Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBN4_LEIBR

TriTrypDb:

LbrM.21.0420 , LBRM2903_210008700

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.720
CLV_C14_Caspase3-7	247	251	PF00656	0.565
CLV_NRD_NRD_1	10	12	PF00675	0.543
CLV_NRD_NRD_1	118	120	PF00675	0.635
CLV_NRD_NRD_1	217	219	PF00675	0.831
CLV_NRD_NRD_1	36	38	PF00675	0.538
CLV_PCSK_KEX2_1	10	12	PF00082	0.543
CLV_PCSK_KEX2_1	120	122	PF00082	0.648
CLV_PCSK_KEX2_1	217	219	PF00082	0.831
CLV_PCSK_KEX2_1	36	38	PF00082	0.542
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.648
DEG_SPOP_SBC_1	228	232	PF00917	0.558
DOC_ANK_TNKS_1	216	223	PF00023	0.569
DOC_MAPK_gen_1	89	97	PF00069	0.691
DOC_MAPK_MEF2A_6	90	99	PF00069	0.417
DOC_PP4_FxxP_1	267	270	PF00568	0.659
DOC_USP7_MATH_1	168	172	PF00917	0.663
DOC_USP7_MATH_1	202	206	PF00917	0.655
DOC_USP7_MATH_1	216	220	PF00917	0.767
DOC_WW_Pin1_4	126	131	PF00397	0.650
DOC_WW_Pin1_4	177	182	PF00397	0.674
DOC_WW_Pin1_4	204	209	PF00397	0.813
LIG_14-3-3_CanoR_1	49	56	PF00244	0.527
LIG_14-3-3_CanoR_1	83	92	PF00244	0.574
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_FHA_1	228	234	PF00498	0.557
LIG_FHA_2	14	20	PF00498	0.496
LIG_FHA_2	144	150	PF00498	0.728
LIG_FHA_2	245	251	PF00498	0.636
LIG_LIR_Apic_2	265	270	PF02991	0.766
LIG_LIR_Gen_1	17	27	PF02991	0.522
LIG_LIR_Nem_3	17	23	PF02991	0.516
LIG_LIR_Nem_3	180	186	PF02991	0.521
LIG_MYND_1	270	274	PF01753	0.643
LIG_NRBOX	110	116	PF00104	0.488
LIG_PCNA_PIPBox_1	137	146	PF02747	0.442
LIG_SH2_NCK_1	190	194	PF00017	0.797
LIG_SH2_SRC	190	193	PF00017	0.797
LIG_SH2_STAP1	20	24	PF00017	0.525
LIG_SH2_STAT5	63	66	PF00017	0.497
LIG_SH3_3	178	184	PF00018	0.718
LIG_SH3_3	92	98	PF00018	0.411
LIG_UBA3_1	111	120	PF00899	0.501
MOD_CK1_1	176	182	PF00069	0.641
MOD_CK1_1	2	8	PF00069	0.410
MOD_CK1_1	203	209	PF00069	0.600
MOD_CK1_1	226	232	PF00069	0.602
MOD_CK1_1	246	252	PF00069	0.568
MOD_CK1_1	77	83	PF00069	0.646
MOD_CK2_1	13	19	PF00069	0.459
MOD_CK2_1	143	149	PF00069	0.724
MOD_GlcNHglycan	157	160	PF01048	0.740
MOD_GlcNHglycan	164	167	PF01048	0.681
MOD_GlcNHglycan	175	178	PF01048	0.489
MOD_GlcNHglycan	202	205	PF01048	0.828
MOD_GlcNHglycan	218	221	PF01048	0.761
MOD_GlcNHglycan	225	228	PF01048	0.750
MOD_GlcNHglycan	233	236	PF01048	0.669
MOD_GlcNHglycan	65	68	PF01048	0.381
MOD_GlcNHglycan	76	79	PF01048	0.448
MOD_GlcNHglycan	86	89	PF01048	0.492
MOD_GSK3_1	173	180	PF00069	0.740
MOD_GSK3_1	200	207	PF00069	0.728
MOD_GSK3_1	216	223	PF00069	0.718
MOD_GSK3_1	227	234	PF00069	0.689
MOD_N-GLC_1	162	167	PF02516	0.531
MOD_NEK2_1	115	120	PF00069	0.585
MOD_NEK2_1	175	180	PF00069	0.714
MOD_NEK2_1	262	267	PF00069	0.754
MOD_PIKK_1	123	129	PF00454	0.770
MOD_PKA_2	216	222	PF00069	0.822
MOD_PKA_2	48	54	PF00069	0.534
MOD_PKB_1	121	129	PF00069	0.771
MOD_Plk_4	262	268	PF00069	0.522
MOD_ProDKin_1	126	132	PF00069	0.639
MOD_ProDKin_1	177	183	PF00069	0.675
MOD_ProDKin_1	204	210	PF00069	0.816
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.546
TRG_ENDOCYTIC_2	20	23	PF00928	0.521
TRG_ER_diArg_1	119	122	PF00400	0.643
TRG_ER_diArg_1	135	138	PF00400	0.564
TRG_ER_diArg_1	216	218	PF00400	0.824
TRG_ER_diArg_1	9	11	PF00400	0.553
TRG_NLS_MonoCore_2	119	124	PF00514	0.526
TRG_NLS_MonoExtC_3	118	123	PF00514	0.773
TRG_NLS_MonoExtN_4	119	124	PF00514	0.766
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD3	Leptomonas seymouri	49%	100%
A0A3S7WWE9	Leishmania donovani	74%	100%
A4HZ35	Leishmania infantum	74%	99%
E9AV03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QCH9	Leishmania major	70%	97%