Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBM2_LEIBR

TriTrypDb:

LbrM.21.0300 , LBRM2903_210007300

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000118	histone deacetylase complex	3	1
GO:0000812	Swr1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0097346	INO80-type complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HBM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM2

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0031491	nucleosome binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.310
CLV_NRD_NRD_1	284	286	PF00675	0.296
CLV_NRD_NRD_1	313	315	PF00675	0.334
CLV_NRD_NRD_1	94	96	PF00675	0.215
CLV_PCSK_KEX2_1	186	188	PF00082	0.310
CLV_PCSK_KEX2_1	284	286	PF00082	0.323
CLV_PCSK_KEX2_1	313	315	PF00082	0.273
CLV_PCSK_KEX2_1	556	558	PF00082	0.595
CLV_PCSK_KEX2_1	94	96	PF00082	0.215
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.310
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.595
CLV_PCSK_SKI1_1	245	249	PF00082	0.271
CLV_PCSK_SKI1_1	419	423	PF00082	0.246
CLV_PCSK_SKI1_1	430	434	PF00082	0.243
CLV_Separin_Metazoa	427	431	PF03568	0.359
DEG_APCC_DBOX_1	344	352	PF00400	0.428
DEG_APCC_DBOX_1	418	426	PF00400	0.446
DEG_SCF_TRCP1_1	201	207	PF00400	0.359
DEG_SPOP_SBC_1	160	164	PF00917	0.445
DOC_CDC14_PxL_1	348	356	PF14671	0.428
DOC_CDC14_PxL_1	500	508	PF14671	0.277
DOC_CDC14_PxL_1	520	528	PF14671	0.196
DOC_CKS1_1	329	334	PF01111	0.359
DOC_CKS1_1	395	400	PF01111	0.510
DOC_CYCLIN_RxL_1	416	426	PF00134	0.461
DOC_CYCLIN_yClb3_PxF_3	504	512	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.461
DOC_MAPK_DCC_7	388	396	PF00069	0.510
DOC_MAPK_gen_1	185	194	PF00069	0.359
DOC_MAPK_gen_1	250	257	PF00069	0.456
DOC_MAPK_MEF2A_6	388	396	PF00069	0.510
DOC_PP2B_LxvP_1	131	134	PF13499	0.445
DOC_PP2B_LxvP_1	18	21	PF13499	0.375
DOC_PP2B_LxvP_1	61	64	PF13499	0.461
DOC_PP4_FxxP_1	135	138	PF00568	0.417
DOC_PP4_FxxP_1	389	392	PF00568	0.415
DOC_SPAK_OSR1_1	388	392	PF12202	0.510
DOC_USP7_MATH_1	120	124	PF00917	0.385
DOC_USP7_MATH_1	196	200	PF00917	0.515
DOC_USP7_MATH_1	232	236	PF00917	0.454
DOC_USP7_MATH_1	283	287	PF00917	0.456
DOC_USP7_MATH_1	369	373	PF00917	0.535
DOC_USP7_MATH_1	37	41	PF00917	0.652
DOC_USP7_MATH_1	534	538	PF00917	0.618
DOC_WW_Pin1_4	320	325	PF00397	0.491
DOC_WW_Pin1_4	328	333	PF00397	0.483
DOC_WW_Pin1_4	336	341	PF00397	0.510
DOC_WW_Pin1_4	394	399	PF00397	0.471
DOC_WW_Pin1_4	52	57	PF00397	0.581
LIG_14-3-3_CanoR_1	175	181	PF00244	0.569
LIG_14-3-3_CanoR_1	284	288	PF00244	0.471
LIG_14-3-3_CanoR_1	367	376	PF00244	0.359
LIG_14-3-3_CanoR_1	496	504	PF00244	0.442
LIG_14-3-3_CanoR_1	581	585	PF00244	0.445
LIG_Actin_WH2_2	298	315	PF00022	0.375
LIG_APCC_ABBA_1	4	9	PF00400	0.366
LIG_APCC_ABBAyCdc20_2	3	9	PF00400	0.446
LIG_BRCT_BRCA1_1	151	155	PF00533	0.440
LIG_BRCT_BRCA1_1	161	165	PF00533	0.388
LIG_deltaCOP1_diTrp_1	128	135	PF00928	0.510
LIG_FHA_1	175	181	PF00498	0.359
LIG_FHA_1	220	226	PF00498	0.429
LIG_FHA_1	246	252	PF00498	0.471
LIG_FHA_1	264	270	PF00498	0.471
LIG_FHA_1	31	37	PF00498	0.490
LIG_FHA_1	329	335	PF00498	0.467
LIG_FHA_1	369	375	PF00498	0.491
LIG_FHA_1	411	417	PF00498	0.510
LIG_FHA_1	424	430	PF00498	0.491
LIG_FHA_1	478	484	PF00498	0.466
LIG_FHA_2	336	342	PF00498	0.565
LIG_FHA_2	395	401	PF00498	0.510
LIG_FHA_2	41	47	PF00498	0.620
LIG_LIR_Apic_2	132	138	PF02991	0.398
LIG_LIR_Apic_2	387	392	PF02991	0.415
LIG_LIR_Gen_1	109	120	PF02991	0.366
LIG_LIR_Gen_1	128	138	PF02991	0.486
LIG_LIR_Gen_1	162	173	PF02991	0.415
LIG_LIR_Gen_1	253	262	PF02991	0.461
LIG_LIR_Nem_3	109	115	PF02991	0.366
LIG_LIR_Nem_3	128	133	PF02991	0.486
LIG_LIR_Nem_3	152	158	PF02991	0.444
LIG_LIR_Nem_3	162	168	PF02991	0.396
LIG_LIR_Nem_3	253	257	PF02991	0.460
LIG_LYPXL_SIV_4	170	178	PF13949	0.359
LIG_MYND_1	352	356	PF01753	0.428
LIG_NRBOX	143	149	PF00104	0.510
LIG_NRBOX	378	384	PF00104	0.471
LIG_NRBOX	424	430	PF00104	0.461
LIG_PCNA_PIPBox_1	418	427	PF02747	0.461
LIG_PCNA_yPIPBox_3	581	595	PF02747	0.508
LIG_Pex14_1	267	271	PF04695	0.424
LIG_SH2_CRK	230	234	PF00017	0.384
LIG_SH2_CRK	88	92	PF00017	0.471
LIG_SH2_GRB2like	227	230	PF00017	0.510
LIG_SH2_SRC	19	22	PF00017	0.485
LIG_SH2_SRC	464	467	PF00017	0.411
LIG_SH2_STAP1	290	294	PF00017	0.515
LIG_SH2_STAT5	171	174	PF00017	0.359
LIG_SH2_STAT5	19	22	PF00017	0.392
LIG_SH2_STAT5	227	230	PF00017	0.415
LIG_SH2_STAT5	254	257	PF00017	0.517
LIG_SH2_STAT5	271	274	PF00017	0.498
LIG_SH2_STAT5	347	350	PF00017	0.428
LIG_SH3_1	346	352	PF00018	0.415
LIG_SH3_2	340	345	PF14604	0.461
LIG_SH3_3	326	332	PF00018	0.538
LIG_SH3_3	337	343	PF00018	0.356
LIG_SH3_3	346	352	PF00018	0.389
LIG_SH3_3	359	365	PF00018	0.415
LIG_SH3_3	501	507	PF00018	0.495
LIG_SH3_3	90	96	PF00018	0.471
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.444
LIG_SUMO_SIM_anti_2	518	524	PF11976	0.219
LIG_SUMO_SIM_par_1	176	182	PF11976	0.359
LIG_SUMO_SIM_par_1	358	363	PF11976	0.359
LIG_TRAF2_1	123	126	PF00917	0.461
LIG_TRAF2_1	298	301	PF00917	0.359
LIG_TYR_ITIM	228	233	PF00017	0.461
LIG_UBA3_1	268	273	PF00899	0.359
LIG_WRC_WIRS_1	254	259	PF05994	0.445
LIG_WRC_WIRS_1	584	589	PF05994	0.449
LIG_WW_2	504	507	PF00397	0.351
MOD_CDK_SPxxK_3	52	59	PF00069	0.360
MOD_CK1_1	164	170	PF00069	0.500
MOD_CK1_1	199	205	PF00069	0.441
MOD_CK1_1	208	214	PF00069	0.444
MOD_CK1_1	220	226	PF00069	0.349
MOD_CK1_1	23	29	PF00069	0.566
MOD_CK1_1	323	329	PF00069	0.428
MOD_CK1_1	40	46	PF00069	0.462
MOD_CK1_1	485	491	PF00069	0.519
MOD_CK1_1	498	504	PF00069	0.336
MOD_CK1_1	511	517	PF00069	0.388
MOD_CK1_1	537	543	PF00069	0.454
MOD_CK2_1	120	126	PF00069	0.452
MOD_CK2_1	295	301	PF00069	0.407
MOD_CK2_1	40	46	PF00069	0.620
MOD_CK2_1	485	491	PF00069	0.662
MOD_CK2_1	567	573	PF00069	0.476
MOD_DYRK1A_RPxSP_1	328	332	PF00069	0.359
MOD_GlcNHglycan	181	184	PF01048	0.241
MOD_GlcNHglycan	201	204	PF01048	0.282
MOD_GlcNHglycan	207	210	PF01048	0.239
MOD_GlcNHglycan	219	222	PF01048	0.148
MOD_GlcNHglycan	315	318	PF01048	0.238
MOD_GlcNHglycan	371	374	PF01048	0.310
MOD_GlcNHglycan	39	42	PF01048	0.500
MOD_GlcNHglycan	487	490	PF01048	0.622
MOD_GlcNHglycan	491	495	PF01048	0.581
MOD_GlcNHglycan	500	503	PF01048	0.387
MOD_GlcNHglycan	513	516	PF01048	0.470
MOD_GlcNHglycan	532	535	PF01048	0.412
MOD_GlcNHglycan	536	539	PF01048	0.562
MOD_GSK3_1	156	163	PF00069	0.445
MOD_GSK3_1	174	181	PF00069	0.445
MOD_GSK3_1	204	211	PF00069	0.482
MOD_GSK3_1	21	28	PF00069	0.543
MOD_GSK3_1	32	39	PF00069	0.650
MOD_GSK3_1	477	484	PF00069	0.755
MOD_GSK3_1	511	518	PF00069	0.565
MOD_GSK3_1	530	537	PF00069	0.542
MOD_N-GLC_1	204	209	PF02516	0.256
MOD_N-GLC_1	476	481	PF02516	0.467
MOD_N-GLC_1	540	545	PF02516	0.481
MOD_N-GLC_2	436	438	PF02516	0.261
MOD_N-GLC_2	448	450	PF02516	0.181
MOD_NEK2_1	147	152	PF00069	0.492
MOD_NEK2_1	178	183	PF00069	0.517
MOD_NEK2_1	219	224	PF00069	0.420
MOD_NEK2_1	263	268	PF00069	0.471
MOD_NEK2_1	36	41	PF00069	0.616
MOD_NEK2_1	510	515	PF00069	0.502
MOD_NEK2_1	532	537	PF00069	0.435
MOD_NEK2_2	11	16	PF00069	0.348
MOD_NEK2_2	149	154	PF00069	0.510
MOD_PIKK_1	255	261	PF00454	0.428
MOD_PIKK_1	323	329	PF00454	0.445
MOD_PIKK_1	410	416	PF00454	0.438
MOD_PIKK_1	442	448	PF00454	0.461
MOD_PKA_1	313	319	PF00069	0.359
MOD_PKA_2	174	180	PF00069	0.456
MOD_PKA_2	283	289	PF00069	0.471
MOD_PKA_2	313	319	PF00069	0.395
MOD_PKA_2	477	483	PF00069	0.659
MOD_PKA_2	485	491	PF00069	0.706
MOD_PKA_2	495	501	PF00069	0.288
MOD_PKA_2	580	586	PF00069	0.504
MOD_Plk_1	263	269	PF00069	0.471
MOD_Plk_1	518	524	PF00069	0.429
MOD_Plk_4	156	162	PF00069	0.415
MOD_Plk_4	164	170	PF00069	0.415
MOD_Plk_4	220	226	PF00069	0.428
MOD_Plk_4	233	239	PF00069	0.428
MOD_Plk_4	263	269	PF00069	0.501
MOD_Plk_4	518	524	PF00069	0.457
MOD_ProDKin_1	320	326	PF00069	0.491
MOD_ProDKin_1	328	334	PF00069	0.483
MOD_ProDKin_1	336	342	PF00069	0.510
MOD_ProDKin_1	394	400	PF00069	0.471
MOD_ProDKin_1	52	58	PF00069	0.564
MOD_SUMO_for_1	555	558	PF00179	0.340
TRG_DiLeu_BaEn_1	264	269	PF01217	0.428
TRG_DiLeu_BaEn_3	300	306	PF01217	0.359
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.560
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.406
TRG_ENDOCYTIC_2	230	233	PF00928	0.422
TRG_ENDOCYTIC_2	254	257	PF00928	0.504
TRG_ENDOCYTIC_2	290	293	PF00928	0.522
TRG_ENDOCYTIC_2	88	91	PF00928	0.471
TRG_ER_diArg_1	185	188	PF00400	0.461
TRG_ER_diArg_1	283	285	PF00400	0.560
TRG_ER_diArg_1	312	314	PF00400	0.546
TRG_ER_diArg_1	569	572	PF00400	0.368
TRG_ER_diArg_1	93	95	PF00400	0.415
TRG_NES_CRM1_1	375	387	PF08389	0.544
TRG_NLS_MonoCore_2	185	190	PF00514	0.461
TRG_NLS_MonoExtC_3	184	189	PF00514	0.510
TRG_NLS_MonoExtN_4	185	190	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I4	Leptomonas seymouri	53%	94%
A0A0S4IXC8	Bodo saltans	35%	100%
A0A3R7KCE3	Trypanosoma rangeli	43%	100%
A0A3S7WWF5	Leishmania donovani	79%	100%
A2WNB0	Oryza sativa subsp. indica	26%	100%
A4HZB0	Leishmania infantum	79%	100%
D0A1L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AUZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
O94241	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P0CM04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	100%
P0CM05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	100%
P45890	Drosophila melanogaster	27%	100%
Q09443	Caenorhabditis elegans	28%	100%
Q12509	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QCJ2	Leishmania major	78%	98%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5NBI2	Oryza sativa subsp. japonica	26%	100%
Q6BML9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	100%
Q6CJF4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q6FKE7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q74ZV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	100%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q8LGE3	Arabidopsis thaliana	26%	100%
V5B0N4	Trypanosoma cruzi	44%	100%