Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBM0_LEIBR

TriTrypDb:

LbrM.21.0280 , LBRM2903_210007100

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.531
CLV_NRD_NRD_1	246	248	PF00675	0.510
CLV_NRD_NRD_1	304	306	PF00675	0.569
CLV_NRD_NRD_1	376	378	PF00675	0.465
CLV_NRD_NRD_1	453	455	PF00675	0.468
CLV_PCSK_KEX2_1	142	144	PF00082	0.512
CLV_PCSK_KEX2_1	246	248	PF00082	0.510
CLV_PCSK_KEX2_1	304	306	PF00082	0.515
CLV_PCSK_KEX2_1	376	378	PF00082	0.465
CLV_PCSK_KEX2_1	453	455	PF00082	0.468
CLV_PCSK_SKI1_1	384	388	PF00082	0.483
CLV_PCSK_SKI1_1	455	459	PF00082	0.682
DEG_APCC_DBOX_1	151	159	PF00400	0.357
DEG_APCC_DBOX_1	389	397	PF00400	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SPOP_SBC_1	203	207	PF00917	0.435
DOC_CKS1_1	366	371	PF01111	0.290
DOC_CYCLIN_RxL_1	374	385	PF00134	0.476
DOC_CYCLIN_RxL_1	452	462	PF00134	0.456
DOC_MAPK_DCC_7	222	230	PF00069	0.646
DOC_MAPK_gen_1	222	230	PF00069	0.646
DOC_MAPK_gen_1	246	254	PF00069	0.574
DOC_MAPK_gen_1	304	312	PF00069	0.527
DOC_MAPK_gen_1	376	383	PF00069	0.512
DOC_MAPK_gen_1	453	461	PF00069	0.609
DOC_MAPK_MEF2A_6	180	187	PF00069	0.555
DOC_MAPK_MEF2A_6	224	232	PF00069	0.602
DOC_MAPK_MEF2A_6	376	383	PF00069	0.512
DOC_MAPK_NFAT4_5	376	384	PF00069	0.518
DOC_USP7_MATH_1	203	207	PF00917	0.474
DOC_USP7_MATH_1	436	440	PF00917	0.679
DOC_WW_Pin1_4	278	283	PF00397	0.684
DOC_WW_Pin1_4	365	370	PF00397	0.289
DOC_WW_Pin1_4	459	464	PF00397	0.599
LIG_14-3-3_CanoR_1	135	145	PF00244	0.516
LIG_14-3-3_CanoR_1	154	159	PF00244	0.459
LIG_14-3-3_CanoR_1	376	380	PF00244	0.489
LIG_14-3-3_CanoR_1	521	526	PF00244	0.326
LIG_BIR_III_2	250	254	PF00653	0.567
LIG_Clathr_ClatBox_1	407	411	PF01394	0.521
LIG_deltaCOP1_diTrp_1	267	272	PF00928	0.605
LIG_deltaCOP1_diTrp_1	483	487	PF00928	0.545
LIG_DLG_GKlike_1	521	529	PF00625	0.325
LIG_EVH1_1	431	435	PF00568	0.743
LIG_FHA_1	139	145	PF00498	0.586
LIG_FHA_1	192	198	PF00498	0.554
LIG_FHA_1	233	239	PF00498	0.560
LIG_FHA_1	351	357	PF00498	0.427
LIG_FHA_1	366	372	PF00498	0.315
LIG_FHA_1	7	13	PF00498	0.723
LIG_FHA_2	135	141	PF00498	0.520
LIG_FHA_2	203	209	PF00498	0.453
LIG_FHA_2	269	275	PF00498	0.495
LIG_GBD_Chelix_1	379	387	PF00786	0.524
LIG_GBD_Chelix_1	398	406	PF00786	0.484
LIG_LIR_Apic_2	363	369	PF02991	0.527
LIG_LIR_Gen_1	483	493	PF02991	0.579
LIG_LIR_Nem_3	355	360	PF02991	0.541
LIG_LIR_Nem_3	427	431	PF02991	0.647
LIG_LIR_Nem_3	483	488	PF02991	0.571
LIG_LYPXL_SIV_4	338	346	PF13949	0.546
LIG_NRBOX	382	388	PF00104	0.577
LIG_NRBOX	399	405	PF00104	0.355
LIG_NRBOX	74	80	PF00104	0.489
LIG_PCNA_yPIPBox_3	390	399	PF02747	0.524
LIG_PDZ_Class_1	528	533	PF00595	0.430
LIG_RPA_C_Fungi	372	384	PF08784	0.449
LIG_SH2_SRC	339	342	PF00017	0.293
LIG_SH2_STAP1	339	343	PF00017	0.480
LIG_SH2_STAP1	352	356	PF00017	0.357
LIG_SH2_STAP1	56	60	PF00017	0.522
LIG_SH2_STAT5	352	355	PF00017	0.513
LIG_SH2_STAT5	366	369	PF00017	0.433
LIG_SH2_STAT5	504	507	PF00017	0.592
LIG_SH3_3	124	130	PF00018	0.501
LIG_SH3_3	263	269	PF00018	0.468
LIG_SH3_3	429	435	PF00018	0.683
LIG_SH3_3	57	63	PF00018	0.445
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.449
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.458
LIG_SUMO_SIM_anti_2	70	77	PF11976	0.470
LIG_SUMO_SIM_par_1	183	188	PF11976	0.510
LIG_SUMO_SIM_par_1	228	235	PF11976	0.598
LIG_SUMO_SIM_par_1	405	412	PF11976	0.507
LIG_TRAF2_1	271	274	PF00917	0.441
LIG_TRAF2_1	86	89	PF00917	0.401
LIG_TYR_ITIM	82	87	PF00017	0.391
MOD_CK1_1	157	163	PF00069	0.488
MOD_CK1_1	191	197	PF00069	0.541
MOD_CK1_1	475	481	PF00069	0.677
MOD_CK2_1	134	140	PF00069	0.523
MOD_CK2_1	157	163	PF00069	0.492
MOD_CK2_1	203	209	PF00069	0.453
MOD_CK2_1	268	274	PF00069	0.522
MOD_CK2_1	30	36	PF00069	0.539
MOD_CK2_1	379	385	PF00069	0.526
MOD_CK2_1	521	527	PF00069	0.331
MOD_GlcNHglycan	208	213	PF01048	0.678
MOD_GlcNHglycan	242	245	PF01048	0.488
MOD_GlcNHglycan	411	414	PF01048	0.585
MOD_GlcNHglycan	420	423	PF01048	0.676
MOD_GlcNHglycan	474	477	PF01048	0.710
MOD_GlcNHglycan	498	501	PF01048	0.550
MOD_GlcNHglycan	53	56	PF01048	0.622
MOD_GSK3_1	134	141	PF00069	0.586
MOD_GSK3_1	204	211	PF00069	0.659
MOD_GSK3_1	375	382	PF00069	0.447
MOD_GSK3_1	58	65	PF00069	0.600
MOD_N-GLC_1	217	222	PF02516	0.440
MOD_NEK2_1	232	237	PF00069	0.550
MOD_NEK2_1	379	384	PF00069	0.455
MOD_NEK2_1	402	407	PF00069	0.462
MOD_NEK2_2	528	533	PF00069	0.324
MOD_PIKK_1	112	118	PF00454	0.517
MOD_PIKK_1	21	27	PF00454	0.715
MOD_PIKK_1	217	223	PF00454	0.441
MOD_PK_1	154	160	PF00069	0.375
MOD_PKA_2	134	140	PF00069	0.539
MOD_PKA_2	203	209	PF00069	0.453
MOD_PKA_2	375	381	PF00069	0.498
MOD_PKA_2	481	487	PF00069	0.451
MOD_PKB_1	152	160	PF00069	0.402
MOD_Plk_1	88	94	PF00069	0.512
MOD_Plk_2-3	514	520	PF00069	0.588
MOD_Plk_4	30	36	PF00069	0.556
MOD_Plk_4	402	408	PF00069	0.480
MOD_ProDKin_1	278	284	PF00069	0.668
MOD_ProDKin_1	365	371	PF00069	0.287
MOD_ProDKin_1	459	465	PF00069	0.600
TRG_DiLeu_BaEn_1	394	399	PF01217	0.543
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.531
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.554
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.426
TRG_ENDOCYTIC_2	84	87	PF00928	0.401
TRG_ER_diArg_1	142	144	PF00400	0.420
TRG_ER_diArg_1	222	225	PF00400	0.656
TRG_ER_diArg_1	245	247	PF00400	0.534
TRG_ER_diArg_1	303	305	PF00400	0.564
TRG_ER_diArg_1	328	331	PF00400	0.314
TRG_NES_CRM1_1	397	411	PF08389	0.538
TRG_NLS_MonoExtN_4	453	458	PF00514	0.459
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I200	Leptomonas seymouri	45%	90%
A0A0S4IXJ4	Bodo saltans	25%	100%
A0A3R7KNI1	Trypanosoma rangeli	30%	89%
A0A3S5H793	Leishmania donovani	78%	100%
A4HZA8	Leishmania infantum	78%	100%
E9AUY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QCJ4	Leishmania major	78%	100%
V5DGY6	Trypanosoma cruzi	29%	100%