RTR1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtr1/RPAP2 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HBN5_LEIBR

TriTrypDb:

LbrM.21.0430 , LBRM2903_210008800

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.647
CLV_C14_Caspase3-7	149	153	PF00656	0.613
CLV_C14_Caspase3-7	199	203	PF00656	0.456
CLV_MEL_PAP_1	254	260	PF00089	0.484
CLV_NRD_NRD_1	130	132	PF00675	0.794
CLV_NRD_NRD_1	184	186	PF00675	0.616
CLV_NRD_NRD_1	456	458	PF00675	0.382
CLV_NRD_NRD_1	540	542	PF00675	0.472
CLV_PCSK_KEX2_1	130	132	PF00082	0.734
CLV_PCSK_KEX2_1	345	347	PF00082	0.773
CLV_PCSK_KEX2_1	456	458	PF00082	0.414
CLV_PCSK_KEX2_1	502	504	PF00082	0.527
CLV_PCSK_KEX2_1	540	542	PF00082	0.472
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.648
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.454
CLV_PCSK_SKI1_1	177	181	PF00082	0.525
CLV_PCSK_SKI1_1	196	200	PF00082	0.577
CLV_PCSK_SKI1_1	300	304	PF00082	0.675
CLV_PCSK_SKI1_1	373	377	PF00082	0.508
CLV_PCSK_SKI1_1	434	438	PF00082	0.578
CLV_PCSK_SKI1_1	456	460	PF00082	0.348
CLV_PCSK_SKI1_1	467	471	PF00082	0.373
CLV_PCSK_SKI1_1	503	507	PF00082	0.417
CLV_PCSK_SKI1_1	541	545	PF00082	0.407
CLV_PCSK_SKI1_1	559	563	PF00082	0.327
CLV_PCSK_SKI1_1	63	67	PF00082	0.462
CLV_PCSK_SKI1_1	85	89	PF00082	0.507
DEG_APCC_DBOX_1	176	184	PF00400	0.530
DEG_APCC_DBOX_1	372	380	PF00400	0.500
DEG_APCC_DBOX_1	58	66	PF00400	0.446
DEG_SPOP_SBC_1	102	106	PF00917	0.493
DOC_CYCLIN_RxL_1	538	546	PF00134	0.483
DOC_CYCLIN_RxL_1	556	564	PF00134	0.259
DOC_CYCLIN_RxL_1	665	674	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	600	606	PF00134	0.440
DOC_MAPK_gen_1	502	510	PF00069	0.331
DOC_PP1_RVXF_1	25	32	PF00149	0.462
DOC_PP2B_LxvP_1	583	586	PF13499	0.529
DOC_PP4_FxxP_1	241	244	PF00568	0.458
DOC_PP4_FxxP_1	604	607	PF00568	0.458
DOC_USP7_MATH_1	102	106	PF00917	0.583
DOC_USP7_MATH_1	143	147	PF00917	0.660
DOC_USP7_MATH_1	198	202	PF00917	0.609
DOC_USP7_MATH_1	249	253	PF00917	0.341
DOC_USP7_MATH_1	272	276	PF00917	0.565
DOC_USP7_MATH_1	291	295	PF00917	0.521
DOC_USP7_MATH_1	317	321	PF00917	0.655
DOC_USP7_MATH_1	5	9	PF00917	0.613
DOC_USP7_MATH_1	613	617	PF00917	0.417
DOC_USP7_MATH_1	666	670	PF00917	0.413
DOC_USP7_MATH_1	89	93	PF00917	0.705
DOC_USP7_UBL2_3	502	506	PF12436	0.317
DOC_WW_Pin1_4	240	245	PF00397	0.462
DOC_WW_Pin1_4	256	261	PF00397	0.376
DOC_WW_Pin1_4	476	481	PF00397	0.479
DOC_WW_Pin1_4	614	619	PF00397	0.416
LIG_14-3-3_CanoR_1	196	201	PF00244	0.500
LIG_14-3-3_CanoR_1	438	442	PF00244	0.371
LIG_14-3-3_CanoR_1	472	480	PF00244	0.509
LIG_Actin_WH2_2	266	283	PF00022	0.489
LIG_Actin_WH2_2	368	385	PF00022	0.433
LIG_Actin_WH2_2	424	440	PF00022	0.449
LIG_Actin_WH2_2	49	65	PF00022	0.418
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BIR_III_2	152	156	PF00653	0.509
LIG_BRCT_BRCA1_1	258	262	PF00533	0.526
LIG_BRCT_BRCA1_1	545	549	PF00533	0.458
LIG_BRCT_BRCA1_1	598	602	PF00533	0.363
LIG_Clathr_ClatBox_1	441	445	PF01394	0.491
LIG_Clathr_ClatBox_1	560	564	PF01394	0.431
LIG_FHA_1	31	37	PF00498	0.472
LIG_FHA_1	411	417	PF00498	0.482
LIG_FHA_1	453	459	PF00498	0.355
LIG_FHA_1	552	558	PF00498	0.419
LIG_FHA_1	615	621	PF00498	0.462
LIG_FHA_2	197	203	PF00498	0.471
LIG_FHA_2	37	43	PF00498	0.507
LIG_FHA_2	523	529	PF00498	0.557
LIG_FHA_2	657	663	PF00498	0.387
LIG_LIR_Gen_1	487	497	PF02991	0.289
LIG_LIR_Gen_1	564	572	PF02991	0.416
LIG_LIR_Gen_1	646	656	PF02991	0.451
LIG_LIR_Gen_1	68	78	PF02991	0.382
LIG_LIR_Nem_3	259	264	PF02991	0.531
LIG_LIR_Nem_3	265	269	PF02991	0.499
LIG_LIR_Nem_3	274	280	PF02991	0.480
LIG_LIR_Nem_3	487	492	PF02991	0.524
LIG_LIR_Nem_3	564	568	PF02991	0.415
LIG_LIR_Nem_3	646	652	PF02991	0.443
LIG_LIR_Nem_3	68	74	PF02991	0.396
LIG_LYPXL_yS_3	266	269	PF13949	0.509
LIG_MLH1_MIPbox_1	258	262	PF16413	0.526
LIG_NRBOX	556	562	PF00104	0.370
LIG_PDZ_Class_3	671	676	PF00595	0.503
LIG_Pex14_2	237	241	PF04695	0.459
LIG_SH2_CRK	264	268	PF00017	0.534
LIG_SH2_CRK	424	428	PF00017	0.487
LIG_SH2_CRK	565	569	PF00017	0.422
LIG_SH2_SRC	264	267	PF00017	0.541
LIG_SH2_STAP1	160	164	PF00017	0.605
LIG_SH2_STAP1	250	254	PF00017	0.487
LIG_SH2_STAP1	424	428	PF00017	0.487
LIG_SH2_STAP1	460	464	PF00017	0.298
LIG_SH2_STAT5	165	168	PF00017	0.563
LIG_SH2_STAT5	261	264	PF00017	0.533
LIG_SH2_STAT5	35	38	PF00017	0.458
LIG_SH3_3	211	217	PF00018	0.656
LIG_SH3_3	42	48	PF00018	0.516
LIG_SH3_3	429	435	PF00018	0.756
LIG_SH3_3	477	483	PF00018	0.423
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.345
LIG_SUMO_SIM_par_1	558	564	PF11976	0.321
LIG_TYR_ITIM	563	568	PF00017	0.411
LIG_UBA3_1	179	187	PF00899	0.531
LIG_UBA3_1	496	502	PF00899	0.282
LIG_WRC_WIRS_1	167	172	PF05994	0.405
LIG_WW_3	431	435	PF00397	0.620
MOD_CDK_SPK_2	476	481	PF00069	0.479
MOD_CK1_1	101	107	PF00069	0.646
MOD_CK1_1	109	115	PF00069	0.674
MOD_CK1_1	14	20	PF00069	0.463
MOD_CK1_1	30	36	PF00069	0.478
MOD_CK1_1	320	326	PF00069	0.601
MOD_CK1_1	491	497	PF00069	0.315
MOD_CK1_1	592	598	PF00069	0.425
MOD_CK2_1	105	111	PF00069	0.707
MOD_CK2_1	36	42	PF00069	0.487
MOD_CK2_1	495	501	PF00069	0.283
MOD_CK2_1	522	528	PF00069	0.430
MOD_CK2_1	613	619	PF00069	0.487
MOD_GlcNHglycan	100	103	PF01048	0.621
MOD_GlcNHglycan	105	108	PF01048	0.601
MOD_GlcNHglycan	13	16	PF01048	0.588
MOD_GlcNHglycan	292	296	PF01048	0.583
MOD_GlcNHglycan	316	320	PF01048	0.733
MOD_GlcNHglycan	355	358	PF01048	0.583
MOD_GlcNHglycan	367	370	PF01048	0.587
MOD_GlcNHglycan	413	416	PF01048	0.683
MOD_GlcNHglycan	474	477	PF01048	0.346
MOD_GlcNHglycan	573	576	PF01048	0.413
MOD_GlcNHglycan	634	637	PF01048	0.260
MOD_GlcNHglycan	7	10	PF01048	0.641
MOD_GlcNHglycan	91	94	PF01048	0.649
MOD_GSK3_1	315	322	PF00069	0.692
MOD_GSK3_1	448	455	PF00069	0.371
MOD_GSK3_1	472	479	PF00069	0.603
MOD_GSK3_1	484	491	PF00069	0.407
MOD_GSK3_1	543	550	PF00069	0.399
MOD_GSK3_1	551	558	PF00069	0.341
MOD_GSK3_1	592	599	PF00069	0.414
MOD_GSK3_1	89	96	PF00069	0.635
MOD_GSK3_1	98	105	PF00069	0.605
MOD_N-GLC_1	364	369	PF02516	0.474
MOD_N-GLC_1	448	453	PF02516	0.434
MOD_N-GLC_2	339	341	PF02516	0.503
MOD_N-GLC_2	591	593	PF02516	0.366
MOD_NEK2_1	103	108	PF00069	0.695
MOD_NEK2_1	222	227	PF00069	0.631
MOD_NEK2_1	233	238	PF00069	0.446
MOD_NEK2_1	36	41	PF00069	0.430
MOD_NEK2_1	394	399	PF00069	0.591
MOD_NEK2_1	437	442	PF00069	0.507
MOD_NEK2_1	448	453	PF00069	0.434
MOD_NEK2_1	488	493	PF00069	0.419
MOD_NEK2_1	543	548	PF00069	0.465
MOD_NEK2_1	571	576	PF00069	0.428
MOD_NEK2_1	596	601	PF00069	0.353
MOD_NEK2_2	272	277	PF00069	0.310
MOD_PIKK_1	302	308	PF00454	0.632
MOD_PIKK_1	47	53	PF00454	0.557
MOD_PKA_2	437	443	PF00069	0.500
MOD_PKA_2	58	64	PF00069	0.500
MOD_Plk_1	250	256	PF00069	0.460
MOD_Plk_2-3	163	169	PF00069	0.425
MOD_Plk_2-3	495	501	PF00069	0.376
MOD_Plk_2-3	58	64	PF00069	0.481
MOD_Plk_4	250	256	PF00069	0.492
MOD_Plk_4	265	271	PF00069	0.353
MOD_Plk_4	27	33	PF00069	0.594
MOD_Plk_4	272	278	PF00069	0.601
MOD_Plk_4	437	443	PF00069	0.487
MOD_Plk_4	484	490	PF00069	0.500
MOD_Plk_4	592	598	PF00069	0.449
MOD_ProDKin_1	240	246	PF00069	0.460
MOD_ProDKin_1	256	262	PF00069	0.376
MOD_ProDKin_1	476	482	PF00069	0.476
MOD_ProDKin_1	614	620	PF00069	0.406
TRG_DiLeu_BaEn_4	119	125	PF01217	0.527
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.614
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.318
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.364
TRG_ENDOCYTIC_2	266	269	PF00928	0.502
TRG_ENDOCYTIC_2	424	427	PF00928	0.486
TRG_ENDOCYTIC_2	565	568	PF00928	0.406
TRG_ENDOCYTIC_2	71	74	PF00928	0.470
TRG_ER_diArg_1	456	458	PF00400	0.414
TRG_NES_CRM1_1	162	176	PF08389	0.416
TRG_NES_CRM1_1	661	674	PF08389	0.437
TRG_NLS_MonoExtN_4	182	189	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	559	564	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT3	Leptomonas seymouri	48%	100%
A0A3Q8IF20	Leishmania donovani	77%	93%
A4HZ36	Leishmania infantum	77%	93%
D0A1N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AV04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	89%
Q4QCH8	Leishmania major	73%	100%