Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBM4_LEIBR

TriTrypDb:

LbrM.21.0320 , LBRM2903_210007600

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.392
CLV_NRD_NRD_1	109	111	PF00675	0.291
CLV_NRD_NRD_1	358	360	PF00675	0.463
CLV_NRD_NRD_1	398	400	PF00675	0.372
CLV_NRD_NRD_1	423	425	PF00675	0.380
CLV_NRD_NRD_1	47	49	PF00675	0.643
CLV_NRD_NRD_1	77	79	PF00675	0.521
CLV_NRD_NRD_1	89	91	PF00675	0.662
CLV_PCSK_FUR_1	75	79	PF00082	0.430
CLV_PCSK_FUR_1	87	91	PF00082	0.352
CLV_PCSK_KEX2_1	108	110	PF00082	0.291
CLV_PCSK_KEX2_1	205	207	PF00082	0.417
CLV_PCSK_KEX2_1	398	400	PF00082	0.376
CLV_PCSK_KEX2_1	46	48	PF00082	0.642
CLV_PCSK_KEX2_1	77	79	PF00082	0.533
CLV_PCSK_KEX2_1	89	91	PF00082	0.677
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.396
CLV_PCSK_SKI1_1	131	135	PF00082	0.429
CLV_PCSK_SKI1_1	14	18	PF00082	0.492
CLV_PCSK_SKI1_1	193	197	PF00082	0.375
CLV_PCSK_SKI1_1	205	209	PF00082	0.348
CLV_PCSK_SKI1_1	271	275	PF00082	0.369
CLV_PCSK_SKI1_1	294	298	PF00082	0.350
CLV_PCSK_SKI1_1	424	428	PF00082	0.420
CLV_PCSK_SKI1_1	467	471	PF00082	0.417
DEG_APCC_DBOX_1	423	431	PF00400	0.492
DEG_Nend_UBRbox_1	1	4	PF02207	0.393
DEG_SPOP_SBC_1	247	251	PF00917	0.445
DEG_SPOP_SBC_1	56	60	PF00917	0.577
DOC_CKS1_1	219	224	PF01111	0.526
DOC_CKS1_1	382	387	PF01111	0.462
DOC_CYCLIN_RxL_1	335	344	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.521
DOC_MAPK_gen_1	205	213	PF00069	0.427
DOC_MAPK_gen_1	398	407	PF00069	0.460
DOC_MAPK_gen_1	587	596	PF00069	0.539
DOC_MAPK_gen_1	9	19	PF00069	0.415
DOC_MAPK_MEF2A_6	12	21	PF00069	0.515
DOC_MAPK_MEF2A_6	318	327	PF00069	0.304
DOC_MAPK_MEF2A_6	511	520	PF00069	0.351
DOC_PP2B_LxvP_1	24	27	PF13499	0.575
DOC_PP2B_LxvP_1	67	70	PF13499	0.672
DOC_USP7_MATH_1	238	242	PF00917	0.705
DOC_USP7_MATH_1	247	251	PF00917	0.620
DOC_USP7_MATH_1	488	492	PF00917	0.368
DOC_USP7_MATH_1	55	59	PF00917	0.581
DOC_USP7_MATH_1	562	566	PF00917	0.525
DOC_USP7_MATH_1	578	582	PF00917	0.347
DOC_USP7_MATH_2	27	33	PF00917	0.416
DOC_WW_Pin1_4	162	167	PF00397	0.675
DOC_WW_Pin1_4	214	219	PF00397	0.490
DOC_WW_Pin1_4	31	36	PF00397	0.656
DOC_WW_Pin1_4	381	386	PF00397	0.469
LIG_14-3-3_CanoR_1	2	10	PF00244	0.325
LIG_14-3-3_CanoR_1	206	215	PF00244	0.426
LIG_14-3-3_CanoR_1	285	293	PF00244	0.465
LIG_14-3-3_CanoR_1	367	371	PF00244	0.521
LIG_14-3-3_CanoR_1	442	447	PF00244	0.274
LIG_14-3-3_CanoR_1	455	461	PF00244	0.274
LIG_14-3-3_CanoR_1	486	494	PF00244	0.457
LIG_14-3-3_CanoR_1	535	541	PF00244	0.446
LIG_Actin_WH2_2	164	179	PF00022	0.543
LIG_Actin_WH2_2	184	199	PF00022	0.388
LIG_Actin_WH2_2	257	273	PF00022	0.363
LIG_Actin_WH2_2	538	555	PF00022	0.497
LIG_APCC_ABBA_1	1	6	PF00400	0.307
LIG_eIF4E_1	287	293	PF01652	0.383
LIG_FHA_1	171	177	PF00498	0.460
LIG_FHA_1	198	204	PF00498	0.468
LIG_FHA_1	287	293	PF00498	0.465
LIG_FHA_1	317	323	PF00498	0.366
LIG_FHA_1	377	383	PF00498	0.393
LIG_FHA_1	407	413	PF00498	0.379
LIG_FHA_1	478	484	PF00498	0.281
LIG_FHA_1	63	69	PF00498	0.457
LIG_FHA_1	80	86	PF00498	0.628
LIG_FHA_2	221	227	PF00498	0.546
LIG_FHA_2	375	381	PF00498	0.427
LIG_LIR_Gen_1	135	144	PF02991	0.343
LIG_LIR_Gen_1	151	162	PF02991	0.586
LIG_LIR_Gen_1	344	352	PF02991	0.408
LIG_LIR_Gen_1	443	450	PF02991	0.274
LIG_LIR_LC3C_4	184	189	PF02991	0.424
LIG_LIR_Nem_3	135	139	PF02991	0.335
LIG_LIR_Nem_3	278	282	PF02991	0.371
LIG_LIR_Nem_3	344	348	PF02991	0.384
LIG_LIR_Nem_3	443	449	PF02991	0.274
LIG_LIR_Nem_3	480	484	PF02991	0.276
LIG_LIR_Nem_3	505	510	PF02991	0.487
LIG_LIR_Nem_3	97	102	PF02991	0.363
LIG_LYPXL_yS_3	507	510	PF13949	0.370
LIG_MAD2	177	185	PF02301	0.542
LIG_MYND_3	518	522	PF01753	0.390
LIG_PDZ_Class_2	591	596	PF00595	0.509
LIG_Pex14_2	99	103	PF04695	0.399
LIG_PTB_Apo_2	97	104	PF02174	0.396
LIG_SH2_CRK	136	140	PF00017	0.363
LIG_SH2_CRK	446	450	PF00017	0.289
LIG_SH2_STAT3	351	354	PF00017	0.460
LIG_SH2_STAT5	102	105	PF00017	0.327
LIG_SH2_STAT5	138	141	PF00017	0.409
LIG_SH2_STAT5	260	263	PF00017	0.353
LIG_SH2_STAT5	282	285	PF00017	0.491
LIG_SH2_STAT5	287	290	PF00017	0.454
LIG_SH2_STAT5	351	354	PF00017	0.451
LIG_SH2_STAT5	368	371	PF00017	0.312
LIG_SH2_STAT5	374	377	PF00017	0.397
LIG_SH2_STAT5	4	7	PF00017	0.530
LIG_SH2_STAT5	500	503	PF00017	0.432
LIG_SH3_3	216	222	PF00018	0.563
LIG_SH3_3	251	257	PF00018	0.406
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.308
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.297
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.430
LIG_SUMO_SIM_par_1	186	192	PF11976	0.382
LIG_SUMO_SIM_par_1	25	34	PF11976	0.408
LIG_SUMO_SIM_par_1	264	269	PF11976	0.405
LIG_SUMO_SIM_par_1	305	312	PF11976	0.484
LIG_SUMO_SIM_par_1	403	409	PF11976	0.372
LIG_TRAF2_1	113	116	PF00917	0.453
LIG_TYR_ITIM	134	139	PF00017	0.394
LIG_UBA3_1	342	349	PF00899	0.364
LIG_WRC_WIRS_1	171	176	PF05994	0.484
LIG_WRC_WIRS_1	375	380	PF05994	0.396
LIG_WRC_WIRS_1	478	483	PF05994	0.350
LIG_WW_1	257	260	PF00397	0.334
MOD_CDC14_SPxK_1	217	220	PF00782	0.560
MOD_CDK_SPxK_1	214	220	PF00069	0.509
MOD_CK1_1	227	233	PF00069	0.778
MOD_CK1_1	249	255	PF00069	0.681
MOD_CK1_1	537	543	PF00069	0.454
MOD_CK2_1	220	226	PF00069	0.532
MOD_CK2_1	428	434	PF00069	0.493
MOD_GlcNHglycan	230	233	PF01048	0.786
MOD_GlcNHglycan	251	254	PF01048	0.690
MOD_GlcNHglycan	43	46	PF01048	0.740
MOD_GlcNHglycan	430	433	PF01048	0.544
MOD_GlcNHglycan	471	474	PF01048	0.432
MOD_GlcNHglycan	490	493	PF01048	0.336
MOD_GlcNHglycan	553	556	PF01048	0.273
MOD_GlcNHglycan	81	85	PF01048	0.625
MOD_GSK3_1	179	186	PF00069	0.458
MOD_GSK3_1	214	221	PF00069	0.580
MOD_GSK3_1	224	231	PF00069	0.736
MOD_GSK3_1	296	303	PF00069	0.487
MOD_GSK3_1	362	369	PF00069	0.544
MOD_GSK3_1	451	458	PF00069	0.308
MOD_GSK3_1	465	472	PF00069	0.251
MOD_GSK3_1	547	554	PF00069	0.425
MOD_N-GLC_1	227	232	PF02516	0.619
MOD_NEK2_1	30	35	PF00069	0.709
MOD_NEK2_1	41	46	PF00069	0.736
MOD_NEK2_1	469	474	PF00069	0.339
MOD_NEK2_1	79	84	PF00069	0.542
MOD_NEK2_2	57	62	PF00069	0.487
MOD_PIKK_1	230	236	PF00454	0.616
MOD_PIKK_1	277	283	PF00454	0.489
MOD_PIKK_1	328	334	PF00454	0.467
MOD_PIKK_1	534	540	PF00454	0.496
MOD_PIKK_1	568	574	PF00454	0.327
MOD_PKA_2	366	372	PF00069	0.551
MOD_PKA_2	456	462	PF00069	0.368
MOD_PKA_2	534	540	PF00069	0.353
MOD_Plk_1	502	508	PF00069	0.356
MOD_Plk_1	80	86	PF00069	0.586
MOD_Plk_4	170	176	PF00069	0.435
MOD_Plk_4	183	189	PF00069	0.380
MOD_Plk_4	456	462	PF00069	0.393
MOD_Plk_4	547	553	PF00069	0.388
MOD_ProDKin_1	162	168	PF00069	0.664
MOD_ProDKin_1	214	220	PF00069	0.509
MOD_ProDKin_1	31	37	PF00069	0.661
MOD_ProDKin_1	381	387	PF00069	0.465
MOD_SUMO_rev_2	155	160	PF00179	0.452
MOD_SUMO_rev_2	422	427	PF00179	0.421
TRG_DiLeu_BaEn_1	156	161	PF01217	0.361
TRG_DiLeu_BaEn_1	321	326	PF01217	0.360
TRG_DiLeu_BaEn_2	114	120	PF01217	0.517
TRG_DiLeu_BaEn_4	422	428	PF01217	0.427
TRG_ENDOCYTIC_2	136	139	PF00928	0.370
TRG_ENDOCYTIC_2	38	41	PF00928	0.700
TRG_ENDOCYTIC_2	4	7	PF00928	0.481
TRG_ENDOCYTIC_2	446	449	PF00928	0.289
TRG_ENDOCYTIC_2	466	469	PF00928	0.145
TRG_ENDOCYTIC_2	507	510	PF00928	0.370
TRG_ER_diArg_1	108	110	PF00400	0.272
TRG_ER_diArg_1	46	48	PF00400	0.642
TRG_ER_diArg_1	579	582	PF00400	0.453
TRG_ER_diArg_1	77	79	PF00400	0.535
TRG_ER_diArg_1	88	90	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C5	Leptomonas seymouri	68%	78%
A0A0S4J3H1	Bodo saltans	40%	100%
A0A1X0NYY0	Trypanosomatidae	50%	96%
A0A3S7WWD8	Leishmania donovani	89%	100%
A0A422NII4	Trypanosoma rangeli	50%	100%
A4HZB3	Leishmania infantum	88%	100%
D0A1L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AUZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	81%
Q4QCI9	Leishmania major	89%	100%
V5BG17	Trypanosoma cruzi	50%	100%