Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function, DUF607, putative

Species:

Leishmania braziliensis

UniProt:

A4HBN3_LEIBR

TriTrypDb:

LbrM.21.0410 , LBRM2903_210008600

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	9
GO:0016020	membrane	2	9
GO:0019866	organelle inner membrane	4	9
GO:0031090	organelle membrane	3	9
GO:0031966	mitochondrial membrane	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HBN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN3

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	9
GO:0006874	intracellular calcium ion homeostasis	7	9
GO:0006875	obsolete intracellular metal ion homeostasis	6	9
GO:0009987	cellular process	1	9
GO:0019725	cellular homeostasis	2	9
GO:0030003	intracellular monoatomic cation homeostasis	5	9
GO:0042592	homeostatic process	3	9
GO:0048878	chemical homeostasis	4	9
GO:0050801	monoatomic ion homeostasis	5	9
GO:0051560	mitochondrial calcium ion homeostasis	8	9
GO:0055065	obsolete metal ion homeostasis	7	9
GO:0055074	calcium ion homeostasis	8	9
GO:0055080	monoatomic cation homeostasis	6	9
GO:0055082	intracellular chemical homeostasis	3	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	9
GO:0072507	obsolete divalent inorganic cation homeostasis	7	9
GO:0098771	inorganic ion homeostasis	6	9

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005216	monoatomic ion channel activity	4	9
GO:0005261	monoatomic cation channel activity	5	9
GO:0005262	calcium channel activity	6	9
GO:0008324	monoatomic cation transmembrane transporter activity	4	9
GO:0015075	monoatomic ion transmembrane transporter activity	3	9
GO:0015085	calcium ion transmembrane transporter activity	6	9
GO:0015267	channel activity	4	9
GO:0015291	secondary active transmembrane transporter activity	4	9
GO:0015292	uniporter activity	5	9
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	9
GO:0022803	passive transmembrane transporter activity	3	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0022890	inorganic cation transmembrane transporter activity	4	9
GO:0046873	metal ion transmembrane transporter activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.259
CLV_NRD_NRD_1	24	26	PF00675	0.415
CLV_PCSK_KEX2_1	180	182	PF00082	0.262
CLV_PCSK_KEX2_1	24	26	PF00082	0.458
CLV_PCSK_KEX2_1	95	97	PF00082	0.183
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.192
CLV_PCSK_SKI1_1	122	126	PF00082	0.248
CLV_PCSK_SKI1_1	180	184	PF00082	0.185
CLV_Separin_Metazoa	5	9	PF03568	0.508
DEG_APCC_DBOX_1	95	103	PF00400	0.408
DOC_MAPK_gen_1	8	15	PF00069	0.623
DOC_PP4_FxxP_1	147	150	PF00568	0.179
DOC_USP7_MATH_1	61	65	PF00917	0.652
DOC_USP7_UBL2_3	210	214	PF12436	0.526
DOC_WW_Pin1_4	67	72	PF00397	0.560
LIG_14-3-3_CanoR_1	8	14	PF00244	0.557
LIG_Actin_WH2_2	74	91	PF00022	0.479
LIG_BRCT_BRCA1_1	50	54	PF00533	0.538
LIG_DCNL_PONY_1	1	4	PF03556	0.526
LIG_deltaCOP1_diTrp_1	137	145	PF00928	0.340
LIG_eIF4E_1	9	15	PF01652	0.511
LIG_FHA_1	150	156	PF00498	0.281
LIG_FHA_1	44	50	PF00498	0.588
LIG_LIR_Gen_1	137	148	PF02991	0.208
LIG_LIR_Gen_1	158	169	PF02991	0.285
LIG_LIR_Gen_1	173	183	PF02991	0.340
LIG_LIR_Gen_1	185	194	PF02991	0.380
LIG_LIR_Nem_3	137	143	PF02991	0.204
LIG_LIR_Nem_3	158	164	PF02991	0.336
LIG_LIR_Nem_3	173	179	PF02991	0.342
LIG_LIR_Nem_3	185	191	PF02991	0.358
LIG_LYPXL_yS_3	116	119	PF13949	0.379
LIG_PCNA_PIPBox_1	121	130	PF02747	0.379
LIG_PDZ_Class_3	217	222	PF00595	0.496
LIG_Pex14_2	143	147	PF04695	0.205
LIG_SH2_STAP1	157	161	PF00017	0.223
LIG_SH2_STAT5	140	143	PF00017	0.289
LIG_SH2_STAT5	153	156	PF00017	0.157
LIG_TRAF2_1	218	221	PF00917	0.457
MOD_CDK_SPK_2	67	72	PF00069	0.560
MOD_CK1_1	66	72	PF00069	0.668
MOD_CK2_1	215	221	PF00069	0.557
MOD_GlcNHglycan	15	18	PF01048	0.328
MOD_GlcNHglycan	157	160	PF01048	0.335
MOD_GlcNHglycan	29	32	PF01048	0.503
MOD_GlcNHglycan	65	68	PF01048	0.505
MOD_GSK3_1	35	42	PF00069	0.701
MOD_GSK3_1	62	69	PF00069	0.675
MOD_GSK3_1	72	79	PF00069	0.617
MOD_GSK3_1	84	91	PF00069	0.482
MOD_GSK3_1	9	16	PF00069	0.646
MOD_N-GLC_1	61	66	PF02516	0.458
MOD_N-GLC_1	72	77	PF02516	0.329
MOD_NEK2_1	13	18	PF00069	0.581
MOD_NEK2_1	136	141	PF00069	0.380
MOD_NEK2_1	155	160	PF00069	0.263
MOD_NEK2_1	48	53	PF00069	0.568
MOD_NEK2_1	54	59	PF00069	0.557
MOD_NEK2_1	88	93	PF00069	0.516
MOD_PIKK_1	76	82	PF00454	0.487
MOD_PK_1	72	78	PF00069	0.524
MOD_PKA_2	84	90	PF00069	0.531
MOD_PKA_2	9	15	PF00069	0.616
MOD_Plk_1	136	142	PF00069	0.340
MOD_Plk_1	72	78	PF00069	0.609
MOD_Plk_4	157	163	PF00069	0.323
MOD_Plk_4	9	15	PF00069	0.637
MOD_ProDKin_1	67	73	PF00069	0.558
MOD_SUMO_for_1	105	108	PF00179	0.379
MOD_SUMO_rev_2	203	212	PF00179	0.553
TRG_ENDOCYTIC_2	116	119	PF00928	0.414
TRG_ENDOCYTIC_2	140	143	PF00928	0.219
TRG_ENDOCYTIC_2	167	170	PF00928	0.246
TRG_ENDOCYTIC_2	176	179	PF00928	0.456
TRG_ENDOCYTIC_2	202	205	PF00928	0.464
TRG_ER_diArg_1	179	181	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEX8	Leptomonas seymouri	42%	100%
A0A0S4JH33	Bodo saltans	29%	100%
A0A1X0NNH4	Trypanosomatidae	27%	91%
A0A1X0NXF2	Trypanosomatidae	36%	93%
A0A422MZA0	Trypanosoma rangeli	38%	97%
A0A422NQP4	Trypanosoma rangeli	27%	94%
D0A1N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%