Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBM9_LEIBR

TriTrypDb:

LbrM.21.0370 , LBRM2903_210008200

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HBM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	153	159	PF00089	0.537
CLV_NRD_NRD_1	161	163	PF00675	0.535
CLV_NRD_NRD_1	174	176	PF00675	0.617
CLV_NRD_NRD_1	236	238	PF00675	0.563
CLV_PCSK_FUR_1	47	51	PF00082	0.523
CLV_PCSK_KEX2_1	161	163	PF00082	0.496
CLV_PCSK_KEX2_1	49	51	PF00082	0.540
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.540
CLV_PCSK_SKI1_1	229	233	PF00082	0.412
CLV_PCSK_SKI1_1	276	280	PF00082	0.355
CLV_PCSK_SKI1_1	302	306	PF00082	0.385
CLV_PCSK_SKI1_1	53	57	PF00082	0.664
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	112	115	PF00134	0.381
DOC_MAPK_gen_1	104	112	PF00069	0.314
DOC_MAPK_gen_1	161	172	PF00069	0.270
DOC_MAPK_gen_1	49	59	PF00069	0.441
DOC_MAPK_gen_1	87	95	PF00069	0.318
DOC_MAPK_MEF2A_6	257	264	PF00069	0.417
DOC_MAPK_MEF2A_6	89	97	PF00069	0.312
DOC_MAPK_RevD_3	34	50	PF00069	0.351
DOC_MIT_MIM_1	183	193	PF04212	0.403
DOC_PP1_RVXF_1	227	234	PF00149	0.320
DOC_PP2B_LxvP_1	112	115	PF13499	0.437
DOC_PP2B_LxvP_1	93	96	PF13499	0.453
DOC_SPAK_OSR1_1	120	124	PF12202	0.328
DOC_SPAK_OSR1_1	156	160	PF12202	0.352
DOC_USP7_MATH_1	138	142	PF00917	0.377
DOC_USP7_UBL2_3	238	242	PF12436	0.277
DOC_WW_Pin1_4	115	120	PF00397	0.416
DOC_WW_Pin1_4	250	255	PF00397	0.392
LIG_14-3-3_CanoR_1	156	160	PF00244	0.346
LIG_14-3-3_CanoR_1	276	281	PF00244	0.410
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	117	121	PF00533	0.400
LIG_BRCT_BRCA1_1	30	34	PF00533	0.376
LIG_CSL_BTD_1	168	171	PF09270	0.309
LIG_FHA_1	177	183	PF00498	0.375
LIG_FHA_1	41	47	PF00498	0.303
LIG_LIR_Gen_1	43	52	PF02991	0.272
LIG_LIR_Nem_3	166	172	PF02991	0.317
LIG_SH2_CRK	178	182	PF00017	0.333
LIG_SH2_GRB2like	178	181	PF00017	0.250
LIG_SH2_STAP1	178	182	PF00017	0.359
LIG_SH2_STAT5	178	181	PF00017	0.448
LIG_SH2_STAT5	226	229	PF00017	0.284
LIG_SH2_STAT5	45	48	PF00017	0.335
LIG_SH3_3	293	299	PF00018	0.410
LIG_Sin3_3	283	290	PF02671	0.355
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.298
LIG_TRAF2_1	141	144	PF00917	0.407
LIG_WRC_WIRS_1	19	24	PF05994	0.570
LIG_WRC_WIRS_1	243	248	PF05994	0.320
MOD_CDK_SPK_2	115	120	PF00069	0.417
MOD_CDK_SPxxK_3	250	257	PF00069	0.338
MOD_CK1_1	300	306	PF00069	0.572
MOD_CK2_1	138	144	PF00069	0.391
MOD_CK2_1	255	261	PF00069	0.238
MOD_Cter_Amidation	159	162	PF01082	0.477
MOD_GlcNHglycan	219	222	PF01048	0.563
MOD_GlcNHglycan	281	284	PF01048	0.371
MOD_GSK3_1	144	151	PF00069	0.340
MOD_GSK3_1	242	249	PF00069	0.294
MOD_N-GLC_1	131	136	PF02516	0.560
MOD_NEK2_1	155	160	PF00069	0.351
MOD_NEK2_1	181	186	PF00069	0.427
MOD_NEK2_1	215	220	PF00069	0.437
MOD_NEK2_1	241	246	PF00069	0.286
MOD_NEK2_1	98	103	PF00069	0.463
MOD_NEK2_2	131	136	PF00069	0.406
MOD_PKA_1	176	182	PF00069	0.407
MOD_PKA_2	155	161	PF00069	0.393
MOD_Plk_1	131	137	PF00069	0.403
MOD_Plk_1	144	150	PF00069	0.424
MOD_Plk_1	165	171	PF00069	0.407
MOD_Plk_1	75	81	PF00069	0.370
MOD_Plk_4	165	171	PF00069	0.373
MOD_Plk_4	181	187	PF00069	0.341
MOD_Plk_4	286	292	PF00069	0.349
MOD_Plk_4	29	35	PF00069	0.484
MOD_Plk_4	40	46	PF00069	0.358
MOD_ProDKin_1	115	121	PF00069	0.412
MOD_ProDKin_1	250	256	PF00069	0.393
MOD_SUMO_rev_2	239	244	PF00179	0.298
MOD_SUMO_rev_2	253	259	PF00179	0.332
TRG_ENDOCYTIC_2	178	181	PF00928	0.415
TRG_ENDOCYTIC_2	45	48	PF00928	0.266
TRG_ER_diArg_1	161	163	PF00400	0.296
TRG_NES_CRM1_1	38	51	PF08389	0.238
TRG_NLS_Bipartite_1	161	179	PF00514	0.251
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H6	Leptomonas seymouri	47%	89%
A0A1X0NXE2	Trypanosomatidae	26%	100%
A0A3S5IR94	Trypanosoma rangeli	28%	100%
A0A3S7WWC8	Leishmania donovani	76%	99%
A4HZB8	Leishmania infantum	76%	99%
D0A1M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AUZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	91%
Q4QCI4	Leishmania major	75%	100%
V5B0L2	Trypanosoma cruzi	29%	100%