Matrin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein C, putative

Species:

Leishmania braziliensis

UniProt:

A4HBN0_LEIBR

TriTrypDb:

LbrM.21.0380 , LBRM2903_210008300

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	5
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	3
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

A4HBN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBN0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.584
CLV_NRD_NRD_1	46	48	PF00675	0.614
CLV_NRD_NRD_1	49	51	PF00675	0.613
CLV_NRD_NRD_1	56	58	PF00675	0.606
CLV_NRD_NRD_1	64	66	PF00675	0.632
CLV_PCSK_FUR_1	43	47	PF00082	0.602
CLV_PCSK_KEX2_1	138	140	PF00082	0.459
CLV_PCSK_KEX2_1	40	42	PF00082	0.591
CLV_PCSK_KEX2_1	45	47	PF00082	0.585
CLV_PCSK_KEX2_1	56	58	PF00082	0.528
CLV_PCSK_KEX2_1	64	66	PF00082	0.584
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.459
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.671
CLV_PCSK_PC7_1	41	47	PF00082	0.592
CLV_PCSK_SKI1_1	196	200	PF00082	0.745
DEG_Nend_UBRbox_2	1	3	PF02207	0.809
DOC_PP2B_LxvP_1	169	172	PF13499	0.784
DOC_PP2B_LxvP_1	234	237	PF13499	0.818
DOC_PP2B_PxIxI_1	155	161	PF00149	0.590
DOC_PP2B_PxIxI_1	188	194	PF00149	0.644
DOC_PP4_FxxP_1	175	178	PF00568	0.806
DOC_USP7_MATH_1	102	106	PF00917	0.614
DOC_USP7_MATH_1	176	180	PF00917	0.761
DOC_USP7_MATH_1	222	226	PF00917	0.837
DOC_WW_Pin1_4	144	149	PF00397	0.644
DOC_WW_Pin1_4	185	190	PF00397	0.730
DOC_WW_Pin1_4	204	209	PF00397	0.508
DOC_WW_Pin1_4	211	216	PF00397	0.777
DOC_WW_Pin1_4	49	54	PF00397	0.596
LIG_14-3-3_CanoR_1	226	234	PF00244	0.803
LIG_14-3-3_CanoR_1	86	91	PF00244	0.530
LIG_CaM_NSCaTE_8	90	97	PF13499	0.527
LIG_EVH1_1	169	173	PF00568	0.784
LIG_EVH1_2	171	175	PF00568	0.783
LIG_FHA_1	180	186	PF00498	0.744
LIG_FHA_1	193	199	PF00498	0.657
LIG_LIR_Gen_1	105	113	PF02991	0.607
LIG_LIR_Gen_1	77	83	PF02991	0.488
LIG_LIR_Nem_3	105	110	PF02991	0.508
LIG_LIR_Nem_3	77	81	PF02991	0.491
LIG_RPA_C_Fungi	221	233	PF08784	0.580
LIG_SH2_CRK	107	111	PF00017	0.602
LIG_SH2_NCK_1	107	111	PF00017	0.500
LIG_SH2_STAP1	107	111	PF00017	0.500
LIG_SH2_STAT5	75	78	PF00017	0.436
LIG_SH3_1	168	174	PF00018	0.626
LIG_SH3_1	212	218	PF00018	0.574
LIG_SH3_3	167	173	PF00018	0.654
LIG_SH3_3	198	204	PF00018	0.648
LIG_SH3_3	212	218	PF00018	0.755
LIG_SH3_3	3	9	PF00018	0.690
LIG_SUMO_SIM_par_1	207	214	PF11976	0.565
MOD_CDK_SPxxK_3	185	192	PF00069	0.727
MOD_CDK_SPxxK_3	49	56	PF00069	0.593
MOD_CK1_1	179	185	PF00069	0.554
MOD_CK1_1	213	219	PF00069	0.743
MOD_CK1_1	225	231	PF00069	0.830
MOD_CK2_1	225	231	PF00069	0.791
MOD_CK2_1	32	38	PF00069	0.586
MOD_GlcNHglycan	165	168	PF01048	0.701
MOD_GlcNHglycan	185	188	PF01048	0.553
MOD_GlcNHglycan	2	6	PF01048	0.694
MOD_GlcNHglycan	227	230	PF01048	0.578
MOD_GlcNHglycan	29	32	PF01048	0.669
MOD_GSK3_1	179	186	PF00069	0.550
MOD_GSK3_1	210	217	PF00069	0.756
MOD_GSK3_1	221	228	PF00069	0.586
MOD_GSK3_1	82	89	PF00069	0.511
MOD_NEK2_1	81	86	PF00069	0.453
MOD_NEK2_1	94	99	PF00069	0.474
MOD_PKA_2	225	231	PF00069	0.830
MOD_PKA_2	94	100	PF00069	0.590
MOD_Plk_1	179	185	PF00069	0.554
MOD_Plk_4	102	108	PF00069	0.553
MOD_Plk_4	112	118	PF00069	0.456
MOD_Plk_4	194	200	PF00069	0.745
MOD_ProDKin_1	144	150	PF00069	0.646
MOD_ProDKin_1	185	191	PF00069	0.727
MOD_ProDKin_1	204	210	PF00069	0.511
MOD_ProDKin_1	211	217	PF00069	0.776
MOD_ProDKin_1	49	55	PF00069	0.594
MOD_SUMO_rev_2	207	214	PF00179	0.565
MOD_SUMO_rev_2	35	42	PF00179	0.667
TRG_ENDOCYTIC_2	106	109	PF00928	0.511
TRG_ENDOCYTIC_2	78	81	PF00928	0.482
TRG_ER_diArg_1	42	45	PF00400	0.585
TRG_ER_diArg_1	46	48	PF00400	0.610
TRG_NES_CRM1_1	108	120	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S9	Leptomonas seymouri	65%	100%
A0A3Q8IA85	Leishmania donovani	78%	100%
A4HZ31	Leishmania infantum	78%	100%
E9AUZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QCI3	Leishmania major	79%	97%