Vacuolar protein sorting-associated protein 51 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vps51/Vps67, putative

Species:

Leishmania braziliensis

UniProt:

A4HBN1_LEIBR

TriTrypDb:

LbrM.21.0390 , LBRM2903_210008400

Length:

1038

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	5
GO:0005829	cytosol	2	5
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	5
GO:0099023	vesicle tethering complex	2	5
GO:0110165	cellular anatomical entity	1	5
GO:1990745	EARP complex	2	1

Expansion

Sequence features

A4HBN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	5
GO:0006996	organelle organization	4	5
GO:0007030	Golgi organization	5	5
GO:0007034	vacuolar transport	4	1
GO:0007041	lysosomal transport	5	1
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016192	vesicle-mediated transport	4	5
GO:0016197	endosomal transport	4	5
GO:0016482	cytosolic transport	4	5
GO:0032456	endocytic recycling	5	5
GO:0042147	retrograde transport, endosome to Golgi	5	5
GO:0046907	intracellular transport	3	5
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0051641	cellular localization	2	5
GO:0051649	establishment of localization in cell	3	5
GO:0051668	localization within membrane	3	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0098876	vesicle-mediated transport to the plasma membrane	4	5
GO:0006869	lipid transport	5	4
GO:0008104	protein localization	4	4
GO:0015031	protein transport	4	4
GO:0033036	macromolecule localization	2	4
GO:0045184	establishment of protein localization	3	4
GO:0070727	cellular macromolecule localization	3	4
GO:0071702	organic substance transport	4	4
GO:0071705	nitrogen compound transport	4	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.204
CLV_C14_Caspase3-7	238	242	PF00656	0.488
CLV_NRD_NRD_1	14	16	PF00675	0.489
CLV_NRD_NRD_1	179	181	PF00675	0.455
CLV_NRD_NRD_1	805	807	PF00675	0.603
CLV_NRD_NRD_1	86	88	PF00675	0.374
CLV_NRD_NRD_1	89	91	PF00675	0.400
CLV_PCSK_FUR_1	87	91	PF00082	0.355
CLV_PCSK_KEX2_1	14	16	PF00082	0.485
CLV_PCSK_KEX2_1	179	181	PF00082	0.403
CLV_PCSK_KEX2_1	317	319	PF00082	0.543
CLV_PCSK_KEX2_1	34	36	PF00082	0.423
CLV_PCSK_KEX2_1	70	72	PF00082	0.297
CLV_PCSK_KEX2_1	86	88	PF00082	0.297
CLV_PCSK_KEX2_1	89	91	PF00082	0.297
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.543
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.684
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.410
CLV_PCSK_SKI1_1	114	118	PF00082	0.410
CLV_PCSK_SKI1_1	163	167	PF00082	0.510
CLV_PCSK_SKI1_1	283	287	PF00082	0.450
CLV_PCSK_SKI1_1	758	762	PF00082	0.434
CLV_PCSK_SKI1_1	855	859	PF00082	0.434
CLV_Separin_Metazoa	83	87	PF03568	0.330
DEG_APCC_DBOX_1	327	335	PF00400	0.455
DEG_APCC_DBOX_1	70	78	PF00400	0.297
DEG_APCC_DBOX_1	757	765	PF00400	0.475
DEG_SPOP_SBC_1	606	610	PF00917	0.716
DOC_CDC14_PxL_1	634	642	PF14671	0.336
DOC_CKS1_1	969	974	PF01111	0.558
DOC_CYCLIN_yClb5_NLxxxL_5	322	331	PF00134	0.475
DOC_MAPK_DCC_7	44	54	PF00069	0.507
DOC_MAPK_HePTP_8	368	380	PF00069	0.461
DOC_MAPK_MEF2A_6	371	380	PF00069	0.578
DOC_MAPK_MEF2A_6	615	624	PF00069	0.331
DOC_MAPK_MEF2A_6	741	748	PF00069	0.366
DOC_PP1_RVXF_1	164	171	PF00149	0.425
DOC_PP2B_LxvP_1	304	307	PF13499	0.432
DOC_PP2B_LxvP_1	622	625	PF13499	0.465
DOC_PP2B_LxvP_1	894	897	PF13499	0.620
DOC_PP4_MxPP_1	1010	1013	PF00568	0.649
DOC_USP7_MATH_1	29	33	PF00917	0.533
DOC_USP7_MATH_1	37	41	PF00917	0.558
DOC_USP7_MATH_1	410	414	PF00917	0.513
DOC_USP7_MATH_1	451	455	PF00917	0.690
DOC_USP7_MATH_1	648	652	PF00917	0.495
DOC_USP7_MATH_1	690	694	PF00917	0.527
DOC_USP7_MATH_1	713	717	PF00917	0.621
DOC_USP7_MATH_1	850	854	PF00917	0.556
DOC_USP7_MATH_1	875	879	PF00917	0.763
DOC_USP7_MATH_1	933	937	PF00917	0.818
DOC_USP7_MATH_1	949	953	PF00917	0.626
DOC_USP7_MATH_1	960	964	PF00917	0.599
DOC_USP7_MATH_1	976	980	PF00917	0.796
DOC_USP7_MATH_1	990	994	PF00917	0.705
DOC_USP7_UBL2_3	831	835	PF12436	0.479
DOC_WW_Pin1_4	792	797	PF00397	0.405
DOC_WW_Pin1_4	888	893	PF00397	0.754
DOC_WW_Pin1_4	907	912	PF00397	0.749
DOC_WW_Pin1_4	937	942	PF00397	0.615
DOC_WW_Pin1_4	954	959	PF00397	0.711
DOC_WW_Pin1_4	968	973	PF00397	0.527
LIG_14-3-3_CanoR_1	1007	1011	PF00244	0.567
LIG_14-3-3_CanoR_1	105	113	PF00244	0.410
LIG_14-3-3_CanoR_1	257	262	PF00244	0.414
LIG_14-3-3_CanoR_1	357	364	PF00244	0.507
LIG_14-3-3_CanoR_1	426	435	PF00244	0.258
LIG_14-3-3_CanoR_1	548	552	PF00244	0.408
LIG_14-3-3_CanoR_1	63	69	PF00244	0.373
LIG_14-3-3_CanoR_1	724	730	PF00244	0.547
LIG_Actin_WH2_2	243	259	PF00022	0.467
LIG_Actin_WH2_2	532	550	PF00022	0.365
LIG_Actin_WH2_2	626	643	PF00022	0.357
LIG_Actin_WH2_2	70	88	PF00022	0.402
LIG_BIR_III_4	353	357	PF00653	0.412
LIG_BRCT_BRCA1_1	55	59	PF00533	0.279
LIG_BRCT_BRCA1_1	784	788	PF00533	0.364
LIG_CtBP_PxDLS_1	504	508	PF00389	0.409
LIG_FHA_1	1025	1031	PF00498	0.668
LIG_FHA_1	108	114	PF00498	0.279
LIG_FHA_1	343	349	PF00498	0.421
LIG_FHA_1	419	425	PF00498	0.440
LIG_FHA_1	461	467	PF00498	0.343
LIG_FHA_1	530	536	PF00498	0.350
LIG_FHA_1	538	544	PF00498	0.327
LIG_FHA_1	547	553	PF00498	0.362
LIG_FHA_1	564	570	PF00498	0.438
LIG_FHA_1	63	69	PF00498	0.281
LIG_FHA_1	716	722	PF00498	0.620
LIG_FHA_1	740	746	PF00498	0.518
LIG_FHA_1	785	791	PF00498	0.354
LIG_FHA_1	80	86	PF00498	0.264
LIG_FHA_1	838	844	PF00498	0.445
LIG_FHA_1	889	895	PF00498	0.748
LIG_FHA_2	110	116	PF00498	0.279
LIG_FHA_2	435	441	PF00498	0.440
LIG_FHA_2	565	571	PF00498	0.291
LIG_FHA_2	627	633	PF00498	0.418
LIG_FHA_2	682	688	PF00498	0.655
LIG_FHA_2	78	84	PF00498	0.342
LIG_GBD_Chelix_1	527	535	PF00786	0.410
LIG_LIR_Gen_1	346	354	PF02991	0.330
LIG_LIR_Gen_1	390	399	PF02991	0.430
LIG_LIR_Gen_1	629	639	PF02991	0.414
LIG_LIR_Gen_1	776	784	PF02991	0.462
LIG_LIR_Nem_3	223	228	PF02991	0.441
LIG_LIR_Nem_3	346	352	PF02991	0.305
LIG_LIR_Nem_3	390	394	PF02991	0.491
LIG_LIR_Nem_3	55	61	PF02991	0.297
LIG_LIR_Nem_3	629	634	PF02991	0.397
LIG_LIR_Nem_3	776	782	PF02991	0.470
LIG_LIR_Nem_3	97	103	PF02991	0.279
LIG_MLH1_MIPbox_1	55	59	PF16413	0.297
LIG_MYND_1	892	896	PF01753	0.588
LIG_NRBOX	423	429	PF00104	0.472
LIG_PCNA_PIPBox_1	753	762	PF02747	0.283
LIG_PCNA_yPIPBox_3	371	381	PF02747	0.383
LIG_PDZ_Class_2	1033	1038	PF00595	0.747
LIG_Pex14_1	627	631	PF04695	0.491
LIG_SH2_CRK	536	540	PF00017	0.411
LIG_SH2_CRK	631	635	PF00017	0.332
LIG_SH2_GRB2like	467	470	PF00017	0.369
LIG_SH2_GRB2like	58	61	PF00017	0.410
LIG_SH2_NCK_1	593	597	PF00017	0.522
LIG_SH2_SRC	442	445	PF00017	0.523
LIG_SH2_STAP1	103	107	PF00017	0.279
LIG_SH2_STAP1	467	471	PF00017	0.400
LIG_SH2_STAP1	593	597	PF00017	0.522
LIG_SH2_STAP1	64	68	PF00017	0.357
LIG_SH2_STAP1	717	721	PF00017	0.621
LIG_SH2_STAP1	832	836	PF00017	0.571
LIG_SH2_STAT3	717	720	PF00017	0.609
LIG_SH2_STAT3	759	762	PF00017	0.441
LIG_SH2_STAT5	249	252	PF00017	0.500
LIG_SH2_STAT5	442	445	PF00017	0.416
LIG_SH2_STAT5	58	61	PF00017	0.302
LIG_SH2_STAT5	64	67	PF00017	0.256
LIG_SH2_STAT5	717	720	PF00017	0.609
LIG_SH2_STAT5	759	762	PF00017	0.344
LIG_SH2_STAT5	774	777	PF00017	0.498
LIG_SH3_3	361	367	PF00018	0.570
LIG_SH3_3	43	49	PF00018	0.613
LIG_SH3_3	743	749	PF00018	0.563
LIG_SH3_3	833	839	PF00018	0.341
LIG_SH3_3	871	877	PF00018	0.729
LIG_SH3_3	879	885	PF00018	0.718
LIG_SH3_3	893	899	PF00018	0.787
LIG_SH3_3	917	923	PF00018	0.765
LIG_SH3_3	969	975	PF00018	0.585
LIG_SH3_3	977	983	PF00018	0.719
LIG_SUMO_SIM_anti_2	508	515	PF11976	0.452
LIG_SUMO_SIM_anti_2	618	624	PF11976	0.476
LIG_SUMO_SIM_par_1	339	346	PF11976	0.495
LIG_SUMO_SIM_par_1	503	508	PF11976	0.397
LIG_SUMO_SIM_par_1	905	910	PF11976	0.513
LIG_TRAF2_1	272	275	PF00917	0.377
LIG_TRAF2_1	885	888	PF00917	0.750
LIG_UBA3_1	789	798	PF00899	0.536
LIG_WRC_WIRS_1	286	291	PF05994	0.412
MOD_CDC14_SPxK_1	795	798	PF00782	0.477
MOD_CDK_SPxK_1	792	798	PF00069	0.441
MOD_CK1_1	139	145	PF00069	0.518
MOD_CK1_1	173	179	PF00069	0.506
MOD_CK1_1	206	212	PF00069	0.476
MOD_CK1_1	38	44	PF00069	0.691
MOD_CK1_1	508	514	PF00069	0.625
MOD_CK1_1	546	552	PF00069	0.352
MOD_CK1_1	564	570	PF00069	0.286
MOD_CK1_1	598	604	PF00069	0.606
MOD_CK1_1	605	611	PF00069	0.683
MOD_CK1_1	677	683	PF00069	0.707
MOD_CK1_1	865	871	PF00069	0.671
MOD_CK1_1	937	943	PF00069	0.654
MOD_CK1_1	965	971	PF00069	0.603
MOD_CK2_1	1022	1028	PF00069	0.691
MOD_CK2_1	105	111	PF00069	0.315
MOD_CK2_1	257	263	PF00069	0.538
MOD_CK2_1	434	440	PF00069	0.431
MOD_CK2_1	564	570	PF00069	0.292
MOD_CK2_1	77	83	PF00069	0.359
MOD_CK2_1	875	881	PF00069	0.552
MOD_CK2_1	933	939	PF00069	0.771
MOD_CK2_1	983	989	PF00069	0.518
MOD_GlcNHglycan	107	110	PF01048	0.279
MOD_GlcNHglycan	263	266	PF01048	0.685
MOD_GlcNHglycan	4	7	PF01048	0.620
MOD_GlcNHglycan	404	407	PF01048	0.443
MOD_GlcNHglycan	412	415	PF01048	0.435
MOD_GlcNHglycan	452	456	PF01048	0.708
MOD_GlcNHglycan	597	600	PF01048	0.524
MOD_GlcNHglycan	604	607	PF01048	0.634
MOD_GlcNHglycan	643	646	PF01048	0.658
MOD_GlcNHglycan	664	668	PF01048	0.705
MOD_GlcNHglycan	676	679	PF01048	0.624
MOD_GlcNHglycan	693	696	PF01048	0.669
MOD_GlcNHglycan	700	703	PF01048	0.598
MOD_GlcNHglycan	708	711	PF01048	0.549
MOD_GlcNHglycan	749	752	PF01048	0.538
MOD_GlcNHglycan	799	802	PF01048	0.580
MOD_GlcNHglycan	852	855	PF01048	0.439
MOD_GlcNHglycan	864	867	PF01048	0.568
MOD_GlcNHglycan	931	934	PF01048	0.813
MOD_GlcNHglycan	936	939	PF01048	0.690
MOD_GlcNHglycan	951	954	PF01048	0.543
MOD_GlcNHglycan	962	965	PF01048	0.530
MOD_GSK3_1	1016	1023	PF00069	0.657
MOD_GSK3_1	105	112	PF00069	0.296
MOD_GSK3_1	169	176	PF00069	0.515
MOD_GSK3_1	199	206	PF00069	0.494
MOD_GSK3_1	257	264	PF00069	0.526
MOD_GSK3_1	273	280	PF00069	0.474
MOD_GSK3_1	281	288	PF00069	0.424
MOD_GSK3_1	292	299	PF00069	0.332
MOD_GSK3_1	35	42	PF00069	0.691
MOD_GSK3_1	426	433	PF00069	0.440
MOD_GSK3_1	508	515	PF00069	0.666
MOD_GSK3_1	537	544	PF00069	0.271
MOD_GSK3_1	560	567	PF00069	0.383
MOD_GSK3_1	598	605	PF00069	0.676
MOD_GSK3_1	639	646	PF00069	0.541
MOD_GSK3_1	674	681	PF00069	0.518
MOD_GSK3_1	735	742	PF00069	0.502
MOD_GSK3_1	846	853	PF00069	0.518
MOD_GSK3_1	861	868	PF00069	0.620
MOD_GSK3_1	886	893	PF00069	0.602
MOD_GSK3_1	929	936	PF00069	0.787
MOD_GSK3_1	937	944	PF00069	0.568
MOD_LATS_1	703	709	PF00433	0.656
MOD_N-GLC_1	29	34	PF02516	0.473
MOD_N-GLC_1	861	866	PF02516	0.579
MOD_N-GLC_1	941	946	PF02516	0.540
MOD_N-GLC_2	216	218	PF02516	0.287
MOD_N-GLC_2	336	338	PF02516	0.489
MOD_NEK2_1	170	175	PF00069	0.417
MOD_NEK2_1	256	261	PF00069	0.384
MOD_NEK2_1	273	278	PF00069	0.500
MOD_NEK2_1	281	286	PF00069	0.523
MOD_NEK2_1	505	510	PF00069	0.638
MOD_NEK2_1	529	534	PF00069	0.320
MOD_NEK2_1	535	540	PF00069	0.309
MOD_NEK2_1	543	548	PF00069	0.342
MOD_NEK2_1	561	566	PF00069	0.342
MOD_NEK2_1	569	574	PF00069	0.508
MOD_NEK2_1	597	602	PF00069	0.560
MOD_NEK2_1	725	730	PF00069	0.583
MOD_NEK2_1	782	787	PF00069	0.457
MOD_NEK2_1	928	933	PF00069	0.788
MOD_NEK2_2	109	114	PF00069	0.279
MOD_NEK2_2	460	465	PF00069	0.369
MOD_PIKK_1	128	134	PF00454	0.410
MOD_PIKK_1	139	145	PF00454	0.537
MOD_PIKK_1	208	214	PF00454	0.538
MOD_PIKK_1	293	299	PF00454	0.450
MOD_PIKK_1	382	388	PF00454	0.477
MOD_PIKK_1	39	45	PF00454	0.629
MOD_PIKK_1	426	432	PF00454	0.515
MOD_PIKK_1	537	543	PF00454	0.317
MOD_PIKK_1	774	780	PF00454	0.314
MOD_PIKK_1	965	971	PF00454	0.521
MOD_PK_1	203	209	PF00069	0.568
MOD_PKA_1	70	76	PF00069	0.297
MOD_PKA_2	1006	1012	PF00069	0.597
MOD_PKA_2	1015	1021	PF00069	0.667
MOD_PKA_2	2	8	PF00069	0.513
MOD_PKA_2	256	262	PF00069	0.388
MOD_PKA_2	356	362	PF00069	0.553
MOD_PKA_2	547	553	PF00069	0.474
MOD_PKA_2	62	68	PF00069	0.328
MOD_PKA_2	674	680	PF00069	0.501
MOD_PKA_2	70	76	PF00069	0.264
MOD_PKB_1	661	669	PF00069	0.623
MOD_Plk_1	155	161	PF00069	0.538
MOD_Plk_1	185	191	PF00069	0.436
MOD_Plk_1	273	279	PF00069	0.412
MOD_Plk_1	318	324	PF00069	0.479
MOD_Plk_1	713	719	PF00069	0.516
MOD_Plk_1	880	886	PF00069	0.524
MOD_Plk_4	257	263	PF00069	0.407
MOD_Plk_4	273	279	PF00069	0.398
MOD_Plk_4	281	287	PF00069	0.372
MOD_Plk_4	508	514	PF00069	0.643
MOD_Plk_4	547	553	PF00069	0.362
MOD_Plk_4	626	632	PF00069	0.383
MOD_Plk_4	655	661	PF00069	0.556
MOD_Plk_4	735	741	PF00069	0.629
MOD_Plk_4	784	790	PF00069	0.346
MOD_Plk_4	990	996	PF00069	0.514
MOD_ProDKin_1	792	798	PF00069	0.419
MOD_ProDKin_1	888	894	PF00069	0.755
MOD_ProDKin_1	907	913	PF00069	0.744
MOD_ProDKin_1	937	943	PF00069	0.614
MOD_ProDKin_1	954	960	PF00069	0.707
MOD_ProDKin_1	968	974	PF00069	0.530
MOD_SUMO_for_1	316	319	PF00179	0.547
MOD_SUMO_for_1	69	72	PF00179	0.355
MOD_SUMO_rev_2	118	127	PF00179	0.283
MOD_SUMO_rev_2	830	837	PF00179	0.538
MOD_SUMO_rev_2	887	892	PF00179	0.689
TRG_DiLeu_BaEn_1	251	256	PF01217	0.387
TRG_DiLeu_BaEn_1	618	623	PF01217	0.484
TRG_DiLeu_BaEn_1	94	99	PF01217	0.279
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.416
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.469
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.393
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.467
TRG_DiLeu_LyEn_5	251	256	PF01217	0.500
TRG_ENDOCYTIC_2	103	106	PF00928	0.279
TRG_ENDOCYTIC_2	225	228	PF00928	0.363
TRG_ENDOCYTIC_2	349	352	PF00928	0.319
TRG_ENDOCYTIC_2	536	539	PF00928	0.425
TRG_ENDOCYTIC_2	58	61	PF00928	0.410
TRG_ENDOCYTIC_2	631	634	PF00928	0.372
TRG_ER_diArg_1	14	17	PF00400	0.482
TRG_ER_diArg_1	178	180	PF00400	0.404
TRG_ER_diArg_1	660	663	PF00400	0.716
TRG_ER_diArg_1	85	87	PF00400	0.375
TRG_ER_diArg_1	88	90	PF00400	0.400
TRG_NES_CRM1_1	386	397	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	819	823	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P847	Leptomonas seymouri	64%	100%
A0A1X0NYZ3	Trypanosomatidae	35%	100%
A0A3S7WWG5	Leishmania donovani	75%	97%
A0A422MZA8	Trypanosoma rangeli	35%	100%
A4HZ32	Leishmania infantum	75%	97%
D0A1N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AV00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4QCI2	Leishmania major	75%	99%
V5BKM5	Trypanosoma cruzi	37%	100%