Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBM8_LEIBR

TriTrypDb:

LbrM.21.0360 , LBRM2903_210008100

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HBM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.457
CLV_NRD_NRD_1	223	225	PF00675	0.492
CLV_NRD_NRD_1	64	66	PF00675	0.389
CLV_PCSK_KEX2_1	17	19	PF00082	0.457
CLV_PCSK_KEX2_1	223	225	PF00082	0.494
DEG_SPOP_SBC_1	23	27	PF00917	0.712
DOC_MAPK_MEF2A_6	50	57	PF00069	0.630
DOC_PP4_FxxP_1	4	7	PF00568	0.538
DOC_USP7_MATH_1	23	27	PF00917	0.737
DOC_USP7_UBL2_3	59	63	PF12436	0.517
DOC_WW_Pin1_4	19	24	PF00397	0.595
DOC_WW_Pin1_4	229	234	PF00397	0.710
DOC_WW_Pin1_4	3	8	PF00397	0.657
LIG_14-3-3_CanoR_1	10	16	PF00244	0.565
LIG_14-3-3_CanoR_1	183	190	PF00244	0.592
LIG_14-3-3_CanoR_1	223	228	PF00244	0.756
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	43	47	PF00533	0.669
LIG_FHA_1	130	136	PF00498	0.376
LIG_GBD_Chelix_1	69	77	PF00786	0.283
LIG_LIR_Gen_1	122	131	PF02991	0.300
LIG_LIR_Nem_3	122	126	PF02991	0.290
LIG_LIR_Nem_3	92	98	PF02991	0.313
LIG_LYPXL_yS_3	118	121	PF13949	0.357
LIG_Pex14_2	4	8	PF04695	0.539
LIG_SH2_CRK	116	120	PF00017	0.384
LIG_SH2_NCK_1	227	231	PF00017	0.734
LIG_SH2_STAP1	100	104	PF00017	0.371
LIG_SH2_STAP1	227	231	PF00017	0.622
LIG_SH2_STAT5	131	134	PF00017	0.388
LIG_SH3_3	230	236	PF00018	0.694
LIG_SH3_3	54	60	PF00018	0.648
LIG_SH3_4	59	66	PF00018	0.521
LIG_UBA3_1	94	103	PF00899	0.427
MOD_CDC14_SPxK_1	232	235	PF00782	0.610
MOD_CDK_SPK_2	229	234	PF00069	0.646
MOD_CDK_SPxK_1	229	235	PF00069	0.615
MOD_CDK_SPxxK_3	3	10	PF00069	0.652
MOD_CK1_1	217	223	PF00069	0.770
MOD_CK1_1	22	28	PF00069	0.733
MOD_CMANNOS	8	11	PF00535	0.443
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.617
MOD_GlcNHglycan	157	160	PF01048	0.324
MOD_GlcNHglycan	196	199	PF01048	0.542
MOD_GlcNHglycan	219	222	PF01048	0.509
MOD_GlcNHglycan	236	239	PF01048	0.400
MOD_GlcNHglycan	60	63	PF01048	0.425
MOD_GSK3_1	145	152	PF00069	0.327
MOD_GSK3_1	182	189	PF00069	0.627
MOD_GSK3_1	19	26	PF00069	0.672
MOD_GSK3_1	190	197	PF00069	0.614
MOD_GSK3_1	209	216	PF00069	0.800
MOD_GSK3_1	28	35	PF00069	0.704
MOD_N-GLC_2	36	38	PF02516	0.397
MOD_NEK2_1	182	187	PF00069	0.665
MOD_PKA_1	223	229	PF00069	0.739
MOD_PKA_1	234	240	PF00069	0.744
MOD_PKA_2	182	188	PF00069	0.585
MOD_PKA_2	223	229	PF00069	0.727
MOD_PKB_1	30	38	PF00069	0.594
MOD_ProDKin_1	19	25	PF00069	0.595
MOD_ProDKin_1	229	235	PF00069	0.709
MOD_ProDKin_1	3	9	PF00069	0.653
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.629
TRG_ENDOCYTIC_2	118	121	PF00928	0.357
TRG_ER_diArg_1	222	224	PF00400	0.615
TRG_NLS_MonoExtN_4	63	69	PF00514	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P849	Leptomonas seymouri	51%	94%
A0A1X0NXE6	Trypanosomatidae	27%	100%
A0A3Q8IBS2	Leishmania donovani	73%	100%
A4HZB7	Leishmania infantum	73%	100%
E9AUZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QCI5	Leishmania major	71%	100%