.643
DOC_USP7_MATH_1	58	62	PF00917	0.738
DOC_USP7_MATH_1	63	67	PF00917	0.722
DOC_USP7_MATH_1	645	649	PF00917	0.632
DOC_USP7_MATH_1	684	688	PF00917	0.641
DOC_USP7_UBL2_3	257	261	PF12436	0.503
DOC_USP7_UBL2_3	293	297	PF12436	0.448
DOC_USP7_UBL2_3	472	476	PF12436	0.506
DOC_USP7_UBL2_3	488	492	PF12436	0.263
DOC_USP7_UBL2_3	612	616	PF12436	0.396
DOC_WW_Pin1_4	119	124	PF00397	0.428
DOC_WW_Pin1_4	206	211	PF00397	0.448
DOC_WW_Pin1_4	362	367	PF00397	0.723
DOC_WW_Pin1_4	397	402	PF00397	0.450
DOC_WW_Pin1_4	641	646	PF00397	0.666
LIG_14-3-3_CanoR_1	143	147	PF00244	0.351
LIG_14-3-3_CanoR_1	244	254	PF00244	0.370
LIG_BIR_III_2	545	549	PF00653	0.472
LIG_BIR_III_4	348	352	PF00653	0.663
LIG_BIR_III_4	433	437	PF00653	0.347
LIG_BRCT_BRCA1_1	208	212	PF00533	0.458
LIG_BRCT_BRCA1_1	86	90	PF00533	0.418
LIG_CtBP_PxDLS_1	607	612	PF00389	0.433
LIG_eIF4E_1	413	419	PF01652	0.517
LIG_FHA_1	21	27	PF00498	0.710
LIG_FHA_1	3	9	PF00498	0.540
LIG_FHA_1	569	575	PF00498	0.425
LIG_FHA_1	583	589	PF00498	0.500
LIG_FHA_2	170	176	PF00498	0.401
LIG_FHA_2	332	338	PF00498	0.496
LIG_FHA_2	372	378	PF00498	0.763
LIG_FHA_2	420	426	PF00498	0.545
LIG_FHA_2	617	623	PF00498	0.511
LIG_HP1_1	548	552	PF01393	0.481
LIG_LIR_Apic_2	17	21	PF02991	0.445
LIG_LIR_Gen_1	105	114	PF02991	0.295
LIG_LIR_Gen_1	198	207	PF02991	0.464
LIG_LIR_Gen_1	435	445	PF02991	0.486
LIG_LIR_Nem_3	105	110	PF02991	0.311
LIG_LIR_Nem_3	195	199	PF02991	0.326
LIG_LIR_Nem_3	209	215	PF02991	0.411
LIG_LIR_Nem_3	242	246	PF02991	0.382
LIG_LIR_Nem_3	282	288	PF02991	0.387
LIG_LIR_Nem_3	299	305	PF02991	0.396
LIG_LIR_Nem_3	435	440	PF02991	0.482
LIG_NRBOX	653	659	PF00104	0.499
LIG_SH2_CRK	165	169	PF00017	0.317
LIG_SH2_CRK	200	204	PF00017	0.434
LIG_SH2_CRK	207	211	PF00017	0.500
LIG_SH2_CRK	437	441	PF00017	0.519
LIG_SH2_GRB2like	199	202	PF00017	0.330
LIG_SH2_STAP1	165	169	PF00017	0.317
LIG_SH2_STAT5	245	248	PF00017	0.390
LIG_SH2_STAT5	302	305	PF00017	0.404
LIG_SH2_STAT5	413	416	PF00017	0.498
LIG_SH2_STAT5	437	440	PF00017	0.467
LIG_SH2_STAT5	482	485	PF00017	0.335
LIG_SH2_STAT5	582	585	PF00017	0.412
LIG_SH2_STAT5	653	656	PF00017	0.498
LIG_SH2_STAT5	94	97	PF00017	0.195
LIG_SH3_3	120	126	PF00018	0.295
LIG_SH3_3	349	355	PF00018	0.595
LIG_SH3_3	363	369	PF00018	0.648
LIG_SH3_3	516	522	PF00018	0.601
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.476
LIG_SUMO_SIM_anti_2	400	407	PF11976	0.493
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.733
LIG_SUMO_SIM_par_1	22	27	PF11976	0.564
LIG_SUMO_SIM_par_1	4	9	PF11976	0.433
LIG_SUMO_SIM_par_1	547	553	PF11976	0.617
LIG_TRAF2_1	334	337	PF00917	0.586
LIG_TRFH_1	397	401	PF08558	0.395
LIG_TYR_ITIM	300	305	PF00017	0.256
LIG_UBA3_1	651	655	PF00899	0.636
LIG_WRC_WIRS_1	551	556	PF05994	0.736
MOD_CDK_SPxK_1	641	647	PF00069	0.671
MOD_CK1_1	192	198	PF00069	0.446
MOD_CK1_1	335	341	PF00069	0.579
MOD_CK1_1	40	46	PF00069	0.705
MOD_CK1_1	553	559	PF00069	0.668
MOD_CK1_1	56	62	PF00069	0.673
MOD_CK1_1	84	90	PF00069	0.295
MOD_CK2_1	192	198	PF00069	0.459
MOD_CK2_1	331	337	PF00069	0.522
MOD_CK2_1	362	368	PF00069	0.680
MOD_CK2_1	371	377	PF00069	0.650
MOD_CK2_1	419	425	PF00069	0.544
MOD_CK2_1	47	53	PF00069	0.677
MOD_Cter_Amidation	610	613	PF01082	0.443
MOD_Cter_Amidation	632	635	PF01082	0.520
MOD_GlcNHglycan	191	194	PF01048	0.408
MOD_GlcNHglycan	26	29	PF01048	0.697
MOD_GlcNHglycan	276	280	PF01048	0.382
MOD_GlcNHglycan	368	372	PF01048	0.734
MOD_GlcNHglycan	539	542	PF01048	0.677
MOD_GlcNHglycan	555	558	PF01048	0.710
MOD_GlcNHglycan	56	59	PF01048	0.683
MOD_GlcNHglycan	60	63	PF01048	0.636
MOD_GlcNHglycan	83	86	PF01048	0.313
MOD_GSK3_1	2	9	PF00069	0.574
MOD_GSK3_1	20	27	PF00069	0.671
MOD_GSK3_1	275	282	PF00069	0.465
MOD_GSK3_1	32	39	PF00069	0.691
MOD_GSK3_1	331	338	PF00069	0.556
MOD_GSK3_1	358	365	PF00069	0.677
MOD_GSK3_1	367	374	PF00069	0.617
MOD_GSK3_1	49	56	PF00069	0.686
MOD_GSK3_1	553	560	PF00069	0.681
MOD_GSK3_1	63	70	PF00069	0.628
MOD_GSK3_1	641	648	PF00069	0.643
MOD_N-GLC_1	148	153	PF02516	0.410
MOD_N-GLC_1	397	402	PF02516	0.485
MOD_N-GLC_1	40	45	PF02516	0.705
MOD_N-GLC_1	53	58	PF02516	0.724
MOD_N-GLC_1	557	562	PF02516	0.686
MOD_NEK2_1	217	222	PF00069	0.530
MOD_NEK2_1	239	244	PF00069	0.355
MOD_NEK2_1	24	29	PF00069	0.655
MOD_NEK2_1	419	424	PF00069	0.507
MOD_NEK2_1	444	449	PF00069	0.417
MOD_NEK2_1	6	11	PF00069	0.444
MOD_NEK2_1	90	95	PF00069	0.381
MOD_PIKK_1	677	683	PF00454	0.407
MOD_PK_1	452	458	PF00069	0.456
MOD_PKA_2	142	148	PF00069	0.357
MOD_PKA_2	536	542	PF00069	0.562
MOD_Plk_1	148	154	PF00069	0.405
MOD_Plk_1	275	281	PF00069	0.421
MOD_Plk_4	142	148	PF00069	0.363
MOD_Plk_4	495	501	PF00069	0.429
MOD_Plk_4	505	511	PF00069	0.349
MOD_Plk_4	569	575	PF00069	0.557
MOD_Plk_4	90	96	PF00069	0.175
MOD_ProDKin_1	119	125	PF00069	0.428
MOD_ProDKin_1	206	212	PF00069	0.451
MOD_ProDKin_1	362	368	PF00069	0.725
MOD_ProDKin_1	397	403	PF00069	0.449
MOD_ProDKin_1	641	647	PF00069	0.667
MOD_SUMO_for_1	296	299	PF00179	0.473
TRG_ENDOCYTIC_2	165	168	PF00928	0.319
TRG_ENDOCYTIC_2	200	203	PF00928	0.454
TRG_ENDOCYTIC_2	243	246	PF00928	0.386
TRG_ENDOCYTIC_2	302	305	PF00928	0.404
TRG_ENDOCYTIC_2	437	440	PF00928	0.509
TRG_ENDOCYTIC_2	577	580	PF00928	0.374
TRG_ER_diArg_1	392	395	PF00400	0.484
TRG_ER_diArg_1	75	77	PF00400	0.541
TRG_NLS_MonoExtN_4	73	78	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ8	Leptomonas seymouri	64%	98%
A0A0S4J2F1	Bodo saltans	43%	100%
A0A1X0NYU3	Trypanosomatidae	50%	100%
A0A3S5H794	Leishmania donovani	85%	99%
A0A422MZJ3	Trypanosoma rangeli	48%	100%
A4HZ41	Leishmania infantum	85%	99%
D0A1P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AV09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
O33064	Mycobacterium leprae (strain TN)	29%	100%
P48360	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P56522	Rattus norvegicus	33%	100%
P65529	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P82861	Salvelinus fontinalis	30%	100%
P9WJI0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WJI1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q4QCH3	Leishmania major	84%	100%
Q54KG7	Dictyostelium discoideum	28%	100%
Q61578	Mus musculus	32%	100%
Q9V3T9	Drosophila melanogaster	30%	100%
V5BQ55	Trypanosoma cruzi	52%	100%