Major vault protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major vault protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HBL9_LEIBR

TriTrypDb:

LbrM.21.0260 , LBRM2903_210007000

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.253
CLV_C14_Caspase3-7	294	298	PF00656	0.286
CLV_C14_Caspase3-7	381	385	PF00656	0.364
CLV_C14_Caspase3-7	83	87	PF00656	0.559
CLV_NRD_NRD_1	175	177	PF00675	0.183
CLV_NRD_NRD_1	311	313	PF00675	0.299
CLV_NRD_NRD_1	413	415	PF00675	0.273
CLV_NRD_NRD_1	52	54	PF00675	0.287
CLV_PCSK_KEX2_1	175	177	PF00082	0.161
CLV_PCSK_KEX2_1	311	313	PF00082	0.299
CLV_PCSK_KEX2_1	413	415	PF00082	0.299
CLV_PCSK_PC7_1	409	415	PF00082	0.278
CLV_PCSK_SKI1_1	436	440	PF00082	0.491
CLV_PCSK_SKI1_1	444	448	PF00082	0.633
CLV_PCSK_SKI1_1	8	12	PF00082	0.466
DOC_CKS1_1	189	194	PF01111	0.364
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.258
DOC_MAPK_gen_1	311	317	PF00069	0.319
DOC_MAPK_MEF2A_6	57	65	PF00069	0.332
DOC_PP4_FxxP_1	184	187	PF00568	0.383
DOC_PP4_FxxP_1	244	247	PF00568	0.219
DOC_USP7_MATH_1	118	122	PF00917	0.302
DOC_WW_Pin1_4	127	132	PF00397	0.363
DOC_WW_Pin1_4	188	193	PF00397	0.364
DOC_WW_Pin1_4	205	210	PF00397	0.218
DOC_WW_Pin1_4	459	464	PF00397	0.523
DOC_WW_Pin1_4	55	60	PF00397	0.322
DOC_WW_Pin1_4	97	102	PF00397	0.562
LIG_BIR_II_1	1	5	PF00653	0.761
LIG_BIR_III_2	89	93	PF00653	0.400
LIG_CtBP_PxDLS_1	467	471	PF00389	0.466
LIG_EVH1_2	66	70	PF00568	0.287
LIG_FHA_1	14	20	PF00498	0.372
LIG_FHA_1	164	170	PF00498	0.364
LIG_FHA_1	189	195	PF00498	0.364
LIG_FHA_1	248	254	PF00498	0.283
LIG_FHA_1	260	266	PF00498	0.380
LIG_FHA_1	32	38	PF00498	0.417
LIG_FHA_1	332	338	PF00498	0.432
LIG_FHA_1	356	362	PF00498	0.350
LIG_FHA_1	43	49	PF00498	0.361
LIG_FHA_1	430	436	PF00498	0.313
LIG_FHA_2	137	143	PF00498	0.295
LIG_FHA_2	148	154	PF00498	0.144
LIG_FHA_2	377	383	PF00498	0.459
LIG_FHA_2	384	390	PF00498	0.493
LIG_FHA_2	45	51	PF00498	0.306
LIG_LIR_Apic_2	113	118	PF02991	0.301
LIG_LIR_Gen_1	216	227	PF02991	0.264
LIG_LIR_Gen_1	25	31	PF02991	0.268
LIG_LIR_Gen_1	320	329	PF02991	0.237
LIG_LIR_Nem_3	129	135	PF02991	0.374
LIG_LIR_Nem_3	216	222	PF02991	0.400
LIG_LIR_Nem_3	25	29	PF02991	0.301
LIG_LIR_Nem_3	266	270	PF02991	0.211
LIG_LIR_Nem_3	320	325	PF02991	0.443
LIG_LIR_Nem_3	392	397	PF02991	0.364
LIG_LIR_Nem_3	45	49	PF02991	0.324
LIG_Pex14_1	115	119	PF04695	0.325
LIG_SH2_CRK	322	326	PF00017	0.256
LIG_SH2_CRK	407	411	PF00017	0.552
LIG_SH2_NCK_1	380	384	PF00017	0.364
LIG_SH2_PTP2	402	405	PF00017	0.364
LIG_SH2_SRC	26	29	PF00017	0.262
LIG_SH2_SRC	288	291	PF00017	0.269
LIG_SH2_SRC	402	405	PF00017	0.364
LIG_SH2_SRC	49	52	PF00017	0.383
LIG_SH2_STAP1	274	278	PF00017	0.262
LIG_SH2_STAP1	407	411	PF00017	0.268
LIG_SH2_STAT5	190	193	PF00017	0.383
LIG_SH2_STAT5	214	217	PF00017	0.208
LIG_SH2_STAT5	257	260	PF00017	0.373
LIG_SH2_STAT5	26	29	PF00017	0.279
LIG_SH2_STAT5	288	291	PF00017	0.256
LIG_SH2_STAT5	300	303	PF00017	0.289
LIG_SH2_STAT5	322	325	PF00017	0.503
LIG_SH2_STAT5	380	383	PF00017	0.537
LIG_SH2_STAT5	402	405	PF00017	0.474
LIG_SH2_STAT5	426	429	PF00017	0.303
LIG_SH2_STAT5	46	49	PF00017	0.305
LIG_SH3_1	460	466	PF00018	0.455
LIG_SH3_3	130	136	PF00018	0.347
LIG_SH3_3	162	168	PF00018	0.364
LIG_SH3_3	322	328	PF00018	0.229
LIG_SH3_3	393	399	PF00018	0.446
LIG_SH3_3	460	466	PF00018	0.551
LIG_SH3_3	60	66	PF00018	0.311
LIG_SH3_3	70	76	PF00018	0.237
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.241
LIG_SUMO_SIM_par_1	249	255	PF11976	0.247
LIG_SUMO_SIM_par_1	466	471	PF11976	0.464
LIG_TRAF2_1	177	180	PF00917	0.364
LIG_TRFH_1	132	136	PF08558	0.250
LIG_TRFH_1	349	353	PF08558	0.274
LIG_TYR_ITSM	318	325	PF00017	0.242
LIG_WRC_WIRS_1	81	86	PF05994	0.378
LIG_WW_1	404	407	PF00397	0.252
LIG_WW_3	65	69	PF00397	0.285
MOD_CDK_SPK_2	188	193	PF00069	0.177
MOD_CDK_SPxK_1	459	465	PF00069	0.504
MOD_CK1_1	100	106	PF00069	0.618
MOD_CK1_1	127	133	PF00069	0.283
MOD_CK1_1	14	20	PF00069	0.343
MOD_CK1_1	200	206	PF00069	0.268
MOD_CK1_1	452	458	PF00069	0.632
MOD_CK2_1	136	142	PF00069	0.289
MOD_CK2_1	147	153	PF00069	0.144
MOD_CK2_1	376	382	PF00069	0.275
MOD_CK2_1	383	389	PF00069	0.328
MOD_Cter_Amidation	309	312	PF01082	0.290
MOD_GlcNHglycan	1	4	PF01048	0.687
MOD_GlcNHglycan	13	16	PF01048	0.415
MOD_GlcNHglycan	215	218	PF01048	0.250
MOD_GlcNHglycan	317	320	PF01048	0.257
MOD_GlcNHglycan	454	457	PF01048	0.448
MOD_GSK3_1	102	109	PF00069	0.346
MOD_GSK3_1	149	156	PF00069	0.286
MOD_GSK3_1	163	170	PF00069	0.239
MOD_GSK3_1	259	266	PF00069	0.351
MOD_GSK3_1	288	295	PF00069	0.250
MOD_GSK3_1	355	362	PF00069	0.384
MOD_GSK3_1	448	455	PF00069	0.564
MOD_GSK3_1	92	99	PF00069	0.509
MOD_N-GLC_1	127	132	PF02516	0.286
MOD_N-GLC_2	33	35	PF02516	0.310
MOD_NEK2_1	110	115	PF00069	0.535
MOD_NEK2_1	13	18	PF00069	0.524
MOD_NEK2_1	317	322	PF00069	0.519
MOD_NEK2_1	468	473	PF00069	0.580
MOD_NEK2_1	96	101	PF00069	0.350
MOD_NEK2_2	106	111	PF00069	0.398
MOD_NEK2_2	383	388	PF00069	0.177
MOD_PIKK_1	317	323	PF00454	0.243
MOD_PIKK_1	355	361	PF00454	0.267
MOD_PKA_2	110	116	PF00069	0.288
MOD_PKA_2	124	130	PF00069	0.251
MOD_Plk_1	136	142	PF00069	0.289
MOD_Plk_2-3	153	159	PF00069	0.177
MOD_Plk_4	14	20	PF00069	0.402
MOD_Plk_4	141	147	PF00069	0.345
MOD_Plk_4	263	269	PF00069	0.240
MOD_Plk_4	345	351	PF00069	0.262
MOD_Plk_4	36	42	PF00069	0.270
MOD_Plk_4	44	50	PF00069	0.304
MOD_Plk_4	92	98	PF00069	0.306
MOD_ProDKin_1	127	133	PF00069	0.359
MOD_ProDKin_1	188	194	PF00069	0.177
MOD_ProDKin_1	205	211	PF00069	0.215
MOD_ProDKin_1	459	465	PF00069	0.525
MOD_ProDKin_1	55	61	PF00069	0.324
MOD_ProDKin_1	97	103	PF00069	0.558
MOD_SUMO_rev_2	2	10	PF00179	0.472
MOD_SUMO_rev_2	269	278	PF00179	0.250
TRG_DiLeu_BaEn_1	36	41	PF01217	0.307
TRG_DiLeu_BaEn_1	368	373	PF01217	0.203
TRG_DiLeu_BaEn_2	262	268	PF01217	0.209
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.265
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.273
TRG_ENDOCYTIC_2	219	222	PF00928	0.434
TRG_ENDOCYTIC_2	26	29	PF00928	0.256
TRG_ENDOCYTIC_2	270	273	PF00928	0.250
TRG_ENDOCYTIC_2	322	325	PF00928	0.214
TRG_ENDOCYTIC_2	407	410	PF00928	0.547
TRG_ER_diArg_1	174	176	PF00400	0.383
TRG_NES_CRM1_1	196	211	PF08389	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J1A8	Bodo saltans	31%	99%
V5BPE1	Trypanosoma cruzi	30%	85%