PDDEXK_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBN7_LEIBR

TriTrypDb:

LbrM.21.0450 , LBRM2903_210009000

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.440
CLV_NRD_NRD_1	349	351	PF00675	0.307
CLV_PCSK_FUR_1	175	179	PF00082	0.456
CLV_PCSK_KEX2_1	177	179	PF00082	0.481
CLV_PCSK_KEX2_1	349	351	PF00082	0.307
CLV_PCSK_KEX2_1	47	49	PF00082	0.442
CLV_PCSK_KEX2_1	5	7	PF00082	0.473
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.409
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.473
CLV_PCSK_SKI1_1	240	244	PF00082	0.388
CLV_PCSK_SKI1_1	327	331	PF00082	0.443
CLV_PCSK_SKI1_1	47	51	PF00082	0.431
CLV_PCSK_SKI1_1	70	74	PF00082	0.353
CLV_PCSK_SKI1_1	85	89	PF00082	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.447
DEG_SCF_FBW7_1	262	267	PF00400	0.498
DEG_SCF_FBW7_2	281	288	PF00400	0.441
DEG_SPOP_SBC_1	117	121	PF00917	0.517
DOC_CKS1_1	202	207	PF01111	0.324
DOC_CKS1_1	282	287	PF01111	0.442
DOC_MAPK_gen_1	175	184	PF00069	0.367
DOC_MAPK_gen_1	217	227	PF00069	0.342
DOC_MAPK_MEF2A_6	220	227	PF00069	0.324
DOC_PP2B_LxvP_1	134	137	PF13499	0.438
DOC_PP4_FxxP_1	202	205	PF00568	0.346
DOC_USP7_MATH_1	10	14	PF00917	0.383
DOC_USP7_MATH_1	30	34	PF00917	0.332
DOC_USP7_UBL2_3	85	89	PF12436	0.507
DOC_WW_Pin1_4	118	123	PF00397	0.501
DOC_WW_Pin1_4	201	206	PF00397	0.348
DOC_WW_Pin1_4	251	256	PF00397	0.543
DOC_WW_Pin1_4	260	265	PF00397	0.614
DOC_WW_Pin1_4	281	286	PF00397	0.646
DOC_WW_Pin1_4	327	332	PF00397	0.495
LIG_14-3-3_CanoR_1	220	224	PF00244	0.290
LIG_14-3-3_CanoR_1	248	258	PF00244	0.617
LIG_14-3-3_CanoR_1	300	309	PF00244	0.393
LIG_Actin_RPEL_3	213	232	PF02755	0.405
LIG_APCC_ABBA_1	225	230	PF00400	0.347
LIG_APCC_Cbox_2	39	45	PF00515	0.451
LIG_BIR_III_4	111	115	PF00653	0.580
LIG_DCNL_PONY_1	1	4	PF03556	0.391
LIG_EH1_1	220	228	PF00400	0.386
LIG_EVH1_2	90	94	PF00568	0.463
LIG_FHA_1	118	124	PF00498	0.517
LIG_FHA_1	177	183	PF00498	0.428
LIG_FHA_2	119	125	PF00498	0.478
LIG_G3BP_FGDF_1	197	202	PF02136	0.481
LIG_LIR_Apic_2	201	205	PF02991	0.363
LIG_LIR_Gen_1	341	352	PF02991	0.423
LIG_LIR_Nem_3	132	138	PF02991	0.344
LIG_LIR_Nem_3	18	24	PF02991	0.368
LIG_LIR_Nem_3	308	312	PF02991	0.360
LIG_LIR_Nem_3	325	329	PF02991	0.546
LIG_LIR_Nem_3	341	347	PF02991	0.446
LIG_LIR_Nem_3	39	44	PF02991	0.447
LIG_PDZ_Class_3	352	357	PF00595	0.387
LIG_Pex14_2	17	21	PF04695	0.371
LIG_Pex14_2	238	242	PF04695	0.454
LIG_SH2_CRK	150	154	PF00017	0.379
LIG_SH2_CRK	309	313	PF00017	0.353
LIG_SH2_SRC	135	138	PF00017	0.392
LIG_SH2_STAP1	221	225	PF00017	0.324
LIG_SH2_STAT3	221	224	PF00017	0.327
LIG_SH2_STAT5	135	138	PF00017	0.426
LIG_SH2_STAT5	237	240	PF00017	0.390
LIG_SH2_STAT5	41	44	PF00017	0.435
LIG_SH3_2	265	270	PF14604	0.616
LIG_SH3_3	252	258	PF00018	0.513
LIG_SH3_3	259	265	PF00018	0.622
LIG_SH3_3	331	337	PF00018	0.493
LIG_SH3_3	87	93	PF00018	0.303
LIG_SUMO_SIM_par_1	48	54	PF11976	0.433
LIG_TYR_ITIM	226	231	PF00017	0.316
LIG_UBA3_1	1	5	PF00899	0.375
LIG_WRC_WIRS_1	199	204	PF05994	0.460
LIG_WRC_WIRS_1	295	300	PF05994	0.468
MOD_CDC14_SPxK_1	267	270	PF00782	0.490
MOD_CDK_SPxK_1	264	270	PF00069	0.495
MOD_CK1_1	201	207	PF00069	0.506
MOD_CK1_1	293	299	PF00069	0.326
MOD_CK1_1	54	60	PF00069	0.473
MOD_CK2_1	118	124	PF00069	0.517
MOD_CK2_1	286	292	PF00069	0.535
MOD_CK2_1	312	318	PF00069	0.343
MOD_CK2_1	8	14	PF00069	0.465
MOD_GlcNHglycan	10	13	PF01048	0.374
MOD_GSK3_1	186	193	PF00069	0.404
MOD_GSK3_1	215	222	PF00069	0.523
MOD_GSK3_1	247	254	PF00069	0.469
MOD_GSK3_1	26	33	PF00069	0.483
MOD_GSK3_1	260	267	PF00069	0.557
MOD_GSK3_1	286	293	PF00069	0.536
MOD_N-GLC_1	215	220	PF02516	0.302
MOD_N-GLC_1	300	305	PF02516	0.570
MOD_NEK2_1	247	252	PF00069	0.453
MOD_NEK2_1	26	31	PF00069	0.462
MOD_NEK2_1	294	299	PF00069	0.464
MOD_PIKK_1	274	280	PF00454	0.514
MOD_PKA_2	176	182	PF00069	0.443
MOD_PKA_2	219	225	PF00069	0.255
MOD_PKA_2	247	253	PF00069	0.462
MOD_PKB_1	6	14	PF00069	0.436
MOD_Plk_1	340	346	PF00069	0.446
MOD_Plk_2-3	286	292	PF00069	0.498
MOD_Plk_4	290	296	PF00069	0.473
MOD_Plk_4	330	336	PF00069	0.390
MOD_Plk_4	343	349	PF00069	0.392
MOD_ProDKin_1	118	124	PF00069	0.488
MOD_ProDKin_1	201	207	PF00069	0.341
MOD_ProDKin_1	251	257	PF00069	0.554
MOD_ProDKin_1	260	266	PF00069	0.614
MOD_ProDKin_1	281	287	PF00069	0.634
MOD_ProDKin_1	327	333	PF00069	0.494
MOD_SUMO_rev_2	319	329	PF00179	0.430
MOD_SUMO_rev_2	39	49	PF00179	0.435
MOD_SUMO_rev_2	80	87	PF00179	0.548
TRG_DiLeu_BaEn_4	131	137	PF01217	0.442
TRG_ENDOCYTIC_2	135	138	PF00928	0.332
TRG_ENDOCYTIC_2	150	153	PF00928	0.321
TRG_ENDOCYTIC_2	228	231	PF00928	0.311
TRG_ENDOCYTIC_2	309	312	PF00928	0.350
TRG_ENDOCYTIC_2	41	44	PF00928	0.435
TRG_ER_diArg_1	175	178	PF00400	0.413
TRG_ER_diArg_1	348	350	PF00400	0.311
TRG_NES_CRM1_1	132	144	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D3	Leptomonas seymouri	64%	92%
A0A1X0NXF1	Trypanosomatidae	42%	100%
A0A3Q8IDU8	Leishmania donovani	88%	100%
A4HZ38	Leishmania infantum	88%	100%
D0A1N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AV06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCH6	Leishmania major	88%	100%