Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBN8_LEIBR

TriTrypDb:

LbrM.21.0460 , LBRM2903_210009100

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	10
GO:0019538	protein metabolic process	3	10
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	10
GO:0070647	protein modification by small protein conjugation or removal	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004843	cysteine-type deubiquitinase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008234	cysteine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0019783	ubiquitin-like protein peptidase activity	4	10
GO:0101005	deubiquitinase activity	5	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.700
CLV_C14_Caspase3-7	638	642	PF00656	0.418
CLV_NRD_NRD_1	173	175	PF00675	0.728
CLV_NRD_NRD_1	616	618	PF00675	0.316
CLV_NRD_NRD_1	632	634	PF00675	0.210
CLV_NRD_NRD_1	655	657	PF00675	0.411
CLV_NRD_NRD_1	698	700	PF00675	0.421
CLV_PCSK_KEX2_1	173	175	PF00082	0.729
CLV_PCSK_KEX2_1	220	222	PF00082	0.703
CLV_PCSK_KEX2_1	570	572	PF00082	0.321
CLV_PCSK_KEX2_1	616	618	PF00082	0.316
CLV_PCSK_KEX2_1	632	634	PF00082	0.210
CLV_PCSK_KEX2_1	655	657	PF00082	0.463
CLV_PCSK_KEX2_1	698	700	PF00082	0.421
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.703
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.322
CLV_PCSK_SKI1_1	359	363	PF00082	0.351
CLV_PCSK_SKI1_1	550	554	PF00082	0.421
CLV_PCSK_SKI1_1	578	582	PF00082	0.424
CLV_PCSK_SKI1_1	711	715	PF00082	0.464
DEG_APCC_DBOX_1	308	316	PF00400	0.346
DEG_APCC_DBOX_1	654	662	PF00400	0.421
DEG_SPOP_SBC_1	66	70	PF00917	0.480
DOC_CKS1_1	192	197	PF01111	0.587
DOC_CKS1_1	229	234	PF01111	0.493
DOC_MAPK_gen_1	583	590	PF00069	0.328
DOC_MAPK_HePTP_8	501	513	PF00069	0.421
DOC_MAPK_HePTP_8	580	592	PF00069	0.424
DOC_MAPK_MEF2A_6	504	513	PF00069	0.326
DOC_MAPK_MEF2A_6	583	592	PF00069	0.421
DOC_MAPK_RevD_3	555	571	PF00069	0.322
DOC_PP2B_LxvP_1	162	165	PF13499	0.634
DOC_PP4_FxxP_1	528	531	PF00568	0.346
DOC_PP4_FxxP_1	717	720	PF00568	0.421
DOC_USP7_MATH_1	179	183	PF00917	0.679
DOC_USP7_MATH_1	235	239	PF00917	0.673
DOC_USP7_MATH_1	38	42	PF00917	0.616
DOC_USP7_MATH_1	455	459	PF00917	0.353
DOC_USP7_MATH_1	5	9	PF00917	0.643
DOC_USP7_MATH_1	67	71	PF00917	0.644
DOC_USP7_MATH_1	89	93	PF00917	0.679
DOC_USP7_UBL2_3	359	363	PF12436	0.411
DOC_WW_Pin1_4	164	169	PF00397	0.686
DOC_WW_Pin1_4	191	196	PF00397	0.668
DOC_WW_Pin1_4	202	207	PF00397	0.632
DOC_WW_Pin1_4	225	230	PF00397	0.652
DOC_WW_Pin1_4	303	308	PF00397	0.208
DOC_WW_Pin1_4	476	481	PF00397	0.346
DOC_WW_Pin1_4	50	55	PF00397	0.701
DOC_WW_Pin1_4	640	645	PF00397	0.382
DOC_WW_Pin1_4	85	90	PF00397	0.690
LIG_14-3-3_CanoR_1	144	150	PF00244	0.554
LIG_14-3-3_CanoR_1	212	217	PF00244	0.591
LIG_14-3-3_CanoR_1	264	272	PF00244	0.480
LIG_APCC_ABBAyCdc20_2	504	510	PF00400	0.421
LIG_BIR_III_4	248	252	PF00653	0.482
LIG_BIR_III_4	722	726	PF00653	0.421
LIG_BRCT_BRCA1_1	240	244	PF00533	0.497
LIG_CaM_IQ_9	569	585	PF13499	0.401
LIG_FHA_1	272	278	PF00498	0.560
LIG_FHA_1	360	366	PF00498	0.316
LIG_FHA_1	386	392	PF00498	0.378
LIG_FHA_1	491	497	PF00498	0.363
LIG_FHA_1	552	558	PF00498	0.415
LIG_FHA_1	669	675	PF00498	0.421
LIG_FHA_1	728	734	PF00498	0.310
LIG_FHA_1	76	82	PF00498	0.714
LIG_FHA_1	85	91	PF00498	0.764
LIG_FHA_2	194	200	PF00498	0.701
LIG_FHA_2	460	466	PF00498	0.287
LIG_FHA_2	500	506	PF00498	0.380
LIG_FHA_2	599	605	PF00498	0.421
LIG_FHA_2	636	642	PF00498	0.287
LIG_FHA_2	705	711	PF00498	0.356
LIG_LIR_Apic_2	112	118	PF02991	0.671
LIG_LIR_Apic_2	526	531	PF02991	0.378
LIG_LIR_Gen_1	238	247	PF02991	0.476
LIG_LIR_Gen_1	274	284	PF02991	0.475
LIG_LIR_Gen_1	386	395	PF02991	0.322
LIG_LIR_Gen_1	505	513	PF02991	0.325
LIG_LIR_Gen_1	730	740	PF02991	0.321
LIG_LIR_Nem_3	238	242	PF02991	0.479
LIG_LIR_Nem_3	274	279	PF02991	0.515
LIG_LIR_Nem_3	386	390	PF02991	0.322
LIG_LIR_Nem_3	505	511	PF02991	0.347
LIG_LIR_Nem_3	730	735	PF02991	0.321
LIG_PCNA_PIPBox_1	593	602	PF02747	0.421
LIG_SH2_CRK	115	119	PF00017	0.676
LIG_SH2_CRK	563	567	PF00017	0.322
LIG_SH2_NCK_1	736	740	PF00017	0.377
LIG_SH2_PTP2	732	735	PF00017	0.346
LIG_SH2_SRC	107	110	PF00017	0.675
LIG_SH2_STAP1	415	419	PF00017	0.307
LIG_SH2_STAP1	563	567	PF00017	0.322
LIG_SH2_STAP1	736	740	PF00017	0.377
LIG_SH2_STAT3	692	695	PF00017	0.416
LIG_SH2_STAT5	107	110	PF00017	0.675
LIG_SH2_STAT5	115	118	PF00017	0.674
LIG_SH2_STAT5	294	297	PF00017	0.343
LIG_SH2_STAT5	319	322	PF00017	0.463
LIG_SH2_STAT5	533	536	PF00017	0.393
LIG_SH2_STAT5	599	602	PF00017	0.378
LIG_SH2_STAT5	686	689	PF00017	0.319
LIG_SH2_STAT5	716	719	PF00017	0.398
LIG_SH2_STAT5	732	735	PF00017	0.183
LIG_SH3_2	168	173	PF14604	0.771
LIG_SH3_3	162	168	PF00018	0.656
LIG_SH3_3	189	195	PF00018	0.635
LIG_SH3_3	226	232	PF00018	0.716
LIG_SH3_3	48	54	PF00018	0.488
LIG_SH3_3	585	591	PF00018	0.378
LIG_SUMO_SIM_par_1	182	189	PF11976	0.678
LIG_TRAF2_1	650	653	PF00917	0.414
LIG_TYR_ITIM	734	739	PF00017	0.330
LIG_UBA3_1	340	346	PF00899	0.322
LIG_UBA3_1	565	570	PF00899	0.322
LIG_WRC_WIRS_1	153	158	PF05994	0.496
LIG_WRC_WIRS_1	239	244	PF05994	0.475
LIG_WRC_WIRS_1	424	429	PF05994	0.210
LIG_WRC_WIRS_1	97	102	PF05994	0.490
MOD_CDC14_SPxK_1	170	173	PF00782	0.774
MOD_CDC14_SPxK_1	88	91	PF00782	0.496
MOD_CDK_SPxK_1	167	173	PF00069	0.770
MOD_CDK_SPxK_1	303	309	PF00069	0.208
MOD_CDK_SPxK_1	85	91	PF00069	0.628
MOD_CDK_SPxxK_3	167	174	PF00069	0.773
MOD_CDK_SPxxK_3	202	209	PF00069	0.610
MOD_CK1_1	128	134	PF00069	0.682
MOD_CK1_1	155	161	PF00069	0.693
MOD_CK1_1	167	173	PF00069	0.638
MOD_CK1_1	202	208	PF00069	0.613
MOD_CK1_1	228	234	PF00069	0.646
MOD_CK1_1	238	244	PF00069	0.580
MOD_CK1_1	258	264	PF00069	0.673
MOD_CK1_1	265	271	PF00069	0.608
MOD_CK1_1	425	431	PF00069	0.308
MOD_CK1_1	436	442	PF00069	0.375
MOD_CK1_1	512	518	PF00069	0.404
MOD_CK1_1	53	59	PF00069	0.545
MOD_CK1_1	643	649	PF00069	0.366
MOD_CK1_1	68	74	PF00069	0.597
MOD_CK1_1	8	14	PF00069	0.711
MOD_CK1_1	84	90	PF00069	0.602
MOD_CK2_1	193	199	PF00069	0.692
MOD_CK2_1	323	329	PF00069	0.351
MOD_CK2_1	598	604	PF00069	0.404
MOD_CK2_1	704	710	PF00069	0.358
MOD_GlcNHglycan	130	133	PF01048	0.760
MOD_GlcNHglycan	29	32	PF01048	0.765
MOD_GlcNHglycan	325	328	PF01048	0.365
MOD_GlcNHglycan	474	477	PF01048	0.384
MOD_GlcNHglycan	682	685	PF01048	0.371
MOD_GlcNHglycan	83	86	PF01048	0.713
MOD_GlcNHglycan	93	96	PF01048	0.591
MOD_GSK3_1	109	116	PF00069	0.590
MOD_GSK3_1	151	158	PF00069	0.627
MOD_GSK3_1	163	170	PF00069	0.645
MOD_GSK3_1	212	219	PF00069	0.598
MOD_GSK3_1	251	258	PF00069	0.620
MOD_GSK3_1	260	267	PF00069	0.583
MOD_GSK3_1	27	34	PF00069	0.492
MOD_GSK3_1	344	351	PF00069	0.443
MOD_GSK3_1	425	432	PF00069	0.347
MOD_GSK3_1	438	445	PF00069	0.234
MOD_GSK3_1	455	462	PF00069	0.332
MOD_GSK3_1	472	479	PF00069	0.409
MOD_GSK3_1	512	519	PF00069	0.451
MOD_GSK3_1	635	642	PF00069	0.369
MOD_GSK3_1	8	15	PF00069	0.674
MOD_GSK3_1	81	88	PF00069	0.702
MOD_GSK3_1	96	103	PF00069	0.654
MOD_LATS_1	218	224	PF00433	0.490
MOD_LATS_1	431	437	PF00433	0.316
MOD_N-GLC_1	126	131	PF02516	0.549
MOD_N-GLC_1	179	184	PF02516	0.761
MOD_N-GLC_1	348	353	PF02516	0.421
MOD_N-GLC_1	499	504	PF02516	0.378
MOD_N-GLC_1	619	624	PF02516	0.261
MOD_NEK2_1	100	105	PF00069	0.620
MOD_NEK2_1	113	118	PF00069	0.705
MOD_NEK2_1	126	131	PF00069	0.531
MOD_NEK2_1	151	156	PF00069	0.760
MOD_NEK2_1	201	206	PF00069	0.661
MOD_NEK2_1	216	221	PF00069	0.526
MOD_NEK2_1	24	29	PF00069	0.514
MOD_NEK2_1	255	260	PF00069	0.739
MOD_NEK2_1	277	282	PF00069	0.516
MOD_NEK2_1	344	349	PF00069	0.421
MOD_NEK2_1	447	452	PF00069	0.389
MOD_NEK2_1	668	673	PF00069	0.308
MOD_NEK2_1	90	95	PF00069	0.601
MOD_NEK2_2	289	294	PF00069	0.322
MOD_NEK2_2	415	420	PF00069	0.307
MOD_NEK2_2	551	556	PF00069	0.409
MOD_NMyristoyl	1	7	PF02799	0.620
MOD_PIKK_1	135	141	PF00454	0.733
MOD_PIKK_1	145	151	PF00454	0.706
MOD_PIKK_1	438	444	PF00454	0.312
MOD_PK_1	433	439	PF00069	0.210
MOD_PKA_1	220	226	PF00069	0.500
MOD_PKA_2	220	226	PF00069	0.500
MOD_PKA_2	263	269	PF00069	0.495
MOD_PKA_2	8	14	PF00069	0.743
MOD_Plk_1	24	30	PF00069	0.516
MOD_Plk_1	329	335	PF00069	0.337
MOD_Plk_1	385	391	PF00069	0.382
MOD_Plk_1	415	421	PF00069	0.440
MOD_Plk_1	433	439	PF00069	0.199
MOD_Plk_1	509	515	PF00069	0.333
MOD_Plk_1	606	612	PF00069	0.424
MOD_Plk_1	701	707	PF00069	0.346
MOD_Plk_2-3	598	604	PF00069	0.421
MOD_Plk_4	109	115	PF00069	0.669
MOD_Plk_4	294	300	PF00069	0.421
MOD_Plk_4	329	335	PF00069	0.322
MOD_Plk_4	517	523	PF00069	0.355
MOD_Plk_4	704	710	PF00069	0.321
MOD_ProDKin_1	164	170	PF00069	0.688
MOD_ProDKin_1	191	197	PF00069	0.671
MOD_ProDKin_1	202	208	PF00069	0.626
MOD_ProDKin_1	225	231	PF00069	0.651
MOD_ProDKin_1	303	309	PF00069	0.208
MOD_ProDKin_1	476	482	PF00069	0.346
MOD_ProDKin_1	50	56	PF00069	0.700
MOD_ProDKin_1	640	646	PF00069	0.382
MOD_ProDKin_1	85	91	PF00069	0.693
MOD_SUMO_rev_2	103	113	PF00179	0.719
MOD_SUMO_rev_2	543	548	PF00179	0.451
TRG_DiLeu_BaEn_2	385	391	PF01217	0.322
TRG_DiLeu_BaEn_2	668	674	PF01217	0.421
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.346
TRG_ENDOCYTIC_2	563	566	PF00928	0.322
TRG_ENDOCYTIC_2	716	719	PF00928	0.398
TRG_ENDOCYTIC_2	732	735	PF00928	0.185
TRG_ENDOCYTIC_2	736	739	PF00928	0.336
TRG_ER_diArg_1	308	311	PF00400	0.322
TRG_ER_diArg_1	654	656	PF00400	0.463
TRG_ER_diArg_1	697	699	PF00400	0.421
TRG_NLS_MonoExtN_4	655	660	PF00514	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P852	Leptomonas seymouri	65%	98%
A0A3Q8IB18	Leishmania donovani	74%	100%
A0A422MZT5	Trypanosoma rangeli	41%	100%
A4HZ39	Leishmania infantum	74%	100%
D0A1P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AV07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QCH5	Leishmania major	79%	100%
Q8IQ27	Drosophila melanogaster	23%	79%
V5DGZ8	Trypanosoma cruzi	41%	100%