Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBM6_LEIBR

TriTrypDb:

LbrM.21.0340 , LBRM2903_210007800

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.412
CLV_C14_Caspase3-7	24	28	PF00656	0.492
CLV_NRD_NRD_1	117	119	PF00675	0.610
CLV_NRD_NRD_1	315	317	PF00675	0.562
CLV_NRD_NRD_1	318	320	PF00675	0.602
CLV_NRD_NRD_1	391	393	PF00675	0.496
CLV_NRD_NRD_1	442	444	PF00675	0.714
CLV_NRD_NRD_1	467	469	PF00675	0.480
CLV_NRD_NRD_1	494	496	PF00675	0.567
CLV_PCSK_FUR_1	316	320	PF00082	0.632
CLV_PCSK_KEX2_1	315	317	PF00082	0.562
CLV_PCSK_KEX2_1	318	320	PF00082	0.602
CLV_PCSK_KEX2_1	391	393	PF00082	0.496
CLV_PCSK_KEX2_1	442	444	PF00082	0.714
CLV_PCSK_KEX2_1	467	469	PF00082	0.480
CLV_PCSK_KEX2_1	494	496	PF00082	0.567
CLV_PCSK_SKI1_1	11	15	PF00082	0.628
CLV_PCSK_SKI1_1	299	303	PF00082	0.474
CLV_PCSK_SKI1_1	86	90	PF00082	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DEG_SCF_FBW7_1	257	264	PF00400	0.530
DEG_SPOP_SBC_1	34	38	PF00917	0.505
DOC_CKS1_1	258	263	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	414	420	PF00134	0.494
DOC_MAPK_gen_1	14	22	PF00069	0.665
DOC_MAPK_gen_1	293	302	PF00069	0.473
DOC_MAPK_gen_1	449	459	PF00069	0.468
DOC_MAPK_gen_1	467	474	PF00069	0.440
DOC_MAPK_gen_1	494	500	PF00069	0.641
DOC_MAPK_MEF2A_6	3	10	PF00069	0.463
DOC_MAPK_MEF2A_6	452	459	PF00069	0.557
DOC_MAPK_MEF2A_6	467	476	PF00069	0.360
DOC_MAPK_NFAT4_5	452	460	PF00069	0.366
DOC_PP1_RVXF_1	297	303	PF00149	0.474
DOC_PP2B_LxvP_1	414	417	PF13499	0.453
DOC_PP4_FxxP_1	284	287	PF00568	0.611
DOC_USP7_MATH_1	135	139	PF00917	0.698
DOC_USP7_MATH_1	161	165	PF00917	0.572
DOC_USP7_MATH_1	179	183	PF00917	0.489
DOC_USP7_MATH_1	218	222	PF00917	0.777
DOC_USP7_MATH_1	225	229	PF00917	0.748
DOC_USP7_MATH_1	230	234	PF00917	0.680
DOC_USP7_MATH_1	236	240	PF00917	0.584
DOC_USP7_MATH_1	246	250	PF00917	0.560
DOC_USP7_MATH_1	261	265	PF00917	0.536
DOC_USP7_MATH_1	33	37	PF00917	0.758
DOC_USP7_MATH_1	344	348	PF00917	0.561
DOC_USP7_MATH_1	401	405	PF00917	0.525
DOC_USP7_MATH_1	422	426	PF00917	0.547
DOC_USP7_MATH_1	43	47	PF00917	0.597
DOC_USP7_MATH_1	438	442	PF00917	0.504
DOC_USP7_MATH_1	478	482	PF00917	0.456
DOC_USP7_MATH_1	536	540	PF00917	0.461
DOC_WW_Pin1_4	221	226	PF00397	0.782
DOC_WW_Pin1_4	257	262	PF00397	0.623
DOC_WW_Pin1_4	532	537	PF00397	0.416
DOC_WW_Pin1_4	86	91	PF00397	0.619
LIG_14-3-3_CanoR_1	118	124	PF00244	0.578
LIG_14-3-3_CanoR_1	191	199	PF00244	0.691
LIG_14-3-3_CanoR_1	293	303	PF00244	0.506
LIG_14-3-3_CanoR_1	75	81	PF00244	0.470
LIG_Actin_WH2_2	250	265	PF00022	0.603
LIG_CtBP_PxDLS_1	423	428	PF00389	0.550
LIG_FHA_1	105	111	PF00498	0.484
LIG_FHA_1	139	145	PF00498	0.689
LIG_FHA_1	211	217	PF00498	0.531
LIG_FHA_1	257	263	PF00498	0.601
LIG_FHA_1	295	301	PF00498	0.492
LIG_FHA_1	346	352	PF00498	0.512
LIG_FHA_1	400	406	PF00498	0.575
LIG_FHA_1	409	415	PF00498	0.418
LIG_FHA_1	524	530	PF00498	0.486
LIG_FHA_1	71	77	PF00498	0.589
LIG_FHA_1	93	99	PF00498	0.508
LIG_FHA_2	232	238	PF00498	0.730
LIG_FHA_2	307	313	PF00498	0.489
LIG_FHA_2	446	452	PF00498	0.449
LIG_GBD_Chelix_1	455	463	PF00786	0.424
LIG_Integrin_RGDW_4	207	210	PF00362	0.511
LIG_LIR_Apic_2	79	85	PF02991	0.495
LIG_LIR_Gen_1	380	389	PF02991	0.556
LIG_LIR_Gen_1	539	547	PF02991	0.431
LIG_LIR_Nem_3	380	384	PF02991	0.549
LIG_LIR_Nem_3	519	525	PF02991	0.473
LIG_LIR_Nem_3	539	544	PF02991	0.299
LIG_RPA_C_Fungi	484	496	PF08784	0.388
LIG_SH2_CRK	82	86	PF00017	0.532
LIG_SH2_NCK_1	51	55	PF00017	0.562
LIG_SH2_PTP2	381	384	PF00017	0.551
LIG_SH2_STAP1	29	33	PF00017	0.512
LIG_SH2_STAP1	410	414	PF00017	0.464
LIG_SH2_STAP1	51	55	PF00017	0.562
LIG_SH2_STAT5	19	22	PF00017	0.480
LIG_SH2_STAT5	29	32	PF00017	0.513
LIG_SH2_STAT5	381	384	PF00017	0.586
LIG_SH2_STAT5	399	402	PF00017	0.592
LIG_SH2_STAT5	410	413	PF00017	0.415
LIG_SH2_STAT5	51	54	PF00017	0.475
LIG_SH3_2	258	263	PF14604	0.623
LIG_SH3_3	153	159	PF00018	0.600
LIG_SH3_3	255	261	PF00018	0.659
LIG_SH3_3	414	420	PF00018	0.494
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.436
LIG_SUMO_SIM_par_1	542	548	PF11976	0.436
LIG_TRAF2_1	192	195	PF00917	0.579
LIG_TRAF2_1	321	324	PF00917	0.648
LIG_UBA3_1	7	14	PF00899	0.386
LIG_WRC_WIRS_1	473	478	PF05994	0.409
MOD_CDK_SPK_2	221	226	PF00069	0.716
MOD_CDK_SPxK_1	257	263	PF00069	0.625
MOD_CK1_1	120	126	PF00069	0.562
MOD_CK1_1	138	144	PF00069	0.680
MOD_CK1_1	221	227	PF00069	0.788
MOD_CK1_1	28	34	PF00069	0.507
MOD_CK1_1	36	42	PF00069	0.586
MOD_CK1_1	539	545	PF00069	0.429
MOD_CK1_1	92	98	PF00069	0.507
MOD_CK2_1	140	146	PF00069	0.552
MOD_CK2_1	190	196	PF00069	0.579
MOD_CK2_1	225	231	PF00069	0.576
MOD_CK2_1	236	242	PF00069	0.655
MOD_CK2_1	301	307	PF00069	0.488
MOD_CK2_1	318	324	PF00069	0.433
MOD_CK2_1	344	350	PF00069	0.527
MOD_Cter_Amidation	389	392	PF01082	0.496
MOD_GlcNHglycan	132	135	PF01048	0.653
MOD_GlcNHglycan	137	140	PF01048	0.682
MOD_GlcNHglycan	151	154	PF01048	0.630
MOD_GlcNHglycan	216	219	PF01048	0.758
MOD_GlcNHglycan	228	231	PF01048	0.670
MOD_GlcNHglycan	237	241	PF01048	0.576
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	263	266	PF01048	0.593
MOD_GlcNHglycan	31	34	PF01048	0.658
MOD_GlcNHglycan	429	434	PF01048	0.616
MOD_GlcNHglycan	45	48	PF01048	0.674
MOD_GlcNHglycan	91	94	PF01048	0.504
MOD_GSK3_1	126	133	PF00069	0.593
MOD_GSK3_1	145	152	PF00069	0.717
MOD_GSK3_1	21	28	PF00069	0.586
MOD_GSK3_1	210	217	PF00069	0.689
MOD_GSK3_1	221	228	PF00069	0.719
MOD_GSK3_1	252	259	PF00069	0.577
MOD_GSK3_1	29	36	PF00069	0.567
MOD_GSK3_1	302	309	PF00069	0.590
MOD_GSK3_1	45	52	PF00069	0.623
MOD_GSK3_1	472	479	PF00069	0.413
MOD_GSK3_1	532	539	PF00069	0.491
MOD_N-GLC_1	172	177	PF02516	0.523
MOD_N-GLC_1	246	251	PF02516	0.684
MOD_N-GLC_1	25	30	PF02516	0.500
MOD_NEK2_1	140	145	PF00069	0.553
MOD_NEK2_1	25	30	PF00069	0.516
MOD_NEK2_1	457	462	PF00069	0.387
MOD_NEK2_1	472	477	PF00069	0.510
MOD_NEK2_1	76	81	PF00069	0.465
MOD_NEK2_2	145	150	PF00069	0.542
MOD_NEK2_2	462	467	PF00069	0.442
MOD_NEK2_2	70	75	PF00069	0.509
MOD_OFUCOSY	283	290	PF10250	0.519
MOD_PIKK_1	172	178	PF00454	0.511
MOD_PIKK_1	457	463	PF00454	0.442
MOD_PKA_1	318	324	PF00069	0.576
MOD_PKA_2	117	123	PF00069	0.615
MOD_PKA_2	190	196	PF00069	0.660
MOD_PKA_2	225	231	PF00069	0.770
MOD_PKA_2	318	324	PF00069	0.576
MOD_PKA_2	445	451	PF00069	0.538
MOD_PKB_1	316	324	PF00069	0.639
MOD_Plk_1	120	126	PF00069	0.497
MOD_Plk_1	145	151	PF00069	0.540
MOD_Plk_1	25	31	PF00069	0.511
MOD_Plk_1	336	342	PF00069	0.503
MOD_Plk_4	126	132	PF00069	0.625
MOD_Plk_4	252	258	PF00069	0.546
MOD_Plk_4	36	42	PF00069	0.573
MOD_Plk_4	377	383	PF00069	0.555
MOD_Plk_4	472	478	PF00069	0.409
MOD_ProDKin_1	221	227	PF00069	0.780
MOD_ProDKin_1	257	263	PF00069	0.625
MOD_ProDKin_1	532	538	PF00069	0.410
MOD_ProDKin_1	86	92	PF00069	0.616
MOD_SUMO_rev_2	501	510	PF00179	0.472
TRG_DiLeu_BaEn_4	323	329	PF01217	0.600
TRG_ENDOCYTIC_2	19	22	PF00928	0.573
TRG_ENDOCYTIC_2	2	5	PF00928	0.539
TRG_ENDOCYTIC_2	381	384	PF00928	0.572
TRG_ENDOCYTIC_2	487	490	PF00928	0.460
TRG_ER_diArg_1	315	318	PF00400	0.632
TRG_ER_diArg_1	391	393	PF00400	0.496
TRG_ER_diArg_1	466	468	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K7	Leptomonas seymouri	53%	94%
A0A3S7WWB2	Leishmania donovani	77%	100%
E9AUZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QCI7	Leishmania major	77%	97%